NR Powder

NR Powder Supplier:

Guanjie Biotech is a nicotinamide riboside NR Powder supplier, and our pure NR is a white powder with a content higher than 98%. Nicotinamide riboside (CAS 1341-23-7) is unstable at room temperature, so the commercially available so-called nicotinamide riboside is nicotinamide riboside chloride(CAS 23111-00-4) . If conditions permit, it is best to store it above zero degrees. We have independent factories and production line,including nicotinamide riboside factory. And our nicotinamide riboside chloride powder is high quality and factory price. We can provide you the third party report and other cert. If you are interested in our products, please feel free to contact us:info@gybiotech.com

 

What Is Nicotinamide Riboside NR Powder?

Nicotinamide riboside (NR) Powder is a derivative of vitamin B3 and the precursor of nicotinamide adenine dinucleotide (NAD+, also known as coenzyme I). It appears in many metabolic reactions of cells and participates in the decomposition of proteins, carbohydrates, etc. Compounds and fats, so the life activities of the human body are inseparable from this coenzyme. As cells age or get sick, their number will decrease, and people need to supplement nicotinamide riboside to increase the content of this coenzyme (NAD+), thereby significantly improving the vitality of cells and improving various physiological functions of the human body.

 

Why choose Guanjie Biotech?

● We are a very professional NR bulk powder supplier, which has about 20 years of experience in this line.
●The NR Powder produced by our company has an independent research and development center, in which there are about 10 experts.
●The quality of our Nicotinamide Riboside Bulk Powder is stable and can be stored at room temperature for a long time.
●The price of our Nicotinamide Riboside Chloride Powder is very competitive with good quality. Welcome to inquire.
●Our factory can stock the main products all year round to prevent any delay.
 

Certificate of Analysis

Test	Method	Analyte	Specification	Result
Identify	NMR	Nicotinamide Riboside Cloride	Conforms to structure	Conforms to structure
Purity	HPLC/UV(wt%)	Nicotinamide Riboside Cloride	98%	98.90%
Moisture	Karl Fischer	Water	0.5%	0.30%
Residual Solvents	GC/FID Headspace	Ethyl acetate	5000 ppm* 5000 ppm* 5000 ppm* 5000 ppm* 410 ppm* 3000 ppm* 5000 ppm*	< 20 ppm < 21 ppm 900 ppm 1200 ppm < 40 ppm 500 ppm ND
		Methyl acetate
		Acetic Acid Acetone Acetonitrile
		Methanol
		MTBE
Heavy Metals	ICP-MS	lead Arsenic Cadmium Mecury	0.5 ppm* 1 ppm* 1 ppm* 1 ppm*	< 0.030 ppm < 0.020 ppm < 0.030 ppm < 0.030 ppm
Microbial	USP<2021> USP<2021> USP<2022>	Total Plate Count Yeast and Mold E. coli	1000 CFU/g 100 CFU/g Absent/10g	< 7 CFU/g < 6 CFU/g Absent/10g
Appearance	NA	Color, Form	White to light brown powder	light brown powder
Bulk Density			0.5- 0.6 g/ml	0.51 g/ml
Storage Conditions	Kept cool above zero degree C. But, room temperature during shipment.

 

 

How Is NR Powder Produced?

 

Method of Analysis:

● Appearance: White to light brown NR Powder.

● PH value in water :( NR :500mg , Pure water 5ml. Dissolve NR in pure water, make its concentrations in 100mg/ml, testing by pH meter. After 3 Min take the results .

Acceptance criterion: PH value : 2.0~4.0.

 

● HPLC Purity

Column: Xtimate C18 (4.6 × 250 nm, 5 μm)

Mobile phase A: 20mmol/L NaH2PO4 buffer solution ( 2.4g NaH2PO4 dissolved in water, using 6 mol/L sodium hydroxide solution to adjust the pH to 3.5 , dilute to 1000ml, and filter with 0.22 μm microporous membrane (aqueous membrane) ).

Mobile phase B: methanol (chromatographic grade) Elution gradient

TIME(Min)	Mobile phase A(%)	Mobile phase B(%)
0	99
4	99	1
5	95	5
10	85	15
12	80	20
12.1	99	1
16	99	1

 

Flow rate: 1.0ml/min ; Column temperature: 25°C; Detection wavelength: 260nm ;Injection volume: 20μl

 

Test Sample Preparation (0.35 mg/ml):
Place the NR Powder sample at room temperature (25°C, 40%-60% humidity) until the sample reaches normal temperature. Accurately weigh 0.35 mg of the sample. Add pure water to dissolve the sample and prepare a solution with a concentration of 0.35 mg/ml.

Reference Substance Preparation (0.35 mg/ml):
Place the pure NR Powder reference substance at room temperature (25°C, 40%-60% humidity) until it reaches normal temperature. Accurately weigh 0.35 mg NR bulk Powder of the reference substance. Add pure water to dissolve it and prepare a solution with a concentration of 0.35 mg/ml.

Chromatographic Analysis:
Precisely inject 20 μl of the test solution and 20 μl of the reference solution into the liquid chromatograph. Record the chromatograms of both solutions. Compare the retention times of the main peaks. The retention time of the main peak in the test solution should match the retention time of the main peak in the reference solution.

Acceptance Criterion:
The purity of pure NR Powder should be greater than 98%. The test result should meet the specified quality requirements.

 

● Water Contents 

Purified water: 10–30 mg NR Powder. The solvent consists of methanol (AR) and formamide (AR). The two solvents are added into a titration solvent bottle and mixed at a volume ratio of 2:1. Shake well before use. The commercially available Karl Fischer test solution is calibrated using a moisture analyzer. The calibration is performed three consecutive times. The relative standard deviation (RSD) of the three results should not exceed 3%. If the RSD is higher than 3%, perform the calibration again. Discard the error data and recalculate the RSD. Repeat this process until the RSD of three consecutive results is below 3%. The calibrated Karl Fischer test solution is then used for water content analysis. Acceptance criterion: The water content should be ≤ 2%.

 

HPLC Fingerprint:

 

Is Nicotinamide Riboside Powder Safe?

Nicotinamide riboside NR powder is considered safe when used at the recommended dosage. The U.S. Food and Drug Administration (FDA) has granted NR a New Dietary Ingredient (NDI) status. NR powder has also received Generally Recognized as Safe (GRAS) status. It can be added to foods and beverages within approved levels.

Many in vivo and in vitro studies have evaluated the safety of nicotinamide riboside. The results show that NR is safe when taken at the recommended dose of 3 mg per kilogram of body weight per day. For adults, this equals about 180 mg per day. In addition, two clinical trials showed that taking 1000 mg of NR powder once daily for 6 consecutive days was safe and well-tolerated.

Overall, NR powder has a good safety profile based on current research.

 

What Is The Dosage Of Nicotinamide Riboside NR powder? 

Nicotinamide riboside supplements are available in NR tablets, NR capsules, and NR powder form. The most common dosage recommendation for nicotinamide riboside is to take 250-500 mg per day. The serving size depends on the brand, but the recommended use is usually one to two capsules per day.

NR supplements are sometimes advertised or labeled as "no-flush". This is because nicotinamide riboside is unlikely to cause flushing, which can be a side effect of niacin known as niacin flushing. Using NR supplements is the most common way to increase NAD+ levels. However, small amounts of the vitamin are also found in milk and yeast.

 

FAQs:

1. What Is Nicotinamide Riboside (NR) Powder?

Nicotinamide Riboside NR Powder is a vitamin B3 derivative and a precursor of NAD+ (nicotinamide adenine dinucleotide), an important coenzyme involved in cellular energy metabolism. NR participates in many biological processes, including nutrient metabolism and cellular functions. By increasing NAD+ levels, NR is widely used in dietary supplements, health products, and anti-aging research applications. Guanjie Biotech supplies high-quality NR powder and NR chloride powder with purity higher than 98%.

2. What Is The Difference Between Nicotinamide Riboside And Nicotinamide Riboside Chloride?

Pure nicotinamide riboside (CAS 1341-23-7) has limited stability under normal storage conditions. Therefore, most commercial NR products use nicotinamide riboside chloride (NR chloride, CAS 23111-00-4), which provides better stability and easier handling. NR chloride is the commonly available form used in supplement manufacturing. Guanjie Biotech provides high-purity nicotinamide riboside chloride powder for global customers.

3. What Is The Purity Of NR Powder?

Guanjie Biotech's nicotinamide riboside chloride powder has a purity of ≥98%. The product is tested by professional analytical methods, including HPLC, NMR, ICP-MS, microbial testing, and residual solvent analysis. We can provide third-party test reports, Certificates of Analysis (COA), and related quality documents to support customer quality evaluation.

4. How Should Nicotinamide Riboside Powder Be Stored?

Nicotinamide riboside is sensitive to temperature and environmental conditions. For better stability, NR powder is recommended to be stored in a cool environment above 0°C. During transportation, room temperature shipment is acceptable under suitable packaging conditions. Proper storage helps maintain product quality, purity, and shelf life.

5. How Is Nicotinamide Riboside NR Powder Produced?

Nicotinamide riboside powder is produced through controlled manufacturing processes involving synthesis, purification, drying, and quality testing steps. The production process requires strict control of temperature, moisture, impurities, and microbiological standards. Guanjie Biotech has independent production facilities and a dedicated nicotinamide riboside production line to ensure a stable supply and consistent quality.

 

Our factory:

There are two factories, both in Baoji City and Shangluo City. Guanjie factories cover an area of 7000㎡, including a GMP standard workshop of 2000㎡.

 

Product Qualification

NRC powder is produced in a clean working environment and every step is conducted by highly qualified professionals. Both the production processes of manufacture and itself meet all international standards. And if you need our testing report, we can provide you.

Certification

 

Package & Shipment

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