Vitamin B12 Powder Bulk

Vitamin b12 Supplier:

Guanjie is a supplier of vitamin b12 powder bulk. It also known as cobalamin, is a polycyclic compound containing 3-valent cobalt and is the only vitamin containing the metal element. It is a red crystalline powder, odorless and tasteless, slightly soluble in water and ethanol, most stable under weak acid conditions at pH 4.5-5.0, decomposed in strong acid (pH<2) or alkaline solution, and can be destroyed to a certain extent by heat. 

 

Product Introduction:

There are four nutrients in the vitamin bulk B12 family: hydroxocobalamin, cyanocobalamin, adenosylcobalamin and methylcobalamin. Hydroxocobalamin and cyanocobalamin are the inactivated types. They need to be further converted by the body to be effective. The activated forms, adenosylcobalamin and methylcobalamin, have a strong affinity for neural tissues and function intravenously. They are mostly employed to treat injuries to peripheral nerves.

COA:

Test items	Specifications	Results	Test methods
Characters	Dark red crystals or amorphous or crystallinered powder.	Complies	Visual method
Identification A	UV:The absorption spectrum exhibits maxima at 278+1nm361±1nm and 550+2nm	Complies	USP monograph
	A361nm/A278m:1.70~1.90 A361nm/A550nm:3.15~3.40	1.86 3.27
Identification B	Cobalt:Meets USP requirements	1.86 Complies	USP monograph
Ldentification C	HPLC:The retention time of the major peak of the	3.27	USP monograph
Loss on drying	≤10.0%	3.9%	USP monograph/USP
Assay	97.0%~102.0%	99.0%	USP monograph/USP<731>
Related substances	Total impurities≤3.0%	1.4%	USP monograph/USP
	7β,8β-Lactocyanocobalamin≤1.0%	0.6%
	34-Methylcyanocobalamin≤2.0%	0.2%
	8-Epi-cyanocobalamin≤1.0%	0.2%
	Any other unidentified impurity and50-Carboxycyanocobalamin、32-Carboxycyanocobalamin≤0.5%	0.2%
Acetone	≤5000ppm	116ppm	In house/(GC)
The total aerobic microbial count	≤1000 cfu/g	2.8x10²cfu/g	ChP2020<1105>
The total combined yeasts/mould count	≤100 cfu/g	<10cfu/g	ChP2020<1105>
Conclusion :	The product complies with the specification of USP 43 and in house standard.
Product Usage:	Not For Drug Use

 

Mechanism and applications
Vitamin B12 in food combines with protein. Vitamin b12 powder form is released into the human digestive system through the action of stomach acid, pepsin, and trypsin. And binds to a glycoprotein intrafactor (IF) secreted by gastric mucosal cells.  

Very little organic b12 powder is stored, about 2 to 3 mg in the liver. It is excreted mainly in the urine and partly in the bile. It is used up after the storage capacity is exhausted. After more than half a year before deficiency symptoms.As long as the food is appropriate, there won't be a vitamin bulk B12 deficit because the human body needs relatively little of it. A small number of malabsorbed people must pay special attention.

 

Physiological Effects:

● Increase the utilization rate of folic acid
Synthesizes cyanocobalamin methyl precursors such methylcobalamin and coenzyme B12 during the synthesis of purines and pyrimidines, as well as methionine (which is formed from homocysteine) and choline with folic acid.
it is mainly involved in the methylation of many important compounds. Its deficiency reduces the transfer of methyl groups from methyltetrahydrofolate. This turns folic acid into an unavailable form, leading to folate deficiency.

●Maintenance of nerve myelin metabolism and function
Spinal cord degeneration and nerve problems can result from its deficiency. It may result in serious mental health issues. vitamin b12 powder bulk deficiency can lead to peripheral neuritis. Early signs deficiency in children are abnormal moods, dull expressions, unresponsiveness, and eventually anemia.

● Encourages the formation and growth of red blood cells
converts succinyl coenzyme A, a component of the tricarboxylic acid cycle where succinyl coenzyme A is involved in the manufacture of hemoglobin, from methylmalonyl coenzyme A.
● Involved in DNA synthesis
Metabolism of fats, carbohydrates and proteins, increasing the synthesis of nucleic acids and proteins.

 

Functions
The human body lacks VB12 will cause the blood system, nervous system and metabolic system function abnormally. This will lead to a variety of human diseases. Therefore, through timely supplementation can be effective prevention and treatment of a variety of diseases.
● Hyperhomocysteinemia
Homocysteine is an intermediate product of human body substance metabolism.It may result in smooth muscle cell proliferation and endothelial dysfunction, thickening the vascular endothelium, thrombosis, platelet aggregation, and other negative effects. According to clinical research, hyperhomocysteinemia is linked to a number of illnesses, including Alzheimer's disease, stroke, and Parkinson's disease. Folic acid and vitamin b12 powder form are crucial coenzymes that support homocysteine metabolism.
Supplementation can effectively promote homocysteine metabolism. Reduce the concentration of blood homocysteine, so as to prevent and control a variety of neurological diseases.

● Megaloblastic anemia
Megaloblastic anemia is due to the long-term lack of vitamin b12 powder bulk or folic acid. This anemia is caused by a long-term deficiency of vitamin B12 or folic acid in the body, which leads to an impairment of DNA synthesis during the division of megaloblastic red blood cells. This type of anemia is characterized by a decrease in the number of red blood cells, but the volume of red blood cells becomes larger, so that they appear to be huge. Clinical studies have shown that 1 month of oral or intramuscular injection of vitamin B12 can effectively improve megaloblastic anemia and promote the proliferation of red blood cells.

● Diabetic peripheral neuropathy
Diabetic peripheral neuropathy is one of the complications of diabetes. Its main pathogenesis is that high blood glucose leads to abnormal metabolism of peripheral nerves. This causes damage to the terminal nerves, commonly found in the limbs, often manifested as numbness, pain and sensory abnormalities at the ends of the limbs. Clinical studies have shown that vitamin B12 supplementation (commonly used is methylcobalamin) can effectively promote peripheral nerve tissue repair. It can reduce and delay the clinical manifestations of diabetic peripheral neuropathy.

● Neuropathic pain
There are many types of pain caused by neuropathic injury. The common ones are nerve root type cervical spondylosis, lumbar disc herniation, trigeminal neuralgia, carpal tunnel syndrome and so on. The basic mechanism of these diseases is due to a variety of pathologic factors leading to different degrees of damage to peripheral nerves. Clinical pain can be seen in various forms, such as pinprick-like, discharge-like and so on. And may be accompanied by the loss of innervated muscle function, resulting in functional limitations. Supplementation of vitamin B12 can effectively repair damaged nerves, relieve nerve pain, and improve the function of the corresponding innervated muscles.

What Kind of people are prone to vitamin b12 wholesale deficiency?
Vitamin B12 is not synthesized by the human body, so it needs to be consumed from food every day. However, poor dietary habits, diseases, medications and other factors will lead to the body's intake and absorption of vitamin B12 is not enough to meet the body's needs. This leads to a variety of reactions such as anemia, neuroinflammatory reactions, and insomnia.
● Gastrointestinal function degradation, disordered people
The absorption of vitamin B12 requires the synergistic action of the stomach and small intestine. The endogenous factors secreted by the cells of the stomach wall combine with vitamin b12 powder bulk in food to form a complex. It is safely transported to the small intestine, where it passes through the end of the jejunum where the complex is combined with proteins secreted by the small intestine and absorbs the bulk b12 powder into the body through chimerism. However, if you suffer from atrophic gastritis, gastric ulcer, enteritis or have undergone gastrointestinal surgery, you are prone to gastrointestinal motility and secretion insufficiency, resulting in vitamin B12 can not be inhaled into the body, resulting in a lack of the body.

 

● People who take oral gastric acid inhibitors for a long time
Clinical inhibition of gastric acid secretion is one of the basic treatments for a variety of diseases such as gastroesophageal reflux, gastric ulcers, and Helicobacter pylori infection. Commonly used drugs include H2 receptor antagonists and proton pump inhibitors. However, long-term oral gastric acid inhibitors can lead to a decrease in the amount of endogenous factors secreted by the stomach wall. This results in vitamin bulk B12 being digested by gastric acid as it passes through the stomach, leading to significant loss.

● People who eat a single diet
Foods rich in bulk powders b12 are mostly meat, eggs and shellfish. Therefore, the human body will not be deficient in case of moderate intake, but if someone has a long-term vegetarian diet or does not eat any meat at all, it will lead to a serious lack of vitamin B12 intake.

● Increased physiological needs
Sometimes the body's need for vitamin B12 increases. The most frequent situations are pregnancy and postpartum, and the body requires much more powder vitamin B12 in these circumstances. If the mother does not replenish it in a timely manner, it will result in a relative wholesale vitamin b12 deficit because it is primarily used in the synthesis of the baby's nerve cells and hematological system.

 

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Certification

 

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