Pure serrapeptase powder is an enzyme that people use to relieve pain and inflammation. Serrapeptase, an enzyme from the mulberry silkworm, also known as Serratia protease, is a protein hydrolyzing enzyme, meaning it breaks down proteins into amino acids. It was originally isolated from the silkworm's gut bacteria (Serratia E15), which use the enzyme to break down the cocoon wall.
Serrapeptase and Nattokinase
Serrapeptase powder bulk and nattokinase powder are both enzymes that cut proteins. They have both been studied in rats with Alzheimer's disease. A study on zebrafish suggests that serepeptidase may break down amyloid plaques better than nattokinase, but clinical trials comparing the two enzymes are completely lacking.
Some researchers are investigating how the combination of serepeptidase and nattokinase affects biofilms, which often prolong infection. Human studies are needed to determine the role of serrapeptase and nattokinase and their combination. The combination of serrapeptase and nattokinase is being studied, but clinical trials are lacking.
Anticipated Health Benefits of Serrapeptase
• Facial swelling after sinus surgery
Some clinical evidence suggests that serrapeptase may reduce facial swelling after sinus surgery, despite the lack of large-scale studies.
In 174 patients, sertrapeptase reduced swelling of the cheeks after sinus surgery compared to placebo. In two low-quality trials, it reduced jaw swelling after dental surgery. However, in a study of 150 patients undergoing dental surgery, serrapeptase did not show a significant anti-inflammatory effect.
In another low-quality prospective study, serepeptidase mildly reduced pain and swelling caused by soft-tissue injuries to the upper and lower extremities. The aceclofenac that was more effective. Thus, there is a lack of evidence to support the use of serrapeptase to reduce swelling after dental surgery or soft tissue injury. Serrapeptase may reduce facial swelling after certain types of sinus surgery.
• Pain Relief
Although several clinical trials have been conducted, there is insufficient evidence to evaluate the effectiveness of pure serrapeptase powder for pain relief. All published studies have significant limitations, such as small sample sizes and design flaws. Large-scale trials are needed to clarify their findings, which are mixed. In a study of 24 post-wisdom tooth removal patients, serrapeptase reduced pain [.
It also reduced pain by 64% and nocturnal cramps by 53% in a study of 40 patients with inflammatory venous disease. In another low-quality study of 50 patients with leg and arm injuries, it mildly reduced pain. However, after dental surgery (150 patients), it did not show any significant pain relief and performed worse than drugs such as ibuprofen and betamethasone.
Although a number of small clinical trials have been published, there is insufficient evidence that Serrapeptase reduces pain in localized areas of inflammation such as:
✅ Ears and nose
✅ Bronchitis
✅ Sinuses (sinusitis)
✅ Throat (pharyngitis), or (laryngitis).
Scientists are investigating whether this enzyme can affect pain pathways by blocking the release of pain-causing amines such as bradykinin.
• Reduces mucus and other secretions
There is not enough evidence that serrapeptase reduces the density of mucus and other secretions, although some early findings seem promising.
In a study of 29 patients with dyspnea due to chronic bronchitis, serrapeptase improved mucus clearance. It also reduced the amount of sputum and saliva, cough frequency, and neutrophil count. Neutrophilia may be associated with increased sputum and inflammation. A major limitation of this study was its open-label design, which makes a placebo effect likely.
In another study of 193 patients with acute or chronic otolaryngologic disorders, serrapeptase reduced nasal discharge, dysphagia, and nasal obstruction. There is insufficient evidence that serepeptidase dissolves and removes mucus and phlegm, although earlier studies point to its potential.
It's not clear whether serrapeptase improves breast swelling or pain from excess milk. In one study, it reduced breast pain, swelling and firmness in 60 of 70 patients. Further clinical trials are needed to evaluate its safety and effectiveness.
• Venous inflammation
Serrapeptase improved 26/40 patients with superficial thrombophlebitis (pain and inflammation caused by blood clots in the veins). It reduced some symptoms such as pain, inflammation and skin plaques (erythema). We cannot draw any conclusions from this study; more clinical studies are needed.
• Dental Implant Inflammation
Peri-implantitis is an inflammation of the hard and soft tissues of the implant. Patients treated with serrapeptase heal faster and have a lower rate of implant failure than patients treated with placebo or NSAIDs. Further trials are needed to determine the effectiveness of serrapeptase on dental implant inflammation .
• Carpal tunnel syndrome
The effect of serrapeptase on carpal tunnel syndrome is unknown. In a small study, 13 out of 20 patients with carpal tunnel syndrome improved after taking serrapeptase. However, four patients had a relapse. Follow-up trials are necessary .
• Lack of evidence (animal and cellular studies)
There is no clinical evidence to support the use of serrapeptase for any of the conditions listed in this section.
The following is a summary of the available animal and cellular studies and should guide further research efforts. However, the studies listed below should not be interpreted as supporting any health benefits.
• Clots and plaques
In the lab, Serrapeptase breaks down fibrin, a clotting molecule. Scientists are exploring whether it helps remove blood clots and plaques in animals and cell cultures, but human studies have not yet been conducted. Other research groups are investigating whether serrapeptase can disrupt fibronectin-based microbial biofilms in petri dishes. These biofilms adhere to mucous membranes and other surfaces. Fibronectin is also responsible for scar tissue. It remains to be determined in clinical trials whether serrapeptase can reduce excess scar tissue by breaking down fibrin. Scientists believe that serrapeptase may break down fibrin, but clinical trials are lacking.
• Alzheimer's Disease.
Several researchers are studying the effects of pure serrapeptase powder on animal models of Alzheimer's disease. However, many of the studies appear to have a beneficial effect on Alzheimer's disease in animals, but have failed to make it through clinical trials. Because clinical trials have not been conducted, we do not yet know how serepeptidase affects the risk or progression of Alzheimer's disease.
In rats, serrapeptase increased levels of BDNF and IGF-1, both of which protect brain cells. It also decreased the activity of the inflammatory markers TGF-β and IL-6, which may be high in patients with Alzheimer's disease. Amyloid beta plaques and low acetylcholine have been linked to Alzheimer's disease. Scientists are studying how the enzyme serepeptidase affects amyloid plaques in zebrafish, as well as levels of acetylcholinesterase, an enzyme that breaks down acetylcholine, in the animals. The effect of serrapeptase on Alzheimer's disease in humans is unknown.
•Inflammation
According to one hypothesis, dead cells and tissues (cellular debris) cause inflammation by overstimulating the immune system. Some scientists believe that serepeptidase may facilitate the breakdown of these fragments, theoretically helping to drain fluids and harmful substances from the site of inflammation. This hypothesis has not been confirmed.
Some cell culture studies have focused on how serepeptidase affects:
✅ Toxins that cause swelling and pain.
✅ Cyclooxygenase, an enzyme that produces different inflammatory molecules after injury or infection.
These mechanisms have not been explored in humans.
Despite the prevailing opinion, there is no scientific evidence to support the use of serrapeptase in
✅ Fibroid tumors (non-cancerous growths in the female uterus)
✅ Vestibular cysts (swelling of the vestibular gland)
✅ Endometriosis (abnormal growth of uterine tissue)
Guanjie is a pure serrapeptase powder supplier and manufacture. If you are interested in our information, welcome to enquiry us: info@gybiotech.com.
