Bulk Azelaic Acid Powder

Raw Material Azelaic Acid Manufacturer | Consistent Quality and Bulk Supply

Guanjie Biotech supplies azelaic acid to the global market in four specifications-78%, 88%, 95%, and 98%-with an annual production capacity of 600 metric tons. Azelaic acid is also called Nonanedioic acid powder. Bulk nonanedioic acid is packaged in 25 kg (net weight) bags or drums and should be stored in a sealed container, protected from moisture and light. Centered on large-scale production and rigorous quality control, the company provides downstream clients in the pharmaceutical, cosmetic, and chemical industries with high-quality azelaic acid raw materials that feature consistent batch-to-batch quality and a comprehensive range of specifications.

 

COA:

Item	Specification	Result	Test Methods
Assay GC	Azelaic acid ≥98%	99.17%	GC
Item	Specification	Result
Chemical Physical Control
Particle Size	100% pass 80 mesh	Qualified	80 Mesh Screen
Loss on drying	≤1.0%	0.25%	5g / 105℃ / 2hrs
Residue on Ignition	≤0.1%	0.09%	2g / 525℃ / 3hrs
Appearance	Fine powder	Qualified	Visual
Color	White or off white	Qualified	Visual
Odor	Typical	Qualified	Organoleptic
Taste	Typical	Qualified	Olfactory
Heavy Metals	NMT10ppm	Qualified	ICP/MS
Arsenic (As)	NMT1ppm	Qualified	ICP/MS
Lead (Pb)	NMT1ppm	Qualified	ICP/MS
Mercury(Hg)	NMT1ppm	Qualified	ICP/MS
Microbiology Control
Total Plate Count	NMT1,000cfu/g	Qualified	USP
Total Yeast & Mold	NMT100cfu/g	Qualified	USP
E.Coli.	Negative	Negative	AOAC
Salmonella	Negative	Negative	USP
Staphylococcus	Negative	Negative	USP
Packing & Storage	Packed in paper drums and two plastic bags inside. N.W.: 25 kg Store in a well-closed container away from moisture.
Shelf Life	Two years if sealed and stored away from direct sunlight and heat.

 

Chemical Structure and Physicochemical Properties

Azelaic acid powder (CAS 123-99-9) is a white to off-white crystalline powder widely used as a raw material in cosmetic formulations, pharmaceutical research, and chemical manufacturing. Its molecular formula is C9H16O4, its molecular weight is 188.22 g/mol, and its EINECS number is 204-669-1. Its chemical structure, HOOC-(CH2)7-COOH, contains two terminal carboxyl groups and a seven-carbon methylene chain. This structure allows azelaic acid to form salts and esters and makes it useful in organic synthesis.

Physical and Chemical Properties

Azelaic acid powder is slightly soluble in cold water, more soluble in hot water, and readily soluble in ethanol. Its white or off-white appearance makes it suitable for various cosmetic and industrial applications. A fine particle size with 100% passing through an 80-mesh sieve helps improve dispersion and mixing during formulation.

Important quality specifications include loss on drying (≤1.0%), residue on ignition (≤0.1%), and controlled heavy metal levels. Microbiological specifications, including total aerobic microbial count and yeast and mold limits, are also important for evaluating raw material quality.

Azelaic Acid Purity Grades and Quality Control

Guanjie Biotech supplies bulk azelaic acid powder in different purity grades, including 78%, 88%, 95%, and 98%. Our 98% grade product can achieve an actual assay of over 99%, subject to batch-specific test results. These specifications provide different options for cosmetic ingredient manufacturers, pharmaceutical raw material buyers, and industrial customers.

During production, Guanjie Biotech controls related substances, including homologous dicarboxylic acids such as suberic acid and sebacic acid. We also monitor impurity profiles and key quality parameters to support batch consistency.

 

What Is Azelaic Acid Used In Pharmaceutical and Dermatological Field?

Azelaic acid is a well-established active ingredient in dermatological formulations, particularly for acne and rosacea management. According to approved drug labeling, 15% azelaic acid formulations are used to treat inflammatory papules and pustules associated with rosacea, while 20% azelaic acid cream is indicated for acne treatment. Its main mechanisms of action include:

• Antibacterial Action

Azelaic acid inhibits the growth of skin bacteria, including Cutibacterium acnes, helping reduce bacterial activity associated with acne.

• Keratin Regulation

It helps normalize follicular keratinization, reducing the accumulation of dead skin cells and helping improve clogged pores, whiteheads, and blackheads.

• Pigmentation Control

Azelaic acid inhibits tyrosinase activity, helping regulate melanin production and improve the appearance of post-inflammatory hyperpigmentation and melasma.

• Anti-Inflammatory Action

It helps reduce inflammatory responses, making it useful in formulations designed for acne-prone and redness-prone skin.

For manufacturers, the quality of azelaic acid powder is important for formulation consistency and product development. Guanjie Biotech supplies 98% and 95% azelaic acid raw materials for pharmaceutical and cosmetic applications. The 98% grade is suitable for applications requiring higher purity, while the 95% grade can serve as a raw material for pharmaceutical intermediate synthesis, subject to process and quality requirements. As an experienced azelaic acid powder supplier, Guanjie Biotech provides batch-specific Certificates of Analysis (COA) and testing information to support B2B procurement, raw material evaluation, and quality audits.

 

What Is Azelaic Acid Used In Skincare and Cosmetics?

As a versatile azelaic acid cosmetic ingredient, it offers several formulation benefits, making it suitable for creams, lotions, serums, and other personal care products.

• Acne Care and Oil Control

Azelaic acid is commonly used in formulations for acne-prone skin. It has antimicrobial and anti-inflammatory properties and can help reduce the growth of Cutibacterium acnes. It also promotes normal skin cell turnover, helping reduce the buildup of dead skin cells that can contribute to clogged pores, blackheads, and closed comedones. Therefore, azelaic acid for acne-prone skin is a popular ingredient choice in functional skincare products.

• Skin Brightening and Hyperpigmentation Care

Another important application of azelaic acid powder in skincare is improving uneven skin tone. Azelaic acid can inhibit tyrosinase activity and reduce excess melanin production. It is commonly incorporated into products designed to improve the appearance of post-acne marks, dark spots, and hyperpigmentation. This makes azelaic acid for skin brightening a relevant ingredient for serums, creams, and lotions.

• Soothing and Redness Care

Azelaic acid has anti-inflammatory properties that make it useful in skincare products designed for redness-prone and blemish-prone skin. It is also used in formulations for skin conditions such as rosacea. The final formulation should be optimized to balance product performance and skin tolerance.

• Improving Skin Texture

By supporting normal skin cell turnover, azelaic acid helps improve the appearance of rough skin and uneven texture. It can also help reduce the appearance of clogged pores, making it a useful ingredient in products targeting dullness and uneven skin texture.

• Cosmetic Formulation and Grade Selection

Cosmetic-grade azelaic acid powder is valued for its chemical stability and versatility in formulation development. It can be incorporated into creams, lotions, and serums with suitable formulation techniques.

Guanjie Biotech supplies bulk azelaic acid powder in different purity grades, including 98%, 95%, 88%, and 78%, to meet different formulation and purchasing requirements. We can provide samples and product information to support ingredient evaluation and grade selection for cosmetic manufacturers and B2B buyers.

 

What Is Azelaic Acid Used In Industrial and Chemical Applications?

Azelaic acid powder is an aliphatic dicarboxylic acid widely used as a chemical intermediate in industrial manufacturing and fine chemical synthesis. Its two carboxyl groups allow it to participate in various chemical reactions, making it a useful raw material for polymers, plasticizers, lubricants, and other chemical products.

• Raw Material for Polymer Production

Azelaic acid is used in the production of polyamides, polyesters, and other polymer materials. It can act as a monomer or modifying component to improve flexibility, low-temperature performance, and processing properties. One important derivative is dioctyl azelate (DOZ), an ester plasticizer known for its low-temperature flexibility, low volatility, and good plasticizing efficiency. DOZ is used in PVC and other plastic formulations. Azelaic acid is also used in the manufacture of polyamide resins and specialty materials.

• Metalworking Fluids and Lubricants

Industrial-grade azelaic acid can serve as a raw material for lubricant additives, corrosion inhibitors, and metalworking fluid formulations. Its derivatives and salts can help improve lubrication and corrosion protection in certain industrial applications. These properties make azelaic acid useful in the development of specialty lubricants and metal surface protection products.

• Raw Material for Fine Chemical Synthesis

As a versatile azelaic acid raw material, it is used in organic synthesis to produce esters, amides, and metal salts. These derivatives have applications in fragrances, lubricating oil additives, specialty chemicals, and other industrial formulations. Its chemical structure provides opportunities for further modification through esterification, amidation, and salt formation.

• Cosmetic and Other Applications

Cosmetic-grade azelaic acid powder is used as an ingredient in skincare formulations. It is commonly selected for products designed for acne-prone skin and uneven skin tone. Certain azelaic acid derivatives also have applications in personal care and hair care formulations. Other reported applications include soap formulations and specialty consumer products, depending on the formulation requirements and applicable regulations.

• Azelaic Acid Purity Grades and Supply

Azelaic acid powder is available in different purity grades according to its intended application. Industrial-grade materials are commonly used in plasticizers, lubricants, and chemical synthesis, while higher-purity specifications are selected for cosmetic, pharmaceutical, and specialized applications.

Guanjie Biotech is an experienced azelaic acid supplier and manufacturer, offering 78%, 88%, 95%, and 98% purity specifications. These options provide flexibility for different industrial and cosmetic raw material requirements. We support bulk azelaic acid supply for B2B customers seeking reliable specifications and ingredient sourcing solutions.

 

Application Selection Guide

For various downstream scenarios, Guanjie Biotech offers the following selection recommendations:

Applications	Recommended	Selection Rationale
Topical dermatological preparations, pharmaceutical intermediates	98%	High purity, low impurity levels, and controlled microbial content-meeting pharmaceutical-grade requirements.
High-end functional skincare products (acne treatment, skin brightening, soothing)	98%/95%	Consistent assay, white appearance, excellent dispersibility, and superior compatibility with various formulations.
General cosmetics and functional formulations	95%/88%	Balances efficacy and cost, making it ideal for large-scale formulation development.
Industrial intermediates, plasticizers, polyester/nylon synthesis	88%/78%	Highly cost-effective; suitable for industrial-scale reactions and material modification.
Metalworking, lubricants, and anti-rust additives	78%/88%	Reliable industrial-grade supply, well-suited for additive formulations.
Fragrances, oils, and raw materials for organic synthesis	88%/95%	Optimal balance of reactivity and purity, ideal for derivatization and synthesis.

FAQs：

Q1: What is the difference between 95% and 98% azelaic acid?

The main difference between 95% and 98% azelaic acid is the specified assay and impurity profile. The 98% grade provides a higher concentration of azelaic acid and may be preferred for formulations or synthesis processes with stricter purity requirements. The 95% grade offers an alternative for applications where its specifications meet the technical requirements.

When choosing between these grades, manufacturers should consider assay, related substances such as suberic acid and sebacic acid, formulation compatibility, and production costs.

Q2: Is azelaic acid powder water-soluble?

Azelaic acid is slightly soluble in cold water, more soluble in hot water, and readily soluble in ethanol. Its solubility is an important consideration when developing azelaic acid serums, creams, lotions, and other formulations.

Cosmetic formulators should evaluate solvent selection, pH, temperature, concentration, and crystallization behavior to achieve suitable product stability and ingredient dispersion.

Q3: What is azelaic acid used for in skincare and cosmetic formulations?

Azelaic acid is widely used in skincare formulations targeting acne-prone skin, uneven skin tone, and visible redness. It has several properties that make it valuable for cosmetic and dermatological product development.

It helps regulate follicular keratinization, making it useful in formulations targeting clogged pores and acne-prone skin. Its tyrosinase-inhibiting activity makes it relevant to products targeting dark spots and post-inflammatory hyperpigmentation. Its anti-inflammatory properties also make it suitable for redness-care formulations.

Cosmetic manufacturers commonly incorporate azelaic acid into creams, lotions, gels, and serums, depending on formulation requirements and regulatory restrictions.

Q4: What concentration of azelaic acid is commonly used in skincare products?

The concentration of azelaic acid depends on the product category, intended application, and local regulatory requirements. Cosmetic formulations may use concentrations ranging from 5% to 10%, while higher-concentration products may require additional safety and regulatory evaluations.

In certain markets, approved 15% azelaic acid gel formulations are used for rosacea, while 20% cream formulations are used for acne treatment. These are examples of regulated dermatological products rather than universal cosmetic recommendations.

Manufacturers should determine the appropriate concentration through formulation testing and regulatory review.

Q5:How should azelaic acid powder be stored?

Azelaic acid should be stored in a cool, dry place, away from direct sunlight, excessive heat, and moisture. Containers should remain tightly sealed when not in use to prevent moisture absorption and powder clumping.

 

Azelaic Acid Powder Production Capacity

Guanjie Biotech has an annual production capacity of 600 metric tons of azelaic acid powder, providing a stable and reliable bulk supply for global customers. Our large-scale manufacturing capabilities support long-term orders, consistent product specifications, and batch-to-batch quality control. As an experienced azelaic acid manufacturer, we focus on dependable production and wholesale supply.

Azelaic Acid Powder Packaging

Our bulk azelaic acid is available in standard 25 kg bags or drums. Bagged products use composite packaging with an inner plastic liner, while drummed products are packed in fiber drums or suitable containers. Both packaging options provide effective sealing and moisture protection. Each label includes the product name, specifications, batch number, net weight, production date, and storage conditions for easy identification and traceability.

 

Azelaic Acid Storage Conditions and Shelf Life

Store azelaic acid powder in a cool, dry place, protected from direct sunlight, heat, and moisture. Keep containers tightly sealed when not in use. Under the specified storage conditions, the product has a shelf life of two years. Proper storage helps prevent moisture absorption and clumping, maintaining product handling and dosing consistency.

Azelaic Acid Quality Control

Guanjie Biotech implements batch-level quality testing for azelaic acid, including GC assay, particle size, loss on drying, residue on ignition, heavy metals by ICP-MS, and microbial testing according to applicable USP/AOAC methods. A batch-specific Certificate of Analysis (COA) is available. We also support supplier audits, sample verification, and regulatory documentation requirements for B2B customers. And our Azelaic Acid powder passes Halal, ISO9001, KOSHER, HACCP, and other patents.

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