Bulk NMN Powder has been a hot topic nowadays. NMN recaptured its former glory. Scientific research for all organ systems of the body is frequent. It is helping the health of the population in terms of anti-aging and wellness. The most memorable events in the field of NMN. The human phase II clinical trials in China, the United States and Japan were published successively. Adding a higher level of evidence for the utility of NMN. In this article, we will summarize the hotspots and highlights of NMN research for all readers, and we will review the new surprises brought by the "immortality drug" to us in the past year.
NMN's first human phase II clinical trial confirms insulin sensitivity enhancement
In April 2021, the authoritative academic journal Science published the results of the world's first NMN human clinical trial. A total of 25 overweight or obese middle-aged and elderly women (55-75 years old) participated in the trial.
The data showed that after 10 weeks of continuous oral administration of NMN capsules (250 mg daily with breakfast). Subjects showed a substantial increase in AKT threonine 308 and serine 473 phosphorylation levels. Suggesting that NMN significantly enhanced skeletal muscle regeneration and recovery. Insulin sensitivity was elevated in up to 31% of subjects' skeletal muscle. Suggesting that NMN made a long-lasting reversal of the metabolic function of human aging.
NMN human clinical trials successively
In July 2021, a team from the University of Tokyo in Japan completed the second human phase II clinical trial of NMN. The study recruited 20 healthy men over the age of 65 to take 250mg of Bulk NMN Powder daily for 6 or 12 weeks. The study found that subjects taking NMN experienced dramatic improvements in muscle strength and exercise capacity, and even hearing.
Also in July 2021, our team at Guangzhou Sport University completed a Phase II clinical trial. Our study recruited 48 young and middle-aged people between the ages of 27 and 50, and gave 300mg, 600mg, and 1,200mg of NMN per day for up to 6 weeks. It is worth noting that our study's was a randomized double-blind controlled study using the highest level of evidence. The results found that the ability of the muscles to utilize oxygen was substantially enhanced in subjects taking NMN.
Anti-aging Prospects Of NMN
The success of the above three human clinical trials has once again proved that NMN, as an emerging dietary supplement, is safe and reliable, and that longer-term use of NMN has not brought about any adverse effects.
In September 2021, scholars from Fudan University and Shanghai Jiaotong University, China's top universities, and scientists from outside the United Nations, jointly published a review article. Synthesizing the previous clinical trials, the prospect of NMN as an anti-aging product was elaborated in all aspects. The safety of different NAD+ precursors was comprehensively analyzed, and more urgent requirements were put forward for future NMN clinical research.
The scholars concluded that from the available evidence, the administration of NMN is considered to be safe. The use of NMN as a NAD+ precursor does not cause the concentration of nicotinamide, a byproduct of NAD+ metabolism, in the blood to rise to levels that cause side effects.
NMN's Cardioprotective Effects
In March 2021, Nature, a leading international scientific journal, published a heavyweight reviewer article. Several experts in the field of cardiovascular disease were invited to summarize and discuss the importance of NAD+ supplementation for the treatment of aging-related diastolic heart failure.
Not coincidentally, in April 2021, leading scientists such as Eric Verdin, the current head of the Buck Institute, then validated NAD+ precursors such as NMN for the treatment of diastolic heart failure in animal studies. The study gave researchers the first glimpse of cracking the puzzle of diastolic heart failure.
In November 2021, Circulation, a perennial top-ranked cardiovascular journal, published a review article on NAD+ metabolism in relation to cardiac health, aging, and disease. The authors highly recognized that supplementation with NAD+ precursors such as NMN to elevate NAD+ levels could be used to prevent and treat cardiovascular disease.
NMN can help alleviate liver disease of different etiologies
The benefits of NMN for the liver are no longer in the news. This year, there have been numerous studies focusing on the therapeutic effects of NMN on different causes of liver diseases such as non-alcoholic fatty liver disease, alcoholic liver disease, toxic liver injury, etc. These studies have repeatedly confirmed that Bulk NMN Powder is not only a powerful hepatoprotective substance, but also an effective liver protector.
These studies have repeatedly demonstrated that NMN is a potent hepatoprotective substance. Not only can it be used to rescue diet- or alcohol-induced liver steatosis and inflammation, such as "fatty liver" and "alcoholic liver", but it may also be shown in the future to help prevent or treat drug-induced liver.
Clear Eyes:
In February 2021, Prof. David Sinclair published an article in Aging, a top scientific research journal, claiming that NMN has a strong protective effect on the optic nerve. And that this can significantly inhibit the further deterioration of conditions such as retinal detachment. NMN is actually "more of a good thing" under certain circumstances, and supplementing with additional NMN can further minimize retinal damage.
In April 2021, the academic journal J Inflamm Res published an article stating that NMN was able to reduce corneal inflammatory damage caused by tear hyperosmolarity in the early stages of dry eye, preventing further deterioration of the dry eye condition. Director Li Xinyu's team also said that previous studies have confirmed that NMN can promote corneal wound healing and nerve regeneration, and that anti-aging drugs such as NMN are promising to play an important role in the treatment of ocular surface diseases.
In August 2021, British ophthalmologists, including David Garway-Heath, president of the European Glaucoma Society and professor at the Institute of Ophthalmology, University College London, co-authored a review article stating that mitochondrial dysfunction caused by declining levels of NAD+ is closely related to retinal ganglion cell degeneration and glaucoma disease progression. NMN supplementation in animal models of glaucoma has been successful in preventing and delaying the progression of the disease, and it may be possible to go one step further and conduct appropriate human clinical trials for the benefit of glaucoma patients.
Kidney protection studies proliferate
In January 2021, several Italian medical experts published a review in the international scientific research journal Antioxidants & Redox Signaling, saying that a large amount of experimental data in recent years have pointed out that NAD+ supplements have excellent repairing effect on kidney injury, and called on the medical profession to include NAD+ supplements into the standard treatment program for kidney injury.
This year's research on the therapeutic utility of NMN in diabetic nephropathy, acute kidney injury, chronic kidney disease, new crown-associated kidney injury, aging-associated renal interstitial lesions and other renal disorders is proliferating, and it may become the trend of NMN scientific research in the future.
In August 2021, Japanese scholars found that supplementation with NAD+ precursors such as Bulk NMN Powder and activation of NAD+ can remedy the key enzyme in the synthesis pathway, NAMPT. this protects the skin's keratin-forming cells from UV rays, and will help to prevent and treat skin photoaging.
NMN against male reproductive aging?
The research related to NMN against ovarian aging and improvement of female reproductive aging has already made a big splash in 2020. However, research on combating male reproductive aging has not emerged.
In December 2021, Russian researchers studied infertile men and healthy male volunteers and found that infertile men had significantly lower [NAD+]/[NADH] ratios in their semen compared to men with normal reproductive function. This was particularly evident in men with infertility due to oligospermia. The article suggests that such studies of semen biochemistry could provide a blueprint for new treatment modalities. Whether NMN Powder Bulk supplementation can help infertile men realize their dream of fatherhood is a direction that needs to be further explored.
Guanjie has been focused on freeze dried Bulk NMN Powder and vacuum dried NMN raw materials for more than 20 years. If you have any questions, please feel free to contact us: info@gybiotech.com. Let's talk about NMN.
