Best Resveratrol Powder

Best Resveratrol Powder Suppliers:

Guanjie Biotech specializes in Best Resveratrol Powder. We have three products: resveratrol, micronized resveratrol, water-soluble resveratrol. Micronized resveratrol is one of our advanced products. Our resveratrol is insoluble in water. It does not have a high absorption rate in the human body. Ordinary resveratrol particles are 100-500 microns. We use a matrix pulverizer to make it into tiny particles of 2-10 microns. This increases the absorption area by 1000 times, which can effectively increase the absorption rate of resveratrol by the human body.

Why Choose Guanjie Biotech ?

Guanjie researches an original method of combining macroporous resin with a fully enzymatic method.  We have the most advanced grinding technique in our country. And its industrial production is the first time in China, this method can not only obtain high-purity (≥99%) Resveratrol, but also reduce the amount of enzyme used and the cost. Best Resveratrol Powder of Guanjie Technology is our most powerful product,we have 2 producing lines and have the production capacity of Resveratrol 99% 20tons per year. We have been on this line for more than 20 years, there are more than 15 engineers in our team. We have got more than 14 patents for manufacturing of herbal extracts.We are one of the most professional herbal extract manufacturers and suppliers.  If you are intersted inour products, please contact us: info@gybiotech.com.

 

Price of Our Resveratrol:

Different Best Resveratrol Powder specifications have different prices, welcome to enquiry us: info@gybiotech.com.

● Resveratrol( Micronized)

● Natural Resveratrol 50%

● Natural Resveratrol 99%

● Water Soluble 10% Resveratrol

 

Advantages of Micronized Resveratrol, Resveratrol And Water Soluble Resveratrol:

1. Customized Micronized Resveratrol

The most powerful technique for our resveratrol is Micronized Resveratrol Powder. We can make it to micronized to<3µm (D50).It is micronized by a machine named-high-frequency vibration machine,which is used for grind gun powder for the war industry. Usually, most of high purity ingredient from herbs can be micronized easily, some kind of ingredient can be micronized to <5µm (D90), such as resveratrol, but if you do Particles size analysis, the data is not good, some Particles has static electricity, and they come together again, but we can test by electron microscope again.

We use Vibrator method to pulverize the product,Regarding micronization process,it is not the traditional- grinding and milling;we use Vibrator which can produce exciting force and can pulverize the product at the room temperature, Vibrator is the special machine of ordnance factory in our city(Xi'an Modern Chemistry Research Institute),it is specially use in pulverizing gunpowder, such as TNT.It is the Most advanced Grinding technique in our country.

 

The avarage micron size of this batch is as follows:
d(10%) 0.5μm( more than 10% particle diameter less than 0.5μm)
d(50%) 2.0μm( more than 50% particle diameter less than 2.0μm)
d(90%) 5.0μm( more than 90% particle diameter less than 5.0μm)

2. Resveratrol

Guan jie overcomes the problem of low Pure Trans best resveratrol powder content and we have developed an original method of combining macroporous resin with a fully enzymatic method. And its industrial production is the first time in China, this method can not only obtain high-purity (≥99%) Resveratrol, but also reduce the amount of enzyme used and the cost.

 

3.Water Soluble Resveratrol Powder

⑴.Introduction to raw material solubility:

a. Hydroxypropyl- β- Cyclodextrin: easily soluble in water, methanol, ethanol, etc;

b.Resveratrol: easily soluble in methanol, ethanol, ether, acetone, etc;

Our resveratrol another technique is water soluble resveratrol, it is use Hydroxypropyl-β-Cyclodextrin to embed resveratrol. The assay of water soluble resveratrol powder is about 10%.It is fit for make melting-tablets.

 

⑵.Molecular embedding technology principle:

Formation of inclusion complex: Cyclodextrin and its derivatives generally form inclusion complex through non-covalent combination of guest molecules and cavities. Inclusion reaction is a dynamic process. The guest molecules continue to recombine with cyclodextrins, but also continue to recombine. Hydroxypropyl cyclodextrin is easier to form an inclusion complex with suitable guest molecules than the original cyclodextrin, because hydroxypropyl substitution of 2, 3 hydroxyl H atoms increases the length of the cyclodextrin cavity, and the hydroxyl on hydroxypropyl may also form a new hydrogen bond with the guest molecules, increasing the stability of the inclusion complex. Most studies show that hydroxypropyl cyclodextrin and guest molecules mainly form 1:1 inclusion complexes, but there are also 2:1 inclusion complexes or oligomers.

Guest release: The inclusion complex formed by cyclodextrin and its derivatives with the guest is partly for the purpose of protection, slow release or solubilization. In this case, the guest molecule will eventually be released from the cyclodextrin. The main factors leading to or accelerating the release of guest molecules are concentration change and competitive substitution, and the influence of temperature and pH is small. When the concentration of the solution changes greatly, the customer will release in a very short time, and the cyclodextrin compound drug will be released quickly after injection into the body, which has almost no effect on the original pharmacology of the drug. When the binding constant of cyclodextrin and guest molecule is 10-4M-1, the decrease of concentration is enough to make the guest release. However, for the inclusion complex with high binding force, the effect of concentration gradually decreases, even has no effect, and competitive substitution becomes the main factor. Small molecules such as methanol and ethanol can competitively replace the guest of inclusion complex. The binding constant is determined by the properties of cyclodextrin and guest molecule. Hydroxypropyl cyclodextrin has a higher binding constant than the parent cyclodextrin.

 

⑶. Analysis:

The most effective way to achieve insoluble or insoluble matter (embedded matter) is to dissolve the embedded matter in another solvent with the same polarity to form a uniform molecular phase through the principle of similar phase solubility, and then transfer it into the solution of cyclodextrin by dropping it into the cavity of cyclodextrin, and form a stable complex by the van der Waals force of hydrogen bond, Or the complex that can stably exist between cyclodextrin and water has reached the purpose of embedding. Therefore, appropriate solvent can be selected for embedding operation according to the solubility of each component.

Hydroxypropyl- β- Cyclodextrin can be well dissolved in water, but also in methanol and ethanol.

Our goal is to dissolve the insoluble Best Resveratrol Powder in water through embedding technology, so the selection of solvent is very important. Methanol can be mixed with water in any proportion and can dissolve resveratrol.

 

⑷. Programme

Dissolve resveratrol bulk powder in methanol, and then slowly add it to hydroxypropyl- β- In the solution of cyclodextrin. By regulating hydroxypropyl- β- The amount of cyclodextrin, the volume ratio of water and methanol, temperature and pH value are used to obtain better embedding effect.

 

COA:

There are three COA about bulk resveratrol powder as following:

Resveratrol( Micronized)

Product Name: Resveratrol( Micronized)
Item	Specification	Result	Method
Basic Product Information
Genus and Species	Pohygonum cuspidatum Sieb et Zucc．	Conform	/
Part of the Plant	Root	Conform	/
Country of Origin	China	Conform	/
Marker Compounds
Assay(Trans-resveratrol)	>99.0%	99.76%	HPLC
Emodin	<0.07%	0.02%	HPLC
Organoleptic Data
Appearance	Fine Powder	Conform	/
Color	Off-white to light yellow	Conform	/
Odor	Characteristic	Conform	/
Taste	Characteristic	Conform	/
Process Data
Method of Processing	Extraction	Conform	/
Solvent(s) Used	Ethanol & Water	Conform	/
Drying Method	Vacuum drying	Conform	/
Excipient	None	Conform	/
Ratio of Extraction	100:1	Conform	/
Physical Characteristics
Solubility	Soluble in Alcohol	Conform	Visual
Particles size analysis	d(10%)	0.353μm	GB/T 5507-2008
d(50%)	1.392μm
d(90%)	2.951μm
Surface area mean diameter D【3,2】	2.423μm
Volume mean diameter D【4,3】	3.757μm
Size range	0.059-112.0 μm
Loss on drying	<1.0%	0.51%	GB/T 14769-1993
Ash Content	<1.0%	0.48%	AOAC 942.05, 18th
Solvent Residue	Eur Pharm (Alcohol)	298ppm	GJ-QCS-1007
Heavy Metals
Total Heavy Metals	<10 ppm	Conform	USP<231>, method II
As	<2.0 ppm	Conform	AOAC 986.15, 18th
Pb	<2.0 ppm	Conform	AOAC 986.15, 18th
Hg	<0.5 ppm	Conform	AOAC 971.21, 18th
Cd	<0.5 ppm	Conform	AOAC 971.21, 18th
Pesticide Residue
666	<0.2ppm	Conform	GB/T5009.19-1996
DDT	<0.2ppm	Conform	GB/T5009.19-1996
Microbiology
Total Plate Count	<1,000cfu/g	Conform	AOAC 990.12, 18th
Total Yeast & Mold	<100cfu/g	Conform	FDA (BAM) Chapter 18, 8th Ed.
E. Coli	Negative	Negative	AOAC 997.11, 18th
Salmonella	Negative	Negative	FDA (BAM) Chapter 5, 8th Ed.

 

Resveratrol

Product Name Resveratrol
Item	Specification	Result	Method
Basic Product Information
Genus and Species	Pohygonum cuspidatum Sieb et Zucc．	Conform	/
Part of the Plant	Root	Conform	/
Country of Origin	China	Conform	/
Marker Compounds
Assay(Trans-resveratrol)	>99.0%	99.65%	HPLC
Emodin	<0.07%	0.01%	HPLC
Organoleptic Data
Appearance	Fine Powder	Conform	NLS-QCS-1008
Color	Off-white to light yellow	Conform	GB/T 5492-2008
Odor	Characteristic	Conform	GB/T 5492-2008
Taste	Characteristic	Conform	GB/T 5492-2008
Process Data
Method of Processing	Extraction	Conform	/
Solvent(s) Used	Ethanol & Water	Conform	/
Drying Method	Vacuum drying	Conform	/
Excipient	None	Conform	/
Ratio of Extraction	100:1	Conform	/
Physical Characteristics
Melting point	253℃～255℃	254.6℃	GB21781-2008T
Solubility	Soluble in Alcohol	Conform	Visual
Particle Size (80 mesh)	>98.0% pass 80mesh	Conform	GB/T 5507-2008
Loss on drying	<2.0%	0.54%	GB/T 14769-1993
Ash Content	<1.0%	0.21%	AOAC 942.05, 18th
Solvent Residue	Eur Pharm	Conform	NLS-QCS-1007
Heavy Metals
Total Heavy Metals	<10 ppm	Conform	USP<231>, method II
As	<2.0 ppm	Conform	AOAC 986.15, 18th
Lead	<2.0 ppm	Conform	AOAC 986.15, 18th
Mercury	<0.5 ppm	Conform	AOAC 971.21, 18th
Pesticide Residue
666	<0.2ppm	Conform	GB/T5009.19-1996
DDT	<0.2ppm	Conform	GB/T5009.19-1996
Microbiology
Total Plate Count	<1,000cfu/g	Conform	AOAC 990.12, 18th
Total Yeast & Mold	<100cfu/g	Conform	FDA (BAM) Chapter 18, 8th Ed.
E. Coli	Negative	Negative	AOAC 997.11, 18th
Salmonella	Negative	Negative	FDA (BAM) Chapter 5, 8th Ed.

 

Water Soluble Resveratrol Powder

Product Name: Water Soluble Resveratrol Powder
Item	Specification	Result	Method
Basic Product Information
Genus and Species	Pohygonum cuspidatum Sieb et Zucc．	Conform	/
Part of the Plant	Root	Conform	/
Country of Origin	China	Conform	/
Marker Compounds
Assay(Trans-resveratrol)	>10.0%	11.56 %	HPLC
Organoleptic Data
Appearance	Fine Powder	Conform	/
Color	Off-white to light yellow	Conform	/
Odor	Characteristic	Conform	/
Taste	Characteristic	Conform	/
Process Data
Method of Processing	Extraction	Conform	/
Solvent(s) Used	Ethanol & Water	Conform	/
Drying Method	Vacuum drying	Conform	/
Carrier	Betacyclodextrin	Conform	/
Water Solubility	>0.08g/ml	Conform
Ratio of Extraction	100:1	Conform	/
Physical Characteristics
Solubility	Soluble in Alcohol	Conform	Visual
Particle Size (80 mesh)	>98.0% pass 80mesh	Conform	GB/T 5507-2008
Loss on drying	<2.0%	0.68%	GB/T 14769-1993
Ash Content	<1.0%	0.54%	AOAC 942.05, 18th
Solvent Residue	Eur Pharm	Conform	GJ-QCS-1007
Heavy Metals
Total Heavy Metals	<10 ppm	Conform	USP<231>, method II
As	<2.0 ppm	Conform	AOAC 986.15, 18th
Lead	<2.0 ppm	Conform	AOAC 986.15, 18th
Mercury	<0.5 ppm	Conform	AOAC 971.21, 18th
Pesticide Residue
666	<0.2ppm	Conform	GB/T5009.19-1996
DDT	<0.2ppm	Conform	GB/T5009.19-1996
Microbiology
Total Plate Count	<1,000cfu/g	Conform	AOAC 990.12, 18th
Total Yeast & Mold	<100cfu/g	Conform	FDA (BAM) Chapter 18, 8th Ed.
E. Coli	Negative	Negative	AOAC 997.11, 18th
Salmonella	Negative	Negative	FDA (BAM) Chapter 5, 8th Ed.

 

Flow Chart:

Testing report:

 

 

Area Percent Report:

 

Patents Production Process:

Guanjie Biology has studied pure best resveratrol powder for more than 20 years, and we have obtained two patents in the production process:

● A kind of protection device for extraction equipment
Patent No.: CN114632345A

The invention discloses a protective device for an extraction device, which comprises an extraction tank body, a placement box is fixedly arranged in the middle of the upper end of the extraction tank body, a rotary motor is fixedly arranged inside the placement box, an upper fixing frame is fixedly arranged at the upper end of the side wall of the rotary motor, a lower fixing frame is fixedly arranged at the lower end of the rotary motor, and a connecting bearing is fixedly arranged at the middle of the lower fixing frame, The output end of the rotary motor is fixedly connected with a rotary shaft through a connecting bearing, and the side wall of the rotary shaft is fixedly connected with a plurality of crushing knives. The invention discloses a protective device for extraction equipment, which can prevent the stress concentration between the equipment, avoid the damage of the parts inside the equipment, effectively fix and shock the motor, prevent the motor from producing large vibration when working, make the lower cutting knife run more stably, have higher safety performance, and prevent users from being burned by high-temperature steam leakage, further increase the safety of the device, which is worth promoting. It is worth popularizing to further increase the safety of the device.
 

● A kind of concentration equipment for easy disassembly
Patent No.: CN112843843A

The invention discloses a concentration device which is easy to disassemble, including a fixing ring plate and a cylinder. The fixing ring plate is located at the outer side of the cylinder, the inner fixing sleeve of the fixing ring plate is provided with a No. 2 fixing ring, the middle fixing sleeve of the cylinder is provided with a No. 1 fixing ring, and both sides of the No. 2 fixing ring are provided with bolts at the upper and lower ends of the fixing ring plate, One end of the four bolts close to the cylinder is threaded through the No. 2 fixing ring and sleeved at the inner end of the No. 1 fixing ring. A fixing seat is fixedly arranged at the center of the upper end face of the cylinder. A motor is fixedly arranged at the center of the upper end face of the fixing seat. The output end of the motor is fixedly connected with a rotation rod. The lower end of the rotation rod is penetrated through the fixing seat and the cylinder to the interior of the cylinder 19. The invention discloses a concentration device which is easy to disassemble, and the concentration device which is easy to disassemble is convenient to disassemble, saving time and labor.

 

Physical and chemical properties

Best Resveratrol Powder is Insoluble in water, soluble in ethanol, acetone and other organic solvents

 

Advantage

Wild raw material from Qinling mountain.Customized micronized powder and Water-soluble resveratrol.

 

Our factory:

There are two factories both in Baoji city and Shangluo City, Guanjie factories covers an area of 7000㎡, including GMP standard workshop of 2000㎡.

 

Product Qualification

Best Resveratrol Powder is produced in a clean working environment and every step is conducted by highly qualified professionals. Both the production processes of manufacture and the resveratrol 98 powder itself meet all international standards. And if you need our testing report, we can provide you.

 

Testing Center:

Both the production processes of manufacture and the product itself meet all international standards. And if you need our testing report, we can provide you.

 

Certification

We have obtained the NON-GMO by Pony test international group. And we get the certifications about HALAL,ISO 9001,ISO 22000,Kosher, PAHS,SC and so on.

 

 

Package&Warehouse:

 

Shipment:

DHL, FEDEX, Sea freight,Air freight you can choose.

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