Water-soluble Resveratrol Powder

What Is Water-soluble Resveratrol Powder?

Guanjie Biotech is a water-soluble Resveratrol Powder supplier. Our water-soluble resveratrol uses hydroxypropyl-β-cyclodextrin to embed resveratrol. It is produced using hydroxypropyl-β-cyclodextrin to encapsulate resveratrol, enhancing its solubility and stability. This technology helps improve bioavailability and ease of formulation in beverages, functional foods, and nutraceutical products. Water-soluble resveratrol maintains the natural activity of resveratrol while enabling better application performance in water-based systems. The assay of water-soluble resveratroL powder is about 10%. It is suitable for making melting tablets.

 

We make it only with resveratrol and 2-Hydroxypropyl-β-cyclodextrin. The final user can add some flavor and sweetener to make a tablet.

If you take resveratrol powder and dissolve it with some high-proof alcohol, then add water and flavor and sweetener, and then put it in a bottle and use a dropper to administer it under the tongue, the resveratrol would be dissolved after adding water to the RESV/Alcohol mixture.

 

For the above question, firstly dissolve water-soluble resveratrol powder in alcohol, and then add some water. But if you add more than 70% water, the resveratrol will settle again. So the alcohol V/V must be more than 30%; it looks like a liquor. If make anontransparent jelly, the resveratrol can suspend in it; you don't need to use any alcohol. This is the best way.

We usually sealed in two layers plastic-bags and put in paper-drums, to avoid it from Oxygen.
Concerning Water-soluble Resveratrol Powder, we apply molecular encapsulation technology. The specific technology is as follows:
Introduction to raw material solubility:
(1) Hydroxypropyl- β- Cyclodextrin: easily soluble in water, methanol, ethanol, etc;
(2) Resveratrol: easily soluble in methanol, ethanol, ether, acetone, etc;

 

COA

Item	Specification	Result	Method
Basic Product Information
Genus and Species	Pohygonum cuspidatum Sieb et Zucc．	Conform	/
Part of the Plant	Root	Conform	/
Country of Origin	China	Conform	/
Marker Compounds
Assay(Resveratrol)	≥10%	10.23%	HPLC
Organoleptic Data
Appearance	Powder	Conform	GJ-QCS-1008
Color	Off white	Conform	GB/T 5492-2008
Odor	Characteristic	Conform	GB/T 5492-2008
Taste	Characteristic	Conform	GB/T 5492-2008
Process Data
Method of Processing	Extraction	Conform	/
Solvent(s) Used	Ethanol	Conform	/
Excipient	Hydroxypropyl beta cyclodextrin	Conform	/
Drying Method	Spray drying	Conform	/
Physical Characteristics
Solubility	Soluble in Water	Complies	Visual
Moisture	<5%	2.06%	GB/T 14769-1993
Ash Content	<5%	2.83%	AOAC 942.05, 18th
Solvent Residue	Eur Pharm	Conform	GJ-QCS-1007
Heavy Metals
Total Heavy Metals	<10ppm	Conform	GB 5009.74-2014
As	<2.0ppm	Conform	GB/T 5009.11-2014
Pb	<2.0ppm	Conform	GB 5009.12-2017
Cd	<0.5ppm	Conform	GB 5009.15-2014
Hg	<0.5ppm	Conform	GB/T 5009.17-2014
Pesticide Residue
666	<0.2ppm	Conform	GB/T5009.19-1996
DDT	<0.2ppm	Conform	GB/T5009.19-1996
Microbiology
Total Plate Count	<1,000cfu/g	Conform	AOAC 990.12, 18th
Total Yeast & Mold	<100cfu/g	Conform	FDA (BAM) Chapter 18, 8th Ed.
E. Coli	Negative	Negative	AOAC 997.11, 18th
Salmonella	Negative	Negative	FDA (BAM) Chapter 5, 8th Ed.

 

What Is the Stability of Water-soluble Resveratrol Powder?

1. Stability Test Methods

① Introduction:

The purpose of stability testing is to provide evidence on how the quality of Water-soluble Resveratrol Powder varies with time under the influences of temperature and humidity and to establish recommended storage conditions, retest periods and shelf life.

 

② Responsibility:

QA/QC Director is responsible for the stability study program and is also responsible for the stability samples analyzed as well as the maintenance of the program records.

③ Procedure and Design of Stability Studies:

● Long Term Studies:

The samples of resveratrol bulk powder are closed tightly in polyethylene bags, sealed in PE bags, and packaged in aluminum containers. They are stored under long-term conditions of 252℃ temperature and 60±5% humidity according to ICH/FDA guidelines. The three consecutive process validation batches and one batch every year are sampled and placed on long-term stability testing. After the initial analysis, these Water-soluble Resveratrol Powder samples will be analyzed at intervals of 3, 6, 9, 12, 18, 24 and 36 months. The results to date demonstrate that Resveratrol is stable at 25±2℃temperature and 60±5% humidity conditions.

 

● Accelerated Studies:

The samples of Water-soluble Resveratrol Powder are placed in polyethylene bags, sealed in PE bags, packaged in aluminum containers and stored at 40±2℃ and 75±5% humidity conditions. The three consecutive batches are taken for testing. After the initial analysis, these Water-Soluble Resveratrol Powder samples are analyzed at 1, 2, 3, and 6 months according to ICH Guidelines. The results to date demonstrate that Resveratrol is stable at 40±2℃ temperature and 75±5% humidity conditions.

 

2. Stability Test Results

The following pages summarize the Accelerated and Long Term Stability Testing results available to date for three batches of Resveratrol. As more data becomes available, we commit to forward this data so that it may be included as annual updates to the Resveratrol Product Drug Master File.

 

What Does Water-soluble Resveratrol Powder Do?

1. Tumor Effects
●Inducing apoptosis of tumor cells:
Water-soluble Resveratrol Powder can activate apoptosis signaling pathways in cells, causing programmed cell death in tumor cells. For example, it can upregulate the expression of pro-apoptotic proteins such as Bax, while downregulating anti-apoptotic proteins. This makes cells prone to apoptosis.
●Inhibiting tumor cell proliferation:
Resveratrol can interfere with the cell cycle of tumor cells and prevent cells from entering the S phase from the G1 phase. This can inhibit cell division and proliferation. Its mechanism of action may be related to regulating the expression and activity of cell cycle proteins and their dependent kinases.
●Antioxidation and free radical scavenging:
Water-soluble Resveratrol Powder has a strong antioxidant capacity, which can remove excessive free radicals in the body, reduce the damage of oxidative stress to cell DNA, and reduce the risk of normal cells becoming cancerous. At the same time, it can also enhance the body's own antioxidant defense system and protect cells from oxidative damage.

 

2. Estrogen-like effects and effects on bone metabolism
●Estrogen-like effects:
The chemical structure of resveratrol is similar to that of estrogen, and it can bind to estrogen receptors and exert weak estrogen activity. In some tissues, it can mimic the effects of estrogen. For example, it has a certain protective effect on the cardiovascular system. It may be achieved by regulating blood lipids, inhibiting the proliferation of vascular smooth muscle cells and improving endothelial function.
●Effect on bone metabolism:
On the one hand, the estrogen-like effect of Water-soluble Resveratrol Powder can promote the proliferation and differentiation of osteoblasts and increase bone formation. On the other hand, it can also inhibit the activity and differentiation of osteoclasts and reduce bone resorption. Through this dual effect, resveratrol helps maintain the balance of bone metabolism and prevent bone metabolic diseases such as osteoporosis. Especially for postmenopausal women, due to the decline in estrogen levels in the body and the acceleration of bone loss, resveratrol may have certain preventive and therapeutic value.

3. Regulate immunity
●Enhance immune cell function:
Water-soluble Resveratrol Powder can promote the proliferation and differentiation of T lymphocytes and B lymphocytes and enhance their immune activity. It can also activate macrophages. It can enhance its phagocytic ability and better remove foreign bodies such as pathogens.
●Regulate cytokine secretion:
Cytokines play an important regulatory role in the immune system. Water-soluble Resveratrol Powder can regulate the secretion of cytokines such as interleukins, interferons, and tumor necrosis factors, so that they reach a balanced state that is beneficial to immune defense. For example, it can promote the secretion of anti-inflammatory cytokines and inhibit the overexpression of pro-inflammatory cytokines, thereby alleviating inflammatory responses and maintaining the body's immune homeostasis.
●Activating immune-related signaling pathways:
Water Soluble Resveratrol Powder can activate some signaling pathways related to immune regulation. Such as the NF-κB signaling pathway. It can regulate the function of immune cells and the expression of immune molecules, and enhance the body's immune response ability.

 

Why Choose Guanjie Biotech?

● Strict Quality Control:

We have Hala, ISO9001, PAHS Free, HACCP, NON-GMO, KOSHER, SC and other certificates and SGS, Puni testing, Eurofins Analysis, and UCGS Testing that we can provide.

● Professional team:

We have 20 years of experience in  Water-soluble Resveratrol Powder production, research and sales. Our company has an independent research and development center; there are 10 experts in our research team.

● Warehouse:

in NJ, USA

● Service：

We also focus on value-added services. We are available for service questions and provide information to support your business.

 

Our Factory：

Water-soluble Resveratrol Powder is produced in a clean working environment and every step of the process beginning with the farming pool to packaging, is conducted by highly qualified professionals. Both the production processes of manufacture and the product itself meet all international standards. There are two factories both in Baoji city and Shangluo City, Guanjie factories covers an area of 7000㎡, including GMP standard workshop of 2000㎡.

 

Our Research Center:

We have our house in lab and the cooperative labs. Our products adhere to the strict quality standard.

 

Testing Center:

Both the production processes of manufacture and the water soluble resveratrol powder itself meet all international standards. And if you need our testing report, we can provide you.

 

Certification

We have obtained the NON-GMO by Pony test international group. And we get the certifications about HALAL,ISO 9001,ISO 22000,Kosher, PAHS,SC and so on.

 

 

Package&Warehouse:

 

Shipment:

DHL, Sea freight, FEDEX, you can choose.

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