PQQ Bulk Powder

PQQ Bulk Powder Supplier:

PQQ bulk powder is reddish-orange to reddish-brown with an assay of 99%. Pyrroloquinoline quinone is also called PQQ. Pyrroloquinoline quinone is an emerging ingredient in skincare. It is gradually attracting attention. If you are interested in our products, welcome to inquiry us: info@gybiotech.com.

COA:

What Is PQQ Powder?

PQQ is a new type of coenzyme. It has a limited distribution in nature. Such as fermented soybeans (natto), tea, breast milk, etc. At present, PQQ bulk powder can be mainly extracted from some microbial fermentation products as well as certain plants.

In 1979, a Japanese chemist, Ryuo Sakamoto, used a new extraction method to extract PQQ from a fermented food in a similar study.

In the late 1980s, it was discovered that PQQ was not only an antioxidant, but also stimulated microbial growth and metabolism. It promotes cellular energy production. These discoveries attracted a lot of attention from the scientific community.

 

What Does PQQ Do?

PQQ bulk powder is a bioactive compound widely recognized for its powerful antioxidant activity and its role in cellular energy metabolism. In recent years, PQQ has attracted significant attention in the fields of nutrition, skincare, and anti-aging research due to its ability to protect cells from oxidative damage, promote collagen production, and support cellular repair and regeneration. These biological activities make PQQ an important ingredient in dietary supplements and cosmetic formulations designed to support skin health and overall cellular vitality.

1. Antioxidant

(1) Direct scavenging of free radicals:

PQQ has a special chemical structure. It can directly react with free radicals. Convert them into more stable substances. Free radicals are one of the main factors leading to skin aging. This includes superoxide anion radicals, hydroxyl radicals, etc. PQQ can quickly capture these free radicals and reduce their oxidative damage to skin cells.

 

(2) Activate antioxidant enzyme system:

PQQ bulk powder can activate the intracellular antioxidant enzyme system. Such as superoxide dismutase (SOD), glutathione peroxidase (GPx) and so on. These antioxidant enzymes can catalyze the decomposition of free radicals and reduce the level of oxidative stress. by increasing the activity of antioxidant enzymes, PQQ strengthens the skin's antioxidant defence ability.

 

(3) Maintaining mitochondrial function:

Mitochondria, as the energy factories in the cell, are also the main sites of free radical production. PQQ can protect the structural and functional integrity of mitochondria. It improves the efficiency of mitochondrial energy production and reduces the leakage of free radicals. This helps maintain normal cellular metabolism and function and protects skin cells from oxidative damage.

 

PQQ bulk powder has superb antioxidant capacity. Not only does it have 7.4 times the scavenging activity of Vitamin C against aryloxy radicals, but it also has 6.3 times the scavenging activity of Vitamin C against mono-linear oxygen radicals. It has also been shown that its antioxidant capacity is more than 100 times that of Vitamin C. At the same time, it can be reused by the cells.PQQ is an effective redox cycling agent that can efficiently mitigate oxidative damage.

 

2. Promote collagen production

(1) Activate collagen synthesis signalling pathway:

PQQ can activate the signalling pathways related to collagen production. PQQ bulk powder can activate the signalling pathway related to collagen production, such as the transforming growth factor-β (TGF-β) signalling pathway, which can stimulate fibroblasts to synthesize collagen and increase the elasticity and firmness of the skin, and PQQ can promote collagen synthesis by activating the TGF-β signalling pathway.

 

(2) Regulation of collagen degrading enzyme activity:

Pyrroloquinoline quinone powder can also regulate the activity of collagen-degrading enzymes. For example, matrix metalloproteinases (MMPs), which degrade collagen. This leads to a loss of elasticity and firmness of the skin. pQQ can inhibit the activity of MMPs, reducing collagen degradation and maintaining the amount of collagen in the skin.

 

3. Repair and regeneration

(1) Promote cell proliferation and differentiation:

Pyrroloquinoline quinone PQQ can promote the growth and differentiation of keratin-forming cells, fibroblasts and so on. This promotes the formation of new skin tissue.

 

(2) Regulation of inflammatory response:

Inflammation is another major factor that can contribute to skin damage and delayed healing. PQQ bulk powder has been shown to regulate inflammatory responses by suppressing the production of pro-inflammatory cytokines such as tumor necrosis factor-alpha (TNF-α) and interleukin-1 beta (IL-1β).

At the same time, PQQ can promote the release of anti-inflammatory molecules, including interleukin-10 (IL-10). This balanced regulation of inflammatory pathways helps reduce tissue damage and creates a more favorable environment for skin repair and regeneration.

 

(3) Enhance the skin's self-repair ability:

Another important function of PQQ is its ability to support cellular repair mechanisms. Environmental stressors such as ultraviolet radiation, pollution, and oxidative stress can damage cellular DNA. PQQ helps promote DNA repair processes, reducing the long-term impact of these harmful factors.

In addition, PQQ can influence the regulation of the cell cycle and support the removal of damaged cells through programmed cell death (apoptosis). By eliminating dysfunctional cells and making space for new healthy cells, PQQ contributes to maintaining healthy skin tissue and improving the skin's natural self-repair capacity.

 

 

Is PQQ Powder Safe?

● Toxicological studies:

The safety of PQQ Bulk Powder has been verified in several animal and human studies. In animal experiments, researchers found that PQQ exhibited low toxicity even at high doses. For example, in a rat experiment, continuous administration of high doses of PQQ (up to 500 mg/kg bw/day) did not result in significant adverse effects. This suggests that PQQ is relatively safe even at levels above routine intake.

 

● Human Clinical Trials:

In several clinical trials, bulk pyrroloquinoline quinone powder is beneficial to human health without serious side effects. In one study, where healthy volunteers consumed 20 mg of PQQ daily for 3 months, participants showed improvements in cognitive function and overall health. No serious adverse effects were observed. In another study, volunteers consumed 20 to 40 mg of PQQ daily. the results of the trial also reported no significant adverse effects, further demonstrating the safety of PQQ.

 

● GRAS Certification:

In the United States, pyrroloquinoline quinone bulk powder has received Generally Recognised As Safe (GRAS) certification. Existing scientific studies and expert evaluations have concluded that PQQ is considered safe as a food supplement.

 

Recommended Dosage:

To ensure the safe use of PQQ, it is recommended to follow the scientific studies and the recommended dosage on the product label. Currently, the recommended dose of PQQ bulk powder in common supplements is usually 10 to 40 mg per day. Use within this dosage range is safe.

 

Factory&Team：

 

Guanjie Biotech's factory is fully qualified. We have many kinds production license, carry out the record production of traditional Chinese medicine extracts, and are the record manufacturer of export food production. We have various quality, HALAL and KOSHER certificates. The facilities and equipment are standardized, and the production quality management system is complete.

We have a competent testing capacity, technology, production, quality team. We can provide customized PQQ bulk powderproducts with various active ingredients for customers' PQQ powder specific business and usage needs. At the same time to meet the high-end customer factory inspection, extended audit, filing needs.

 

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