Spermidine Powder has many benifits. And Guanjie has focuses on it. Today let talk about this product. It is a naturally occurring polyamine found in a wide variety of organisms. It is a natural nutrient. It plays a role in stabilizing DNA, promoting cell growth and inducing autophagy in living organisms. The human body, as one of the many organisms, also has spermidine in its body.
Spermidine in the human body mainly comes from the following three ways.
1. Ingested in food.
As mentioned earlier, spermidine exists in almost all living organisms. Then animals, plants and fungi, which are used as food ingredients, naturally contain spermidine. Wheat germ, soybeans, cheese, natto, and fungi such as mushrooms are the ones that contain more spermine.
2. Probiotics synthesized in the intestines.
For example, the intestinal probiotic Bifidobacterium bifidum synthesizes spermidine in the intestines in addition to short-chain fatty acids and vitamins.
3. Intracellular biosynthesis.
In mammals, spermine can be metabolized into spermidine. Guanine can also synthesize spermine under the action of enzymes.
Extension of life span
As mentioned earlier, there are 3 pathway sources of spermidine in the human body. However, as we age, the decrease in cellular metabolic vitality and the decrease in enzyme synthesis vitality in the body make the cellular synthesis of its own spermidine begin to decrease.
At the same time, the intestinal flora changes and the gastrointestinal absorption capacity decreases. This has led to a gradual decrease in both the probiotics that can synthesize Spermidine Powder in the body and those absorbed from food.
The simultaneous decline of the 3 source pathways causes the body's spermidine to begin to decline significantly after the age of 30. And as the age increases, the level of spermidine in the body becomes lower and lower.
An observational study of 78 people published in 2012 showed that whole blood polyamine levels in long-lived people (those over 90 years of age) were similar to those of middle-aged people aged 31-56 years. polyamine levels were relatively low in people in the 60-80 year age group [1].
In 2016, a study on mice published in Nature Medicine showed that oral administration of spermidine enhanced autophagy in the heart, thereby extending the lifespan of mice [2].
Anti-cancer
Published in 2020, Tasuku Honjo's team from Kyoto University found that exogenous supplementation of spermidine improves mitochondrial adaptation and also enhances CD8 T-cell-dependent antitumor immunity, leading to anticancer effects in aged hormonal mice treated with ICB [3].
In 2018, a population-based prospective epidemiologic study also showed that higher daily dietary intake of spermidine was associated with lower cancer-specific mortality [4].
At an earlier time, it was also found that supplementation with spermidine reduced liver fibrosis. Reducing the risk of liver cancer [5].
There are two main mechanisms identified for why spermidine is anti-cancer.
On the one hand, Spermidine Powder competitively inhibits the activity of acetyltransferase EP300 to reduce the acetylation of multiple autophagy-related proteins, thereby inducing autophagy and apoptosis in cancer cells.
On the other hand, spermidine wheat germ extract can also by affecting the interaction between cancer cells and their immune effectors. It promotes the recognition of tumor-associated antigens, thereby eliminating cancer cells.
Cardiovascular protection
Spermidine can help lower blood pressure, lower cholesterol levels, and reduce platelet aggregation, thus protecting the cardiovascular.
In 2017, a study published on mice showed that:
Feeding spermidine to older mice delayed age-related cardiac changes. such as diastolic dysfunction and cardiac hypertrophy, and increased autophagy and mitochondrial autophagy in the heart, promoting cellular repair, improving cardiomyocyte mitochondrial function, and enhancing cardioprotection [6].
In that study, the researchers then also administered a food questionnaire to the population. It was found that dietary levels of spermidine were negatively associated with the risk of cardiovascular disease and hypertension. This suggests that supplementation with spermidine may provide a new strategy for mitigating age-related cardiovascular disease.
Cardiovascular protection
Bulk Spermidine can help lower blood pressure, lower cholesterol levels, and reduce platelet aggregation, thereby protecting the cardiovascular.
In 2017, a study published on mice showed that:
Feeding spermidine to older mice delayed age-related cardiac changes. such as diastolic dysfunction and cardiac hypertrophy, and increased autophagy and mitochondrial autophagy in the heart, promoting cellular repair, improving cardiomyocyte mitochondrial function, and enhancing cardioprotection [6].
In that study, the researchers then also administered a food questionnaire to the population. It was found that dietary levels of spermidine were negatively associated with the risk of cardiovascular disease and hypertension.
This suggests that supplementation with spermidine may provide a new strategy for mitigating age-related cardiovascular disease.
Preventing Neurodegeneration
Autophagy plays a crucial role in preventing neurodegenerative diseases. And spermine acts as an autophagy trigger. Many studies have now shown that "spermine has neuroprotective effects."
In 2013, an article published in the journal Autophagy noted that in Drosophila, feeding spermidine reduced age-dependent olfactory memory decline by inducing autophagy. At the same time, spermidine does so by interacting with the presynaptic active zone of the nerve in the synapse. This to inhibit age-related memory impairment [7].
In 2018, researchers also conducted a 3-month trial in humans. The results showed that "oral administration of spermidine, improved memory performance in older adults with cognitive decline [8]."
Additionally, the Association for Diet and Brain Health also investigated the relationship between Spermidine Powder intake and brain health in older populations. The results showed:
Spermidine intake was positively correlated with hippocampal volume and cortical thickness. This suggests that high spermine intake may be beneficial for brain health [9].
Reducing the risk of obesity
The use of spermidine has been reported to reduce weight gain and obesity-related complications. What is known is that gut microbial dysbiosis may increase the risk of developing metabolic abnormalities and obesity.
An article published in 2020 showed that spermidine supplementation reduced body weight and improved insulin resistance in diet-induced obese mice. This was due to attenuation of metabolic endotoxemia and enhancement of intestinal barrier function
This may be due to the fact that spermidine improves the gut microbiota in obese mice, driving an increase in the NK4A136 flora of the family Trichosporonaceae. And this flora is closely related to gut barrier function.
In 2021, results from a study in obese mice showed that oral administration of spermidine significantly reduced obesity, insulin resistance and hepatic steatosis in mice fed a high-fat diet. This was caused by the activation of brown adipose tissue and metabolic adaptations in skeletal muscle targeted by spermine.Thus, oral administration of spermine has the potential to prevent or treat obesity and its associated complications.
Anti-inflammatory
Spermidine acts as an antioxidant. Spermidine also has potent anti-inflammatory effects in liver injury, colitis and respiratory inflammatory events.
A study in a mouse model showed that the use of spermidine prevented ethanol and lipopolysaccharide-induced liver injury and oxidative stress. This may be due to the reduction of reactive oxygen species and lipid peroxidation by spermidine. In addition, gene expression analysis showed that spermidine inhibited the formation of pro-inflammatory cytokines and liver fibrosis.
In 2021, it was even found that supplementation with spermidine reduced colonic inflammation and disease activity index. What's more, spermidine works by regulating the polarization of M1/M2 macrophages and the activation of T cells in the colon. It has shown powerful preventive and therapeutic effects on colitis.
All of this suggests that spermidine is a great anti-inflammatory substance that reduces the level of inflammation in the body.
Chronic inflammation has long been recognized as an influence on aging as well, so reducing chronic inflammation in the body is also a good defense against the aging of the organism.
These are benefits of spermidine. And Guanjie focuses on spermidine powder wheat germ extract producing and trading for many years. Welcome to enquiry us: info@gybiotech.com.
References:
1.Pucciarelli S, Moreschini B, Micozzi D, De Fronzo GS, Carpi FM, Polzonetti V, Vincenzetti S, Mignini F, Napolioni V. Spermidine and spermine are enriched in whole blood of nona/centenarians. Rejuvenation Res. 2012 Dec;15(6):590-5. doi: 10.1089/rej.2012.1349. Epub 2012 Nov 16. PMID: 22950434.
Tobias Eisenberg, Mahmoud Abdellatif, Sabrina Schroeder, Uwe Primessnig, Slaven Stekovic, Tobias Pendl, Alexandra Harger, Julia Schipke, Andreas Zimmermann, Albrecht Schmidt, Mingming Tong, Christoph Ruckenstuhl, Christopher Dammbrueck, Angelina S Gross, Viktoria Herbst, Christoph Magnes, Gert Trausinger, Sophie Narath, Andreas Meinitzer, Zehan Hu, Alexander Kirsch, Kathrin Eller, Didac Carmona-Gutierrez, Sabrina Büttner, Federico Pietrocola, Oskar Knittelfelder, Emilie Schrepfer, Patrick Rockenfeller,Corinna Simonini, Alexandros Rahn, Marion Horsch, Kristin Moreth, Johannes Beckers, Helmut Fuchs, Valerie Gailus-Durner, Frauke Neff, Dirk Janik, Birgit Rathkolb, Jan Rozman, Martin Hrabe de Angelis, Tarek Moustafa, Guenter Haemmerle, Manuel Mayr, Peter Willeit, Marion von Frieling-Salewsky, Burkert Pieske,Luca Scorrano, Thomas Pieber, Raimund Pechlaner, Johann Willeit, Stephan J Sigrist, Wolfgang A Linke, Christian Mühlfeld, Junichi Sadoshima, Joern Dengjel, Stefan Kiechl, Guido Kroemer, Simon Sedej &Frank Madeo.Cardioprotection and lifespan extension by the natural polyamine spermidine.
Al-Habsi M, Chamoto K, Matsumoto K, Nomura N, Zhang B, Sugiura Y, Sonomura K, Maharani A, Nakajima Y, Wu Y, et al. Spermidine activates mitochondrial trifunctional protein and improves antitumor immunity in mice. Science. 2022;378(6618):eabj3510. doi: 10.1126/science.abj3510.
Spermidine enhances cardiovascular health.Charlotte Ridler Nature Reviews Endocrinology volume 13, page66 (2017)
Spermidine-triggered autophagy ameliorates memory during aging.Stephan J Sigrist,Didac Carmona-Gutierrez,Varun K Gupta,Anuradha Bhukel,Sara Mertel,Tobias Eisenberg & show all Pages 178-179 | Received 16 Oct 2013, Accepted 22 Oct 2013, Published online: 15 Nov 2013.
8.Schwarz C, Stekovic S, Wirth M, Benson G, Royer P, Sigrist SJ, Pieber T, Dammbrueck C, Magnes C, Eisenberg T, Pendl T, Bohlken J, Köbe Tet al, . Safety and tolerability of spermidine supplementation in mice and older adults with subjective cognitive decline. Aging (Albany NY). 2018 Jan 8; 10:19-33.
