Berberine Hydrochloride Powder

Berberine Hydrochloride Powder Supplier: 

Guanjie Biotech specializes in bulk Berberine Hydrochloride Powder supply. We have our own factory and labs for 20 years. Berberine HCL is extracted from Golden Cypress raw material. Its specification includes 97% to 98% of Berberine HCL with a yellow crystalline powder appearance. We use the Titration testing method. As a professional plant extract Berberine Hydrochloride bulk Powder supplier, we can provide berberine hydrochloride powder products and services to your satisfaction.

Why choose Guanjie Biotech?

● Our berberine hydrochloride powder can be customized with OEM/ODM and packaged in sachets for your convenience.

● With the help of professional shipping agents, we ensure that your goods are exported safely and swiftly.

● We are always ready to provide the best service according to your requirements.

● Our Berberine hydrochloride powder has been certified with ISO 9001-22000, SC, KOSHER, and HALAL.

● The School of Chemistry and Materials Science, Northwest University, has a Practical Base for Master's Students.

● Our company boasts of an independent research and development center led by a team of 10 experts.

 

COA:

Analysis Item	Specification	Method
Assay: Berberine Hydrochloride	≥97 0%	HPLC(on anhydrous basis)
Appearance Color Odor & taste Identification Loss on Drying Total ash Sieve analysis	Fine Powder Yellow characteristic Identical to R.S. sample ≤12.0% ≤0.5% 100% through 80 mesh	Organoleptic Organoleptic Organoleptic HPTLC Eur.Ph.7.0<2.8. 17> Eur.Ph.7.0<2.4. 16> USP36<786>
Heavy metals: Lead(Pb) Arsenic(As) Cadmium(Cd) Mercury(Hg)	≤3.0 mg/kg ≤2.0 mg/kg ≤1.0 mg/kg ≤0 1 mg/kg	Eur.Ph.7.0<2.2.58>ICP-MS Eur.Ph.7.0<2.2.58>ICP-MS Eur.Ph.7.0<2.2.58>ICP-MS Eur Ph 7 0<2 2 58>ICP-MS
Residual solvents Residual pesticides Non irradiated	Meet Eur.Ph.7.0 <5.4> Meet USP36<561> ≤700	Eur.Ph.7.0<2.4.24> USP36<561> EN13751:2002
Microbiology Total Plate Count Yeast & Mold E.Coli Salmonella	Non irradiated ≤10000cfu/g ≤1000cfu/g Negative Negative	USP36<61> USP36<61> USP36<62> USP36<62>

 

Titration Testing Method:

Titration is a common method used to determine the concentration of a substance in solution.  We will be titrating berberine hydrochloride powder sample to determine its concentration. Here's a step-by-step guide on how to do this:

 

● Materials Needed:

- Berberine Hydrochloride Powder

- NaOH solution (sodium hydroxide)

- Phenolphthalein indicator

- Burette

- Erlenmeyer flask

- Distilled water

- Pipette

 

● Procedure:

1. Weigh out a known amount of bulk Berberine Hydrochloride Powder (e.g., 0.1 g) and dissolve it in a small amount of distilled water in an Erlenmeyer flask.

2. Add a few drops of phenolphthalein indicator to the solution. This will turn the solution pink.

3. Fill the burette with NaOH solution. Record the initial burette reading.

4. Slowly add the NaOH solution to the Erlenmeyer flask while stirring the solution. Keep adding the NaOH solution until the pink color of the indicator just disappears. This indicates the endpoint of the titration.

5. Record the final burette reading.

6. Repeat the titration three times to obtain an average volume of NaOH solution used.

7. Calculate the concentration using the following formula:

Concentration (mg/mL) = [(volume of NaOH solution used x normality of NaOH solution x 336.4) / weight taken]

 

Note: The molecular weight is 371.8 g/mol.

 

This method can provide an accurate determination of the concentration in solution, allowing for precise dosing and formulation of bulk Berberine Hydrochloride Powder drugs or supplements containing this compound.

 

Flow Chart:

 

Guanjie Biotech produces Berberine Hydrochloride Powder, a key bioactive alkaloid, from Golden cypress.

● Raw Material Requirement (Comply with quality standard):

The process begins with plant raw material that must meet strict quality specifications. This ensures the final product's safety, potency, and is free from contaminants like heavy metals or microbes.

● Initial Preparation (Picking):

The raw plant matter undergoes inspection and cleaning to remove non-medicinal parts (e.g., dirt, stems, foreign materials) and impurities, ensuring only the highest quality material proceeds.

● Size Reduction (Crushing):

The cleaned botanical material is mechanically crushed into uniform pieces of approximately 12mm. This increases the surface area, which is crucial for maximizing the efficiency of the chemical extraction in the next step.

● Alkaloid Liberation (Extraction):

The crushed material is mixed with lime water (calcium hydroxide solution) and sodium chloride. The alkaline lime water converts berberine into a soluble form, while the salt helps force the alkaloids out of the plant cells (salting-out), significantly improving extraction yield.

●Initial Isolation (Alkalizing Crystal & Filtering):

The mixture is processed to encourage the initial crystallization of the crude berberine alkaloids. These crystals are then separated from the leftover plant pulp and liquid through a filtration process.

● Purification Step (Dissolving):

The crude crystals are dissolved again in water, and the pH is carefully adjusted. This re-dissolution allows for further purification, as many impurities will not re-dissolve, leaving them behind.

● Salt Formation (Acidification Filtration):

Bulk Hydrochloric Acid (HCl) is added to the purified solution. This critical step causes the berberine to react with the acid to form the stable and bioavailable salt-Berberine Hydrochloride. The newly formed crystals are then collected via a second filtration.

● Moisture Removal (Drying):

The wet Berberine HCl crystals are dried at a controlled temperature of 75°C-80°C. This specific range effectively removes moisture without degrading the heat-sensitive compound.

● Final Product (Fine Powder):

The output of the drying process is a high-purity, potent fine Berberine Hydrochloride Powder. This Berberine HCL powder is the standard form used in pharmaceutical and supplement manufacturing.

The final Berberine Hydrochloride Powder is packaged in airtight, light-resistant containers to protect its stability, potency, and quality until it is used to manufacture end-user products like capsules or tablets.

 

Application:

Berberine Hydrochloride Powder is commonly used in both the food industry and cosmetic industry due to its various health benefits. Here are some examples:

● Food industry: 

It is used as a food additive to improve the color and texture of food. It is commonly found in baked goods, beverages, and condiments.

 

● Cosmetic industry: 

Berberine Hydrochloride Powder is used in various cosmetic products due to its anti-inflammatory and antibacterial properties. It is commonly found in skincare products, such as acne treatments, as well as in hair care products, such as shampoos and conditioners.

 

Factory&Team：

 

Certification

 

Package & Shipment

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