Sodium Aesculin

Sodium Aesculin Suppliers: Bulk Sodium Aesculin Sourcing Solutions & OEM Service

Guanjie Biotech is a professional Sodium Aesculin supplier. Sodium Aesculin powder is extracted from the fruit of the horse chestnut. We offer a variety of specifications to meet different application needs. It is available as a white powder or white crystalline powder. Our products are produced under strict quality control standards to ensure consistency and purity.  Guanjie Biotech has focused on plant extracts for over 20 years. During this time, we have gained extensive industry experience and technical expertise. We are committed to using natural raw materials and maintaining high product quality. Our team works closely with customers to provide reliable products and professional service. We offer stable supply, competitive prices, and dependable support for customers around the world. If you're interested in our offerings, don't hesitate to get in touch with us at: info@gybiotech.com.

 

Why Choose Guanjie Biotech?

●Sodium Aescinate stands as our flagship product; we operate two production lines with an annual production capacity of 20 tons of Sodium Aescinate 98%.

 

What Is Sodium Aesculin?

The primary components are Aescin Sodium A and Aescin Sodium B. Sodium Aesculin is a triterpene saponin containing a sester bond, extracted from the dried mature seeds of the horse chestnut plant, Aesculus hippocastanum. Clinically, it is utilized for treating cerebral edema, swelling due to trauma or surgery, and venous reflux disorders.

 

COA:

Item	Specification	Result	Method
Basic Product Information
Genus and Species	Aesculus hippocastanum L.	Conform	/
Part of the Plant	Seed	Conform	/
Country of Origin	China	Conform	/
Marker Compounds
Escin (C55H85NaO24)	97.5%~102%	97.8%	HPLC
Aescin A	25.5%~44.5%	38.4%
Aesculuside B	20.5%~34.5%	29.5%
Organoleptic Data
Appearance	White powder or crystalline powder	White crystalline powder	GJ-QCS-1008
Solubility	Easily soluble in water, slightly soluble in ethanol and extremely slightly soluble in dilute hydrochloric acid solution	Conform	/
Clarity and color of the solution	The solution should be clear and colorless	Conform	/
Odor	Characteristic	Conform	GB/T 5492-2008
Taste	Characteristic	Conform	GB/T 5492-2008
Rotation	-16.0-- -26.0	-18.9	/
Process Data
Method of Processing	Extraction	Conform	/
Solvent(s) Used	Grain alcohol/water	Conform	/
Excipient	None	Conform	/
Physical Characteristics
Loss on Drying	<5.0%	2.30%	GB/T 14769-1993
PH	5.2~6.8	6.2
Kali salt	≤0.20%	Conform
Arsenic salt	≤0.0002%	Conform
Heavy Metals
Total Heavy Metals	≤0.0015%	Conform	/
Microbiology
Total Plate Count	<100/g	Conform	/
Bacterial endotoxin	< 8EU/1mg	Conform	/

 

How to test Sodium Aesculin?

There are four kinds of target ingredients in the Sodium Aesculin product: Escin IA, Escin IB, Isoescin IA, Isoescin IB

The retention time of the target ingredient peak in the chromatogram of the assay preparation corresponds to that of the target ingredient peak in the chromatogram of the Standard preparation as obtained in the assay.

ASSAY (TOTAL ISOFLAVONES CONTENT):

By high-performance liquid chromatography.

Chromatographic Conditions:

Instrument:	Shimadzu LC-9A Pumps, SPD 6A UV Detector
	SIL 6B Auto Injector and CR 7A Data
	Processor
Column:	NOVAPACK, C18 , 5μm, 150x4.6mm
Mobile phase :	CH3CN:0.4% Phosphoric Acid Water solution (30:8:62);adjust the PH to 2.1
Flow rate:	1.0 ml/minute
Detector:	UV-220 nm
Injection volume:	20 microliters

 

Standard Preparation

Working Standard Solution

Accurately weigh approximately 6 mg each of Escin IA, Escin IB, Isoescin IA, and Isoescin IB reference standards (collectively recorded as W1). Transfer the weighed standards into a clean 10 mL volumetric flask. Add an appropriate quantity of methanol to dissolve the contents completely, ensuring full solubilization through gentle mixing or sonication if necessary. After dissolution, dilute to volume with methanol and mix thoroughly to obtain a homogeneous working standard solution suitable for chromatographic analysis.

Sample Preparation

Accurately weigh 50 mg of the test Sodium Aesculin sample (recorded as W2) and transfer it into a previously dried 10 mL volumetric flask to avoid moisture interference. Add methanol to dissolve the sample completely. If required, sonicate briefly to facilitate dissolution and ensure uniform extraction of the analytes. After complete dissolution, dilute to the mark with methanol and mix well to produce a clear and uniform test solution for analysis.

Chromatographic Procedure

Inject equal volumes (20 µL) of both the standard preparation and the sample preparation separately into the chromatographic system. Each solution should be injected in triplicate to ensure analytical precision and reproducibility. Record the chromatograms obtained for each injection and carefully note the peak areas corresponding to the individual target components, namely Escin IA, Escin IB, Isoescin IA, and Isoescin IB. The average peak area values obtained from replicate injections should be used for quantitative calculations.

Calculation

The content of each target component in the Sodium Aesculin sample is calculated using the following formula:

One target ingredient (%) = (At × W1 × Ps × 100%) / (As × W2)

Where:

At = Peak area of the specific target ingredient in the test preparation chromatogram

As = Peak area of the corresponding ingredient in the standard preparation chromatogram

W1 = Weight of the reference standard used (mg)

W2 = Weight of the test sample (mg)

Ps = Purity or content of the corresponding reference standard (%)

Total Escins Content

The total escins content, expressed as percentage weight by weight (% w/w), is calculated as the sum of all quantified escin components:

Total Escins Content (% w/w) = Escin IA (% w/w) + Escin IB (% w/w) + Isoescin IA (% w/w) + Isoescin IB (% w/w)

This calculation represents the overall escin concentration present in the analyzed sample.

 

 

Is Sodium Aesculin Safe?

● Generally safe when used correctly

Sodium aesculin is generally considered safe when used at recommended levels. It is widely used in laboratory media, cosmetic products, and research applications. Safety guidelines should always be followed during use.

● Derived from natural plant sources

Sodium aesculin is the sodium salt of aesculin. Aesculin is a natural compound found in plants such as horse chestnut. Because of its natural origin and long history of use in scientific research, sodium aesculin has an established safety profile.

● Low toxicity

Studies show that sodium aesculin has low acute toxicity when used properly. Under normal laboratory and industrial conditions, it is considered safe to handle. It also shows good compatibility with biological systems when used within recommended limits.

● Suitable for topical and laboratory use

Sodium aesculin is commonly used in topical formulations and microbiological culture media. When added at appropriate concentrations, it usually causes little or no irritation. Proper formulation and correct dosage are important for maintaining product safety.

● Product quality is important

The safety of sodium aesculin depends on its quality and purity. Manufacturers should follow strict production standards and quality control procedures. High-purity raw materials help reduce the risk of contamination and ensure consistent product performance. Choosing reliable suppliers is an important part of maintaining safety.

● Avoid excessive intake

Although sodium aesculin is safe in approved applications, excessive intake should be avoided. Using it for purposes that have not been evaluated for safety may increase the risk of unwanted effects. Oral use should only occur when supported by safety assessments and regulatory approval.

● Special precautions for sensitive groups

Certain groups should be more careful when using products containing sodium aesculin. This includes pregnant women, children, and people with existing medical conditions. These individuals should seek advice from a qualified healthcare professional before use.

 

FAQs:

1. What is Sodium Aesculin made from?

Answer: Sodium Aesculin is extracted from horse chestnut seeds. It is obtained from the mature seeds of Aesculus hippocastanum through a controlled extraction process.

2. What purity of Sodium Aesculin do you supply?

Answer: We supply high-purity Sodium Aesculin. Our product contains 97.5%–102% Escin, verified by HPLC with strict quality control for every batch.

3. How do you test Sodium Aesculin quality?

Answer: Every batch is HPLC tested. We analyze Escin IA, Escin IB, Isoescin IA, and Isoescin IB, plus heavy metals, microbiology, moisture, and purity.

4. Is your Sodium Aesculin water soluble?

Answer: Yes, it dissolves easily in water. It is readily water soluble, slightly soluble in ethanol, making it suitable for multiple formulation applications.

5. Why choose Guanjie Biotech as your Sodium Aesculin supplier?

Answer: We provide stable quality and reliable supply. With 20+ years of experience, advanced laboratories, global customers, and competitive pricing, we support long-term partnerships.

6. Is Sodium Aesculin safe to use?

Answer: Yes, when used correctly. High-purity Sodium Aesculin has low toxicity and is commonly used in laboratory, cosmetic, and approved industrial applications.

7. Can you provide OEM, bulk orders, and worldwide shipping?

Answer: Yes, we support global bulk supply. We offer flexible quantities, stable production, OEM support, professional documentation, and worldwide shipment for B2B customers.

 

Factory&Team：

 

Certification

 

Package & Shipment

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