Cytidine Diphosphate Choline Powder

Cytidine Diphosphate Choline Powder Supplier：

Guanjie Biotech is a professional Cytidine Diphosphate Choline Powder supplier. Cytidine Diphosphate Choline Powder is also called Citicoline powder. As a professional Citicoline manufacturer and exporter, we are committed to delivering premium-grade bulk CDP-Choline to clients worldwide in the pharmaceutical, nutraceutical, and food industries. Our Cytidine Diphosphate Choline Powder is produced under strict quality control standards, ensuring high purity, excellent solubility, and consistent performance. At Guanjie Biotech, we prioritize product safety, traceability, and customization, offering flexible packaging and documentation support to meet our customers' specific regulatory and formulation needs. With years of industry experience and a professional R&D team, we ensure that every batch meets international standards.

Although citicoline is present in cells in extremely small amounts, some cell types may be made to generate it. A multitude of enzymatic reactions are necessary for its creation, with the phosphorylation reaction being the most important one. To maintain cytosolic choline's intracellular concentration, the process of cytosolic choline production is strictly regulated.

 

COA:

Items	Standard	Results
Appearance	White crystalloid powder	Conforms
Identification	1> Chemical reaction 2> The retention time of a major peak meets the requirements. 3> IR:consistent with the spectrum obtained with reference substance.	1> Positive reaction 2> Confirmed 3> Confirmed
Acid Value	Between 2.5~3.5	2.7
Clarity and color of solution	Clarifying,colorless	Conforms
Ammonium	≤0.05%	Conforms
Heavy Metals	≤10ppm	Conforms
Arsenic	≤2ppm	Conforms
Free phosphoric acids	≤0.1%	Conforms
5'-CMP	≤1.0%	0.23%
Loss on drying	≤5.0%	2.8%
Dry content(C14H26N4O11P2)	≥98%	99.3%
Total Plate count	Not more than 1000CFU/g	<10CFU/g
Yeast&Mold	Not more than 100CFU/g	<10CFU/g
E.Coli	Negative	Negative
Conclusion	Confirmed with the requirement

Flow chart:

Enzyme Manufacturing

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Biocatalytic Reaction

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Filtration

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Refined filtration

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lon Exchange

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Concentrated crystallization

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Centrifugal separation

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Dry sifting

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Mixed powder

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Inner packing

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Metal detection CCP1

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Outsourcing warehousing

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Finished product

 

What Are Cytidine Diphosphate Choline Powder Sources?

There are many sources of Cytidine Diphosphate Choline Powder. It can also be found naturally in a variety of foods.

●Eggs

Eggs are one of the most concentrated natural sources of cytidine and choline. A single large egg contains approximately 147 mg of CDP-Choline, which accounts for nearly one-third of the recommended daily intake. In addition to citicoline, eggs are also rich in high-quality protein and essential vitamins like B12 and D, making them an excellent brain-friendly food.

● Beef Liver

Beef liver is among the most potent animal-based sources of citicoline. A 100-gram serving delivers roughly 500 mg of CDP-Choline, making it an ideal choice for those looking to boost their intake through whole foods. Alongside citicoline, beef liver provides iron, zinc, vitamin A, and other nutrients that help enhance immune function, support red blood cell production and promote overall vitality.

●Dried Small Fish

Though often overlooked, dried small fish such as anchovies or sardines are an excellent source of CDP-Choline. A 100-gram portion contains around 500 mg of citicoline, similar to beef liver. These fish are also rich in omega-3 fatty acids, calcium, and protein, making them a nutritious addition to a balanced diet.

●Peanuts

Peanuts are a plant-based source of citicoline, though the concentration is lower compared to animal-based foods. A 100-gram serving contains about 60 mg of CDP-Choline. While not as dense in citicoline, peanuts can contribute to daily intake when consumed regularly in moderation. They also provide healthy fats, fiber, and plant protein.

●Soybeans

Soybeans are one of the best vegetarian sources of cytidine diphosphate choline. A 100-gram serving of soybeans provides approximately 107 mg of CDP-Choline, making them an excellent choice for individuals on plant-based diets. Soybeans also deliver complete protein, isoflavones, and essential amino acids, supporting both brain and overall health.

 

What are the benefits of Cytidine Diphosphate Choline Powder?

1. Protects the optic nerve

Recent research has explored the potential neuroprotective effects of Cytidine Diphosphate Choline Powder in models of retinal neurodegeneration. In a study using primary retinal cell cultures derived from rat embryos, researchers examined whether CDP-Choline influences cell survival and protects neurons under stress conditions that mimic optic nerve damage.

In the first phase, retinal cultures were treated with various concentrations of CDP-Choline (up to 1000 μM). The effects were assessed through markers of apoptosis and cysteine asparaginase activation, along with immunocytochemical analysis to identify neurons and glial cells.

Next, researchers introduced excitotoxic levels of glutamate and high-glucose (HG) media known to induce neuronal damage. These harmful conditions were applied with and without CDP-Choline treatment to evaluate its protective capacity.

The results revealed that CDP-Choline was non-toxic to retinal glial cells at concentrations below 1000 μM. Moreover, at 100 μM, it significantly reduced neuronal cell damage, inhibited apoptosis, and helped preserve synaptic connections in both glutamate- and HG-exposed cultures.

These findings support the conclusion that CDP-Choline Powder offers protective effects on retinal neurons and may help safeguard the optic nerve under degenerative conditions.

 

2. Protection of the macula

A clinical study evaluated the protective effects of Cytidine Diphosphate Choline Powder on the macula following LASIK surgery, using Optical Coherence Tomography Angiography (OCTA) to examine the retinal microvascular structure.

● The study included two groups: 45 patients who received CDP-Choline post-LASIK and 48 control participants who did not.

● Key retinal parameters-foveal avascular zone (FAZ), superficial vessel density (SVD), and deep vessel density (DVD)-were assessed preoperatively, and again at 1 month and 3 months after surgery in both the central and paracentral regions of the macula.

● Before surgery, there were no statistically significant differences (P > 0.05) between the two groups in terms of supraretinal or subretinal vascular obstructions across all quadrants (superior, inferior, temporal, and nasal).

● However, at both 1 month and 3 months postoperatively, the group that received CDP-Choline powder showed significant improvements (P < 0.05) in reducing retinal vascular obstruction, particularly in the superior and inferior quadrants of both central and paracentral retinal regions, compared to the control group.

These findings suggest that CDP-Choline supplementation may offer a protective effect on macular microvasculature following refractive surgery, supporting its potential role in ocular health.

● Supports Optic Nerve Repair in Glaucoma

Cytidine Diphosphate Choline Powder plays a critical role in the synthesis of phosphatidylcholine, a key component of neuronal membranes. By enhancing phospholipid metabolism, it contributes to increased levels of neurotransmitters in the central nervous system.

When administered orally or intravenously, CDP-Choline is metabolized into cytidine and choline, which cross the blood-brain barrier and are re-synthesized into CDP-Choline within brain cells. This process has been shown to have neuroprotective effects in various neurological conditions, including glaucoma, amblyopia, Parkinson's disease, and stroke, by promoting optic nerve regeneration and improving neural signaling.

 

● Promotes Corneal Nerve Regeneration After LASIK

Cytidine Diphosphate Choline Powder has also demonstrated a positive effect on corneal nerve healing following LASIK surgery. In a prospective, controlled clinical study involving 78 patients (mean age 26.8 ± 7.6 years), CDP-Choline was administered within one month post-surgery for a treatment duration of 1 month. A control group of 78 eyes from 78 individuals (mean age 26.1 ± 7.4 years) received no CDP-Choline.

Corneal sensitivity was evaluated using a Cochet-Bonnet esthesiometer at baseline and at 1, 2, 3, 4, 6, 8, and 12 weeks post-LASIK. The results showed that patients in the CDP-Choline group exhibited significantly higher corneal sensitivity than the control group at weeks 1 through 6 (P < 0.05). By weeks 8 and 12, no statistically significant difference remained between the two groups.

These findings suggest that Cytidine Diphosphate Choline Powder may play a key role in accelerating corneal nerve regeneration, particularly during the early stages of recovery following LASIK surgery.

 

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