Neohesperidin Dihydrochalcone NHDC

Neohesperidin Dihydrochalcone NHDC Supplier

Guanjie Biotech is a professional premium Neohesperidin Dihydrochalcone (NHDC) Powder (CAS: 20702-77-6) manufacturer and global supplier . Derived from natural citrus flavonoids (neohesperidin extracted from bitter orange, Citrus aurantium L.) and processed through catalytic hydrogenation, our NHDC powder delivers high potency, zero calories, and exceptional stability across food, pharmaceutical, and animal feed applications.

NHDC is recognized globally not only as an intense low-calorie sweetener-providing 1,500 to 1,800 times the sweetness of sucrose-but also as a powerful bitterness blocker and flavor modifier. It effectively masks unpleasant metallic, astringent, or bitter tastes in active pharmaceutical ingredients (APIs), botanical extracts, functional beverages, and animal feeds.

 

 

Why choose Guanjie Biotech As Your Neohesperidin Dihydrochalcone NHDC Supplier?

● High Purity & Quality Assurance:

Assayed at ≥98.0% by HPLC, manufactured in ISO9001, ISO22000, and GMP-compliant facilities.

●Synergistic Sweetness Profile:

Exhibits strong synergy when blended with other sweeteners like Aspartame, Sucralose, Stevia, and Cyclamate, boosting perceived sweetness while reducing overall formulation costs.

● Superior Bitterness & Astringency Masking:

Inhibits bitter receptors even at sub-sweetening threshold concentrations (1–5 ppm).

● High Thermal & pH Stability:

Stable under high-temperature food processing (pasteurization, UHT, baking) and across a wide pH range (pH 2.0 to 11.0).

● Full Regulatory Compliance:

Complies with EU E959 regulations, US FDA GRAS status, FEMA 3811, and USP/EP quality benchmarks. Certified Halal and Kosher.

 

Neohesperidin Dihydrochalcone NHDC COA:

Analysis	Specification	Result
Neohesperidin Dihydrochalcone,w/% ( HPLC )	≥98.0%	98.14%
Naringin dihydrochalcone,w/%	≤2.0%	1.07%
Physical & Chemical Control
Appearance	White to yellowish powder	Conforms
Odor	Characteristic	Conforms
Taste	Very intense sweet	Conforms
Partical Size	95% pass 80 mesh	Conforms
Loss on Drying	≦12.0%	8.02%
Residue on Ignition	≦0.2%	0.11%
Heavy Metals	≤10ppm	Conforms
Arsenic	≤1ppm	Conforms
Lead	≤1ppm	Conforms
MERCURY(Hg)	Not detected	Conforms
Microbiological Tests
Total Plate Count	≤1000cfu/g	Conforms
Total Yeast & Mold	≤100cfu/g	Conforms
E.Coli.	Negative	Negative
Salmonelia	Negative	Negative
Conclusion： Conform to the specification.
Storage： Store in a cool and dry place, keep away from direct strong heat.
Expire Date：24 Months

 

How Is Neohesperidin Dihydrochalcone Produced?

As a NHDC powder wholesale supplier, we strictly control the quality. Neohesperidin dihydrochalcone powder (NHDC) is a high-intensity sweetener and flavor modifier. Its production process involves multiple chemical transformations, catalytic hydrogenation reactions, and rigorous purification and quality control. This process uses neohesperidin as the core raw material. Structural transformation is completed in a catalytic system and reducing environment, ultimately yielding a high-purity Neohesperidin Dihydrochalcone NHDC powder product.

In industrial production, key quality control steps determine the purity, safety, and application performance of the product. Guanjie Biotech strictly adheres to the following five key control points. These control points ensure that the supplied NHDC powder meets a high purity standard of ≥98.0% (HPLC).

 

• First, raw material purity control.

The structural stability of neohesperidin raw materials is the foundation of high-quality Neohesperidin Dihydrochalcone NHDC. Strict screening of neohesperidin raw materials is required during production to ensure the integrity of its flavonoid skeleton, providing a stable precursor for subsequent hydrogenation reactions.

• Second, hydrogenation reaction condition control.

The hydrogenation reaction is the core step in realizing the conversion of neohesperidin to dihydrochalcone. This is achieved through precise control of reaction temperature, pressure, and the type and amount of catalyst. This process effectively ensures the consistency of conversion rate and product structure. Neohesperidin Dihydrochalcone NHDC avoids the formation of unwanted isomers, thus obtaining a high-purity target product.

• Third, the impurity removal process.

After hydrogenation, a small amount of byproducts and residual metal catalysts are produced. Multi-stage purification techniques must be used to remove these impurities. Common methods include recrystallization, membrane separation, or column chromatography. These operations ensure that the Neohesperidin Dihydrochalcone NHDC product meets the stringent purity and residual solvent limits required by the food and pharmaceutical industries.

• Fourth, microbial control.

Neohesperidin Dihydrochalcone NHDC can be used in food and oral formulations. Therefore, it must meet strict food-grade safety standards. GMP regulations should be implemented throughout the entire production process. Specific measures include environmental monitoring, equipment cleaning validation, and microbial testing of the final product. Testing items include total bacterial count, coliform bacteria, mold, and yeast. These steps ensure that the product meets hygiene standards.

• Fifth, particle size control.

The particle size distribution of the Neohesperidin Dihydrochalcone NHDC powder directly affects its dissolution rate and dispersion uniformity in aqueous solution. Through processes such as micronization or air classification, NHDC powder can be adjusted to a suitable particle size range. This can improve its instant solubility and batch consistency in applications such as beverages and liquid formulations.

Based on the above process control, the Neohesperidin Dihydrochalcone NHDC supplied by Guanjie Biotech can be consistently tested by high-performance liquid chromatography (HPLC), and the content can be consistently maintained at ≥98.0%. Our products combine high purity, high safety, and excellent processing suitability, making them a reliable raw material choice for food, beverage, and pharmaceutical companies.

 

What is Neohesperidin Dihydrochalcone Used For?

Neohesperidin dihydrochalcone powder breaks the application limits of traditional sweeteners. It is used in food, pharmaceuticals, health products, feed, and daily chemicals. It is a versatile functional raw material.

• Food Industry

• Pharmaceuticals and Health Products

The pharmaceutical industry is one of the main application areas for natural Neohesperidin Dihydrochalcone NHDC. Many tablets, capsules, oral liquids, and traditional Chinese medicine preparations have strong bitterness or off-flavors. These tastes can reduce patient compliance. Neohesperidin Dihydrochalcone NHDC powder is an effective pharmaceutical flavoring agent. It masks bitterness at very low dosages. It leaves no aftertaste. It does not react with active pharmaceutical ingredients. It does not affect drug efficacy or physical-chemical properties.

Neohesperidin Dihydrochalcone NHDC also shows antioxidant, anti-inflammatory, and metabolism-related activity. It can support the function of health supplements. It is widely used in liver-support, blood sugar support, antioxidant, and gut health products. It provides both taste improvement and functional value.

• Livestock Feed Field

As a compliant feed additive, neohesperidin dihydrochalcone powder improves feed palatability. It masks bitter flavors from soybean meal and additives. This increases feed intake in livestock, piglets, and poultry. It reduces feed refusal and improves feeding efficiency.

Neohesperidin Dihydrochalcone NHDC powder may also support metabolic regulation in animals and improve growth performance. It can help reduce feed consumption and improve farming efficiency. Its antioxidant properties may reduce oxidative stress and improve immune resistance. It is widely used in livestock feed, aquatic feed, and young animal feed formulations.

• Daily Chemicals and Other Fields

In daily chemical products, NHDC is used in toothpaste, mouthwash, and oral sprays. It replaces traditional sweeteners and improves taste quality. It reduces bitterness and harshness in oral care products and helps freshen breath. Neohesperidin Dihydrochalcone NHDC powder may also provide mild antioxidant and gum-supporting effects.

In functional skincare products, NHDC can be used as an antioxidant ingredient. It helps reduce free radical damage and supports skin anti-aging. In addition, it is also used in the tobacco and flavor industries. It helps improve aroma, mask off-flavors, and enhance overall product quality.

 

Frequently Asked Questions (FAQ)

Q1: What is the primary difference between NHDC and standard sweeteners like Stevia or Sucralose?

NHDC sweetener is not only a sweetener (1500-1800x sucrose) but also an exceptional flavor modifier and bitterness blocker. Unlike Stevia, which can exhibit a metallic or bitter aftertaste at high concentrations, Neohesperidin DC has a slow sweetness onset with a long, licorice-like cooling aftertaste. It is frequently blended with Sucralose or Stevia to eliminate lingering bitterness.

 

Q2: What is the regulatory approval status of NHDC Powder globally?

NHDC is fully approved across key international markets:

Europe: Approved as a food additive (E959) under EU Regulation and as a flavor substance (FL-no: 16.061).

United States: Designated GRAS (Generally Recognized As Safe) by FEMA (FEMA No. 3811) for use in food, beverages, and cosmetics.

China: Included in GB2760 as a food additive/sweetener and in the feed additive catalogue.

 

Q3: What are the packaging, storage, and MOQ terms at Guanjie Biotech?

MOQ: 1 kg for trial/sample orders; 25 kg per drum for standard commercial shipments.

Packaging: 1 kg double-layer vacuum aluminum foil bag; 25 kg fiber drum lined with food-grade polyethylene bags.

Storage: Store in a cool, dry, well-ventilated area away from direct sunlight and heat. Shelf life is 24 months when stored unopened in original packaging.

Q4: Can Guanjie Biotech provide technical documentation and custom formulation support?

Yes. We provide complete batch-specific Certificates of Analysis (COA), Safety Data Sheets (SDS), Process Flow Charts, Stability Test Reports, and Allergen/GMO Statements. Free samples (10g–50g) are available upon request for R&D evaluation. As a Bulk NHDC manufacturer, we can provide NHDC 98% HPLC factory direct.

 

Q5: What is the recommended technical dosage of NHDC for sweetness versus flavor masking?

● For Bitterness Masking & Flavor Modification:

The optimal dosage range is 1 ppm to 5 ppm (1–5 mg/L). At sub-threshold levels, NHDC exhibits virtually no detectable sweetness but effectively neutralizes metallic, astringent, or bitter off-notes from active pharmaceutical ingredients (APIs), botanical extracts, or mineral salts.

● For Synergistic Sweetening:

In zero-sugar or low-calorie food and beverage formulations, the recommended usage is 10 ppm to 30 ppm. It is best used in combination with high-intensity sweeteners such as Sucralose, Aspartame, or Stevia to enhance the overall sweetness profile and reduce sweetener cost.

 

Q6: How stable is NHDC Powder under thermal processing and varying pH conditions?

● Thermal Stability:

NHDC displays superior heat resistance. It remains chemically stable during high-temperature processing, including pasteurization, Ultra-High Temperature (UHT) processing, and industrial baking without thermal degradation.

● pH Stability:

NHDC maintains structural integrity and flavor performance across a wide pH spectrum from pH 2.0 to 11.0, making it highly suitable for acidic carbonated soft drinks, fruit juices, and pharmaceutical syrups.

 

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