The autophagy inducer wheat germ extract spermidine has an immunopotentiating effect on human T cells. And low autophagy levels are associated with low response to vaccination. There are two types of spermidine supplements: one is the traditional spermidine extracted from wheat germ in the past, which is relatively expensive. The second is a synthetic version, or spermidine hydrochloride, which has become relatively inexpensive in recent years.
Researchers in the field of spermidine believe that the two are similar to our supplementation with synthetic and natural vitamin C. There is no fundamental difference between the two in terms of efficacy and health benefits. Spermidine trihydrochloride is the salt version of spermine. When you take it, the salt part of the molecule comes off. This is actually no different than consuming so-called "natural" spermine. Also, wheat germ contains wheat proteins that may also be problematic for some people with celiac disease. So, spermidine HCL is the most popular version of spermine in recent years. If you want to take a spermidine Powder supplement, I recommend spermine HCL as the most cost-effective version of spermine.
Natural Ingredients
Unlike NMN, wheat germ extract spermidine is no mystery. Foods we see every day such as soybeans, mushrooms and cheese are rich in spermidine. At the same time, the human intestinal tract is also a production site for spermidine. The metabolites of intestinal bacteria also contain spermidine, which is required by the human body.
Therefore, there are two major directions for the dietary supply of spermidine. One is to further enrich or extract natural ingredients rich in spermidine. Spermidine becomes one of the core ingredients to meet the necessary content requirements. The second is to increase the supply level of intestinal spermidine by adjusting or strengthening the structure of intestinal flora. Previously, intestinal flora has been shown to have a function in regulating cognition. Spermidine may also be one of the important metabolites.
Supported by multiple factors such as safe, reliable and abundant sources of raw materials, it is easier to transform spermidine from theory to reality. Compared with the many "clouds of doubt" surrounding NMN, wheat germ spermidine may be more easily recognized by society.
Efficacy:
• Spermidine and Autophagy Mechanism
Spermidine, also known as spermidine trihydrochloride. It is a polyamine that is widely distributed in living organisms. It is biosynthesized from putrescine and adenosine methionine.
In 2009, a research result published in Cell Biology, a sub-journal of Nature, unveiled the tide of wheat germ extract spermidine research. The study pointed out that spermine can induce the transcription of autophagy-related genes, thus enhancing cellular autophagy and inhibiting cellular oxidative stress and necrosis. Spermidine was experimentally shown to extend the lifespan of yeast, nematodes and fruit flies. The study immediately drew widespread attention from the community upon its release.
In 2016, Japanese scientist Yoshinori Ohsumi was awarded the Nobel Prize in Physiology and Medicine for his discovery of the mechanism of cellular autophagy, thus confirming the mechanism of cellular autophagy.
Cellular autophagy is a mechanism by which cells renew and protect themselves. It not only eliminates invading bacteria and viruses, but also influences embryonic development and cell mutation, and eliminates damaged proteins and organelles, thus maintaining the overall stability of the body's cells. The activation of spermidine rich wheat germ extract in cellular autophagy clearly makes it even more compelling.
Remarkably, wheat germ extract spermidine's contribution to health doesn't stop there. in January 2018, the top journal Science published a weighty paper on spermine. The article summarized more than 130 scientific advances in recent years, systematically pointing out the multifaceted effects of spermidine. It has a variety of roles, such as slowing down aging, extending lifespan, cardiovascular protection, cancer prevention and anti-cancer, neuromodulation and neuroprotection, and improving metabolic diseases.
• Delaying Cognitive Decline More Relevant
The Global Alzheimer's Disease Report 2018 states that dementia has become a global health problem. One case of dementia will be created every 3 seconds globally. approximately 50 million people worldwide are living with dementia in 2018, and this number will increase to 152 million by 2050.
Cognitive decline not only reduces an individual's quality of life, but also places a heavy burden on families and society. Instead of unrealistically pursuing "life extension", it is more practical to maximize stable cognitive ability.
As early as 2013, a report published in the journal Nature Neuroscience pointed out the role of wheat germ extract spermidine in cognitive regulation. The study noted that simple feeding of spermidine not only restored polyamine levels in aged fruit flies, but also effectively suppressed age-induced memory impairment.
On April 13, 2021, 29 research institutions from Austria, Italy, Japan, Switzerland and other countries jointly published the latest article in the journal Cell Reports. The study shows that a dietary supplement of spermidine can cross the blood-brain barrier in mice and enhance mitochondrial function in the hippocampus, thereby improving cognitive function.
The mechanisms of action of spermidine content of wheat germ are consistent across numerous functional embodiments. They all enhance functionality by activating autophagy in cellular tissues. It promotes eIFA signaling expression and enhances autophagy in senescent mitochondria, which in turn enhances mitochondrial antioxidant function, thereby enhancing cognition.
Spermidine Dosage
From the international biogeek supplementation dose of spermidine Powder, basically in the look at about 20 mg. Some papers have measured 0.9 mg dose of wheat germ extract spermidine per day, the effect is very small, it is recommended or 20 mg large dose is appropriate.
How to take spermidine Powder?
Since wheat germ extract spermidine has a certain acidity, it is highly recommended to make a spermidine hydrochloride solution in order to make it easier to take. Based on the molecular weight of spermine and hydrochloride, 1 gram of spermidine hydrochloride contains 0.57 grams of spermidine. That is 570 mg of spermidine wheat germ extract.
We can mix 1 liter of water and 1 gram of spermidine hydrochloride, stirring vigorously and evenly to blend, to obtain 1 liter of spermidine hydrochloride solution, which contains 570 mg of spermidine. Based on an intake of 20 mg of spermidine per day, this solution would last for 29 days. Therefore, 35 milliliters of spermidine hydrochloride solution can be withdrawn for consumption each day. This means that 1 gram of spermidine HCL can be taken for approximately 1 month. Of course, there may be some error in this. People can take 40 milliliters of Spermidine HCL solution. Shake the solution as well as possible before taking it.
It is worth mentioning that, due to the acidic nature of wheat germ extract spermidine, you should have an accurate measuring device and container to take it as precisely as possible and avoid overdosing.
Guanjie can provide customized products with various active ingredients for customers' Bulk wheat germ extract spermidine specific business and usage needs. If you are interested, please feel free to contact us: info@gybiotech.com.
