Does Nicotinamide Mononucleotide Powder Actually Work？

In recent years, research on NMN powder (nicotinamide mononucleotide powder) has been very hot in the field of anti-aging. A number of academic papers have been published in authoritative academic journals represented by Cell, Nature and Science, and the anti-aging function of NMN has been continuously discovered. And more research is in progress. So what have scientific studies already discovered about NMN's effects?

NAD+ (nicotinamide adenine dinucleotide) is a necessary component for organismal survival. It is found in all cells and has a role in millions of physiological reactions throughout the organism. As a metabolic component and co-molecule in the control of other physiologically active proteins. Its primary function is to provide energy to cells, increase immunity, and expedite tissue repair and regeneration, allowing the body to retain a healthy condition and halt the aging process.

In 2013, a study team lead by Prof. David Sinclair of Harvard Medical School revealed that NAD+ levels rose in 22-month-old mice following one week of oral NMN bulk powder therapy. Key biochemical indicators related to mitochondrial homeostasis and muscle function were restored to a state equivalent to that of young 6-month-old mice. The research results were published in the journal Cell.

Sirtuins are a kind of NAD+-dependent deacetylase protein. It comprises Sirtuins 1 through 7. Nearly 20 years of study have demonstrated that Sirtuins serve an important regulatory role in practically all cellular activities.Sirtuins influence physiological processes such as inflammation, cell development, circadian rhythms, energy metabolism, neuronal function, and stress tolerance
In 2019, Prof. Kane A E et al, Department of Genetics, Harvard Medical School, discovered that NMN is a key precursor for NAD+ production in organisms. Many of the favorable benefits (e.g., better metabolism, cardiovascular protection, etc.) that it exerts after increasing intracellular NAD+ levels are mediated via Sirtuin activation.

In 2019, Dr. de Picciotto N E, Department of Integrative Physiology, University of Colorado Boulder, et al. discovered that intraperitoneal injection of NMN enhanced arterial Sirtuin1 activity and corrected age-related vascular dysfunction and oxidative stress in mice. In addition to activating Sirtuin1, additional routes can be exploited to minimize oxidative stress and enhance vascular function in older animals. For example, nicotinamide mononucleotide powder can influence the activity of Sirtuin3 in mitochondria, lowering oxidative stress and improving physiological function.

In addition to affecting the activity of Sirtuins, the level of NAD+ in the body is also an important substrate for the DNA repair enzymes PARPs (polyadenosine diphosphate ribose polymerase) to function.

In 2017, a team of researchers led by Prof. David Sinclair at Harvard Medical School discovered the mechanism by which NAD+ repairs DNA damage. As NAD+ levels decline with age, the DNA repair enzyme PARP1 is increasingly bound by DBC1 (breast cancer deletion factor 1) to form the PARP1-DBC1 complex. This complex prevents PARP1 from repairing damaged DNA, and increasing NAD+ levels interferes with PARP1-DBC1 complex formation, thereby restoring PARP1's DNA repair activity. Reduced DNA damage was found in radiation-exposed aged mice after one week of oral administration of nicotinamide mononucleotide powder. The research results were published in the journal Science.

Metabolism, is a collection of life-sustaining chemical reactions in an organism. It is the general term for the chemical reactions that sustain life in an organism. These reactions enable organisms to grow and reproduce, maintain their structures, and respond to their environment. Metabolism is the process by which organisms continually exchange matter and energy, and once the exchange of matter and energy ceases, the organism's life ends.

In 2019, a study by Prof. Nina Klimova et al. at the University of Maryland School of Medicine found that intraperitoneal injections of NMN led to a significant increase in mitochondrial NAD+ levels in the hippocampus of the brains of laboratory rats, and a rise in the levels of ATP, an energy molecule, in brain tissues, which increased the organism's bioenergetic metabolism. In addition, NMN can also improve the activity of antioxidant enzymes in the mitochondria, reducing the production of reactive oxygen species.

In December 2019, a study published in the Journal of Affective Disorders showed that NMN was able to improve cortisol-induced depression in mice. In this trial, nicotinamide mononucleotide powder improved energy metabolism and mitochondrial function and corrected negative behavior in depressed mice.

In 2020, a study by Dr. Xiaoxian Jie from Zhejiang University of Technology and others found that after oral administration of NMN to depressed mice, it improved mitochondrial energy metabolism in the hippocampus and liver cells of the brain of the mice by increasing the level of NAD+ and activating Sirtuin 3, thus alleviating the depressive symptoms.

Blood vessels are the "conduits of blood flow" and are indispensable tissues for carrying oxygen and nutrients, processing carbon dioxide and metabolites, and regulating body temperature and other vital activities. As we age, blood vessels lose their suppleness and become harder, thicker, and narrower, causing "atherosclerosis.

In 2018, a research team led by Prof. David Sinclair of Harvard Medical School found that when 18-month-old mice were orally administered with nicotinamide mononucleotide powder for 2 months, the number and density of capillaries were restored to the level of young mice, and muscle perfusion and dissolved oxygen content were increased at rest, and the exercise endurance of the old mice was improved by 58%-80%, and the level of lactic acid in the blood after exercise was decreased. The research was published in the journal Cell. In 2016, Dr. de Picciotto N E, Department of Integrative Physiology, University of Colorado at Boulder, et al. found that oral administration of NMN restored endothelium-dependent diastolic dysfunction (EDD) and nitric oxide NO-mediated EDD in carotid arteries of aged mice, reduced aortic pulse-walking velocity (aPWV), decreased nitrotyrosine, reversed collagen I, and increased collagen I. The results were published in the journal Cell. It reduces the aortic pulse conduction rate (aPWV), reduces nitrotyrosine, reverses collagen I, increases elastin and restores vascular SIRT1 activity, thus maintaining the elasticity of blood vessels and maintaining the healthy state of blood vessels.

Weight can reflect a person's health condition. Weight not only affects the quality of life and health, but also becomes the cause of other chronic diseases. Weight management refers to regulating the balance of body energy and material metabolism through rational nutrition and moderate exercise. Both underweight and overweight are prone to increase the risk of chronic diseases.

In 2017, a team led by Prof. Margaret J. Morris of the University of New South Wales School of Medicine conducted a series of studies on the effects of NMN weight management, and found that in genetically obese mice, both NMN and exercise reduced obesity and led to improved glucose tolerance and mitochondrial function. However, nicotinamide mononucleotide powder appeared to have a stronger effect on hepatic fat catabolism (Hadh) and anabolism (Fasn) than exercise, possibly because NMN injections increase NAD+ levels in the body which activates the Sirtuins protein, which increases hepatic fat catabolism and anabolism.

The health of the heart is a matter of life and death for the human body, and it is vital to maintain heart function.

In 2014, Dr. Yamamoto T et al. from New Jersey Medical School showed that intraperitoneal injection of NMN in mice significantly increased NAD+ levels in the heart and prevented the decrease of NAD+ during ischemia, and that NMN protected the heart from ischemia/reperfusion injury. In 2017, Mice successfully protected against ischemia/reperfusion injury by short-term intraperitoneal injection of NMN, as shown by Dr. Rongli Zhang et al. from Case Western Reserve University School of Medicine. 2017 saw the effective prevention of mice's pressure overload-induced heart failure by short-term intraperitoneal injections of NMN, according to research conducted by Dr. Rongli Zhang et al. at Case Western Reserve University School of Medicine. This was due to NMN's ability to shield the mitochondria's ultrastructure, lower reactive oxygen species, and stop heart cell death.

Early vascular and neurodegenerative cognitive impairment can be brought on by neurovascular disease. Vascular dementia and Alzheimer's disease have been associated with risk factors such diabetes, midlife hypertension, obesity, physical inactivity, and smoking. It is crucial to preserve neurovascular function in order to prevent neurodegenerative illnesses.

The University of Oklahoma Health Sciences Center's Dr. Tarantini S. et al. discovered in 2019 that an intraperitoneal injection of NMN significantly protected the aging mice's cerebral microvasculature. Additionally, nicotinamide mononucleotide powder reduced endothelial oxidative stress in the cerebral microvasculature, enhancing endothelial function and preserving neurovascular coupling (NVC) responses in the aging mice's cortex, potentially leading to improved cortical function. In 2020, Dr. Tamas Kiss and colleagues at the University of Oklahoma Health Sciences Center discovered that intraperitoneal injection of nicotinamide mononucleotide powder restored cellular NAD + levels in senescent rats, therefore improving cognition, increasing cerebral blood flow, and salvaging neurovascular function.

Insulin Resistance (IR) is a condition in which a normal dosage of insulin delivers less of the typical biological impact; it is defined as a reduction in the sensitivity of the target organ of insulin action to the action of insulin. The level of insulin resistance is described by insulin sensitivity.The lower the insulin sensitivity, the less effective the unit of insulin is and the less it breaks down sugar.Type 2 diabetes is caused by low insulin production for one thing; low insulin sensitivity for another.

In 2016, a study by Dr. Kelly L. Stromsdorfer et al. at Washington University School of Medicine found that decreased levels of NAD+ in adipose tissue of obese and aged mice were associated with severe multi-organ insulin resistance. By administering NMN to animals given drinking water with a particular enzyme inactivation that causes insulin resistance, insulin resistance was reversed and plasma free fatty acid concentrations were lowered. In mice with type 2 diabetes mellitus, intraperitoneal injection of NMN increases NAD+ levels, which in turn improves glucose tolerance, lipid distribution, and hepatic insulin sensitivity (Dr. Yoshino J et al., Department of Developmental Biology, University of Washington School of Medicine, 2012). Additionally, it improved the sensitivity of the liver to insulin and restored the expression of genes linked to the circadian rhythm, inflammatory response, and oxidative stress.

A long-term study on mice with oral nicotinamide mononucleotide powder was carried out in 2016 by a research team headed by Prof. Shinichiro Imai of Washington University School of Medicine. NMN administered orally for a year prevented a variety of physiological declines associated with aging, including aging-associated weight gain, metabolism elevation, physical strength enhancement, improved insulin sensitivity and plasma fat indexes, improved visual acuity, enhanced immune function, and prevention of bone density decline. These findings were made after comparing the mice that received NMN orally for a year with those that did not receive NMN for normal aging.Furthermore, nicotinamide mononucleotide powder is not poisonous or harmful.Robert Huizenga, M.D. of Harvard University and Cedars-Sinai Medical Center reported on April 20, 2020, that a 55-year-old patient with severe (respiratory distress, temperature 39.4°C) neocoronary arthritis improved after receiving an oral NMN cocktail for 12 hours. Absolute lymphocyte counts increased by 85%, and after 10 days, viral testing came back negative.

Decline in oocyte quality is a limiting factor in female fertility. This decline in oocyte quality occurs with a rapid decline in NAD + levels with age.

A research published in the February 2020 edition of Cell Report discovered that using the precursor of NAD +, NMN, improved oocyte quality in elderly rats, resulting in increased fertility.These advantages of nicotinamide mononucleotide powder also extended to the developing embryo, countering the negative effects of mother age on embryo growth. These findings imply that restoring NAD+ levels helps to improve reproduction in female animals.

Guanjie produces high quality bulk NMN powder. Guanjie uses freeze dried process and vacuum dried process to produce high-purity NMN of ≥99%. If you are interested, please feel free to contact us: info@gybiotech.com. Let's talk about NMN bulk.