Glutathione Bulk Powder

Glutathione Bulk Powder Supplier：

Guanjie Biotech's Glutathione (GSH) Powder appears as a white crystalline powder. It is soluble in water and practically insoluble in 99.5% ethanol. To ensure a stable and reliable supply, we have both independent manufacturing facilities and long-term cooperative production partners. We maintain strict quality control through our experienced in-house quality testing team. Upon request, bulk glutathione samples can also be tested by an independent third-party laboratory. Guanjie Biotech is committed to providing high-quality Glutathione powder with competitive pricing and consistent product performance. We welcome inquiries from customers worldwide and look forward to supporting your business needs.

Why Choose Guanjie Biotech?

● Two independent factories and three production line.

● Professional research team and have own labs

● Provide the third party testing.

● Have strong Collaborators:Northwestern University and Chinese Academy of Sciences research center

 

Identification:

Determine the infrared absorption spectrum of Glutathione, previously dried, as directed in the potassium bromide disk method under Infrared Spectrophotometry <2.25>, and compare the spectrum with the

Reference Spectrum: both spectra exhibit similar absorption intensities at the same wavenumbers.

 

Optical rotation:

<2.49> [a]20D : －15.5 – －17.5° (after drying, 2 g, water, 50 mL, 100 mm).

 

CAS NO.: 70-18-8

(2S)-2-Amino-4-[1-(carboxymethyl) carbamoyl-(2R)-2-sulfanylethylcarbamoyl] butanoic acid [70-18-8] Glutathione, when dried, contains not less than98.0% and not more than 101.0% of C10H17N3O6S.

 

COA:

Test Items		Specification	Result
Description		A white crystalline powder	A white crystalline powder
Assay (bas on dry)		98.0%~ 101.0%	99.0%
Identification	IR	Similar with the Reference Spectrum	Complies
	Optical Rotation	- 15.5°~- 17.5°	- 16.7°
Inorganic impurities	Chlorides	Not more than 200ppm	Complies
	Arsenic	Not more than 2ppm	Complies
	Chlorides	Not more than 200ppm	Complies
	Sulphates	Not more than 300ppm	Complies
	Heavy Metals	Not more than 10ppm	Complies
	Iron	Not more than 10ppm	Complies
	Cadmium	Not more than 1ppm	Complies
	Lead	Not more than 3ppm	Complies
	Mercury	Not more than 1ppm	Complies
	Residue on Ignition	Not more than 0. 1%	0.06%
Organic impurities	Total	Not more than 2.0%	1.3%
	GSSG	Not more than 1.5%	0.4%
Clearity and color of solution		Clear and Colorless	Clear and Colorless
Residual solvents		Meet the requirement	Complies
Loss on Drying		Not more than 0.5%	0.2%
Microbiology	Total plate count	≤1000cfu/g	Complies
	Yeast and mold count	≤100cfu/g	Complies
	Total coliforms	≤100cfu/g	Complies
	E. coli	Absent/10g	Complies
	S. aureus	Absent/10g	Complies
	Salmonella	Absent/10g	Complies
Conclusion		Complies with the standard of USP 41

 

How Is Glutathione Produced?

Glutathione bulk powder can be produced through four main methods: solvent extraction, enzymatic synthesis, microbial fermentation, and chemical synthesis. Among these methods, enzymatic synthesis and fermentation are widely used because they provide high purity, good stability, and are suitable for food, nutraceutical, and pharmaceutical applications.

Guanjie Biotech primarily uses two production technologies for glutathione bulk powder: the enzymatic method and the fermentation method. Both processes are designed to ensure consistent quality, high glutathione content, and reliable large-scale production.

One of the most common production routes is the extraction of glutathione from yeast cells. Special strains of brewer's yeast or baker's yeast are cultivated under carefully controlled fermentation conditions to accumulate high levels of intracellular glutathione. During fermentation, factors such as temperature, pH, oxygen supply, and nutrient composition are optimized to maximize glutathione production.

After the fermentation process is completed, the yeast cells are harvested and separated from the fermentation broth. The cells are then disrupted using physical or enzymatic techniques to release the glutathione stored inside the cells. Following cell disruption, the extract undergoes a series of purification steps to remove proteins, polysaccharides, pigments, and other impurities.

The purified solution is further concentrated and refined through filtration, decolorization, and crystallization processes. These steps help improve the purity and stability of the final product. After purification, the glutathione is dried using advanced drying technology to obtain a fine powder with good flowability and storage stability.

Quality control is performed throughout the entire manufacturing process. Each batch is tested for purity, moisture content, heavy metals, microbial contamination, and other key quality indicators. This ensures that the final glutathione bulk powder meets industry standards and customer requirements.

 

Saccharomyces cerevisiae

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First Stage Fermentation

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Second Stage Fermentation

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Fermentation Liguid Separation

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L-Glutathione Enriched Yeast

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Extraction

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L-Glutathione Enriched Yeast Extract

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Purification

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L-Glutathione Reduced Solution

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Filter

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L-Glutathione Reduced Solution

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Crystallization Drying

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L-Glutathione Reduced

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Packing

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Glutathione Reduced Product

 

Advantages：

● High purity:

The Glutathione Bulk Powder extracted from yeast is of high purity, which means it is free from other contaminants or impurities.

● Natural source:

Brewer's or baker's yeast is a natural source of GSH, making it a preferable choice for those seeking natural and organic supplements.

● Cost-effective:

The extraction process of GSH from yeast is relatively less expensive than other sources, making it a cost-effective alternative.

● Easy availability:

Yeast is readily available and is a commonly used ingredient in the food industry. Hence, the availability of GSH extracted from yeast is easy.

 

Stability and Reactivity

● Chemical Stability

Stable under normal temperatures and pressures.

● Conditions to Avoid

Incompatible materials, dust generation, excess heat, strong oxidants.

●Incompatibilities with Other Materials

Oxidizing agents.

●Hazardous Decomposition Products

Carbon monoxide, irritating and toxic fumes and gases, carbon dioxide.

●Hazardous Polymerization:

Has not been reported.