Pure Quercetin Powder

Pure Quercetin Powder Supplier:

Guanjie Biotech specializes in pure quercetin powder, which is from Sophora Japonica L.. It is yellow powder with the assay of 95% HPLC, 98% UV. Quercetin powder is practically insoluble in water and soluble in aqueous alkaline sol.. Each batch of our products is same quality. Welcome to enquire at info@gybiotech.com.

Why choose Guanjie Biotech?

1. We guarantee the quality is in conformity with the Certificate of Analysis provided by us, if not, we accept 100% exchange, return back and refund.

2. Our pure quercetin powder products are certified with ISO 9001, SC, KOSHER, HALAL, and HACCP.

3. Our factory makes sure the product quality steps:

First of all, we will prepare samples for approval.

Secondly, after getting approved, our team will set up a process craft and form an inside drawing to follow it.

Thirdly, during production, we have FQC, IQC, IPQC, and OQC to control the quality.

4. Warehouse in NJ, USA;

5. Our company has an independent research and development center; there are 10 experts in our research team.

Specification

TEST ITEM	SPECIFICATION	RESULTS
Appearance	Yellow powder	Yellow powder
Identification	Must positive	Complies
Solubility	Practically insoluble in water	Complies
	Soluble in aqueous alkaline sol.	Complies
Loss on drying	≤4.0%	2.1%
Residue on ignition	≤0.5%	0.28%
Mesh size	100% pass 80 mesh	Complies
Assay (on dry product)	≥95.0%(HPLC method)	95.7%
	≥98.0%(UV method)	Complies
Heavy Metal	≤10ppm	<10ppm
Cadmium	≤1ppm	Complies
Lead	≤3ppm	Complies
Mercury	≤0.1ppm	Complies
Arsenic	≤1ppm	Complies
Total plate count	≤1000CFU/g	Complies
Yeast & Mould	≤100CFU/g	Complies
E.Coli	Absent	Absent
Salmonella	Absent	Absent
Storage	Preserve in well-closed, dark, cool and dry place.
Conclusion	Comply with all standards.

 

Flow Chart

Production Process

Guanjie Biotech specializes in producing high-purity quercetin powder extracted from Sophora japonica, a well-known botanical source rich in quercetin glycosides. The alcohol solvent extraction method is a proven technique to efficiently isolate pure quercetin powder while ensuring product safety and bioactivity.

Raw Material Preparation

The process begins with sourcing high-quality Sophora japonica flower buds, which contain abundant quercetin derivatives. Guanjie Biotech carefully selects raw materials that meet stringent botanical identification and quality standards to ensure high flavonoid content and minimal impurities.

Once received, the Sophora japonica material undergoes thorough cleaning to remove dirt, foreign matter, and any residual contaminants. The cleaned botanical material is then dried under controlled temperature conditions to reduce moisture content to below 10%, optimizing extraction efficiency and preventing microbial growth.

After drying, the material is pulverized into a fine powder to increase the surface area, facilitating more effective solvent penetration during extraction.

 

Alcohol Solvent Extraction

The primary extraction step uses food-grade ethanol as the solvent due to its excellent safety profile, efficiency in dissolving flavonoids, and compliance with regulatory requirements.

•Extraction Conditions:
The pure quercetin powder powdered Sophora japonica is mixed with a 60-70% ethanol solution at a controlled solid-to-liquid ratio (typically 1:10 to 1:15 w/v). The mixture is heated to 60-70°C and maintained for 2 to 4 hours under continuous stirring. This temperature range balances optimal quercetin solubility and minimizes thermal degradation.

•Multiple Extraction Cycles:
To maximize yield, the extraction is often repeated 2-3 times. After each cycle, the ethanol extract is separated from the solid residue via filtration.

•Filtration:
The liquid extract undergoes fine filtration to remove particulate impurities, plant fibers, and residual solids, producing a clarified quercetin-rich ethanol solution.

 

Concentration and Purification

The ethanol extract contains a mixture of quercetin and other flavonoid compounds, pigments, and non-flavonoid constituents. To concentrate the quercetin and remove impurities, Guanjie Biotech uses the following purification step to get pure quercetin powder.

•Rotary Evaporation:
The filtered ethanol solution is concentrated under reduced pressure using a rotary evaporator at 50-60°C to remove the bulk of ethanol and water, resulting in a thick quercetin extract.

•Solvent Partitioning:
The concentrated extract may be subjected to solvent partitioning with non-polar solvents like petroleum ether to remove fats, chlorophyll, and other non-polar impurities, leaving a flavonoid-rich fraction.

•Recrystallization:
To achieve high purity, recrystallization is performed by dissolving the concentrate in a suitable solvent (e.g., hot ethanol) and then cooling slowly to precipitate pure quercetin crystals.

 

Drying and Milling

The purified quercetin crystals are collected by filtration and washed to remove residual solvents and impurities. The crystals are then dried in a vacuum oven or fluidized bed dryer at controlled low temperatures (below 60°C) to eliminate moisture while preserving bioactivity.

The dried quercetin crystals are subsequently milled into a fine pure quercetin powder, achieving the desired particle size suitable for diverse applications in dietary supplements, pharmaceuticals, and cosmetics.

 

Quality Control and Packaging

At Guanjie Biotech, strict quality control protocols are implemented at every stage to ensure the purity, potency, and safety of the final quercetin powder.

•Purity Testing:
High-performance liquid chromatography (HPLC) is employed to quantify quercetin content and verify purity, which typically exceeds 95-98%.

•Microbial Testing:
The product is tested for microbial contaminants to meet pharmacopeial standards.

•Residual Solvent Analysis:
Gas chromatography (GC) ensures residual ethanol and other solvent levels are within safe limits.

•Heavy Metals and Pesticides:
The final product undergoes rigorous screening to confirm compliance with international safety standards.

Once validated, the pure quercetin powder is packaged in moisture-proof, light-resistant containers to maintain stability and shelf life during transportation and storage.

 

Guanjie Biotech offers a high-purity, safe, and bioactive pure quercetin powder that meets the demanding needs of global nutraceutical and pharmaceutical markets.

 

Our Factory

 

Certification

Factory Equipment & Laboratory Detection

Package & Shipment

 

 

 

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