Levodopa Powder

Levodopa Powder Suppliers:

Bulk Levodopa Powder is one of our most powerful products, we have 2 production lines and have a production capacity of 50 tons per year. It is from the seeds of the legume cat bean Mucuna cochinchinensis (Lour) Tang et Wang. It is a white or slightly white crystalline powder. We use HPLC (external standard method) and we have different specifications: L-dopa: 15%, 20%, 40%, 50%, 99%. Other specifications can be customized. And the third-party testing report can also be provided. Our factory is near Qin Ling Mountain, which is convenient for us to gather and harvest raw materials.  

 

Why choose Guanjie?

● No strong acid or alkali is used, no solvent residue, and no damage to the active ingredients of the product.

● With Levodopa Powder production process, the product retains the original nutrients in quinoa beans. After analysis of third-party testing data, it contains 20 kinds of amino acids, including 8 kinds of amino acids necessary for the human body.

● 100% natural, without any additives

 

Specification

Item	Specification	Result	Method
Basic Product Information
Genus and Species	Mucuna Cochin Chinensis	Conform	/
Part of the Plant	Seeds	Conform	/
Country of Origin	China	Conform	/
Marker Compounds
Levodopa	>98.0%	99.56%	HPLC
Organoleptic Data
Appearance	Powder	Conform	GJ-QCS-1008
Color	A white or slightly white crystalline powder	Conform	GB/T 5492-2008
Odor	Characteristic	Conform	GB/T 5492-2008
Taste	Characteristic	Conform	GB/T 5492-2008
Process Data
Method of Processing	Extraction	Conform	/
Solvent(s) Used	Ethanol & Water	Conform	/
Drying Method	Vacuum drying	Conform	/
Excipient	None	Conform	/
Physical Characteristics
Optical rotation	- 1.27° to - 1.34°	- 1.29°	/
PH	4.5 to 7.0	5.6	/
Solubility	Slightly soluble in water, practically insoluble in alcohol.	Conform	Visual
Particle Size (80 mesh)	80.0% pass 80mesh	Conform	GB/T 5507-2008
Moisture	<2.0%	0.4%	GB/T 14769-1993
Ash Content	<1.0%	0.06%	AOAC 942.05, 18th
Solvent Residue	Eur.Pharm	Conform	GJ-QCS-1007
Heavy Metals
Total Heavy Metals	<10ppm	Conform	USP <231>, method II
As	<2.0ppm	Conform	AOAC 986.15, 18th
Pb	<2.0ppm	Conform	AOAC 986.15, 18th
Cd	<0.5ppm	Conform	AOAC 986.15, 18th
Hg	<0.5ppm	Conform	AOAC 971.21, 18th
Microbiology
Total Plate Count	<1,000cfu/g	Conform	AOAC 990.12, 18th
Total Yeast & Mold	<100cfu/g	Conform	FDA (BAM) Chapter 18, 8th Ed.
E. Coli	Negative	Negative	AOAC 997.11, 18th
Salmonella	Negative	Negative	FDA (BAM) Chapter 5, 8th Ed.

 

Flow Chart:

 

Levodopa Powder (L-Dopa) is the primary prodrug used in the management of Parkinson's disease, and its natural extraction from the Macuna pruriens (velvet bean) plant is a sophisticated biotechnological process. Guanjie Biotech's flowchart outlines a meticulous and multi-stage production method that ensures high purity and efficacy of the final product. This process can be broken down into several key phases: Material Preparation, Extraction, Separation, Concentration, and Final Processing.

● Phase 1: Material Preparation and Initial Washing

The entire process begins with the sourcing of high-quality raw materials. The primary ingredient is the Macuna pruriens bean, which is naturally rich in L-Dopa. The first and crucial step is to thoroughly wash the materials to free them of impurities. This is not a simple rinse; it is a critical purification stage where dirt, soil, microbial contaminants, and other foreign particles are removed from the bean's surface. This step is vital for ensuring the final Levodopa Powder product's safety and minimizing potential contaminants that could interfere with the subsequent chemical processes. Following the initial wash, the beans are often crushed or ground to increase the surface area, which significantly enhances the efficiency of the extraction phase that follows.

● Phase 2: The Extraction Process

Extraction is the heart of the operation, where the Levodopa Powder is separated from the solid plant matrix. Guanjie Biotech employs a specific aqueous extraction method. The prepared bean material is subjected to a solvent-in this case, acidic water. The use of an acidic solution (often with a carefully controlled pH using a mild acid like citric or hydrochloric acid) is a strategic choice. L-Dopa is more stable and soluble in acidic conditions, which helps maximize its yield and prevent degradation that can occur in neutral or alkaline environments.

The process is intensified by being conducted over 3 hours, 2 times. This indicates a double-extraction technique. The first extraction pulls out the majority of the available L-DOPA, while the second cycle ensures a more complete recovery, leaving minimal valuable compound behind in the spent plant material. This repetitive process guarantees a high extraction yield, making the operation both efficient and economical.

● Phase 3: Separation and Purification

After extraction, the mixture is a slurry containing the desired liquid extract (with dissolved L-Dopa) and solid plant residue. The next step is centrifugation. This process uses high-speed rotational force to separate the heavier solid particles from the lighter liquid rapidly. The output is a clear liquid extract, now free of the majority of its suspended solids. This "clear liquid" is the first purified form of L-Dopa in solution.

To achieve further clarity and purity, the liquid undergoes filtration. This likely involves passing the centrifuged liquid through a series of filters, including perhaps membrane filters, to remove any remaining fine or colloidal particles. This results in the filtered liquid, a highly clarified solution ready for the concentration stage of Levodopa Powder.

● Phase 4: Concentration and Drying

The filtered liquid is still mostly water, with L-Dopa dissolved in it. To transform it into a powder, the water must be removed. This is first achieved through decompress concentration. This technique, often involving vacuum evaporation, lowers the boiling point of water, allowing it to be removed at a lower temperature. This is critical because L-Dopa is heat-sensitive; using high temperatures would degrade the compound. The result is a concentrated liquid-a viscous syrup rich in L-Dopa.

The concentrated liquid is then transformed into a solid form through spray drying. This is a pivotal step in modern powder production. The concentrate is pumped into a hot drying chamber and atomized into a fine mist of tiny droplets. The hot gas in the chamber instantly evaporates the water from each droplet, leaving behind a fine, dry particle of L-Dopa and other natural constituents from the bean. The output is a dry, free-flowing half-product in powder form.

● Phase 5: Final Processing and Quality Assurance

The spray-dried Levodopa Powder powder is considered a "half-product" because it requires final preparation before it can be packaged. It may undergo grinding to ensure a consistent and uniform particle size, which is essential for product stability, dissolution, and accurate dosing. It might also be mixed or blended with a small, approved amount of excipient (like a flow agent) to enhance the powder's handling properties and stability.

Finally, the powder is packed into airtight, light-resistant containers to protect it from moisture and oxidation, which can degrade L-Dopa. Crucially, the product is tested rigorously at this final stage. Quality control tests verify the product's identity, potency (L-Dopa percentage), purity (ensuring the absence of heavy metals, microbes, and other contaminants), and overall safety. Only after passing these stringent tests is the material released as the finished product: pure Levodopa Powder.

In conclusion, Guanjie Biotech's process demonstrates a harmonious blend of traditional botanical extraction with modern separation and drying technologies. Each step, from the initial wash to the final test, Levodopa Powder is designed to maximize yield, protect the integrity of the heat-sensitive L-Dopa molecule, and ensure a final product of the highest possible purity and quality for therapeutic use.

 

 

Applications:

● Healthcare and Clinical Applications:
Levodopa Powder is a critical active pharmaceutical ingredient (API) primarily used in the management of Parkinson's disease and related neurological disorders. Its core clinical application is in treating dopa-responsive dystonia, where it significantly alleviates motor symptoms by restoring dopamine levels in the brain. Furthermore, it is applied in managing hepatic coma; by improving neural function and alertness, it aids in awakening patients and ameliorating the symptoms associated with this condition.

● Dietary Supplement and Wellness Applications:
Beyond pharmaceutical use, this natural Levodopa Powder extract serves important functions in the wellness and supplement industry. It is known to promote restful sleep and support musculoskeletal health by potentially increasing bone density and muscle strength, offering a natural approach to managing osteoporosis. Additionally, it is recognized for its benefits in enhancing libido and improving sexual performance.

Factory&Team：

 

Certification

 

Package & Shipment

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