PQQ Powder

PQQ Powder Supplier:

Guanjie Biotech is specilizing in PQQ powder (Pyrroloquinoline Quinone Powder) researching, producing and trading for 20 years. We strictly follow the quality standards. The PQQ bulk Powder production management and production process are carried out under the ISO management system to ensure that the product's qualification. This is divided into pqq acid powder and pqq disodium salt powder. It is reddish brown powder and water-soluble. We test it by HPLC. You have multiple form choices – Disodium Salt & Acid form. As a professional supplier, we can provide high-quality products and services.

 

 

Why choose Guanjie Biotech?

● Innovative technology:

We focus on the development of patented natural products with 16 patented technologies.

● International Certification System:

Passed ISO9001, ISO22000, IP(non-GMO), QS, Kosher, Halal etc.

● A strict quality control system:

Almost all the testing items of the PQQ Powder were tested in-house. It includes the assay, water, Odor, Heavy Metals,solvent residue, pesticide residue, protein, microbiological, and so on.

● Professional shipping:

Professional shipping agents has cooperated with us for more than 20 years,ensure that the goods can be exported safely and quickly.

● Certificate:

ISO9001, ISO22000, IP(non-GMO), QS, Kosher, Halal, HACCP and 16 patents.

 

Specification

There are two reports. One is PQQ disodium salt, and the other is PQQ acid.

● Pyrroloquinoline Quinone Disodium Salt

Item	Specification	Result	Method
Basic Product Information
Country of Origin	China	Conform	/
Marker Compounds
Assay(dry basis )	98%	99.14%	HPLC
Organoleptic Data
Appearance	Powder	Conform	GJ-QCS-1008
Color	Reddish orange to Reddish brown	Conform	GB/T 5492-2008
Odor	Characteristic	Conform	GB/T 5492-2008
Taste	Salty	Conform	GB/T 5492-2008
Identification	Positive match with standard	Matches	/
Physical Characteristics
Particle Size 20 mesh)	98.0%pass 20mesh	Conform	GB/T 5507-2008
Moisture	<12%	5.26%	GB/T 14769-1993
Heavy Metals
Total Heavy Metals(as Pb)	<10 ppm	Conform	USP <231>, method II
Arsenic	<1.0 ppm	Conform	AOAC 986.15, 18th
Lead	<0.5 ppm	Conform	AOAC 986.15, 18th
Mercury	<0.1 ppm	Conform	AOAC 971.21, 18th
Cadmium	<1.0 ppm	Conform	AOAC 986.15, 18th
Pesticide Residue
666	<0.2ppm	Conform	GB/T5009.19-1996
DDT	<0.2ppm	Conform	GB/T5009.19-1996
Microbiology
Total Plate Count	<1,000cfu/g	Conform	AOAC 990.12, 18th
Total Yeast & Mold	<100cfu/g	Conform	FDA (BAM) Chapter 18, 8th Ed.
E. Coli	Negative	Negative	AOAC 997.11, 18th
Salmonella	Negative	Negative	FDA (BAM) Chapter 5, 8th Ed.

 

● PQQ Acid

Test Items	Parameters	Test Results
Appearance	Fine Powder	Complies
Color	Reddish orange to reddish brown	Complies
Taste	Sour	Complies
Identification	Positive match with standard	Matches
Assay(Dry Basis)	Not less than 98%	99.4%
Loss on drying	Not more than 12%	10.7%
Particle size	Not less than 99% through 20mesh	>99.0%
Heavy metals	Not more than 10ppm	<10ppm
As	Not more than 1.0ppm	Not detected
Cd	Not more than 1.0ppm	Not detected
Pb	Not more than 0.5ppm	Not detected
Hg	Not more than 0.1ppm	Not detected
Aerobic plate count	Not more than 1000cfu/g	<10cfu/g
Yeast&Mold	Not more than 100cfu/g	<10cfu/g
E.Coli	Negative	Negative
Salmonella	Negative	Negative
Country of Origin	China

 

Product Introduction:

Pyrroloquinoline quinone powder is a super antioxidant that occurs naturally in soil and PQQ Powder is also produced by soil bacteria, and plants are able to absorb it. Parsley and peppers in vegetables, kiwi and papaya in fruits, green tea and oolong tea in beverages, and tofu all contain about 30 ng/g, while natto has a higher PQQ content of 61 ng/g. PQQ is found in various tissues of the human body and is concentrated in breast milk (140 to 180 ng of PQQ in ml of breast milk) and is an essential growth factor for development.

 

PQQ Disodium Salt Flow Chart

Improved Crystal Form

 

 

 

Extraction Method:

Guanjie Biotech uses the chemical Synthesis method to produce PQQ Powder.

● It is more cost-effective and consistent.

● ~60% less in cost

● Ease of process expansion & controls.

● Improved physical attributes – less hygroscopic, higher purity

 

 

Crystallization remodeling:

Supported by the Chinese Academy of Sciences   ● Low hygroscopicity ●High stability ●Excellent storage ●Performance ●Wide application ●Prospect

Chromatographic conditions:

Equipment: HPLC

Mobile phase: 0.1 M CH3COOH: 0.1 M CH3COONH4 = 30 : 70 (pH 5.1)

Wavelength: 259 nm

Run time: 10 min

Flow rate: 1.5 mL/min

Injection volume: 20 ul

Detector: Ultraviolet (UV) detector

Chromatographic column: C18 (4.6 mm × 150 mm, 5μm)

Column temperature: 40°C

Solution preparation

 

● Test solution:

Accurately weigh 20 mg PQQ Powder of the analyte to be measured in a 50 mL volumetric flask, dissolve with mobile phase ultrasonication, dilute to the scale and mix well.

 

● Reference solution:

Accurately weigh 20mg of the reference standard in a 50mL volumetric flask, dissolve with mobile phase and dilute to the scale, mix well.

 

Record the chromatogram and peak area of each peak. Calculate the percentage of the main peak by area normalization method.

 

Excellent Quality and Traceable System

• High Resolution MS Data

• HPLC

 

Stability Data

 

Pure PQQ Disodium Salt Stability Study Report

Conditions: Temperature: 25±2℃ Humidity: 60±5％ Packaging: Foil bag with inner polyethylene liner

ITEM	LIMITS	TIME O	Month(s)
			3	6	9	12	18	24	36
Lot Number: 004-20110201
Appearance	Red to Reddish Brown	Reddish Brown	Reddish Brown	Reddish Brown	Reddish Brown	Reddish Brown	Reddish Brown	Reddish Brown	Reddish Brown
Moisture	≤12.0%	6.8%	6.6%	6.7%	6.9%	7.0%	7.2%	7.3%	7.5%
Assay	≥98.0%	99.4%	99.5%	99.2%	99.1%	99.0%	99.2%	99.0%	99.1%
Lot Number: 004-20110202
Appearance	Red to Reddish Brown	Reddish Brown	Reddish Brown	Reddish Brown	Reddish Brown	Reddish Brown	Reddish Brown	Reddish Brown	Reddish Brown
Moisture	≤12.0%	5.0%	5.2%	5.4%	5.5%	5.3%	5.2%	5.3%	5.6%
Assay	≥98.0%	99.6%	99.4%	99.5%	99.3%	99.6%	99.4%	99.2%	99.2%
Lot Number: 004-20110203
Appearance	Red to Reddish Brown	Reddish Brown	Reddish Brown	Reddish Brown	Reddish Brown	Reddish Brown	Reddish Brown	Reddish Brown	Reddish Brown
Moisture	≤12.0%	7.6%	7.8%	7.5%	7.9%	8.0%	8.2%	8.3%	8.5%
Assay	≥98.0%	99.7%	99.5%	99.8%	99.4%	99.5%	99.3%	99.2%	99.3%

 

PQQ Safety:

Third-party PQQ Powder certification by authoritative testing organizations in China   ● Acute toxicity test ● Ames test ● Micronucleus test ● Chromosomal aberration test

Benefits of Using PQQ Powder

1:Cardiovascular Support

● Supports energy (ATP) metabolism by the mitochondria.

● Provides powerful antioxidant protection from damaging free radicals.

 

2:Cognitive Support

● Prevents cognitive decline (memory loss, learning difficulty, etc.) due to age, stroke or neurodegenerative disorders.

● Protects and restores damaged brain and nerve cells.

 

3:Increased Energy Production

● Mitochondria produce ATP (Energy).

● PQQ Powder protects existing mitochondria and promotes mitochondrial generation.

● More functional mitochondria = more energy!

 

Function

● Improve the body's immune function

● Prevent and treat the liver damage, Can significantly reduce serum bilirubin, alanine aminotransferase levels, make liver function normal, regulate liver damage and have a very good curative effect on liver disease.

● Regulate various neurological diseases, PQQ Powder is a new kind of water-soluble vitamins, can promote the synthesis of neural factors in the human body, regulate various neurological diseases.

● Promote the absorption of amino acids, PQQ is the prosthetic group of quinone protease, participate in the respiratory electron transport chain, in the human body

through the effect of glucose, can promote the absorption of amino acids.

 

Principle of PQQ to enhance immunity
PQQ is a bioactive substance with a unique structure. Its molecular structure contains a pyrrole ring and a thiol group. This gives it strong antioxidant properties. In the human body, PQQ is widely available. It is mainly distributed in tissues such as liver, kidney and muscle. Studies have shown that PQQ Powder can improve immunity through a variety of ways, including the following:

 

● Promote immune cell activation
PQQ can stimulate the activation and proliferation of immune cells and enhance the resistance of the immune system. It is found that Pyrroloquinoline Quinone Powder can promote the activation and proliferation of immune cells such as macrophages, natural killer cells and T cells, thus improving immunity.

● Regulate the level of immune factors
PQQ can also regulate the level of immune factors, including tumor necrosis factor alpha (TNF-α), interleukin 6 (IL-6) and interferon gamma (IFN-γ). These immune factors play an important role in the immune response. the regulatory effect of PQQ can enhance immunity.

 

● Anti-inflammatory effect
Inflammation is a common reaction of the immune system against external invasion. However, excessive or prolonged inflammation may have negative effects on the body. Research has found that PQQ powder has an anti-inflammatory effect. It can reduce the inflammatory response by inhibiting the production of inflammatory factors. This anti-inflammatory effect may help regulate the function of the immune system and improve immunity.

 

Our Factory&Team:

Guanjie Biotech factory covers an area of 7000㎡, including a GMP standard workshop of 2000㎡ and an advanced lab of 500㎡. Our product and quality control center is beside our office, we have all kinds of testing machine, such as HPLC, GC, AAS ,melting point, specific optical rotation,bacterial detection,PH,Ash content, and so on. We are cooperating with several third-party parties such as SGS, Eurofin, UNQD to test our products and make a guarantee of the PQQ powder quality for the customers. We Tested The Assay, Water,odor, Heavy Metals ,solvent Residue,pesticide Residue,protein,microbiological, and so on.

 

Certification

Our factory and lab passed ISO9001, ISO22000, IP(non-GMO), QS, Kosher, Halal etc.

Package & Shipment

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