Alpha-Ketoglutaric Acid Powder

Alpha-ketoglutaric Acid Powder Supplier:

Guanjie Biotech provide high quality Alpha-ketoglutaric acid powder. With a sound enterprise quality assurance system, Guanjie implements strict quality control standards. We are a professional team dedicated to the production, research, and sale of α-Ketoglutaric Acid Powder. We can provide you with high-quality Alpha-ketoglutaric acid powder at the best price. Guanjie is your best choice. Our clients come from all over the world, and we receive high praise from them.

 

Introduction

Alpha-ketoglutaric acid powder is a fine white crystalline powder, representing either of two keto-based derivatives of glutaric acid. Its salt is an important biological compound. It participates in the tricarboxylic acid cycle in living organisms to produce amino acids and can be used as a dietary supplement.

 

COA:

  

Items	Specifications	Results
Appearance	White or almost white crystals or crystalline powder	Conforms
State of solution	≥95.0%	98.3%
Iron(Fe)	≤10ppm	<10ppm
Heavy Metals(Pb)	≤10ppm	<10ppm
Arsenic	≤3ppm	<3ppm
Loss on drying	≤0.5%	0.29%
Residue on ignition	≤0.5%	0.26%
Assay	98.0~102.0%	98.9%
Conclusion: This batch is confirming with the standard of Enterprise Internal.

 

Function

● Tricarboxylic acid cycle

Alpha-ketoglutaric acid is an important metabolic intermediate in the microbial tricarboxylic acid cycle, serving as a key node connecting the metabolism of carbon and nitrogen in the cell. Its position in the cycle is after isocitrate and before succinyl-coA. At this site, the replenishment of this intermediate metabolite can be achieved by the self-transamination of glutamate to produce α-ketoglutaric acid, as well as by the action of glutamate dehydrogenase on glutamate.

 

● Making amino acids

Glutamate reacts with glutamine synthase, utilizing a molecule of ATP to produce glutamyl phosphate. This intermediate is then attacked by ammonia as a nucleophile to form glutamine and inorganic phosphoric acid.

 

● Dietary supplements

Alpha-ketoglutaric acid powder is sold as a dietary supplement, known as AKG or A-KG, to fitness enthusiasts or bodybuilders who claim it can improve performance during peak training. Sellers claim this is based on research showing that excess ammonia can bind to α-ketoglutaric acid and be carried away to reduce the many problems caused by ammonia poisoning. However, studies demonstrating the effectiveness of alpha-ketoglutarate in reducing ammonia poisoning have only been conducted in patients already undergoing hemodialysis.

 

Application

● Mainly used as a component of sports nutrition drinks.

● Alpha-ketoglutaric acid powder is also utilized as organic intermediates and biochemical reagents, serving as matching reagents to measure liver function.

 

Physiological Action

α-ketoglutaric acid is a type of multi-action short-chain carboxylic acid that shows no toxicity and exhibits high stability in aqueous solutions. In vivo, AKG serves not only as an important transitional product in the TCA cycle but also as a precursor of L-glutamate, L-glutamine, L-proline, and L-arginine. Experiments conducted on animals showed that AKG, glutamine, and glutamate ingested by animals were absorbed and metabolized in the upper part of the small intestine, where up to 95% of glutamate and 70% of glutamine were degraded into CO2, while only 40% of AKG was degraded. The remaining AKG can be utilized for metabolic processes in intestinal cells and peripheral tissues.

 

Production Method

● Mix 225 g of triethyl oxalosuccinate with 600 mL of concentrated hydrochloric acid and place the mixture in a container. Distill and concentrate the liquid to 140℃ to obtain 110-112 g of α-ketoylglutaric acid. The yield is 92-93%.

 

● preparation

Triethyl Oxalosuccinate: Add 360 mL of anhydrous ethanol to a reaction vessel equipped with an agitator and reflux condenser. Gradually add 23 g of clean sodium metal in batches. After addition, heat the mixture to reflux to complete the reaction with the sodium metal. Transfer to a distillation apparatus and distill off the ethanol. Simultaneously, continue adding toluene until the internal temperature reaches 105℃. Cool the mixture to room temperature, then add 650 mL of anhydrous ether. Stir in 146 g of diethyl oxalate and then add 174 g of diethyl succinate (1.0 mol). Let the mixture stand at room temperature for 12 hours. After stirring, add 500 mL of water to separate the organic layer, which is then extracted with 150 mL of water. Combine the water layers, acidify with concentrated hydrochloric acid, and precipitate the oily substance. Separate the oil layer and extract the water layer with ether three times. Combine the organic layers and dry with anhydrous magnesium sulfate.

 

Recover the ether to obtain 235 to 250 g of yellow oil compound with a yield of 86% to 91%. α-Keto-glutaric Acid: In a reaction vessel equipped with a blender and reflux condenser, add 225 g of the above compound, 330 mL of concentrated hydrochloric acid, and 660 mL of water. Stir the mixture and reflux for 4 hours. Concentrate under reduced pressure to dryness (60-70 ℃). Add 200 mL of nitroethane to the residue, heat to dissolve, and filter while hot. Combine the nitroethane solution, then stir the mixture at 0-10 ℃ for 5 hours. After filtration and drying at 90℃ for 4 hours, obtain 88-99 g of compound with a yield of 73%-83%.

 

Factory Equipment & Laboratory Detection

Our factory: We have two factories located in Baoji City and Shangluo City. Guanjie factories cover an area of 7000㎡, including a GMP standard workshop of 2000㎡.

 

 

Our Testing Center:

● Alpha-ketoglutaric acid Powder adheres to strict quality standards. All products can be tested, and products requested by customers will be sent to the third-party testing center for testing.

● Contract with Third-Party Lab: Our products adhere to strict quality standards. All products can be tested, and products requested by customers will be sent to the third-party testing center for testing.

 

 

Testing Equipment:

Alpha-ketoglutaric acid Powder can be tested. If you need our testing report, we can provide the third-party report.

 

Packing:

● For 1-5 kg: Two plastic bags inside, aluminum foil bag outside.

● For 25 kg: Paper drum with two plastic bags inside.

 

Qualification Of Company

We adhere to the corporate mission of creating a healthy life, strictly control product quality, and are certified with ISO quality management system certificate, ISO 9001-22000, SC, KOSHER, HALAL, and other certifications. Guanjie Biotech continuously strives to innovate and improve its control standards. At the same time, it has been granted a number of patents.

 

Delivery:

1-3 working days after payment or PO

 

Shipment:

Transit could be DHL, UPS, TNT, FEDEX, or EMS. For mass orders, it will be delivered by air or sea.

Hot Tags: alpha-ketoglutaric acid powder, China alpha-ketoglutaric acid powder manufacturers, suppliers, factory, 5-HTP Powder, Pure L-Theanine Powder, raw powders 5-htp, Pure Resveratrol Powder, Cycloastragenol Powder, 5-htp powder bulk