Alpha-Ketoglutaric Acid AKG Powder

Alpha-Ketoglutaric Acid AKG Powder Supplier:

Guanjie Biotech is one of the Alpha-Ketoglutaric Acid AKG Powder suppliers. Alpha-Ketoglutaric Acid Powder is also called AKG powder. It is an important biological compound, commonly used in various industrial and health fields. Guanjie Biotech is an Alpha-Ketoglutaric Acid Powder manufacturer. It is a high-purity white crystalline powder with excellent solubility, easily soluble in water. From raw material to final product, we control the quality strictly.  Welcome to enquire with us at info@gybiotech.com.

 

COA: 

Product NAME：AKG
QUANTITY：5000 KG		Production date：2025.03.26
Batch No：20250326		Report date：2025.03.29
Standard：usp		Shelf life：2 years
Tests	Limits		Test results
Description	white or almost white crystals or crystalline powder		Conform
Assay(HPLC)	≥98%		99.69%
Melting point	113~117℃		114~116℃
Fe	≤10ppm		Conform
Transmittance	≥97%		98.4%
Loss on drying	≤0.50%		0.23%
Residue on ignition	≤0.2%		0.06%
Heavy Metals	≤10ppm		Conform
Arsenic	3ppm		Conform
Conclusion: Conforms with USP standard strictly

What Is the properties of Alpha-Ketoglutaric Acid AKG Powder?

Alpha-Ketoglutaric Acid AKG Powder contains two carboxyl groups and one ketone group. Its chemical formula is C5H6O5, and its molecular structure consists of one ketone group and two carboxyl groups. The AKG powder produced by Guanjie Biotech is a white crystalline powder. Alpha-Ketoglutaric Acid AKG Powder is soluble in water due to the strong hydrophilic groups in its molecule. Additionally, AKG has low acidity and does not decompose easily, making it suitable for use in various formulations and applications.

 

 

 

What Are Alpha-Ketoglutaric Acid Functions?

The Alpha-Ketoglutaric Acid AKG Powder has multiple important mechanisms of action in the body. As a key intermediate in the tricarboxylic acid cycle (TCA cycle), AKG not only provides energy for cells but also participates in protein and amino acid metabolism, exhibits antioxidant effects, supports cellular repair, and aids in immune regulation.

1. Basic Mechanisms of Action

• Promotes energy metabolism

Alpha-Ketoglutaric Acid AKG Powder is an important intermediate product in the tricarboxylic acid cycle, which helps cells produce ATP by facilitating chemical reactions in the cycle. It is the main source of cellular energy. As a key node in the cycle, the presence of AKG helps increase the metabolic efficiency of cells, providing an adequate energy supply to the organs and tissues in the body. This mechanism is particularly important during high-energy demand situations, such as high-intensity exercise or increased stress. By supporting cellular ATP production, AKG plays a fundamental role in maintaining the body's physical and metabolic balance.

• Supports mitochondrial function

Mitochondria are the energy factories of the cell. AKG plays an important role in maintaining mitochondrial function. After entering the mitochondria, Alpha-Ketoglutaric Acid AKG Powder participates in the tricarboxylic acid cycle, providing key substrates for energy production. Studies have shown that alpha-ketoglutaric acid (AKG) powder improves mitochondrial efficiency by protecting mitochondrial DNA from oxidative damage and slowing cellular aging. This enhances overall cellular viability.

 

2. Antioxidant effects

• Fights oxidative stress

Alpha-Ketoglutaric Acid AKG Powder plays an important antioxidant role in the body. It effectively scavenges reactive oxygen species (ROS) and other free radicals from cells. Under oxidative stress, excess free radicals attack DNA, proteins, and lipid molecules in cells, causing damage and accelerating aging. AKG, as a potent antioxidant, reacts with free radicals and neutralizes them, protecting cells from oxidative stress. It has been found that Alpha-Ketoglutaric Acid AKG Powder reduces oxidative stress in cells by lowering the levels of oxidative damage markers, which plays a positive role in preventing aging and chronic diseases.

• Protects DNA and proteins

AKG protects intracellular DNA and proteins from free radical attacks through its antioxidant mechanism. This protective mechanism is important in preventing genetic mutations, maintaining normal cellular function, and slowing down aging. The role of antioxidants is to delay or prevent oxidative damage to cellular components. Alpha-Ketoglutaric Acid AKG Powder plays a dual role in this process. It not only neutralizes free radicals but also maintains the stability of cell structure and function by enhancing the cell's self-repair mechanism. Therefore, the antioxidant effect of AKG is particularly effective in cell repair and aging retardation.

 

3. Amino acid metabolism regulation

• Promotes amino acid synthesis and transport

Alpha-Ketoglutaric Acid AKG Powder is one of the core molecules of amino acid metabolism in the body. In particular, it plays a key role in the metabolism of glutamate and glutamine. As an important nutrient for cell division and growth, glutamine is vital for the health of immune cells, intestinal cells, and muscle cells. AKG, as a precursor substance of glutamine, promotes its synthesis in the body, enhancing cellular function. In addition, alpha-ketoglutaric acid bulk powder participates in amino acid transport and synthesis through transamination, making the process of amino acid metabolism in the body more balanced and efficient.

•Reduces Ammonia Accumulation

During amino acid metabolism, the body produces ammonia, a nitrogenous waste product. AKG can help reduce the accumulation of ammonia by combining with it to form glutamic acid, which can have toxic effects on the nervous system and other tissues, thereby preventing ammonia toxicity. Additionally, Alpha-Ketoglutaric Acid AKG Powder promotes the urea cycle, helping the body excrete ammonia effectively. It reduces the toxic effects of ammonia in the body. For patients with impaired liver function or renal insufficiency, AKG is significantly effective in supporting ammonia metabolism and maintaining nitrogen balance.

 

4.Protective Effects on Muscles

• Enhances Muscle Synthesis

Alpha-Ketoglutaric Acid AKG Powder can also promote muscle protein synthesis by enhancing the availability of amino acids in the body, particularly key amino acids such as leucine. It stimulates muscle cell protein synthesis, which helps maintain muscle mass and stamina. Alpha-ketoglutaric acid (AKG) powder has become an important supplement ingredient for both the elderly population and athletes. In addition, Alpha-Ketoglutaric Acid AKG Powder effectively supports muscle synthesis and repair by boosting ATP production efficiency and providing cells with sufficient energy.

• Immune System Regulation

AKG is an important nutrient for many types of immune cells. In particular, the proliferation and activity of immune cells, such as leukocytes and macrophages, require sufficient energy and amino acid support. Alpha-Ketoglutaric Acid AKG Powder provides key nutrients for immune cells, promotes their proliferation and activity, and enhances the body's immune defense capabilities. Furthermore, AKG bulk powder helps immune cells function more effectively in response to pathogens or infections by improving mitochondrial function.

• Regulating Immune Response

AKG can also influence the immune response by regulating the release of cytokines and immune mediators. In inflammatory responses, Alpha-Ketoglutaric Acid AKG Powder reduces tissue damage by inhibiting the production of inflammatory cytokines and alleviating the body's excessive immune response. For chronic inflammation or autoimmune diseases, AKG can be used as a co-modulator. Alpha-ketoglutaric acid (AKG) powder helps the body restore immune homeostasis and reduce the negative impact of inflammation on health.

 

5. Potential of AKG in Anti-Aging and Disease Protection

• Anti-Aging Effects

As we age, Alpha-Ketoglutaric Acid AKG Powder levels decline, and the efficiency of the tricarboxylic acid cycle decreases, which affects mitochondrial function and accelerates the aging process. AKG supplementation can slow the age-induced decline in mitochondrial function and improve cellular energy production, thereby slowing down the aging process. Additionally, Alpha-Ketoglutaric Acid AKG Powder reduces free radical and oxidative stress damage through antioxidant mechanisms, helping to extend cellular lifespan and reduce the risk of aging-related diseases.

 

• Role in Chronic Disease Protection

Alpha-Ketoglutaric Acid AKG Powder also has great potential in the protection against chronic diseases. For example, patients with metabolic diseases such as diabetes and hypertension often suffer from increased oxidative stress and imbalances in cellular metabolism. AKG supports mitochondrial function, reduces oxidative stress, and supports amino acid metabolism. Alpha-ketoglutaric acid (AKG) powder may help patients improve their overall metabolic function and reduce the incidence of chronic diseases.

 

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