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Diosmin Powder
Other name: Citrus Aurantium Extract, Geranyl, Diomin
Source: Citrus aurantium L. , Diosmin is a semi-synthetic flavonoid, derivative of hesperidin.
CAS number: 520-27-4
Specification: 90%~103%
Molecular formula: C28H32O15
Test Method: HPLC
Characters: Light yellow hygroscopic powder
Certifications: Halal,ISO9001,PAHS Free,NON-GMO,KOSHER,SC
Payment term: L/C, D/A, D/P, T/T,DP at sight
Delivery term: DHL, FEDEX, Air freight,Sea freight
MOQ: 1KG
Shelf time: Two years
Description
Diosmin Powder supplier
Guanjie Biotech is a high-purity Diosmin Powder supplier, an important ingredient for the pharmaceutical and nutraceutical industries. Our Diosmin is a semi-synthetic flavonoid derived from hesperidin, which is sourced from the reputable botanical Citrus aurantium L. We ensure our product meets the most rigorous quality standards. It is a light yellow, hygroscopic powder with a specification purity range of 90% to 103%, as verified by the precise High-Performance Liquid Chromatography (HPLC) test method. Guanjie Biotech is committed to providing reliable, high-quality ingredients to support the formulation of venotonic and vascular health products. We are your dedicated partner for a high-quality and consistent supply of Diosmin Powder. Welcome to enquire with us at info@gybiotech.com.

Why Choose Guanjie Biotech?
● Innovative technology:
We are experts in natural ingredients. Our team has developed 20 patents to ensure our products are innovative and effective.
● Globally Recognized Quality
We meet the world's strictest standards. Our certifications include ISO9001, ISO22000, and others for quality and food safety. We are also certified Kosher, Halal, and non-GMO to serve all markets.
● Your Safety is Our Priority
We have a strict quality control system. We test almost everything about Diosmin Powder in our own lab, including purity, heavy metals, pesticides, and microbes. This ensures every batch is safe and effective.
● Reliable and Fast Shipping
We have worked with the same professional shipping partners for over 15 years. They ensure your goods are exported safely and delivered to you quickly and without hassle.
COA:
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Manufacturing Date: JUNE 10, 2021 |
Batch No.: 210603 |
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Expiry Date: JUNE 10, 2024 |
Batch Size: 1,000 kg |
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Specification: Ph. Eur. 10.0 |
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Nature of Test |
Specifications |
Test Results |
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CHARACTERS |
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- Appearance |
Greyish-yellow or light yellow hygroscopic powder. |
Light yellow hygroscopic powder. |
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- Solubility |
Practically insoluble in water, soluble in dimethyl sulphoxide, practically insoluble in ethanol (96%). It dissolves in dilute solutions of alkali hydroxides. |
Conforms |
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IDENTIFICATION |
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A. Infrared absorption spectrophotometry (2.2.24) |
Comparison: diosmin CRS |
Conforms |
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B. Examine the chromatograms obtained in the Assay |
The principal peak in the chromatogram obtained with the test solution is similar in retention time and size to the principal peak in the chromatogram obtained with reference solution (a). |
Conforms |
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TESTS |
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- Iodine (2.2.36) & (2.5.10) |
≤ 0.1% |
< 0.1 % |
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- Related substances (HPLC) (2.2.29) |
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-- impurity A: acetoisovanillone |
≤ 0.5 % |
0.01 % |
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-- impurity B: hesperidin |
≤ 4.0 % |
0.33% |
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-- impurity C: isorhoifolin |
≤ 3.0 % |
2.1 % |
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-- impurity D: 6-iododiosmin |
≤ 0.6 % |
0.07 % |
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-- impurity E: linarin |
≤ 3.0 % |
1.9 % |
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-- impurity F: diosmetin |
≤ 2.0 % |
0.63 % |
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-- unspecified impurities, for each impurity |
≤ 0.4 % |
0.16 % |
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-- total |
≤ 8.5 % |
5.3% |
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- Heavy metals |
ICH Q3D |
Conforms |
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- Water (2.5.12) |
≤ 6.0 % |
4.3 % |
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- Sulfated ash (2.4.14) |
≤ 0.2 % |
0.10 % |
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ASSAY(HPLC), anhydrous substance (2.2.29) |
90.0%-102.0% |
93.5 % |
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PARTICLE SIZE DISTRIBUTION (2.9.12) & (2.9.38) |
100% pass 80 mesh sieve |
100% pass 80 mesh sieve |
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RESIDUAL SOLVENTS (2.4.24) & (5.4) |
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- Methanol |
≤ 3000 ppm |
0 ppm |
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- Ethanol |
≤ 5000 ppm |
0 ppm |
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- Pyridine |
≤ 200 ppm |
51 ppm |
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MICROBIOLOGICAL TESTS (2.6.12) & (2.6.13) |
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- Total aerobic microbial count |
≤ 103 CFU/g |
< 10 CFU/g |
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- Total yeasts and moulds count |
≤ 102 CFU/g |
< 10 CFU/g |
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- Escherichia coli |
Absent in 1 g |
Absent in 1 g |
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Conclusion: The test results conform to ph. eur. 10.0. |
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Storage: In an airtight container. In a dry, cool place protected from light. |
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What Is Diosmin Powder?
Diosmin Powder is a natural substance, a type of flavonoid, that comes from citrus fruits like the bitter orange (Citrus Aurantium L.). It is processed from a compound called hesperidin. The powder itself has a light yellow color and can easily absorb moisture from the air.In the body, diosmin works to support vein health. It helps to strengthen the walls of your veins, which can improve blood flow. It also helps reduce the thickness of your blood, allowing it to move more easily. This improved circulation can help reduce swelling (edema) by helping your body drain excess fluid more effectively. In short, diosmin is a powerful plant-based ingredient known for its benefits for blood vessels and circulation. If you would like to learn more about our high-quality Diosmin Powder, please feel free to contact us.
What Is The Safety Of Diosmin Powder?
Diosmin powder has been extensively used for decades, particularly in supporting venous and vascular health. Its widespread use in pharmaceutical and nutraceutical products is underpinned by a substantial body of research and clinical experience that confirms its favorable safety profile when manufactured and used appropriately.
Favorable Toxicity Profile and Clinical History
Diosmin Powder has been the subject of numerous toxicological studies. Acute and chronic toxicity studies in animal models have demonstrated that diosmin has a very low order of toxicity, with a high LD50 (the lethal dose for 50% of a test population), indicating that it requires an exceptionally high dose to cause acute harm. More importantly, its long-term use in clinical settings, often at doses ranging from 500 mg to 1000 mg per day, has consistently shown it to be well-tolerated. The most common reported side effects are mild and transient, typically involving the gastrointestinal system, such as minor stomach discomfort, diarrhea, or nausea. These effects are often dose-dependent and usually subside without discontinuing treatment.
Importance of Purity and Manufacturing Quality
The safety of any ingredient is intrinsically linked to its quality. High-purity diosmin powder, like that supplied by reputable manufacturers, minimizes the risk of contaminants that could pose health risks. A rigorous quality control system is essential. This involves in-house testing for critical parameters including:
• Heavy Metals:
Ensuring levels of lead, arsenic, cadmium, and mercury are well below stringent regulatory limits.
• Pesticide Residues:
Verifying the absence of harmful agrochemicals from the raw citrus material.
• Microbiological Contamination:
Confirming the powder is free from harmful bacteria, yeast, and mold.
• Solvent Residues:
Ensuring any solvents used in the extraction and semi-synthesis process are fully removed.
When a diosmin powder supplier adheres to international standards like ISO and carries certifications such as Kosher, Halal, and non-GMO, it provides further assurance of a controlled and transparent manufacturing process, directly contributing to the product's safety.
Regulatory Status and Drug Interactions
Diosmin is approved as a prescription drug in many countries and is widely available as a dietary supplement in others, such as the United States. This regulatory acceptance is based on reviewed safety data. Regarding drug interactions, diosmin is not known to have significant or dangerous interactions with most common medications. However, as a precaution, individuals taking medications metabolized by specific liver enzymes (like CYP3A4) or blood-thinners (anticoagulants) should consult a healthcare professional before use, as flavonoids can theoretically potentiate their effects. This is a standard precaution for many natural compounds.
Recommended Usage and Specific Populations
For the general adult population, Diosmin Powder is considered safe when used at recommended doses. However, as with any bioactive compound, certain populations should exercise caution. Due to a lack of sufficient safety data, its use is not generally recommended for pregnant or breastfeeding women, or for very young children, unless under direct medical supervision. While allergic reactions are rare, individuals with a known allergy to citrus fruits should be cautious when first using diosmin.
User Evaluation

Mark

Daniel Skiba

Erik Anukul
Our factory---Guanjie Technology
Guanjie Technology is one of the most professional herbal extract manufacturers and suppliers. Guanjie has been on this line for more than 17 years, and there are more than 15 engineers in our team. We have more than 20 patents for the manufacturing of herbal extracts. Guanjie factory covers an area of 7000㎡, including a GMP standard workshop of 2000m2 and an advanced lab of 500m2.

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