Urolithin A powder

Urolithin A Powder for Dietary Supplements | High-Purity Urolithin A Bulk Ingredient Manufacturer

As a leading bulk Urolithin A supplier, Guanjie Biotech utilizes an advanced ethyl acetate substitution reaction method to deliver 99% high-purity raw ingredients for dietary supplements. Supported by state-of-the-art independent factories, specialized R&D laboratories, and research collaborations with Northwestern University and the Chinese Academy of Sciences, we achieve a bulk Urolithin A production capacity of 20 tons annually. We can provide high-purity Urolithin A to support your needs. Contact our technical sales team for wholesale quotes and specifications info@gybiotech.com.

 

What is Urolithin A?

Urolithin A is produced by intestinal flora and is a natural metabolite of ellagitannins, a class of compounds found in pomegranates and some other fruits and nuts.

Urolithin A is a natural metabolite of Ellagitannins, a group of compounds found in pomegranates and some other fruits and nuts. Scientists at the Swiss Federal Institute of Technology in Lausanne and other institutions have found that urolithin A may help to slow down the specific ageing process by improving the function of cellular mitochondria.

 

Why Choose Guanjie Biotech As Your Urolithin A Powder Supplier?

● Advanced Manufacturing Capabilities:

Powered by two state-of-the-art factories and three specialized production lines, Guanjie Biotech ensures scalable, continuous supply for global orders.

●Expert Technical Support:

Backed by a professional research and sales team dedicated to serving dietary supplement, pharmaceutical, and nutraceutical brands.

●Internationally Certified Quality:

Fully ISO, Halal, and Kosher certified to meet rigorous global compliance and market standards.

●Strict End-to-End Quality Control:

We maintain uncompromised product stability, monitoring batch quality from raw material selection to semi-finished processing and final output.

●Independent Verification:

Guanjie Biotech partners with qualified third-party testing laboratories to verify 99% purity, safety, and heavy metal compliance.

●Rapid Customer Response:

We guarantee rapid support with a maximum 1-hour response time for all inquiries, technical quotes, and post-sales support.

 

COA

Items	Specifications	Test Results	Method
Appearance	Off-white to yellow powder	Light yellow powder	Visual
Identification	The spectrum corresponds to reference	Conforms	HNMR
Purity	NLT 98.0%	98.9%	HPLC
Water	NMT 1.0%	0.3%	USP<921>
Residue on ignition	NMT 1.0%	0.15%	USP<281>
Heavy Metals	NMT 20 ppm	Conform	USP<231>
Arsenic	NMT 2ppm	Conforms	ICP-MS
Lead	NMT 2ppm	Conforms	ICP-MS
Microbiological Tests
Total Plate Count	NMT 1000cfu/g	Conforms	USP<2021>
Yeast & Mold	NMT 100cfu/g	Conforms	USP<2021>
E. Coli.	Negative in 10g	Negative	USP<2022>
Salmonella	Negative in 10g	Negative	USP<2022>
Packing	Sealed export-grade drum & double of sealed plastic bag.
Conclusion	Product Conforms to Specifications
Storage	Store in a cool and dry place; keep away from strong light and heat.

 

How Is Urolithin A powder Produced?

 

Method of analysis

Column	C18 Inertsil ODS-3 (4.6mm X 250mm X 5μm)
Diluent	Purified water.
Test Solution	Taking 20 mg of the Urolithin A and place in 100ml bottle, to be dissolved in purified water and diluted into a solution containing 0.2mg per 1ml, which was used as the test solution. Appropriate heating or ultrasound can be used to help dissolve
Mobile phase A	0.05%Phosphoric acid aqueous solution
Mobile phase B	Acetonitrile
Wavelength	254nm
Flow rate	1.0mL/min
Column Temp.	30℃
Injection volume	2~5μL
Gradient	Time/min	MP A%	MP B%
	0.00	85	15
	9.00	10	90
	9.10	85	15
	15.00	85	15

 

Mechanism of action: 

Urolithin A improves mitochondrial function by stimulating a process called mitochondrial autophagy (Mitophagy). Mitochondrial autophagy is the targeted phagocytosis and destruction of mitochondria by the cellular autophagy apparatus and is often considered to be the primary mechanism of mitochondrial quality control. Mitochondrial autophagy is an evolutionarily conserved cellular process that removes dysfunctional or redundant mitochondria in order to fine-tune mitochondrial number and maintain energy metabolism.

There are two regulatory pathways for mitochondrial autophagy are.

A: The PINKl-Parkin pathway of mitochondrial autophagy

B: Receptor-mediated mitochondrial autophagy

 

Urolithin A HNMR:

Urolithin A HPLC：

 

 

What Does Urolithin A Do?

Direction	Experimental conditions	Models	Benefits produced by urolithin A powder
Aging Natural aging	Natural aging,premature aging disorder	Mice, nematodes	Increased lifespan due to mitochondrial autophagy
Muscle dysfunction Natural aging	Natural aging,muscular dystrophy	Mice	Increased muscle strength and aerobic exercise
Cardiovascular disease Diabetic myocardium	Diabetic heart muscle,myocardial ischemia,atherosclerosis	Mice	Increased ATP and NAD+ levels and muscle angiogenesis
Neurological diseases Alzheimer's disease	Alzheimer's disease,ischemic neuronal injury, multiple sclerosis	Mice	Prevention of diabetes-related cardiacdysfunction
Inflammation	Acute gastroenteritis,chronic gastroenteritis	Mice	Reduction of blood lipids and angiotensin II levels
Joint and spinal disorders	Intervertebral disc degeneration,knee osteoarthritis	Mice	Improvement of aortic lesions
Metabolic dysfunction	Obesity,diabetes mellitus	Mice	Improvement in cognitive performance
Acute kidney injury	Acute kidney injury	Mice	Reduction in the development and severity of encephalomyelitis
Cancer	Pancreatic cancer	Mice	Improved cognition, reduced neuronal loss and neuroinflammation

 

Recommended Applications of Urolithin A 99% Powder in Different Industries

Urolithin A 99% powder is a high-purity bioactive ingredient widely used in nutraceutical, sports nutrition, cosmetic, pharmaceutical, and biotechnology applications. As demand for advanced health ingredients continues to grow, Urolithin A bulk powder has attracted attention from supplement manufacturers and research organizations due to its potential role in supporting mitochondrial function, cellular health, and healthy aging formulations.

A reliable Urolithin A powder supplier can provide high-quality raw materials with consistent purity and stability for different product development needs. The following sections introduce the major application fields of Urolithin A 99% pure powder.

● Nutraceutical Industry

The nutraceutical industry is one of the primary application areas for Urolithin A powder for supplements. It is commonly used as an ingredient in dietary supplements and functional nutrition products designed for healthy aging, muscle maintenance, antioxidant support, and overall wellness.

Supplement brands use high-purity Urolithin A powder in capsules, tablets, powders, and customized formulations. Its popularity continues to increase as consumers show greater interest in scientifically researched ingredients that support long-term health management.

●Sports Nutrition

Urolithin A 99% powder is increasingly applied in sports nutrition products targeting athletes, fitness enthusiasts, and active individuals. It is associated with mitochondrial health and energy metabolism, making it a valuable ingredient for formulations focused on muscle performance and recovery.

Sports nutrition brands may combine Urolithin A with other functional ingredients to develop advanced products for endurance support, muscle health, and physical performance. As demand grows for innovative sports supplements, bulk Urolithin A supplement ingredients provide manufacturers with flexible formulation options.

●Cosmeceuticals and Anti-Aging Skincare

The cosmetic and personal care industries are exploring Urolithin A powder for its antioxidant and cellular health-related properties. It is being investigated for use in anti-aging skincare formulations designed to protect skin cells from oxidative stress and support skin renewal processes.

Cosmetic manufacturers may incorporate Urolithin A ingredients into creams, serums, and specialized skincare products targeting mature skin. Its potential applications in cellular protection make it an attractive ingredient for next-generation beauty and wellness products.

●Pharmaceutical Research

Urolithin A is also being studied in pharmaceutical research due to its biological activities related to inflammation regulation, metabolic health, and cellular pathways.

Researchers are investigating Urolithin A 99% powder as a potential research compound for applications involving mitochondrial function, neuroprotection, and age-related health conditions. Although further clinical studies are required, its unique mechanism of action continues to attract interest in pharmaceutical development.

●Functional Foods and Beverages

Functional food manufacturers are incorporating Urolithin A bulk powder into innovative nutrition products, including functional beverages, nutrition powders, and wellness foods.

The addition of Urolithin A allows brands to develop products with enhanced nutritional value and meet consumer demand for convenient health solutions. It can be combined with vitamins, minerals, plant extracts, and other active ingredients to create multifunctional formulations.

● Biotechnology Applications

In biotechnology research, Urolithin A is used as a valuable ingredient for studying cellular metabolism, longevity pathways, and autophagy-related mechanisms.

Its relationship with mitochondrial quality control and cellular recycling processes makes it an important research compound for biotechnology companies developing innovative health solutions.

● Animal Nutrition

Urolithin A may also have potential applications in animal nutrition. It can be explored as an ingredient in animal feed formulations designed to support muscle condition, antioxidant defense, and overall animal wellness.

Animal health companies researching functional feed ingredients may consider Urolithin A raw material as part of future nutrition solutions for livestock and companion animals.

●Agricultural Research

Beyond human and animal nutrition, Urolithin A is being explored in agricultural biotechnology research. Scientists are investigating whether bioactive compounds like Urolithin A may influence plant stress responses, nutrient utilization, and sustainable agricultural development.

 

Urolithin A vs. Urolithin B 

Urolithin A and Urolithin B are both bioactive compounds derived from the intestinal microbial metabolism of ellagic acid/ellagic tannins; however, they exhibit significant differences in estrogen receptor affinity, anti-inflammatory potency, and primary areas of research. Below is a detailed comparison.

Comparison	Urolithin A UA	Urolithin B UB
Basic Properties	Hydroxy-6H-dibenzo[b,d]pyran-6-one derivative; gut microbial metabolite	Structurally similar; both are metabolites produced by gut microbiota
Estrogen Receptor Affinity	Very high; IC50 values ​​for ERα and ERβ are 0.4 μM and 0.75 μM, respectively	Much lower; IC50 values ​​for ERα and ERβ are 20 μM and 11 μM, respectively
Anti-inflammatory Activity (Direct Comparison)	Potent; identified as the most active metabolite in inhibiting LPS-induced inflammatory responses (e.g., TNF-α) and inducing IL-10	Possesses antioxidant and anti-inflammatory properties, though its activity is weaker than that of UA in the aforementioned direct comparative studies
Primary Research Areas	Mitochondrial health, muscle function, neuroprotection (Alzheimer's disease), anti-inflammatory effects, AHR antagonism	Renoprotection, osteoarthritis (cartilage protection), anti-cancer (breast cancer), neuroprotection, and inhibition of protein aggregation
Key Mechanisms of Action	Activates mitophagy, inhibits NF-κB, antagonizes the aryl hydrocarbon receptor (AHR)	Upregulates Nrf2/HO-1 and SIRT1/FOXO3 pathways; inhibits the FGFR3/NCOA4/FTH1 axis (anti-ferroptosis)
Representative Findings	Exhibits the strongest anti-inflammatory activity in immune cells; the first dietary AHR antagonist identified	Demonstrates protective effects in models of 5-FU-induced kidney injury and osteoarthritis; shows anti-proliferative and anti-angiogenic potential in triple-negative breast cancer

Urolithin A is generally considered a metabolite with more potent anti-inflammatory and estrogen-related activities, whereas Urolithin B exhibits unique protective mechanisms in specific disease models (such as kidney disease, osteoarthritis, and certain cancers); the two cannot be simply interchanged or equated.

FAQs:

Q1: Why should companies buy Urolithin A Powder directly from a manufacturer?

Buying Urolithin A Powder directly from a manufacturer can provide better supply stability, technical support, and quality traceability. Direct sourcing helps supplement companies reduce supply chain complexity and maintain consistent ingredient quality.

Q2: What applications can your Urolithin A 99% Powder be used in?

Urolithin A 99% Powder is commonly used in anti-aging nutrition, sports nutrition, healthy aging supplements, and mitochondrial health formulations. It can be formulated into capsules, tablets, gummies, and other functional food products.

Q3: Can you provide customized Urolithin A powder specifications or packaging?

Yes. We support customized solutions for Urolithin A bulk powder, including packaging options, product specifications, and supply quantities. Our team works with supplement brands, contract manufacturers, and distributors to support different application needs.

Q4: Why choose Urolithin A 99% powder for supplement formulation?

Urolithin A 99% powder provides a high-purity active ingredient suitable for standardized supplement formulations. A defined purity specification can help manufacturers control active content, batch consistency, and formulation calculations. Buyers should also review the supplier's COA, analytical method, specifications, and contaminant testing before purchasing bulk material.

Q5: Why choose Urolithin A instead of Urolithin B?

Urolithin A is generally preferred for supplement development because it has been studied more extensively, particularly in relation to mitochondrial function, muscle health, and healthy aging. For manufacturers seeking a well-researched Urolithin A 99% powder, it offers a clearer scientific and formulation profile than Urolithin B.

 

Our factory:

There are two factories both in Baoji city and Shangluo City. Guanjie factory covers an area of 7000㎡, including GMP standard workshop of 2000㎡ and advanced lab of 500㎡. Our factory and lab passed ISO9001, ISO22000, IP(non-GMO), QS, Kosher, Halal etc.

 

Guanjie's Team:

 

Certification

For 20 years, Guanjie has been innovating and improving its self-control standards. We have been certified by ISO9001,ISO22000, QS, Halal,Kosher etc.

 

 

Packing:

● 1-5/kg two plastic-bags inside, aluminium foil bag outside

● 25/kg paper drum and two plastic-bags inside.

 

Shipment:

Transit could be DHL,UPS,TNT, FEDEX, EMS. For mass orders, it will be delivered by air or sea. 

 

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