NR Powder

NR Powder Supplier:

Guanjie is a nicotinamide riboside NR Powder supplier, and our NR is a white powder with a content higher than 98%. Nicotinamide riboside (CAS 1341-23-7) is unstable at room temperature, so the commercially available so-called nicotinamide riboside is nicotinamide riboside chloride(CAS 23111-00-4) . If conditions permit, it is best to store it above zero degrees. We have independent factories and production line,including nicotinamide riboside factory. And our nicotinamide riboside chloride powder is high quality and factory price. We can provide you the third party report and other cert. If you are interested in our products, please feel free to contact us:info@gybiotech.com

 

Product Introduction:
Nicotinamide riboside (NR) Powder is a derivative of vitamin B3 and the precursor of nicotinamide adenine dinucleotide (NAD+, also known as coenzyme I). It appears in many metabolic reactions of cells and participates in the decomposition of proteins, carbohydrates, etc. Compounds and fats, so the life activities of the human body are inseparable from this coenzyme. As cells age or get sick, their number will decrease, and people need to supplement nicotinamide riboside to increase the content of this coenzyme (NAD+), thereby significantly improving the vitality of cells and improving various physiological functions of the human body.

 

Why choose Guanjie?

● We are a very professional NR bulk powder supplier, which has about 20 years' experience in this line.
●The NR Powder produced by our company has an independent research and development center, in which, there is about 10 experts.
●The quality of our Nicotinamide Riboside Bulk Powder is stable and can be stored at room temperature for a long time.
●The price of our Nicotinamide Riboside Chloride Powder is very competitive with good quality, welcome to inquiring.
●Our factory can stock the main products all the year round to prevent any delay.
 

Certificate of Analysis

Test	Method	Analyte	Specification	Result
Identify	NMR	Nicotinamide Riboside Cloride	Conforms to structure	Conforms to structure
Purity	HPLC/UV(wt%)	Nicotinamide Riboside Cloride	98%	98.90%
Moisture	Karl Fischer	Water	0.5%	0.30%
Residual Solvents	GC/FID Headspace	Ethyl acetate	5000 ppm* 5000 ppm* 5000 ppm* 5000 ppm* 410 ppm* 3000 ppm* 5000 ppm*	< 20 ppm < 21 ppm 900 ppm 1200 ppm < 40 ppm 500 ppm ND
		Methyl acetate
		Acetic Acid Acetone Acetonitrile
		Methanol
		MTBE
Heavy Metals	ICP-MS	lead Arsenic Cadmium Mecury	0.5 ppm* 1 ppm* 1 ppm* 1 ppm*	< 0.030 ppm < 0.020 ppm < 0.030 ppm < 0.030 ppm
Microbial	USP<2021> USP<2021> USP<2022>	Total Plate Count Yeast and Mold E. coli	1000 CFU/g 100 CFU/g Absent/10g	< 7 CFU/g < 6 CFU/g Absent/10g
Appearance	NA	Color, Form	White to light brown powder	light brown powder
Bulk Density			0.5- 0.6 g/ml	0.51 g/ml
Storage Conditions	Kept cool above zero degree C.. But, room temperature duringshipment.

 

 

Flow Chart:

 

Method of Analysis:

● Appearance: White to light brown NR Powder.

● PH value in water :( NR :500mg , Pure water 5ml. ) Dissolved NR in pure water, make its concentrations in 100mg/ml, testing by pH meter. After 3 Min take the results .

Acceptance criterion: PH value : 2.0~4.0.

 

● HPLC Purity

Column: Xtimate C18 (4.6 × 250 nm, 5 μm)

Mobile phase A: 20mmol/L NaH2PO4 buffer solution ( 2.4g NaH2PO4 dissolved in water, using 6 mol/L sodium hydroxide solution to adjust the pH to 3.5 , dilute to 1000ml, and filter with 0.22 μm microporous membrane (aqueous membrane) ).

Mobile phase B: methanol (chromatographic grade) Elution gradient

TIME(Min)	Mobile phase A(%)	Mobile phase B(%)
0	99
4	99	1
5	95	5
10	85	15
12	80	20
12.1	99	1
16	99	1

 

Flow rate: 1.0ml/min ; Column temperature: 25°C; Detection wavelength: 260nm ;Injection volume: 20μl

 

Test sample (0.35mg/ml): Take the test sample out to the room condition (temperature at 25 ° C, 40%-60% humidity) and get 0.35mg test sample when its temperature come to normal .then add pure water to make a solution containing 0.35mg per 1ml .

Reference substance (0.35mg/ml): Take NR out to the room condition (temperature at 25 ° C, 40%-60% humidity) and get 0.35mg test sample when its temperature come to normal , then add pure water to make a solution containing 0.35mg per 1ml .

 

Precisely take 20μl of the above test solution and the reference solution into the liquid chromatograph, and record the chromatogram. The retention time of the main peak of the test solution is consistent with the retention time of the main peak of the reference solution.

Acceptance criterion: Purity >98%

 

● Water Contents 

Purified water: 10~30mg , the solvent is methanol (AR) and formamide (AR) in a titration solvent bottle. Mix in a volume ratio of 2:1 and shake well. The commercially available Karl Fischer test solution is directly calibrated with a moisture analyzer, and the calibration is performed three times in succession. The RSD of the three results should not exceed 3%. If it exceeds 3%, the calibration is performed once again, and the error data is discarded, and the RSD is recalculated until The RSD of 3 of the results was less than 3%.

Acceptance criterion: Water content ≤ 2% .

 

HPLC Fingerprint:

 

Is Nicotinamide Riboside Powder Safe?

The U.S. Food and Drug Administration has granted nicotinamide riboside "New Food Ingredient (NDI)" status. NR Powder has also obtained "Generally Recognized as Safe (GRAS)" status, and can be added to various foods and beverages at prescribed levels. In numerous in vivo and in vitro toxicity studies, rigorous testing has demonstrated that nicotinamide riboside is safe when taken at the recommended dose of 3 mg per kilogram of body weight per day, or 180 mg per day for adults. In addition, in two clinical trials, it was verified that it is safe to take 1000 mg of nicotinamide riboside powder once a day for 6 consecutive days.

 

Function:

● Delay aging:
Nicotinamide riboside can restore the function of aging cells and rejuvenate weakened human organs, so as to achieve the purpose of delaying aging.

 

●Improve cardiovascular health:
NR powder can improve the function of cardiomyocytes and vascular cells, and also reduce blood lipid levels in the cardiovascular system. Therefore, it can improve cardiovascular function.

And a 2019 study of middle-aged and older adults found that taking oral NR for six weeks lowered systolic blood pressure and vascular stiffness. Both hypertension and arterial stiffness are major indicators of cardiovascular disease, therefore this study implies that taking nicotinamide riboside may lower the risk of related morbidity and mortality.

 

● Improve Brain Health:
NRC powder can improve the vitality of brain cells and other nerve cells, and improve the function of the entire nervous system. Therefore, it can improve brain health and has a better effect on Alzheimer's disease.

 

●Improve fat metabolism:
Nicotinamide riboside powder bulk can reduce the body's absorption of lipids in food, increase the consumption of fat in fat cells, and achieve the purpose of weight loss.

 

●Cosmetic effect:
NR Powder can improve the function of epidermal cells, as well as the function of other cells in the body, and can keep the skin youthful.

 

● Promoting Cognitive Health

As a precursor to NAD+, nicotinamide riboside protects brain cells from oxidative stress that can lead to age-related brain diseases.

Research published in Neurobiology Aging suggests that NAD+ boosts the production of PGC-1-α, a protein that improves mitochondrial function and lowers the risk of cognitive impairment.
Researchers at the National Institute on Aging in Maryland discovered that in mice, NAD+ deficiency causes neuroinflammation, DNA damage, and neuronal degeneration in Alzheimer's disease. More research is needed to completely understand how increasing NAD+ levels with NR supplementation improves cognitive health, but the current study appears promising.

Reducing the risk of cardiovascular disease

 

Supplement and Dosage Information
Nicotinamide riboside supplements are available in NR tablet, NR capsule, and NR powder form. The most common dosage recommendation for nicotinamide riboside is to take 250-500 mg per day. The serving size depends on the brand, but the recommended use is usually one to two capsules per day.

NR supplements are sometimes advertised or labeled as "no-flush". This is because nicotinamide riboside is unlikely to cause flushing, which can be a side effect of niacin known as niacin flushing. Using NR supplements is the most common way to increase NAD+ levels. However, small amounts of the vitamin are also found in milk and yeast.

 

Our factory:

There are two factories both in Baoji city and Shangluo City, Guanjie factories covers an area of 7000㎡, including GMP standard workshop of 2000㎡.

 

Product Qualification

NRC powder is produced in a clean working environment and every step is conducted by highly qualified professionals. Both the production processes of manufacture and itself meet all international standards. And if you need our testing report, we can provide you.

Certification

 

Package & Shipment

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