Sodium Hyaluronate Powder Bulk

What is sodium hyaluronate?

Guanjie Biotech is a Sodium Hyaluronate Powder Bulk supplier. It appears as a white granule or powder and is water-soluble. Bulk Sodium Hyaluronate Powder is insoluble in ethanol, acetone, or ether. It dissolves in water to form a clear solution with viscoelastic properties. This solution is a non-Newtonian fluid with a consistency much greater than that of saline. Its molecular form and physicochemical properties vary depending on the molecular weight. Sodium hyaluronate is found throughout the body. It is composed of repeating disaccharide units made up of glucuronic acid and N-acetylglucosamine. These disaccharide units undergo polymerization to form a high molecular weight linear mucopolysaccharide. Its chemical formula is (C₁₄H₂₀NO₁₁Na)ₙ. Sodium hyaluronate is a type of mucopolysaccharide.

 

COA:

Test Items	Standard	Result
Appearance	White powder	White powder
Sodium Hyaluronate	≥90%	99.10
Glucuronic acid	≥43%	48%
Molecular weight	0.8-1.6X 106	1.1X 106
PH	6.0-8.0	7.2
Loss on drying	<10%	4.1%
Particle Sizk	0.15-0.25	Complies
Heavy metal	<20ppm	Complies
Arsenic	<2ppm	Complies
Heat remaining strong	≤13.0%	12.0%
Bacterial counts	<1000cfu/g	Complies
Mold and Yeast	<100cfu/g	Complies
Staphylococcus aureus	Can not be checkout	Complies
Chlorop seu domonas	Can not be checkout	Complies

 

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Sodium Hyaluronate & Hyaluronic Acid Differences

Sodium hyaluronate ≠ Hyaluronic acid
Sodium Hyaluronate Powder Bulk is the sodium salt of hyaluronic acid.

Although it is common to refer to sodium hyaluronate as hyaluronic acid, the two are not the same substance. Hyaluronic acid (HA), also known as vitric acid, is widely found in living organisms. Its commonly used form is sodium hyaluronate (SH), which is often referred to as hyaluronic acid as well.

Hydrolyzed sodium hyaluronate has a much lower molecular weight, allowing it to be absorbed into deeper layers of the body. Meanwhile, sodium hyaluronate possesses immune-regulating and anti-inflammatory properties, lubricates joints, and helps to beautify and nourish the skin.

 

Molecular weight size

The skin care function of Sodium Hyaluronate Powder Bulk mainly depends on the molecular weight and dosage. Commonly used sodium hyaluronate are:

◆ Ultra-micro sodium hyaluronate (molecular weight less than 10,000 Da)

◆ Small molecule sodium hyaluronate (molecular weight 10,000Da-1,000,000Da)

◆ Medium molecule sodium hyaluronate (molecular weight 1,000,000Da-1,800,000Da)

◆ Sodium hyaluronate macromolecule (molecular weight >1.8 million Da)

 

Sodium hyaluronate with molecular weight above 2,000,000 Da is mainly used for water storage and moisturising, UV protection, etc. 1,200,000-1,600,000 Da is the most commonly used sodium hyaluronate with the highest cost-effectiveness. 200,000-400,000 Da is based on the conventional molecular weight and its molecular weight is lowered by enzyme dissolution, which increases its fluidity. It plays a better moisturising effect in serums. Molecular weight of 10,000 Da or less can penetrate into the stratum corneum of the skin to achieve the function of deep hydration.

 

Functions:

◆ Beauty and Antioxidant Effect

Sodium Hyaluronate Powder Bulk can effectively improve the skin cell survival microenvironment and induce cell proliferation and differentiation. If the skin is exposed to the sun after reddening, blackening, and peeling, sodium hyaluronate powder can promote the proliferation and differentiation of epidermal cells. It also helps regenerate the injured parts of the skin and penetrates into the skin to assist in the metabolism of waste, accelerating cell renewal and metabolism, and enhancing the skin's resistance. This revitalizes the skin and provides a cosmetic benefit.

Sodium hyaluronate in skin care products has antioxidant properties, including reducing UV-induced apoptosis and acid-induced DNA damage. Both in vivo and in vitro, the hydroxyl functional group of hyaluronic acid absorbs reactive oxygen species to scavenge free radicals.

◆ Promotes Wound Healing

Sodium hyaluronate promotes cell proliferation and has beneficial pharmacological effects on wound healing. During the wound healing process, Sodium Hyaluronate Powder Bulk can accelerate wound healing by promoting cell proliferation at the wound site and may also participate in regulating angiogenesis.

◆ Improvement of Inflammatory Response

Sodium hyaluronate exhibits anti-inflammatory activity and can effectively reduce the expression of inflammatory factors, thereby inhibiting related inflammation. Clinically, sodium hyaluronate is often used as a joint cavity injection drug for treating knee osteoarthritis. Studies have shown that when sodium hyaluronate is injected into the joint cavity, it can bind to glycoproteins in the joint cavity to form aggregates. This inhibits the role of glycoproteins in the inflammatory response, slows the degeneration of articular cartilage, promotes the repair of cartilage damage, and reduces inflammation.

◆ Sodium Hyaluronate Moisturizer

The molecular structure of Sodium Hyaluronate Powder Bulk is quite unique. Part of the sub-chains of monosaccharides and monosaccharides are held together by hydrogen bonding, which gives its spatial structure a rigid columnar spiral shape. A large number of hydroxyl groups are present on the inner side of the column. Water molecules bind to hyaluronic acid molecules through polar and hydrogen bonds, enabling sodium hyaluronate to absorb and retain large amounts of water. Different molecular weights of sodium hyaluronate have varying water retention functions. For skin moisturization, ultra-micro sodium hyaluronate, with an extremely small molecular weight, can penetrate the skin to reach its deeper layers. It enhances moisture content within the skin, regulates its metabolism, and improves skin radiance and suppleness. High molecular weight sodium hyaluronate forms a transparent hydration film on the skin's surface, preventing internal water loss. Additionally, compared to other humectants, Sodium Hyaluronate Powder Bulk absorbs the highest amount of moisture in low humidity environments and the least amount in high humidity environments. This unique property makes it adaptable to the skin's needs in different seasons and humidity levels, providing effective moisturizing and nourishing benefits.

 

◆ Regulates water balance and improves skin hydration

Hyaluronic acid is widely found in human skin tissues. Its molecular structure contains many hydrogen bonds and is spatially rigid in the shape of a helical column. The presence of a large number of hydroxyl groups on the inside allows the binding of a large number of water molecules. And these water molecules are very strong within the column, with good water absorption and safety.

 

The reason why the water content of the skin gradually becomes less is that the activity of fibroblasts decreases drastically with age. Its secretion of Sodium Hyaluronate Powder Bulk also decreases dramatically. Sodium hyaluronate ingested externally can be broken down into oligosaccharides by bacteria in the cecum. It is absorbed through the colon into the blood or lymph into the skin throughout the body, increasing fibroblast activity. This causes fibroblasts in the dermis to secrete and produce hyaluronic acid, thus keeping the water content in the skin relatively stable.

 

Applications

◆ Medical Beauty

Sodium Hyaluronate Powder Bulk has a high level of safety as the main component of the extracellular matrix of animal connective tissue. And sodium hyaluronate has a certain viscosity after absorbing water. 1% sodium hyaluronate aqueous solution presents gel-like. It can be used as a filler in cosmetic surgery.

 

◆ Clinical treatment

Sodium Hyaluronate Powder Bulk has the characteristics of natural, degradable and good absorption. It has a wide range of clinical uses. Sodium hyaluronate has good viscoelasticity. It can effectively prevent the occurrence of postoperative shallow anterior chamber complications, delayed blister leakage after trabeculectomy and other ocular diseases. It is more widely used in eye surgeries such as cataract surgery, IOL transplantation and corneal transplantation.

 

◆ Food

Hyaluronic acid is used in cosmetology to moisturise the skin, enhance skin elasticity and prevent skin aging. However, as a biological macromolecule, it is not easy to be absorbed externally. And the degradation of hyaluronic acid into small points (1~5)x105 orally. It is absorbed through the intestine in vivo degradation into monosaccharide, can increase the body synthesis of hyaluronic acid required precursor.

At present, many developed countries have approved Sodium Hyaluronate Powder Bulk can be consumed as a common food additive. In 2021, China will include sodium hyaluronate in the list of new resources of food ingredients, it will be developed in the general food industry.

 

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