Osthole Extract

Osthole Extract Supplier

Guanjie Biotech is a professional osthole extract supplier. We follow strict quality standards. Our products can be fully tested and verified. The raw material is the dried and mature fruit of umbelliferous plants. It is fully water-soluble. It dissolves in water clearly and transparently. There is no precipitation or suspended matter. Osthole extract is a traditional Chinese medicine ingredient. It is widely used in traditional medicine. Osthole extract powder helps to dispel dampness and wind. It also kills parasites and relieves itching. It can warm the kidney and support Yang energy. It is commonly used for vaginal itching, eczema, damp Bi syndrome, low back pain, kidney deficiency, impotence, and cold uterus infertility. High-quality and competitive price. Welcome to enquire with us at info@gybiotech.com.

 

 

COA

Item	Specification	Result	Method
Organoleptic Data
Appearance	Fine Powder	Conform	GJ-QCS-1008
Color	White or almost white	Conform	GB/T 5492-2008
Odor	Characteristic	Conform	GB/T 5492-2008
Taste	Characteristic	Conform	GB/T 5492-2008
Assay	97.0~103.0%	99.9%
Process Data
Method of Processing	Extraction	Conform	/
Solvent(s) Used	Ethanol & Water	Conform	/
Drying Method	Vacuum drying	Conform	/
Excipient	None	Conform	/
Physical Characteristics
Particle Size (100 mesh)	98.0%pass 100mesh	Conform	GB/T 5507-2008
Loss on Drying	<0.8%	0.3%	GB/T 14769-1993
Residue on ingition	<0.2%	0.1%
Ash Content	<5.0%	2.37%	AOAC 942.05, 18th
Heavy Metals
Total Heavy Metals	<10 ppm	Conform	USP<231>, method II
Arsenic	<2.0 ppm	Conform	AOAC 986.15, 18th
Mold	<100cfu	<10cfu
Aerobic Bacteria	<1000cfu	<10cfu
Residual Solvents	Eur.Pharm	Conform	AOAC 986.15, 18th
Pesticides	Negative	Conform	AOAC 971.21, 18th
Microbiology
E. Coli	Negative	Negative	AOAC 997.11, 18th
Salmonella	Negative	Negative	FDA (BAM) Chapter 5, 8th Ed.

 

How Is Osthole Extract Produced?

Osthole extract is produced through a controlled industrial extraction and purification process designed to ensure high purity, stable composition, and compliance with quality standards for use in nutraceuticals, pharmaceuticals, and functional formulations. The production workflow generally follows a multi-stage process that includes raw material selection, extraction, concentration, purification, crystallization, drying, and final packaging under clean production conditions.

• Raw material selection and pretreatment

The process begins with strict raw material selection and pretreatment. The dried fruits of Cnidium monnieri (source of osthole) are selected according to internal quality control standards. Non-medicinal parts, impurities, dust, and foreign materials are removed to ensure a clean and consistent feedstock. This step is critical because raw material quality directly influences yield, purity, and batch-to-batch stability of the final extract.

• Extraction stage

Next is the extraction stage, where the active compounds are separated from the plant matrix using a suitable solvent system, typically ethanol or hydroalcoholic solutions. The plant material is soaked and processed under controlled temperature and time conditions to maximize the dissolution of osthole and related coumarin compounds. After extraction, the mixture undergoes filtration, which removes solid residues and insoluble plant fibers, resulting in a clarified crude extract solution.

• Concentration phase

The filtered solution then enters the concentration phase, where solvents are partially removed under reduced pressure. This step increases the active ingredient concentration and produces a thicker intermediate known as the extractum. Vacuum concentration is commonly used to avoid thermal degradation of heat-sensitive compounds, ensuring the chemical integrity of osthole is preserved.

• Clarification and purification

Following concentration, the material undergoes clarification and purification, often involving rough settling and centrifugation. These steps remove additional suspended particles and trace impurities, resulting in a cleaner crude product. At this stage, the extract is more stable but still contains a mixture of related compounds and minor impurities.

• Crystallization

The next key stage is crystallization, where osthole is selectively separated from the mixture based on solubility differences. By carefully controlling temperature, solvent composition, and cooling rate, osthole is induced to form crystals. This is a critical purification step that significantly enhances product purity and defines the final chemical quality of the extract.

• Drying

Once crystallization is complete, the material is processed through drying, typically at controlled temperatures of around 75°C–80°C. Proper drying ensures the removal of residual moisture and solvents while maintaining compound stability. After drying, the material is milled into a fine powder with a controlled particle size, often standardized to around 80 mesh for uniform dispersion and ease of formulation.

• Packaging

The final steps include split charging, inner packaging, and outer packaging. These operations are carried out in a clean area environment to prevent contamination. Strict hygiene and environmental controls are maintained throughout packaging to ensure product safety, stability, and compliance with industrial standards. Finally, the finished osthole extract is stored under appropriate conditions to preserve its physicochemical properties.

Overall, the production of natural osthole extract combines traditional plant processing with modern separation and purification technologies. Each step-from raw material selection to final packaging-is carefully controlled to ensure high purity, consistent quality, and suitability for use in pharmaceutical and health product applications.

 

FAQs:

1. What is Osthole Extract and what are its main applications?

Osthole Extract is a natural coumarin compound derived from the dried mature fruit of Cnidium monnieri (She Chuang Zi). It is widely used in traditional Chinese medicine and modern health applications. Osthole is known for its properties in supporting dampness elimination, antipruritic effects, and immune balance. It is commonly used in formulations targeting skin discomfort such as eczema and itching, as well as conditions related to kidney deficiency, damp Bi syndrome, and reproductive health support. Due to its high purity and stability, it is suitable for nutraceutical and pharmaceutical applications.

2. How is the quality of Osthole Extract ensured?

Our Osthole Extract is manufactured under strict quality control systems and is fully compliant with international standards such as ISO, HALAL, KOSHER, and GMP requirements. Each batch is tested using advanced analytical equipment, including HPLC, GC-MS, UV, and Atomic Absorption spectroscopy. The product meets strict specifications for purity (≥99%), heavy metals, microbial limits, pesticide residues, and residual solvents. A comprehensive COA (Certificate of Analysis) is available for every shipment to ensure transparency and consistency.

3. What forms of Osthole Extract are available for purchase?
It is commonly supplied as a brown to light yellow powder or concentrated crystalline form. Some Osthole Extract suppliers also offer water-dispersible or customized formulations for specific applications. If you need, our team can provide you high-quality osthole extract.

4. What is the typical minimum order quantity (MOQ) when buying Osthole Extract?
MOQ varies by manufacturer, but for bulk B2B supply it is usually 1 kg to 25 kg for sample or pilot orders, and 25 kg to 100 kg+ for standard wholesale orders.Guanjie Biotech also can provide you free sample.

5. How can I ensure stable quality when sourcing Osthole Extract long-term?
Work with suppliers that provide batch-to-batch consistency reports, standardized extraction processes, and traceable raw material sourcing. Regular third-party testing is also recommended for quality assurance.

6. What purity levels are commonly available for Osthole Extract?
Industrial-grade Osthole Extract is typically available in purity ranges from 10% to 98% osthole content. Higher purity is usually required for pharmaceutical or high-end nutraceutical applications.

 

 

 

Our factory:

There are two factories both in Baoji city and Shangluo City, Guanjie factories covers an area of 7000㎡, including GMP standard workshop of 2000㎡.

 

Product Qualification

Osthole bulk extract is produced in a clean working environment and every step of the process is conducted by highly qualified professionals.

 

Our Testing Equipment:

In order to ensure the quality of our products, UV,HPLC,GC,GC-MS/MS,Atomic Absorption and other equipments that we uses.

Testing Center:

Both the production processes of manufacture and the product itself meet all international standards. And if you need our testing report, we can provide you.

 

Certification

We have obtained the NON-GMO by Pony test international group. And we get the certifications about HALAAL,ISO 9001,ISO 22000,Kosher, PAHS,SC and so on.

 

Package&Warehouse:

 

Payment term

We accept L/C, D/A, D/P, T/T, Western Union, MoneyGram, Paypal.

 

Delivery term

● Dhl

● Fedex

● Sea freight

● Air transport

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