Urolithin A powder

Urolithin A powder Supplier:

Urolithin A powder is a flora-derived metabolite of natural dietary origin that activates mitochondrial autophagy. Guanjie focuses on herbal extract for 20 years. Our Urolithin A is from pomegranates. It has the function of anti-aging. We apply ethyl acetate to substitution reaction method. We have independent factories and labs. And we also cooperate with Northwestern University and Chinese Academy of Sciences research center. Guanjie acquired more than 14 patents for manufacturing of herbal extracts. We can produce it about 20 tons per year. If you are intersted in our products, please contact us:info@gybiotech.com

 

Product Introduction:

Urolithin A is produced by intestinal flora and is a natural metabolite of ellagitannins, a class of compounds found in pomegranates and some other fruits and nuts.

Urolithin A is a natural metabolite of Ellagitannins, a group of compounds found in pomegranates and some other fruits and nuts. Scientists at the Swiss Federal Institute of Technology in Lausanne and other institutions have found that urolithin A may help to slow down the specific ageing process by improving the function of cellular mitochondria.

 

Why Choose Guanjie's Urolithin A powder?

● Two factories and three production lines

● Professional reseach and sale team

● ISO, Halal, Kosher certified

● The stable quality is strictly controleed from raw materials to semi-finished products, and the final products.

● Our company cooperates with qualified third-party testing institutions.

● We can reply you within one hour for any inquire questions and complaint.

 

COA

Items	Specifications	Test Results	Method
Appearance	Off-white to yellow powder	Light yellow powder	Visual
Identification	The spectrum corresponds to reference	Conforms	HNMR
Purity	NLT 98.0%	98.9%	HPLC
Water	NMT 1.0%	0.3%	USP<921>
Residue on ignition	NMT 1.0%	0.15%	USP<281>
Heavy Metals	NMT 20 ppm	Conform	USP<231>
Arsenic	NMT 2ppm	Conforms	ICP-MS
Lead	NMT 2ppm	Conforms	ICP-MS
Microbiological Tests
Total Plate Count	NMT 1000cfu/g	Conforms	USP<2021>
Yeast & Mold	NMT 100cfu/g	Conforms	USP<2021>
E. Coli.	Negative in 10g	Negative	USP<2022>
Salmonella	Negative in 10g	Negative	USP<2022>
Packing	Sealed export grade drum & double of sealed plastic bag.
Conclusion	Product Conforms to Specifications
Storage	Store in a cool and dry place, keep away from strong light and heat.

 

Flow chart

 

Method of analysis

Column	C18 Inertsil ODS-3 (4.6mm X 250mm X 5μm)
Diluent	Purified water.
Test Solution	Taking 20 mg of the Urolithin A and place in 100ml bottle, to be dissolved in purified water and diluted into a solution containing 0.2mg per 1ml, which was used as the test solution. Appropriate heating or ultrasound can be used to help dissolve
Mobile phase A	0.05%Phosphoric acid aqueous solution
Mobile phase B	Acetonitrile
Wavelength	254nm
Flow rate	1.0mL/min
Column Temp.	30℃
Injection volume	2~5μL
Gradient	Time/min	MP A%	MP B%
	0.00	85	15
	9.00	10	90
	9.10	85	15
	15.00	85	15

 

Mechanism of action: 

It improves mitochondrial function by stimulating a process called mitochondrial autophagy (Mitophagy). Mitochondrial autophagy is the targeted phagocytosis and destruction of mitochondria by the cellular autophagy apparatus and is often considered to be the primary mechanism of mitochondrial quality control. Mitochondrial autophagy is an evolutionarily conserved cellular process that removes dysfunctional or redundant mitochondria in order to fine-tune mitochondrial number and maintain energy metabolism.

There are two regulatory pathways for mitochondrial autophagy are.

A: The PINKl-Parkin pathway of mitochondrial autophagy

B: Receptor-mediated mitochondrial autophagy

 

HNMR:

HPLC：

 

 

Functions

Direction	Experimental conditions	Models	Benefits produced by urolithin A powder
Aging Natural aging	Natural aging,premature aging disorder	Mice, nematodes	Increased lifespan due to mitochondrial autophagy
Muscle dysfunction Natural aging	Natural aging,muscular dystrophy	Mice	Increased muscle strength and aerobic exercise
Cardiovascular disease Diabetic myocardium	Diabetic heart muscle,myocardial ischemia,atherosclerosis	Mice	Increased ATP and NAD+ levels and muscle angiogenesis
Neurological diseases Alzheimer's disease	Alzheimer's disease,ischemic neuronal injury, multiple sclerosis	Mice	Prevention of diabetes-related cardiacdysfunction
Inflammation	Acute gastroenteritis,chronic gastroenteritis	Mice	Reduction of blood lipids and angiotensin II levels
Joint and spinal disorders	Intervertebral disc degeneration,knee osteoarthritis	Mice	Improvement of aortic lesions
Metabolic dysfunction	Obesity,diabetes mellitus	Mice	Improvement in cognitive performance
Acute kidney injury	Acute kidney injury	Mice	Reduction in the development and severity of encephalomyelitis
Cancer	Pancreatic cancer	Mice	Improved cognition, reduced neuronal loss and neuroinflammation

 

Recommended Applications: 

The followings are detailed insights into different application fields where urolithin A bulk powder can be utilized:

1. Nutraceutical Industry:

Urolithin A powder is increasingly utilized in the nutraceutical industry for its health-promoting properties. It is incorporated into dietary supplements and functional foods targeting muscle health, antioxidant support, and overall well-being.

2. Sports Nutrition:

Athletes and fitness enthusiasts benefit from urolithin A 99% powder due to its muscle health promotion abilities. It aids in mitochondrial function, enhancing energy production and muscle performance, making it a popular ingredient in sports nutrition products.

3. Cosmeceuticals:

Urolithin A's antioxidant and anti-aging effects are harnessed in the cosmeceutical industry.It is used in skincare products because of its ability to protect skin cells from oxidative damage, reduce inflammation, and promote cellular renewal.

4. Pharmaceutical Research:

Researchers are exploring powder urolithin A for its medicinal properties in the pharmaceutical industry. Its anti-inflammatory, neuroprotective, and metabolic health advantages make it a promising candidate for therapeutic development in neurodegenerative illnesses and metabolic disorders.

 

5. Functional Foods:

Urolithin A is incorporated into functional foods and beverages to enhance their nutritional value. It gives customers with additional health benefits like as antioxidant protection, gut health support, and anti-aging properties, making functional meals more enticing to health-conscious people.

6. Biotechnology:

Biotechnological applications include its use in research related to cellular health, longevity, and metabolic pathways. Its role in regulating autophagy and cellular recycling processes has implications for biotech innovations in areas such as cellular rejuvenation and longevity.

7. Animal Nutrition:

It can benefit animal health as well. It can be added to animal feed formulations to boost muscle strength, antioxidant defenses, and overall well-being in cattle and companion animals.

8. Agricultural Applications:

In agriculture, it could potentially be utilized as a natural growth promoter for crops. Research is ongoing to explore its effects on plant growth, stress tolerance, and nutrient uptake, offering sustainable agricultural solutions.

9. Personal Care Products:

Personal care products like hair care and oral care items can also benefit from the inclusion of urolithin A powder. Its antioxidant and anti-inflammatory properties may help in maintaining scalp health and promoting oral hygiene.

 

Our factory:

There are two factories both in Baoji city and Shangluo City. Guanjie factory covers an area of 7000㎡, including GMP standard workshop of 2000㎡ and advanced lab of 500㎡. Our factory and lab passed ISO9001, ISO22000, IP(non-GMO), QS, Kosher, Halal etc.

 

Guanjie's Team:

 

Certification

For 20 years, Guanjie has been innovating and improving its self-control standards. We have been certified by ISO9001,ISO22000, QS, Halal,Kosher etc.

 

 

Packing:

● 1-5/kg two plastic-bags inside, aluminium foil bag outside

● 25/kg paper drum and two plastic-bags inside.

 

Shipment:

Transit could be DHL,UPS,TNT, FEDEX, EMS. For mass orders, it will be delivered by air or sea. 

 

Hot Tags: urolithin a powder, China urolithin a powder manufacturers, suppliers, factory, pure bulk fisetin, organic acerola cherry powder bulk, Garcinia Extract Powder, Gynostemma Extract Powder, Rice Bran Extract, Natural Beta Carotene Powder