Water-soluble Resveratrol

Water-soluble Resveratrol Supplier:

Guanjie Biotech is a professional water-soluble resveratrol supplier. We use advanced encapsulation technology to transform insoluble resveratrol into a highly bioavailable, water-dispersible form. Our product appears as an off-white powder. As a reliable partner in the nutraceutical and cosmetic industries, Guanjie Biotech ensures consistent quality, high solubility, and superior stability, meeting rigorous international standards for functional ingredient applications. Welcome to enquire with us at info@gybiotech.com.

What is Resveratrol?

Resveratrol is a polyphenol compound, mainly derived from peanuts1, grapes (red wine), Japanese knotweed, mulberries and other plants. Initially, resveratrol was only regarded as a plant antitoxin. Resveratrol is a plant antitoxin produced by grapes themselves during the growth process to prevent fungal infection. Since the "French Paradox" was proposed, many scientists have begun to study resveratrol in depth and found that resveratrol has anti-inflammatory and antioxidant effects. Subsequently, people found that water-soluble resveratrol has certain cardiovascular protection effects. The cardiovascular protection is because resveratrol can dilate blood vessels and has anti-inflammatory and free radical scavenging effects. However, these so-called antioxidant, anti-inflammatory and even cardiovascular protection effects were discovered by scientists in animal experiments.

COA

How to Produce Water-soluble Resveratrol?

Regarding water-soluble resveratrol, we applied molecular encapsulation technology, the specific techniques of which are as follows.

And our water-soluble resveratrol is molecular encapsulation. Specifically, first, let's discuss the solubility of the raw materials. Hydroxypropyl-β-cyclodextrin is quite soluble in water, methanol, and ethanol. Resveratrol, on the other hand, dissolves well in organic solvents like methanol, ethanol, ether, and acetone, but not in water.

What Exactly Is Molecular Encapsulation?

• Cyclodextrin

A cyclodextrin is like a hollow cage. It can hold resveratrol molecules. This inclusion isn't a fixed lock; it's a dynamic process-molecules go in and out, constantly changing. We use hydroxypropyl cyclodextrin because it's more effective than regular cyclodextrin. Why? Adding a hydroxypropyl group to the cyclodextrin is like lengthening the cage at both ends, creating more space and a more stable inclusion. Furthermore, the newly added hydroxyl group can form hydrogen bonds with resveratrol, further strengthening the inclusion complex. In most cases, one cyclodextrin encapsulates one resveratrol, but sometimes two encapsulate one, or more complex structures are formed.

• Release.

Our main purpose in inclusion complexes is to protect the resveratrol, improve its solubility, or control the release rate. Ultimately, the resveratrol still needs to be released from the "cage." What causes this release? Primarily, changes in concentration and competitive substitution. Temperature and pH have relatively little effect. For example, if the solution is diluted, the inclusion complex quickly releases the water-soluble resveratrol. Therefore, once injected into the body, it is released almost immediately, with little impact on efficacy. Generally, when the binding constant is below 10⁻⁴ mol/L, reducing the concentration is sufficient for release. However, if the binding is particularly strong, dilution alone is less effective; in this case, competitive substitution is necessary-small molecules such as methanol and ethanol can displace resveratrol from the "cage." The magnitude of the binding constant depends on the properties of the cyclodextrin and the guest molecule itself; hydroxypropyl cyclodextrin binds more tightly than ordinary cyclodextrin.

Analysis:

The most effective method for encapsulating sparingly soluble or insoluble substances (the encapsulated material) is based on the principle of "like dissolves like." This principle states that solvents with the same polarity can dissolve the encapsulated material in another solvent to form a homogeneous molecular phase. This phase is then added dropwise to a cyclodextrin solution for transfer, placing the encapsulated molecules within the cyclodextrin cavity. Stable complexes are formed through van der Waals forces and hydrogen bonds - complexes that can stably exist between cyclodextrin and water, thus achieving the water-soluble resveratrol encapsulation purpose. Therefore, a suitable solvent can be selected based on the solubility of each component for the encapsulation operation.

Hydroxypropyl-β-cyclodextrin is highly soluble in water and even more so in methanol and ethanol.

Our goal is to dissolve water-insoluble resveratrol in water using encapsulation technology, making solvent selection crucial. Methanol, being miscible with water in any proportion and capable of dissolving water-soluble resveratrol, is the preferred choice.

Plan:

The method involves dissolving water-soluble resveratrol in methanol and then slowly adding it dropwise to a solution of hydroxypropyl-β-cyclodextrin for encapsulation. Better encapsulation results are achieved by adjusting the amount of hydroxypropyl-β-cyclodextrin, the volume ratio of water to methanol, the temperature, and the pH value.

What Is Water-Soluble Resveratrol Powder Used For?

Water-soluble resveratrol powder solves the problem of traditional resveratrol's poor water solubility. With its excellent bioactivity and water dispersibility, it has broad application prospects in food, cosmetics, and pharmaceuticals.

Food and Health Foods
Resveratrol is a natural polyphenol compound with various bioactivities, including antioxidant, anti-aging, and free radical scavenging activities. Water-soluble resveratrol can be directly added to functional beverages, oral liquids, and other water-based food systems. The US market has launched non-alcoholic drinking water with added resveratrol; after a 9-month stability test, the resveratrol content reached 0.1% without degradation. Furthermore, water-soluble resveratrol can also be used in health food tablets and solid beverages, significantly improving their bioavailability.

Cosmetics
Water-soluble resveratrol is widely used in cosmetics, primarily in whitening and anti-aging products. It effectively inhibits tyrosinase activity, reduces pigmentation caused by ultraviolet radiation, and has a good effect on removing age spots. Meanwhile, resveratrol's strong antioxidant capacity can scavenge free radicals, inhibit lipid peroxidation, and delay skin aging. Water-soluble resveratrol prepared using cyclodextrin inclusion technology significantly improves the stability and dispersibility of the active ingredient in formulations, avoiding the precipitation problem common with traditional resveratrol.

Pharmaceuticals: Water-soluble resveratrol can be used in pharmaceutical preparations for the prevention and treatment of cardiovascular diseases, atherosclerosis, etc. Its excellent water solubility effectively improves the oral absorption rate and bioavailability of resveratrol, providing a technological basis for the development of novel pharmaceutical formulations.

In conclusion, water-soluble resveratrol powder, with its excellent solubility and stability, has become an important functional raw material in the food, cosmetics, and pharmaceutical fields.

 

User Evaluation

Ordinary resveratrol is insoluble in water, causing cloudiness and sediment in beverages. We switched to Guanjie Biotech's water-soluble resveratrol. The product is a white powder. HPLC analysis shows a stable content of 98%. The solution is clear and transparent after dissolution, with no noticeable bitterness. We use it in antioxidant beverages. After a 6-month stability test, the active ingredient retention rate exceeded 95%. Customer feedback has been positive. Guanjie Biotech provides a complete Certificate of Account (COA). Technical support ensures stable batches. A trustworthy supplier.

Hive 

 

Previously, the raw material used showed significant batch-to-batch variation and unstable water solubility. After switching to Guanjie Biotech's 50% specification, the mixing uniformity has significantly improved. The raw material is a white powder. It disperses quickly, requiring no special equipment. HPLC data is accurate. Our quality control workload has been greatly reduced. End-customer feedback indicates good absorption. Guanjie Biotech has stable delivery times and timely service response. We are now on our core supplier list.

Herry

 

The challenges of resveratrol lie in dissolution and transdermal absorption. After comparing multiple suppliers, Guanjie Biotech performed best. CAS No. 501-36-0, 98% purity. Dissolves easily in serum formulations. No additional solubilizers required. The finished product is refreshing and non-sticky. No precipitation or discoloration. Users reported improved skin radiance after four weeks. Guanjie Biotech not only provides high-quality water soluble resveratrol but also supports formulation development. Highly recommended.

Mark

 

Why is Resveratrol So Popular?

In the early 1990s, it was discovered that the French diet, rich in saturated fatty acids from meat and dairy products, was detrimental to heart health. However, the French had a very low incidence of cardiomyopathy. This phenomenon became known as the "French Paradox." Scientists compared the dietary habits of Americans and French people and found that the French consumed more red wine. This led to speculation that resveratrol in wine was the secret factor, and thus water-soluble resveratrol became popular. In recent years, resveratrol has become a popular health supplement. Besides Jeunesse Reserve, there are grape seed extract from Trunature (USA), resveratrol capsules from Celex (Canada), and Haiwei brand capsules, among others.

Company Advantages:

Certification

Package & Shipment

Hot Tags: water-soluble resveratrol, China water-soluble resveratrol manufacturers, suppliers, factory