Sialic Acid Powder

Sialic Acid Supplier:

Guanjie Biotech is a professional Sialic Acid supplier, also known as N-acetylneuraminic acid. Our product is a white to off-white powder with excellent water solubility, making it easy to use in food, nutrition, and health product formulations. With an assay of ≥98%, we ensure consistent purity and excellent performance for commercial applications. Guanjie Biotech offers N-Acetylneuraminic Acid powder at competitive pricing, backed by professional service and strict quality control, supported by HALAL, HACCP, ISO, and KOSHER certifications. This ensures we are a dependable partner for global buyers seeking a stable bulk Sialic Acid supply. Please feel free to contact us at info@gybiotech.com.

COA:

Inspection standards	Inspection	Results
Appearance	white to off-white powder	Conforms
Solubleness	dissolves easily in water	Conforms
Specific rotation	-30°~34°	-31.125°
Identification	HPLC RT	Conforms
pH	1.8-2.3	1.99
Residue on ignition	≤1.0%	0.64%
Water	≤2.0%	0.50%
Assay	≥98%	98.49%
Related substances	any individual impurity≤1.0%	0.93%
	gross contaminations≥2.0%	1.44%
Total Plate Count(CFU/g)	≤500	Conforms
Coliforms(CFU/g)	<0.3	Conforms
Mold(CFU/g)	<25	Conforms
Yeast(CFU/g)	<25	Conforms
Solvent Residue(ethyl alcohol)	<3000ppm	Conforms
Heavy metals	≤10ppm	Conforms
Pb	≤0.5 ppm	Conforms
As	≤0.4 ppm	Conforms
Hg	≤0.2 ppm	Conforms
Cd	≤0.5 ppm	Conforms

How To Produce Sialic Acid?

Sialic acid, also known as N-acetylneuraminic acid, is a specialty biochemical used in functional foods, infant formula, nutritional supplements, cosmetics, and pharmaceutical-grade formulations. As market demand for immune-enhancing and cognitive-support ingredients increases, suppliers must demonstrate sound technology, clean manufacturing, and reliable quality control. Guanjie Biotech positions itself in this market as a professional supplier of high-purity sialic acid, offering ≥98% assay, white to off-white powder appearance, and excellent water solubility that supports ease of formulation.

The company focuses on controlled biotechnological production rather than crude extraction. This aligns with current industrial trends: microbial fermentation offers higher yield, greater consistency, and improved scalability compared with extraction from animal-derived raw materials, which may present allergen, cultural, or regulatory barriers. Guanjie Biotech applies food- and GMP-oriented management, supporting applications ranging from dairy enhancement to nutraceutical ingredient supply for brain health formulas.

Raw Materials Selection

Production begins with selecting high-quality raw materials such as glucose, corn steep liquor, lactose, and other carbon or nitrogen sources. These ingredients serve as the nutritional substrates for microbial growth. Calcium chloride is also introduced at specific stages to assist in flocculation and impurity removal.

All raw materials undergo incoming quality inspection to ensure compliance with microbiological and chemical specifications before entering the production line.

Fermentation

Guanjie Biotech uses controlled microbial fermentation to biosynthesize Sialic Acid precursors. The selected microbial strains are cultivated under optimized temperature, pH, airflow, and nutrient conditions. During fermentation, microorganisms convert glucose and other nutrients into target metabolites.

Modern fermentation tanks, automated feeding systems, and online monitoring instruments allow precise control of biochemical reactions, ensuring high yield and product consistency.

Flocculation and Filtration

After fermentation is complete, calcium chloride is added to trigger flocculation. This step helps bind suspended solids and biomass, allowing them to be separated more efficiently.

Filtration removes most of the cellular debris and insoluble impurities, producing a clarified fermentation broth ready for downstream purification.

Sterilization and Ultrafiltration

The pre-purified broth is sterilized to eliminate potential contaminants. Ultrafiltration membranes are then used to remove macromolecules and concentrate the target compounds. This step significantly improves purity by eliminating proteins, polysaccharides, and other large-molecule impurities.

Hydrolysis

Hydrochloric acid is introduced for hydrolysis. This process breaks down bound forms of sialic acid and releases free N-acetylneuraminic acid. Strict pH and temperature controls are applied to prevent degradation and maintain product integrity.

Nanofiltration Concentration

Nanofiltration further removes small molecular impurities and concentrates the hydrolysate. This membrane-based purification refines the product to a higher purity level while reducing unwanted salts and by-products.

Crystallization

Hydrochloric acid and ethanol are added to trigger crystallization. During this stage, Sialic Acid precipitates from the purified solution and forms solid crystals. Controlled cooling rates and solvent ratios ensure the crystal size and purity are uniform and stable.

Drying

The crystallized material is transferred to a drying system. Moisture is removed under controlled temperature and airflow conditions. The drying step prevents microbial growth and ensures stability during storage.

Pulverization

Once dried, the crystalline Sialic Acid is milled into a fine powder. This step improves uniformity, enhances solubility, and prepares the product for accurate mixing and packaging.

Mixing

Before packaging, the powder may be blended to achieve homogeneity, ensuring consistent quality and uniform appearance across batches.

Inner Packaging (Grade D Clean Area)

Inner packaging is carried out in a Grade D clean-area environment to prevent contamination. The powder is sealed into moisture-proof, light-proof containers that maintain product stability throughout its shelf life.

Outer Packaging and Warehousing

The inner-packaged products are placed into protective outer cartons. Clear labeling, batch numbers, and quality documents accompany each shipment. Finally, products enter a temperature-controlled warehouse, where storage conditions are monitored to preserve quality until dispatch.

Analytical testing

Throughout production, quality management follows analytical testing. A high-purity product at ≥98% assay requires constant quantitative analysis through chromatography. Microbiological testing ensures that fermentation and filtration steps comply with safety requirements for food and supplement markets. Heavy metal and solvent residue limits are controlled to meet international regulatory guidelines.

The resulting powder has a white to off-white appearance and dissolves easily in water. High solubility is important for beverage applications, encapsulation, formulation into infant formula, and incorporation into liquid oral nutraceuticals. Purity at ≥98% supports label claims and minimizes matrix interference when combined with other functional compounds such as DHA, phosphatidylserine, and lactoferrin.

We are committed to quality control, process hygiene, equipment precision, and regulatory compliance, ensuring that each batch meets international standards. With reliable production capacity, competitive pricing, and a focus on safety and consistency, Guanjie Biotech is a trusted supplier of premium-grade Sialic Acid for global nutrition and health-related industries.

 

By considering these factors-purity, production method, testing, certifications, physical characteristics, and supply reliability-buyers can confidently select high-quality sialic acid powder. Guanjie Biotech provides a trustworthy option with high-quality products, comprehensive documentation, and strong compliance with international standards.

 

Company Advantages:

 

Certification

 

Package & Shipment

Hot Tags: sialic acid powder, China sialic acid powder manufacturers, suppliers, factory, Alpha-GPC Powder, D-Chiro Inositol Powder, L-carnitine Fumarate Powder