NMN Powder Bulk

NMN Suppliers

Guanjie Biotech specializes in the production of NMN powder bulk. We use advanced freeze and vacuum drying processes to provide high-quality NMN products to the market. The assay of our NMN bulk powder is>99.5%. High quality and competitive price. Welcome to enquiry:info@gybiotech.com.

Why Choose Guanjie Biotech?

• High-Quality Raw Materials

Guanjie Biotech is one of NMN bulk powder manufacturers. We select high-quality raw materials strictly. The company purchases raw materials Nicotinamide Mononucleotide from reliable suppliers and conducts strict testing and screening of them.

 

• Production Process

We use advanced production processes and equipment. Our departments strictly control all aspects of the production process. We have established a perfect quality management system to monitor and test every link in the production process. Our Nmn bulk powder meets the relevant national standards and the company's quality requirements.

 

• Testing and inspection of products

We carry out strict testing and inspection for each batch of nicotinamide mononucleotide powder produced. Our company has established a perfect testing and inspection system, equipped with advanced testing equipment and professional testing personnel. We carry out strict testing and inspection on all the indexes of the products.

 

COA:

● Nicotinamide Mononucleotide(Vacuum-dried)

TEST	METHOD	ANALYTE	SPECIFICATION	RESULT
Identify	NMR	Nicotinamide Mononucleotide	Conforms to structure	Conforms to structure
Purity	HPLC/UV(wt%)	Nicotinamide Mononucleotide	≥99%	99.87%
Moisture	Karl Fischer	Water	≤5%	0.15%
Sodium content			≤1%	0.02%
Bulk density		Weight density	>0.55g/ml	0.54g/ml
PH value		in water at 100mg/ml	2.0-4.0	3.07
Heavy Metals		Lead Arsenic	<5 ppm	0.01ppm
			<5 ppm	0.01ppm
Microbial	USP<2021> USP<2022>	Total Plate Count E. coli	< 750CFU/g < 30MPN/100g	60CFU/g N.D.
Appearance	NA	Color, Form	White to yellowish powder	White powder

 

 

● Nicotinamide Mononucleotide(Freeze-dried)

TEST	METHOD	ANALYTE	SPECIFICATION	RESULT
Identify	NMR	Nicotinamide Mononucleotide	Conforms to structure	Conforms to structure
Purity	HPLC/UV(wt%)	Nicotinamide Mononucleotide	≥99%	99.94%
Moisture	Karl Fischer	Water	≤5%	0.16%
Sodium content			≤1%	0.01%
Bulk density		Weight density	<0.20g/ml	0.16g/ml
PH value		in water at 100mg/ml	2.0-4.0	3.10
Heavy Metals		Lead Arsenic	≤1.0 ppm	0.01ppm
			≤1.0 ppm	0.01ppm
Microbial	USP<2021> USP<2022>	Total Plate Count E. coli	≤ 750CFU/g ≤ 30MPN/100g	50CFU/g N.D.
Appearance	NA	Color, Form	White to yellowish powder	White powder

 

Flow chart:

Chemical Properties

Nicotinamide Mononucleotide is abbreviated as NMN. It is a naturally occurring biologically active nucleotide in the human body. Its chemical formula is C11H15N2O8P and molecular weight is 334.22.NMN is the precursor of nicotinamide adenine dinucleotide (NAD+). NMN is the precursor of nicotinamide adenine dinucleotide (NAD+), which is involved in many important physiological processes in human body.

 

Production process:

We produce NMN powder bulk by freeze-drying and vacuum-drying process.

1. Freeze-drying process

• Maintaining the activity of the substance

The freeze-drying process is carried out at low temperatures to effectively preserve the biological activity of the substance. For temperature-sensitive substances such as NMN, the freeze-drying process maximises the retention of the active ingredients.

• Improved product stability

Freeze-dried products have a low moisture content. This improves the stability of the product. The low moisture content reduces the growth of microorganisms and the occurrence of chemical reactions, extending the shelf life of the product.

• Improved product solubility

Freeze-dried products usually have better solubility. As a result of the freeze-drying process, the moisture in the material is frozen into ice. This then sublimates directly into water vapour, making the structure of the material looser and thus improving the solubility of the product.

• Application of freeze-drying process NMN

Guanjie Biotech's freeze-dried NMN powder bulk has a bulk density of 0.15 g/ml and are mainly used in solid beverage applications.

 

2. Vacuum Drying Process

• Improved drying efficiency

Vacuum drying can be carried out at lower temperatures, thus improving drying efficiency. As the boiling point of water is lowered under vacuum conditions. The water in the material can be evaporated at a lower temperature, which effectively reduces the drying time and energy consumption.

• Maintaining the quality of the material

Vacuum drying prevents chemical reactions such as oxidation and decomposition of the material at high temperatures. This maintains the quality of the material. For temperature-sensitive substances such as NMN, the vacuum drying process effectively protects the active ingredients.

• Reducing the water content of the product

Vacuum drying reduces the moisture content of the material to a low level. Low moisture content reduces the growth of microorganisms and the occurrence of chemical reactions, extending the shelf life of the product.

• Application of vacuum drying process NMN

Guanjie Biotech's vacuum-dried NMN powders with bulk densities is 0.55g/ml and 0.75g/ml, are mainly used in capsule filling applications. A capsule is a kind of dosage form that encapsulates drugs or nutrients in a capsule shell, which has the advantages of convenient consumption and accurate dosage.

 

Applications Of Different Densities

1. NMN powder with a packing density of 0.15g/ml (freeze-drying process)

• Loose and porous:

Due to the freeze-drying process, the water in the material is frozen into ice and then sublimated directly into water vapour. As a result, the structure of NMN becomes loose and porous.

• Good solubility:

The loose and porous structure makes NMN powder bulk soluble in water.

• High biological activity:

The freeze-drying process can effectively maintain the biological activity of NMN, ensuring the quality and efficacy of the product.

Application Areas

• Solid beverages:

NMN powder with a bulk density of 0.15g/ml can be used in solid beverages to meet consumer demand for convenient and healthy beverages. Solid beverages can be directly brewed with boiled water or added to milk, fruit juice and other beverages.

• Health food:

As a substance with potential anti-aging effects, NMN can be used as a raw material for health food. NMN powder with a packing density of 0.15g/ml can be added to health food, which can improve the efficacy and added value of the product.

2. NMN powder with a packing density of 0.55g/ml (vacuum drying process)

• Characteristics

Good flowability:

Vacuum-dried NMN powder has good flowability and is easy to fill into capsules.

• High biological activity:

Vacuum drying process can effectively protect the active ingredients of NMN and ensure the quality and efficacy of the product.

Application Areas

Filling of 0# and 00# capsules:

NMN powders with a bulk density of 0.55g/ml can be filled into 0# and 00# capsules. This meets the consumer's need for a convenient and accurate way to take nutritional supplements. 0# and 00# capsules are typically used to fill larger doses of medications or nutrients for people who need high doses of NMN.

 

3. NMN Powder with a bulk density of 0.75g/ml (Vacuum Drying Process)

• Dense particles:

Vacuum-dried NMN powders are more compact.

• Better flowability:

It has better flowability and is easy to fill in capsules.

• High biological activity

 

Application Areas

1#, 2# Capsule filling:

NMN powders with a bulk density of 0.75g/ml can be filled into 1# and 2# capsules to meet the consumer's need for a convenient and accurate way to take nutritional supplements. 1# and 2# capsules are typically used to fill smaller doses of medications or nutrients. It is ideal for people who need a low dose of pure bulkNMN.

 

NMN in solid beverages

1. Chemical stability

• Effect of pH. The pH range of solid beverages affects the stability of NMN:

The pH range of solid beverages affects the stability of NMN pure powder , which is relatively stable in a neutral pH environment. In more acidic environments (pH < 4), for example, the amide bonds in the NMN molecule may be affected by protonation when the pH of the solid beverage deviates from the neutral range. Since acidic environments provide more hydrogen ions, these hydrogen ions may interact with the nitrogen atoms in the NMN molecule. This increases the possibility of its hydrolysis. In alkaline environments (pH> 8), NMN may undergo deprotonation, again affecting its chemical stability.

 

• Interactions with other ingredients:

Solid beverages usually contain a variety of ingredients such as vitamin C, sucrose and citric acid. Vitamin C is a strong reducing agent and can protect NMN powder bulk from oxidation to some extent. However, if vitamin C is in excess or under adverse storage conditions such as high temperatures and high humidity, chemical reactions may occur. Such as the Melad reaction.

 

2. Physical stability

• Dispersibility and solubility:

In solid beverages, the dispersibility and solubility of NMN bulk are important. Freeze-dried NMN powder has a bulk density of 0.15 g/ml, and its structure is loose and porous. It has good dispersibility and solubility in solid beverages. When brewing solid beverages, NMN can be dispersed quickly and evenly in water, reducing the risk of chemical reactions caused by high localised concentrations. However, if the particles of solid beverages are too large or agglomeration occurs between particles, the dispersibility of NMN may be affected. This results in a part of the NMN not being sufficiently soluble, which in turn affects its stability.

 

• Effect of storage conditions:

Temperature and humidity are key factors affecting the physical stability of NMN in solid beverages. At high temperatures, the water activity in solid beverages may increase and NMN bulk powders tend to absorb moisture. NMN powder bulk are prone to moisture absorption, which may cause agglomeration and change the physical state of NMN. This increases the potential for chemical reactions with other ingredients. For example, when NMN agglomerates, the local concentration within it increases and the rate of reaction may accelerate upon contact with other ingredients. Solid beverages may also harbour microorganisms in high-humidity environments, and the metabolic activities of microorganisms may also affect the stability of NMN.

 

NMN in capsules

1. Chemical stability

• Protective effect of the capsule shell:

The capsule shell provides some protection for NMN in both 0# and 00# capsules (filled with NMN powder at a bulk density of 0.55g/ml) and 1# and 2# capsules (filled with pure NMN powder at a bulk density of 0.75g/ml). The capsule shell prevents NMN from coming into direct contact with the outside air and reduces oxidation. Oxygen in the air is one of the most important factors contributing to the oxidative degradation of NMN. The capsule shell acts as a physical barrier, reducing the probability of oxygen entering the capsule and coming into contact with NMN.

• Stability of the internal microenvironment:

The microenvironment inside the capsule is relatively stable. Compared with solid beverages, NMN in capsules has relatively few interactions with other ingredients. This is because the capsules mainly encapsulate the NMN powder separately, which reduces the chance of chemical reactions with other complex ingredients (e.g., multiple additives in solid beverages).

 

2. Physical Stability

• Maintenance of powder state:

Vacuum dried NMN powder bulk for capsule filling are either homogeneous (packing density of 0.55g/ml) or compact (packing density of 0.75g/ml) with good flowability. NMN maintains a good powder condition in the capsule. NMN powders do not readily agglomerate or clump during capsule storage and transport.

• Effect of storage and transport conditions:

During storage, temperature has an effect on the stability of NMN in the capsule. If the temperature is too high, the capsule shell may soften, affecting its mechanical strength and increasing the risk of capsule rupture. Also, high temperatures may cause changes in the physical state of the bulk NMN powder.

 

Product Qualification

NMN powder bulk is produced in a clean working environment and every step is conducted by highly qualified professionals. 

 

Testing Center:

Both the production processes of manufacture and the product itself meet all international standards. And if you need our testing report, we can provide you.

 

Certification

We have obtained the NON-GMO by Pony Test International Group. And our NMN bulk powder gets the certifications about HALAL,ISO 9001,ISO 22000,Kosher, PAHS,SC and so on.

 

 

Package&Warehouse:

 

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