Nicotinamide Mononucleotide Powder

Nicotinamide Mononucleotide Powder Supplier:

Guanjie Biotech is a bulk Nicotinamide Mononucleotide powder manufacturer that specializes in the research, development, production, and sales of NMN powder to serve customers. We have two production lines and a production capacity of NMN bulk powder. Guanjie Biotech has been in this line for more than 20 years, with over 15 engineers on our team. We have more than 300 customers from the USA, the EU, Southeast Asia, and so on.

Certificate of Analysis:

What is Nicotinamide mononucleotide?

NMN Solubility Test

● Test Conditions：At room temperature, the solubility of high-density (0.5g/ml) and low-density (0.2g/ml) Nicotinamide mononucleotide powder was tested.

Test condition 1: 20ml-purified water, add 2 g-NMN respectively. Solubility 10%

Conclusion: Both high and low densities can dissolve completely, and low densities dissolve faster.

● Test condition 2: 20ml-purified water, 4g Nicotinamide mononucleotide powder was added separately. Solubility 20%

Conclusion: Both high and low densities can dissolve completely, and low densities dissolve faster.

What Are The Metabolic pathways of NMN?

As the precursor of NAD+, NMN's function is also reflected through NAD+. The metabolism of Nicotinamide Mononucleotide Powder and NAD+ is linked together. There are three independent metabolic pathways of NAD+ in the human body. Preiss-Handler pathway, de novo synthesis pathway and remedy synthesis pathway. NAD+ plays a fundamental role in human health, but as we age, the amount of NAD+ in the body gradually decreases, and the communication between mitochondria and the nucleus is impaired. The loss of NAD+ also impairs the ability of cells to produce energy, leading to aging and disease, which may also be the reason why we age.

Comparison of NAD+ supplement methods

From the perspective of NAD+ supplementation, niacin, tryptophan, nicotinamide and NMN/NR, the four precursors of the three metabolic cycles of NAD+, can be supplemented. Niacin, nicotinamide, and tryptophan all have limited intake levels. The combination of niacin (NA) and GPR109A can cause severe flushing in patients, while excessive intake of tryptophan and nicotinamide can also have side effects. Nicotinamide (NAM) can cause liver toxicity by inhibiting Sirtuins. Nicotinic acid becomes Nicotinamide Mononucleotide Powder through the Preiss-Handler pathway, tryptophan becomes NMN through the de novo synthesis pathway, and nicotinamide and NMN/NR become NMN through the remedial synthesis pathway, which produces 85% of the NAD+ source in the body. It is obvious that NMN/NR, as a key substance in the supplementary synthesis pathway, is an ideal choice to supplement NAD+ in vivo. Since NAMPT is a rate-limiting enzyme that supplements the synthetic pathway, supplementation with nicotinamide (NAM) cannot bypass the bottleneck of NAMPT, and NNM/NR is a more competitive option.

NR and NMN

Nicotinamide Mononucleotide Powder and NR are more direct ways to supplement NAD+. When NR enters the human body, NPK1-2 phosphorylation is required to transform it into NMN, and there is no enzyme of NPK1 and NPK2 in mitochondria to convert NR into NMN. Oral NR was digested into NAM in vivo, but still failed to change the restriction of the rate-limiting enzyme NAMPT in the remedial synthesis pathway, and the ability to replenish NAD+ was limited. In conclusion, NMN supplementation is a direct and effective means to supplement NAD+.

Supplement NAD+

Compared with other NAD+ supplementation methods, NMN bypassed the bottleneck of NAMPT rate-limiting enzymes and rapidly replenishment NAD+ in the body. In a 2017 study, Nicotinamide Mononucleotide Powder supplementation significantly increased the activity of NAD+ and SIRT1 four days after supplementation. Older mice treated with NMN had higher levels of NAD+ and SIRT1 activity than younger mice not treated with NMN.

What Are the Side effects of NMN?

Nicotinamide Mononucleotide powder itself is a natural substance in the human body, and also exists in many foods. It is completely natural and harmless. Studies have confirmed that NMN supplementation does not affect the activities of various enzymes in the supplementary synthesis pathway, and oral NMN has no effect on the activities of various enzymes in the supplementary synthesis pathway, such as NAMPT, PARP, and NMNAT, but directly changes the level of NAD+ in vivo.

How is NMN absorbed?

The absorption of Nicotinamide Mononucleotide Powder in the body is very rapid and can rapidly increase NAD+ levels in the body:

1.) It is absorbed intact through the digestive system.

2.) 2~3 minutes into the blood.

3.) Increase the content of NMN in the tissue within 15 minutes.

4.) Rapidly increase the NAD+ level in blood, liver, and other organs.

What is the function of Nicotinamide mononucleotide powder?

● Matter and energy metabolism

Nicotinamide mononucleotide powder enters the body and becomes NAD+, which plays an important role in energy and substance metabolism.

● Prevention of age-related physical decline

Decreased levels of NAD+ in humans. With decreasing age, mice supplemented with NMN showed weight loss, increased energy, and better glycemic control levels, and Nicotinamide mononucleotide powder reversed the physiological decline caused by age.

● DNA repair enzymes

NAD+ is the sole substrate for ADP ribosyltransferase or ribosylpolymerase (PARP), which is located in the nucleus of many cells and is activated when a single strand of DNA breaks, when cells are damaged by free radicals and oxidants. Activated PARP uses Coenzyme I(NAD+) as a substrate to transfer ADP ribose groups to target proteins and generate nicotinamide (Nam). These target proteins are involved in a variety of functions, including DNA repair, gene expression, cell cycle progression, cell survival, chromosome reconstruction and gene stability.

● Cyclic ADP ribose synthetase

Nicotinamide Mononucleotide Powder is the sole substrate of cyclic ADP ribose synthases (cADPRsynthases) or cyclic ribose polymerases (cADP synthases). Cyclic ADP ribose synthetase consists of a pair of extracellular enzymes, called lymphocyte antigens CD38 and CD157, which use NAD as a substrate to generate cyclic ADP ribose, a second messenger for the cell cycle and insulin.

Factory Equipment & Laboratory Detection

Our factory: There are two factories, both in Baoji City and Shangluo City. Guanjie Biotech factories cover an area of 7000㎡, including a GMP standard workshop of 2000㎡.

Our Testing Center:

● Shaanxi Guanjie Technology Co., Ltd adheres to the high-tech and high-quality Nicotinamide mononucleotide powder product. We not only have our own lab, but also the third lab with which we cooperate. Such as Eurofin, SGS, PONY, NSF ,and so on.

● Our products adhere to the strict quality standard. All the products can be tested. And products requested by customers will be sent to the third-party testing center for testing.

●Contract with Third-Party Lab: Our products adhere to the strict quality standard. Nicotinamide Mononucleotide powder can be tested. And products requested by customers will be sent to the third-party testing center for testing.

Testing Equipment:

NMN can be tested. If you need our testing report, we can provide the third-party report.

Packing:

● 1-5/kg two plastic bags inside, aluminium foil bag outside

● 25/kg paper drum and two plastic bags inside.

Qualification Of the Company

Our mission is"come from nature, serve human well-being". We adhere to the corporate mission of creating a healthy life, strictly control product quality, and are certified with ISO quality management system certificate, ISO 9001-22000, SC, KOSHER, HALAL ,and other certifications. Guanjie Biotech has continuously strived to innovate and improve its control standards. At the same time, it was granted a number of patents.

Delivery:

1-3 working days after payment or PO

Shipment:

Transit could be DHL,UPS,TNT, FEDEX, EMS. For mass orders, it will be delivered by air or sea.

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