Luteolin Powder

Luteolin Powder Supplier: 

Guanjie Biotech is high quality bulk luteolin supplier.The luteolin of Guanjie Biotech uses shell and bud two sources. It is yellow powder with 98% specification. With a sound enterprise quality assurance system, we implement the strict quality control standards. We can provide you with high-quality products at the best price. Our clients are from all over the world and we get high praise from them. The physical properties of luteolin determine its high ash content. When the ash content in the market was 10%, Guanjie Biotech applies technology that was first to break through the technology and controlled the ash content within 2%.  Now, according to the different needs of customers, we will control within 5%, 2%, 1%. Our Luteolin Powder products are high-quality with a competitive price. Welcome to enquire with us at info@gybiotech.com.

 

Why Choose Guanjie Biotech?

● Two independent factories and three production line.

● Professional research team and have own labs

● Provide the third party testing.

● Have strong Collaborators:Northwestern University and Chinese Academy of Sciences research center.

 

What Is Luteolin Powder?

Luteolin bulk powder is thought to play an important role in the human body as an antioxidant, a free radical scavenger, an agent in the prevention of inflammation, a promoter of carbohydrate metabolism, and an immune system modulator. It is a naturally occurring molecule known as bioflavonoid, often found in foods including parsley, artichoke leaves,celery, peppers, olive oil, rosemary, lemons, peppermint, sage, thyme, and many others.

 

 

COA

There are two COA reports about Luteolin Powder. One is from the shell, the other is from the bud.

● Shell

Item	Specification	Result	Method
Genus and Species	Arachis hypogaea	Conform	/
Part of the Plant	Shell	Conform	/
Country of Origin	China	Conform	/
Marker Compounds
Luteolin	>98.0%	98.87%	HPLC(Normalization)
Organoleptic Data
Appearance	Fine powder	Conform	GJ-QCS-1008
Color	Yellow-green	Conform	GB/T 5492-2008
Odor &Taste	Characteristic	Conform	GB/T 5492-2008
Process Data
Method of Processing	Extraction	Conform	/
Solvent(s) Used	Ethanol & Water	Conform	/
Drying Method	Vacuum drying	Conform	/
Excipient	None	Conform	/
Ratio of Extraction	60:1	Conform	/
Physical Characteristics
Particle Size (80 mesh)	98.0%pass 80mesh	Conform	GB/T 5507-2008
Moisture	<2.0%	0.8%	GB/T 14769-1993
Ash Content	<2.0%	1.72%	AOAC 942.05, 18th
Heavy Metals
Total Heavy Metals	<10 ppm	Conform	USP<231>, method II
Arsenic	<1.0 ppm	Conform	AOAC 986.15, 18th
Lead	<1.0 ppm	Conform	AOAC 986.15, 18th
Mercury	<0.5 ppm	Conform	AOAC 971.21, 18th
Pesticide Residue
666	<0.2ppm	Conform	GB/T5009.19-1996
DDT	<0.2ppm	Conform	GB/T5009.19-1996
Microbiology
Total Plate Count	<1,000cfu/g	Conform	AOAC 990.12, 18th
Total Yeast & Mold	<100cfu/g	52cfu/g	FDA (BAM) Chapter 18, 8th Ed.
E. Coli	Negative	Negative	AOAC 997.11, 18th
Salmonella	Negative	Negative	FDA (BAM) Chapter 5, 8th Ed.

 

●Bud

Item	Specification	Result	Method
Basic Product Information
Genus and Species	Sophora japonica L.	Conform	/
Part of the Plant	Bud	Conform	/
Country of Origin	China	Conform	/
Marker Compounds
Assay(Luteolin )	98%	98.7%	HPLC
Organoleptic Data
Appearance	Powder	Conform	GJ-QCS-1008
Color	Yellow-green	Conform	GB/T 5492-2008
Odor	Characteristic	Conform	GB/T 5492-2008
Taste	Characteristic	Conform	GB/T 5492-2008
Process Data
Method of Processing	Extraction	Conform	/
Solvent(s) Used	Ethanol and Water	Conform	/
Excipient	None	Conform	/
Drying Method	Vacuum drying	Conform	/
Physical Characteristics
Particle Size (80 mesh)	98.0%pass 80mesh	Conform	GB/T 5507-2008
Moisture	<5%	0.26%	GB/T 14769-1993
Ash Content	<5%	1.53%	AOAC 942.05, 18th
Solvent Residue	Eur Pharm	Conform	GJ-QCS-1007
Heavy Metals
Total Heavy Metals	<10 ppm	Conform	USP<231>, method II
Arsenic	<1.0 ppm	0.25ppm	AOAC 986.15, 18th
Lead	<1.0 ppm	0.30ppm	AOAC 986.15, 18th
Mercury	<0.5 ppm	0.26ppm	AOAC 971.21, 18th
Pesticide Residue
666	<0.2ppm	Conform	GB/T5009.19-1996
DDT	<0.2ppm	Conform	GB/T5009.19-1996
Microbiology
Total Plate Count	<1,000cfu/g	Conform	AOAC 990.12, 18th
Total Yeast & Mold	<100cfu/g	10cfu/g	FDA (BAM) Chapter 18, 8th Ed.
E. Coli	Negative	Negative	AOAC 997.11, 18th
Salmonella	Negative	Negative	FDA (BAM) Chapter 5, 8th Ed.

 

How Is Luteolin Powder Produced?

There are two COA reports flow charts about Luteolin Powder. One is from shell, the other is from bud.

●Shell

Standard Test Procedure:

Description:

PRODUCT	Luteolin	GRADE	In-house
DOCUMENT NO.	GU/AN/1008	DATE OF ISSUE	30. 13. 2004
PPROVIDER	XI'AN GUANYU BIO-TECH CO. LTD.	PAGE No.	02

Light yellow and green powder

 

Identification :

The retention time of the Luteolin Powder peak in the chromatogram of the assay preparation corresponds to that of the Luteolin peak in the chromatogram of the Standard preparation as obtained in assay.

ASSAY (Luteolin content):

By high performance liquid chromatography.

 

Chromatographic Conditions:

Instrument	Shimadzu LC-9A Pumps, SPD 6A UV Detector
SIL 6B Auto Injector and CR 7A Data
Processor
Column	NOVAPACK, C18 , 5μm, 150x4.6mm
Mobile phase	Water: CH3CN (65:35)
Flow rate	1.0 ml/minute
Detector	UV-354 nm
Injection volume	25 microliters

Standard preparation:

Weigh accurately about 3 mg of Luteolin Powder Working Standard (W1) in 25ml volumetric flask, dissolve and make up the volume with methanol.

Sample preparation:

Weigh accurately 5mg(W2) of test sample and Transfer the sample to previously dried 25ml volumetric flask, add methanol to dissolve then make up the volume with methanol.

 

 

Procedure:

Separately inject equal volume (20µl) of the standard preparation and the test preparation into chromatogram in the triplicate and note down the area counts of Luteolin peak calculate the percentage of Luteolin.

 

Calculation:

At and As are the counts of Luteolin peak in the chromatograms of the test preparation and standard preparation respectively. Ps is the contents of Luteolin in standard. 

 
What Is Luteolin Powder Used For?

● Luteolin powder has the function of anti-inflammatory, anti-microbial and anti-viral;

Lignocaine can dose-dependently protect oligodendrocytes against hydrogen peroxide-induced oxidative damage in vitro, strongly inhibit the phagocytosis of myelin by macrophages, significantly reduce the production of cellular reactive oxygen clusters, reduce the expression of iNOS protein, and significantly reduce the level of NO produced by macrophages at low doses.

  
● Luteolin extract powder can reduce the level of hepatic fibrosis and protect liver cells from damage.

Luteolin Powder can reduce the degree of liver fibrosis, decrease the content of hydroxyproline (HYP) and malondialdehyde (MDA) in liver tissue and the expression of type I pre-collagen mRNA, and inhibit the proliferation and collagen synthesis of hepatic stellate cells (HSC) in vitro.

It can also improve the histopathological changes of pulmonary fibrosis caused by bleomycin, reduce the lung weight index, significantly reduce the elevation of MDA and HYP, and inhibit the expression of transforming growth factor-β1 (TGF-β1) mRNA in lung tissue, and inhibit the proliferation of human embryonic lung fibroblasts and promote their apoptosis in vitro. 

 
● Action on blood vessels 

Bulk Luteolin Powder can inhibit vascular endothelial growth factor (VEGF)-induced angiogenesis in rabbit cornea in vivo; it can inhibit tumor growth and blood vessel formation in murine xenograft tumor model; it can inhibit VEGF-induced survival and proliferation of human umbilical vein vascular endothelial cells (HUVECs) in vitro. Significantly inhibits platelet-derived growth factor-BB (PDGF-BB)-induced proliferation and DNA synthesis in vascular smooth muscle cells, and blocks the cell cycle in the G1 phase. It can concentration-dependently reduce the tension of phenylephrine precontracted blood vessels.

● Anti-fertility and hormonal effects 
Lignocaine has a significant dose-dependent anti-fertility activity. It can significantly increase the weight and diameter of the uterus, the thickness of the endometrium and the height of its epithelium after oral administration, and has estrogen-like effects when applied alone, but shows anti-estrogenic effects when combined with ethinyl estradiol. 

● Prevent and control hyperuricemia

Luteolin Powder are natural flavonoids. Flavonoids can prevent hyperuricemia by inhibiting the activity of xanthine oxidase and promoting uric acid excretion in the body by 2 mechanisms. Xanthine oxidase (x0) catalyzes the production of xanthine from hypoxanthine, which is further oxidized to produce uric acid and plays an important role in the pathogenesis of gout. The inhibitory ability of different types of flavonoids on x0 activity varies, with flavonoids being the strongest, followed by flavonols, and dihydroflavonoids, isoflavonoids and flavanols being the weakest. Among the flavonoids, lignans were the most active.  

 
Why Choose Guanjie Biotech?

● We are one of the leading plant extract -bulk Luteolin Powder suppliers integrating R&D, production and sales.

● We always adheres to the Enterprise faith of "quality first, customer first", and sincerely cooperate with you.

● We can offer best service at your request.

 

Our factory and lab:

Guanjie Biotech luteolin factory covers an area of 7000㎡, including GMP standard workshop of 2000㎡ and advanced lab of 500㎡.

 

Quality control:

Our product and quality control center is beside our office, we have all kinds of testing machine, such as: HPLC, GC,AAS,melting point, specific optical rotation,bacterial detection,PH,Ash content, and so on.

 

Contract with Third-Party Lab

We are cooperation with several Authority third parties such as SGS, Eurofin, UNQD to test luteolin 98 and make a guarantee of the quality for the customers.we tested the assay,water,Odor, Heavy Metals ,Solvent Residue,pesticide residue,Protein,Microbiological,so on.

 

Certification

Our mission is"come from the nature, serve the human's well being". We adheres to the corporate mission of creating healthy life, strictly controls product quality and is certified with ISO quality management system certificate, ISO 9001-22000, SC, KOSHER, HALAL and other certification. Guanjie Biotech has continuously strived to innovate and improve its control standards. At the same time, it was granted a number of patent.

 

Package&Warehouse:

 

Shipment:

DHL, Sea freight, FEDEX, you can choose.

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