The results showed that the liposomal NMN group had a greater increase in NAD+ levels. Compared with traditional NMN bulk powder, liposomal NMN showed higher absorption and better utilization. The study suggests that liposomal delivery technology may improve the stability and bioavailability of NMN in the human body.
Liposomes are tiny vesicles made from lipid molecules. They can carry active ingredients and improve their stability and absorption. In nutrition and medicine, liposome technology is widely used to improve bioavailability. Liposomal NMN can pass through cell membranes more easily. This helps improve NMN absorption in the human body. It may also help increase NAD+ levels more effectively. Compared with regular NMN, liposomal NMN powder has advantages in delivery efficiency.
This study used a double-blind, randomized controlled design. The participants were 15 healthy men over 40 years old. They were randomly divided into three groups. Group 1 was the placebo group. Group 2 received regular NMN. Group 3 received liposomal NMN. The study lasted 8 weeks. The first 4 weeks were the supplementation period. The last 4 weeks were the observation period after stopping supplementation. Blood samples were collected before the study, 1 hour after supplementation, after 4 weeks of supplementation, and 4 weeks after stopping supplementation. The researchers measured and recorded NAD+ levels in the blood.
The results showed that the liposomal NMN group had a greater increase in NAD+ levels. After 4 weeks of supplementation, the NAD+ level in the liposomal NMN powder group was much higher than in the placebo group and the regular NMN group. NAD+ levels in the liposomal NMN group also increased clearly within 1 hour after supplementation. This effect remained strong after 4 weeks of continuous use. In comparison, the regular NMN group showed a weaker effect.
These results show that liposome technology can improve NMN absorption. Liposomal NMN powder may raise NAD+ levels faster and maintain good results for a longer time. The study also shows that liposomal delivery technology has strong potential in NMN product development.
Liposome NMN group: NAD+ concentration significantly increased at 1 hour and 4 weeks after administration.
In the traditional NMN group, NAD+ levels increased one hour after use. After four weeks of continuous supplementation, NAD+ levels increased further. However, after stopping supplementation for four weeks, NAD+ levels dropped significantly. This shows that non-liposomal NMN stays in the body for a shorter time. Continuous supplementation may be needed to maintain high NAD+ levels.
In contrast, the liposomal NMN powder group showed better stability. NAD+ levels increased steadily during supplementation. Even after four weeks without supplementation, NAD+ levels remained high. This shows that liposomal technology can improve the absorption and stability of NMN. It can also extend its action time in the body. For people who need long-term NAD+ support, liposomal NMN may provide greater benefits.
After 4 weeks of administration, the NAD+ concentration in the liposomal NMN group was significantly higher than in the non-liposomal NMN group and the placebo group. (Image source: Paper screenshot)
Liposomal technology significantly improves the bioavailability of NMN. Traditional NMN must go through an extracellular conversion process before entering cells. This process takes time and reduces absorption efficiency. Some active ingredients may also be lost during conversion. This limits the amount that actually enters cells. In contrast, liposomal NMN has better delivery ability. The liposome structure is compatible with cell membranes. It helps NMN enter cells more quickly. This reduces conversion steps and improves absorption efficiency. Cells can use NMN faster to produce NAD+. Therefore, liposomal NMN powder is more effective in increasing NAD+ levels in the body.
Liposome technology also improves NMN stability. Ordinary NMN is easily affected by external conditions during storage and after entering the body, such as temperature, humidity, gastric acid, and enzymes. Liposomal encapsulation protects NMN. It reduces the degradation of active ingredients. More active compounds can reach the target site. This improves utilization.
Liposomal NMN also shows a longer duration of action in the body. Because of higher stability, the active ingredients remain active longer. This helps maintain NAD+ levels for a longer time. This is useful for long-term health management.
Research shows that liposomal NMN powder has good effects in the early stage of supplementation. Even after stopping use, the effect can remain for a period of time. This suggests that liposomal delivery can extend the action time of NMN in the body. However, after 4 weeks without supplementation, NAD+ levels decreased in all groups.
This indicates that NMN is not a permanent solution. NAD+ in the body decreases with age, stress, and metabolism. Without continued supplementation, NAD+ levels will still decline. Long-term stable supplementation is important to maintain results. For long-term health management, continuous supplementation is more effective. Traditional NMN intake may help maintain stable NAD+ levels. This supports cellular energy, mitochondrial function, and overall health.
Current research shows clear benefits of liposomal NMN in increasing NAD+. However, studies are still in early stages. More clinical data is needed. Future research should include larger sample sizes. Different ages, health conditions, and lifestyles may show different responses. More targeted studies are needed. Different doses and cycles should also be compared. Researchers need to study low, medium, and high doses. They also need to evaluate long-term safety and stability.
In addition, the anti-aging effects of NMN need more evidence. It is still unclear whether it can improve age-related diseases or support long-term mitochondrial health. These questions require large-scale clinical trials.
With advances in delivery systems and clinical research, liposomal NMN powder may have wider use in health products, functional nutrition, and anti-aging applications. Guanjie Biotech is a liposomal NMN powder supplier. We provide liposomal NMN for the health field. If you are interested in bulk liposomal NMN, welcome to contact our sales team. We can provide high-quality service and liposomal NMN products.
References:
[1].Kawakami, Satoshi. "Intervention Study Comparing Blood NAD+ Concentrations with Liposomal and Non-Liposomal Nicotinamide Mononucleotide."Ann Clin Med Case Rep 14.11 (2025): 1-12.
