Citicoline Sodium Powder

Citicoline Sodium Powder Supplier:

Guanjie is a reliable supplier of Citicoline Sodium Powder for 20 years. It also called Citicolline Powder, which is excellent quality, white powder or crystalloid powder.The content that we can extent to 98%. In order to ensure the quality and purity, we test by HPLC. As a trusted supplier, Guanjie ensures that all products are produced under strict quality control standards to provide the best quality possible to our customers.

Why Choose GuanJie?

● Innovative Technology:
We are committed to developing natural products and has 16 patented technologies.

● International Certification System:
With certifications like IS09001.ISO22000, IP (non-GMO), QS, Kosher, and Halal, you can be sure of the quality of GuanJie's products.

● Strict Quality Control System:
We ensure that almost all testing items are tested in-house, including water, odor, heavy metals, solvent residue, pesticide residue, protein, and microbiological.

●Professional Shipping:
The company works with shipping agents who have been in the business for over 20 years to guarantee the safe and quick export of goods.

●Certificate:
We hold a range of certifications, including ISO9001, ISO22000, IP (non-GMO), QS, Kosher, and Halal.

 

Product Introduction:

Sodium cytarabine is composed of ribose, cytosine, phosphate, and choline. As an endogenous compound, it is an important mediator of phospholipid synthesis in cell membranes and serves as an extrinsic source for the synthesis of acetylcholine, a vital neurotransmitter that plays a crucial role in nucleotide metabolism.

 

COA:

Items	Specification	Results
Appearance	White powder or crystalloid powder; Soluble easily in water	Conforms
Identification	Chemical reaction	Positive reaction
	The retention time of a major peak meets the requirements.	Conforms
	IR: consistent with the spectrum obtained with reference substance.	Conforms
	Show sodium flame	Positive reaction
Acid value	Between 6.0~7.5	6.6
Clarity and color of solution	Clarifying, colorless	Conforms
Related substance	Should meet the requirement	Conforms
Residual Solvents-Methanol	N.M.T. 0.3%	0.12%
Residual Solvents-Acetone	N.M.T. 0.5%	0.05%
Chlorides	N.M.T. 0.05%	Conforms
Ammonium	N.M.T. 0.05%	Conforms
Iron	N.M.T. 0.01%	Conforms
Phosphate	N.M.T. 0.1%	Conforms
Loss on drying	N.M.T. 6.0%	0.6%
Heavy metals	N.M.T. 20ppm	Conforms
Arsenic	N.M.T. 0.0001%	Conforms
Endotoxin	N.M.T. 0.6EU/mg	Conforms
Dry content(C14H25N4NAO11P2)	N.M.T. 98.0%	99.3%

 

Tested Results：

1. Relevant substances

● The peak area of the test solution corresponding to the 5′-cytidylic acid control solution shall not be larger than the main peak area of the control solution (0.3%)

Detected: 0.02%

 

●The peak area of other individual impurities shall not be greater than 0.2 times the main peak area of the control solution (0.2%)

Detected:0.06%

 

●The sum of the peak areas of each impurity shall not be greater than the main peak area of the control solution (0.7%)

Detected:0.11%

 

2. Residual solvent

●Methanol shall not exceed 0.3%- Not detected

●Ethanol shall not exceed 0.3%-0.008%

●Acetone shall not exceed 0.5%-Not detected

●Toluene shall not be more than 0.089% undetected-Comply with the regulations

 

Extraction methods:
There are many reports on the preparation methods of Citicoline Sodium Powder, but they can be broadly categorized into three routes. Guanjie uses a new enzymatic reaction method.
●Organic chemical synthesis method
This method has problems such as the product is difficult to be separated from the condensation agent, not suitable for medicinal use, low reaction conversion rate, many by-products, high cost and serious environmental pollution

 

●Microbial fermentation method
Using yeast, Escherichia coli and other engineering bacteria for fermentation, the method has low product concentration, unstable yield and other problems

 

●Enzyme synthesis method
Using enzymes for biosynthesis reaction, the method is green and environmentally friendly.

 

Cytophosphatidylcholine & Sodium Cytophosphatidylcholine
● Different CAS numbers.
The chemical name of cytarabine is choline cytidine nucleoside diphosphate (CAS: 987-78-0), and it is an acid. On the other hand, the chemical name of cytophosphorylcholine sodium is the monosodium salt of choline cytosine nucleoside diphosphate (CAS: 33818-15-4), which is the sodium salt of cytophosphorylcholine, a type of salt. Therefore, the physicochemical properties of Citicoline Sodium Powder and cytophosphatidylcholine powder chemicals are different.

 

●Different chemical compositions, and their chemical structure formulas and drug names
According to the International WHO's naming rules for drugs, the International Nonproprietary Names (INN) of "cytophosphatidylcholine" and "cytophosphatidylcholine sodium" components are completely different. INN names of the same chemical component can not be inconsistent, making it clear that they are two different chemical components.

 

Factory&Team：

 

Certification

 

Package & Shipment

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