Raw DIM

Raw DIM Powder supplier

Guanjie Biotech is a trusted high-purity Raw DIM Powder supplier, offering a 99% bulk specification. As one of our flagship products, this DIM powder is produced using advanced technology to ensure quality, consistency, and potency. With our own manufacturing facilities and a dedicated R&D team, we maintain strict quality control and continuously improve our production processes. This allows us to provide customers with high-quality DIM at competitive prices. Whether for use in dietary supplements, functional foods, or research applications, our DIM powder meets international standards and can be customized to meet your specific needs. Partner with Guanjie Biotech for reliable supply, technical support, and excellent value in every batch.

What Is 3,3'-Diindolylmethane ?

Raw DIM has many positive effects on the human body. According to research, this product has a good effect on inhibiting the growth of cancerous cells. In addition, the product can reduce acne to a certain extent, prevent prostate hypertrophy, and treat prostate hyperplasia. DIM can stimulate estrogen to decompose into healthy by-products, which means that it is a promising adjuvant treatment for cancer. DIM widely exists in cruciferous vegetables. If you want more detailed information, please feel free to consult us.

 

COA

Items	Specifications	Result	Test Method
Appearance	Off-white to white crystalline powder	Conform	Visual
Odor, Taste	Characteristic	Conform	Sensory
Particle Size	98% pass 80mesh	Conform	GB/T 5507-2008
Content	≥99.0%	99.43%	HPLC
Loss on drying	≤0.5%	0.3%	GB 5009.3-2016
Melting Point	165.0℃~169℃	167℃	GB/T 21781-2008
Heavy Metals	≤10 ppm	Conform	GB 5009.74-2014
Pb	≤2 ppm	Conform	GB 5009.12-2017
As	≤2 ppm	Conform	GB/T 5009.11-2014
Benzene	Without Benzene	Not detected	GB 5009.262-2016
Solvent Residue	Methanol≤3000ppm	Conform	GB 5009.262-2016
Total Plate Count	≤1000cfu/g	Conform	GB 4789.2－2016
Total Yeast & Mold	≤100 cfu/g	Conform	GB 4789.15－2016
E. Coli	Negative	Negative	GB 4789.38-2012
Salmonella	Negative	Negative	GB 4789.31-2016
Staphylococcus aureus	Negative	Negative	GB 4789.10-2016

 

Features

• This Raw DIM can reduce acne and prevent prostate hypertrophy.
• This product helps to enhance the responsiveness and reaction time of the immune system.
• It has important biological and pharmacological activities and is widely used in medicine and health products.
• Research shows that this product can be used as an auxiliary method for cancer treatment.

 

Extraction method

This method describes a streamlined process to simultaneously extract indole-3-methanol and Raw DIM from the edible organs of cruciferous vegetables. The procedure is designed to be efficient, reproducible, and suitable for industrial-scale applications.

Step-by-Step Extraction Process:

Preparation of Fresh Samples

• Select fresh edible organs of cruciferous vegetables (such as broccoli, cabbage, kale, or Brussels sprouts).
• Crush the fresh vegetable samples thoroughly to break down the tissue structure, facilitating subsequent extraction.
• Dry Sample Preparation via Freeze-Drying
• Subject the crushed fresh samples to vacuum freeze-drying to remove moisture without degrading sensitive compounds.
• After drying, pulverize the samples into a fine powder to increase surface area and improve extraction efficiency.

Enzymatic Hydrolysis Reaction

• Mix either the fresh crushed sample or the freeze-dried powdered sample with a citric acid-phosphate buffer solution.
• Carry out an enzymatic hydrolysis reaction under controlled conditions. This step helps to break down precursor compounds in the vegetables, releasing indole-3-methanol and enabling the formation of 3,3′-diindolylmethane.

The result is an enzymatic hydrolysis solution containing the target compounds.

Extraction with Ethyl Acetate

Extract the enzymatic hydrolysis solution using ethyl acetate as the organic solvent.

This step separates the organic components (including indole-3-methanol and DIM) from the aqueous phase.

After extraction, collect the ethyl acetate supernatant and evaporate it to dryness, resulting in a crude extract containing both compounds.

Separation of Indole-3-Methanol and 3,3′-Diindolylmethane

• Redissolve the crude extract in a potassium dihydrogen phosphate-dipotassium hydrogen phosphate buffer solution to maintain a stable pH environment.
• Add ethanol to the solution to saturate indole-3-methanol, facilitating its separation from DIM.
• Allow the mixture to stand undisturbed. Due to differential solubility, two separate phases form: one enriched with indole-3-methanol, the other with 3,3′-diindolylmethane.

Isolation and Purification of Target Compounds

Collect the indole-3-methanol extract and the Raw DIM solution separately.

Evaporate both solutions to remove solvents, yielding purified indole-3-methanol and 3,3′-diindolylmethane as final products.

Advantages Of This Extraction Method:

Simultaneous Extraction:

This Method Allows For The Concurrent Isolation Of Two Valuable Bioactive Compounds-Indole-3-Methanol And Raw DIM-From The Same Raw Material, Maximizing Efficiency.

• Use of Edible Cruciferous Vegetables:
• Utilizing fresh or freeze-dried edible parts of cruciferous vegetables ensures the method relies on safe, natural, and sustainable raw materials.

Simplified Procedure:

The process is straightforward, involving common solvents (ethyl acetate, ethanol) and buffer solutions, which simplifies scale-up and industrial implementation.

Environmentally Friendly:

The use of enzymatic hydrolysis under mild conditions avoids harsh chemicals and excessive energy consumption, reducing environmental impact.

Cost-Effective:

By combining extraction and separation steps and utilizing readily available plant materials, the method is economically attractive for industrial production.

High Purity and Yield:

Controlled enzymatic hydrolysis and stepwise solvent extraction ensure a high-quality extract with a good yield of both target compounds.

 

 

DIM Atlas

3,3'-Diindolylmethane Attention

Raw DIM (3,3'-Diindolylmethane) is a high-purity, off-white to white crystalline powder known for its stability and consistency in quality. This compound is derived from the natural breakdown of indole-3-carbinol, commonly found in cruciferous vegetables. It is widely used in the fields of dietary supplements, cosmetics, and functional foods due to its health-promoting properties.

Solubility Characteristics

Raw DIM powder is insoluble in water, but it is soluble in organic solvents such as methanol and ethyl acetate. This makes it suitable for formulation in various non-aqueous delivery systems.

Shelf Life and Storage Conditions

The Raw DIM powder product has a shelf life of two years, provided it is stored in a cool, dry environment at temperatures below 8°C. It should be protected from strong light and heat, and care must be taken to avoid contact with acidic or oxidizing materials. When exposed to light over extended periods, the powder may gradually take on a reddish hue. However, this discoloration does not significantly affect the product's active content.

Packaging Options

1 kg sealed in aluminum foil bags, with transparent plastic liners for added protection. 25 kg packed in paper drums, lined with black plastic bags to shield the contents from light and moisture.

 

Functions

1. Prevent breast, uterine, and colorectal cancer.

2. Prevent symptoms of prostate hyperplasia.

3.Treat premenstrual conditions.

 

Usage:

Pharmaceutical Intermediates

 

Product Feature

• Raw DIM Powder is a pure white color. lowest solvent residue, highest purity.
• Our company has an independent research and development center; there are 10 experts in our research team.
• Our company has a raw material synthesis workshop,
• Our company has advanced quality instruments and equipment,
• Some of the products are applied for discount, but it depends on the quantity.

 

Certification

Factory Equipment & Laboratory Detection

Package & Shipment

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