NMN (nicotinamide mononucleotide) as a key NAD+ precursor in the field of anti-aging and neurodegenerative diseases has received extensive attention in the scientific and medical fields. NAD+ is an important coenzyme in cells. It is involved in various physiological processes such as cellular energy metabolism, DNA repair, and immune regulation. Guanjie Biotech has focuses on NMN bulk powder for more than 20 years. Today let's talk about its function about preventing stroke. With further research, the potential of NMN in reducing the risk of cognitive impairment in terms of stroke is gradually emerging.
• Blood-brain barrier and NMN
The blood-brain barrier (BBB) is a protective barrier between the brain and blood. It is essential for maintaining the stability of the brain microenvironment. As we age, the integrity of the BBB is compromised, leading to cognitive decline and neurodegenerative diseases. The study by the Peking University team points out that nicotinamide mononucleotide powder has a repairing effect on aging-induced blood-brain barrier damage through the CX43-PARP1-NAD+ signalling pathway.
• Early Explorations of the NMN Experiment
To understand the role of NAD+ in the blood-brain barrier, the researchers did an experiment. They had mice missing a protein called SIRT3. This protein will help regulate NAD+ levels in the body. It turned out that the blood-brain barrier of the mice lacking SIRT3 was severely damaged, whether they were given a stimulus in the lab (with LPS, a substance that mimics infection) or not. The blood-brain barrier is the brain's protective layer, and if it is damaged, the brain is in trouble.
• Mid-term exploration of the NMN experiment
To further explore the role of NAD+ in the aging process, they supplemented a group of mice with nicotinamide mononucleotide powder and observed the effects for up to 12 months. The results showed that NMN supplementation helped improve the health of the blood-brain barrier in both normal mice and mice with a defective CX43 gene. Even under conditions that mimicked acute inflammation, blood-brain barrier disruption was restored by 5 days of NMN bulk powder pretreatment.
• Later Explorations of the NMN Experiment
Finally, the researchers also examined the effects of NMN on stroke. Their NMN intervention, given 5 days before permanent middle cerebral artery occlusion, significantly reduced cerebral infarct volume compared to controls. These data demonstrate the effectiveness of nicotinamide mononucleotide powder dietary supplements in combating vascular degeneration and blood-brain barrier dysfunction in aging and inflammation. It opens new avenues for the prevention and treatment of cognitive impairment after stroke.
This study not only provides a new scientific basis for the use of NMN bulk powder in neuroprotection, but also offers new strategies to address the health challenges posed by global ageing.NMN may become an important tool for improving cognitive health and quality of life in older adults. However, it is worth noting that coming studies need to further explore the efficacy of NMN in different neurological diseases, as well as its long-term safety and efficacy.
NMN and post-stroke cognitive impairment
Stroke, also known as a stroke, is caused by ischaemia or haemorrhage in brain tissue due to the blockage or rupture of a blood vessel in the brain. This not only leads to acute neurological damage. NMN bulk powder can also trigger long-term cognitive impairment. This includes memory loss, poor concentration, executive dysfunction, etc. NMN, a key NAD+ precursor, has been shown to play an important role in maintaining cellular energy metabolism and promoting nerve cell health.
Mechanism of action of NMN
With age, the level of NAD+ in the body gradually declines, which is thought to be one of the causes of age-related cognitive decline.NMN helps to restore and maintain normal cellular function by converting to NAD+, thus potentially ameliorating cognitive deficits after stroke.
Evidence from preclinical studies
Animal model studies have shown that NMN supplementation increases NAD+ levels in the brain, improves the metabolic state of nerve cells, and promotes nerve regeneration and repair. In stroke models, NMN treatment has shown to reduce brain damage and improve neurological recovery. In addition, NMN showed antioxidant and anti-inflammatory effects, which may help protect nerve cells from secondary damage after stroke.
Prospects for clinical studies
Despite the encouraging results of preclinical studies, more clinical studies are needed to validate the use of NMN bulk powder in the treatment of post-stroke cognitive impairment in humans. Ongoing clinical trials are being conducted to evaluate the safety, efficacy, and optimal dosage of NMN. The results of these studies will provide an important scientific basis for the use of NMN as a treatment for post-stroke cognitive impairment.
Safety and Future Directions
NMN, as an endogenous substance, has a relatively high safety profile. However, the safety and side effects of long-term NMN supplementation still need to be evaluated through large-scale clinical studies. Future studies will focus on determining the effectiveness of NMN in patients with different types of stroke and how it can be combined with other rehabilitation therapies to achieve optimal therapeutic outcomes.
References on NMN to diminish the gamble of mental hindrance in stroke. Here are a few important investigations and reports:
A review from Peking College proposes that NMN might assist with fixing age-related harm to the blood-mind obstruction. This might decidedly affect forestalling post-stroke mental disability. The review noticed that NMN bulk powder affects maturing incited blood-mind hindrance harm through the CX43-PARP1-NAD+ flagging pathway.
Another review inspected the impact of NMN on stroke and found that NMN intercession given 5 days before long-lasting center cerebral conduit impediment essentially diminished cerebral infarct volume contrasted with the benchmark group.
Likewise, there are reports referencing that NMN decreases stroke-initiated mind harm and forestalls spillage of the blood-cerebrum boundary, which might decidedly affect forestalling post-stroke mental hindrance.
NMN as a potential treatment. This provides new ideas for the recovery of cognitive impairment after stroke. With deeper research, NMN bulk powder can be an effective tool to improve the quality of life of stroke patients.
Guanjie produces high quality bulk NMN powder. Guanjie uses freeze dried and vacuum dried process to produce the high-purity ≥99%NMN . If you are interested, please feel free to contact us: info@gybiotech.com. Let's talk about NMN bulk.
References:
[1] Shan W, Zhu Y, Ji L, Pan B, Yu Y, Li W, Zhao X, He Q, Liu X, Huang Y, Liao S, Zhou B, Chui D, Chen YE, Sun Z, Dong E, Wang Y, Zheng L. NAD+ rescues aging-induced blood-brain barrier damage via the CX43-PARP1 axis. Neuron. 2023 Nov 15;111(22):3634-3649.e7.
