Vine Tea Extract Dihydromyricetin

Vine Tea Extract Dihydromyricetin Supplier:

Vine Tea Extract Dihydromyricetin is from Vine Tea. Dihydromyricetin is a natural compound obtained from the leaf of the Chinese vine tea. Guanjie Biotech has focused on it for 20 years. We have the assay of 98%. It is white to off-white powder and easily soluble in hot water, hot ethanol and acetone, soluble in ethanol, methanol, very slightly soluble in ethyl acetate, insoluble in chloroform, petroleum ether. High quality and competitive price. We can provide you the third-party testing method. If you are interested in our product, please feel free to contact us:info@gybiotech.com

Product Introduction:

The main active ingredients of Vine Tea Extract Dihydromyricetin are flavonoids. Dihydromyricetin is a special kind of flavonoids. In addition to the general characteristics of flavonoids, it also has the functions of relieving alcohol poisoning, preventing alcoholic liver, and fatty liver. Its odor is pure white needle-like crystal, slightly soluble in water, acidic (pH4-5), stable under acidic conditions. Cosmetic raw materials, daily chemical raw materials, health care products.

 

COA:

Item	Specification	Result	Method
Basic Product Information
Genus and Species	Ampelopsis grossedentata (Hand-Mazz)W.T.wang．	Conform	/
Part of the Plant	Leaves	Conform	/
Country of Origin	China	Conform	/
Marker Compounds
Assay(Dihydromyricetin)	>98.0%	98.32%	HPLC
Organoleptic Data
Appearance	Fine Powder	Conform	NLS-QCS-1008
Color	White yellow	Conform	GB/T 5492-2008
Odor	Characteristic	Conform	GB/T 5492-2008
Taste	Characteristic	Conform	GB/T 5492-2008
Process Data
Method of Processing	Extraction	Conform	/
Solvent(s) Used	Ethanol & Water	Conform	/
Drying Method	Vacuum drying	Conform	/
Excipient	None	Conform	/
Physical Characteristics
Particle Size (80 mesh)	>98.0% pass 60mesh	Conform	GB/T 5507-2008
Loss on drying	<3.0%	1.68%	GB/T 14769-1993
Ash Content	<1.0%	0.21%	AOAC 942.05, 18th
Solvent Residue	Eur Pharm	Conform	NLS-QCS-1007
Heavy Metals
Total Heavy Metals	<10 ppm	Conform	USP <231>, method II
As	<2.0 ppm	Conform	AOAC 986.15, 18th
Lead	<2.0 ppm	Conform	AOAC 986.15, 18th
Mercury	<0.5 ppm	Conform	AOAC 971.21, 18th
Cadmium	<0.5 ppm	Conform	AOAC 971.21, 18th
Pesticide Residue
666	<0.2ppm	Conform	GB/T5009.19-1996
DDT	<0.2ppm	Conform	GB/T5009.19-1996
Microbiology
Total Plate Count	<1,000cfu/g	Conform	AOAC 990.12, 18th
Total Yeast & Mold	<100cfu/g	Conform	FDA (BAM) Chapter 18, 8th Ed.
E. Coli	Negative	Negative	AOAC 997.11, 18th
Salmonella	Negative	Negative	FDA (BAM) Chapter 5, 8th Ed.

DHM Test Method

2.	Test Item: Vine Tea Extract Dihydromyricetin Powder
2.1	Instruments and Equipment
	HPLC Equipment;
	UV Detector
2.2	Reagent：
2.2.1	Methanol: chromatographically purity
2.2.2	Methanol: analytically purity
2.2.3	Acetic acid water 0.1%
2.2.4	Purified water：Wahaha Purified water;
2.2.5	DHM Reference sample：from China National Institute for the Control of Pharmaceutical and Biological Products;
2.3	Chromatographic conditions
2.3.1	Chromatographic colum： colum C18,  4.6mm×250mm , 5µm;
2.3.2	Colum Temp：35℃;
2.3.3	UV Detector：250nm detection wavelength;
2.3.4	Flow rate：1mL/minute;
2.3.5	Sample Volume：10μL;
2.3.6	Mobile Phase：Acetic acid water 0.1%：Acetonitrile=75：25
2.4	Detection Steps
2.4.1	Sample processing Take accurate 15mg DHM into 25mL Volumetric flask, dissolve it with methanol. Take accurate 1mL out of the flask, and dilute it to 10 mL with methanol. Then filter it by 0.45μm microporous membrane as the test sample.
2.4.2	Standard curve preparation Take accurate 15mg Vine Tea Extract Dihydromyricetin Reference sample into 25mL Volumetric flask, dissolve it with methanol to get 0.10mg/mL standard solution. Prepare standard solutions of 0.02, 0.04, 0.06, 0.08, and 0.10 mg/mL DHM. During analysis, equilibrate the analytical column with the eluent solution and perform HPLC analysis on different concentrations of the standard after the baseline is stable, then measure the peak area. Take the peak area as the ordinate and the standard solution concentration as the abscissa to draw the standard curve of DHM. When the linear relationship is good and r is 0.9995 or above, determine the subsequent samples.
2.4.3	Spectrum analysis Inject the prepared sample solution, then record the chromatogram spectrum, the retention time of the standard is used to determine the peak area of DHM. The concentration of the sample DHM could be obtained according to the standard curve.
2.4.4	Calculation equation        Note：X1：Percentage of DHM, %;       C1：Concentration of DHM in the sample solution, mg/mL;    V：Diluted volume of test solution, mL;    W：Sample weight, g.

 

Flow Chart

Production Methods

There are four major methods used to extract Vine Tea Extract Dihydromyricetin from Chinese vine tea bark. These include the Soxhlet extraction method, Ultrasonic-assisted extraction, Microwave-assisted extraction, and Solid-liquid extraction. Each of these methods has its strengths and weaknesses.

 

● Soxhlet extraction method

The plant material is placed in the extraction apparatus and continuously extracted using a solvent (usually ethanol or methanol) until the desired compound is obtained. The Soxhlet extraction method has been used for centuries and remains a popular method of extracting plant compounds. It is relatively easy to perform and is effective in extracting large quantities of compounds.

 

● Ultrasonic-assisted extraction

Vine Tea Extract Dihydromyricetin involves using ultrasound waves to agitate the plant material and solvent mixture. This method is highly efficient and can result in higher yields of the desired compound. Additionally, the ultrasonic waves increase the permeability of the plant cells, making extraction easier and faster.

 

● Microwave-assisted extraction

It is a recently developed method that involves using microwave energy to heat the solvent-plant material mixture. The microwaves cause the solvent to boil, which facilitates the extraction process. This method is significantly faster and more efficient than conventional extraction methods and is highly effective in the extraction of Vine Tea Extract Dihydromyricetin.

 

● Solid-liquid extraction method

The plant material is mixed with a solvent and allowed to sit for several hours to allow the desired compound to diffuse into the solvent. This method is less efficient than the other extraction methods but is highly effective in the extraction of DHM.

 

Applications

● Treatment of Alcohol-Related Disorders

Vine Tea Extract Dihydromyricetin powder has been shown to possess anti-alcohol effects by reducing the symptoms of alcohol intoxication, including headache, nausea, and fatigue. DHM enhances the metabolism of alcohol, reduces the production of free radicals and inflammatory cytokines, and promotes the regeneration of liver cells damaged by alcohol. DHM has also been shown to reduce the risk of developing alcohol addiction by reducing the pleasant effects of alcohol.

 

● Treatment of Liver Diseases

Vine Tea Extract Dihydromyricetin has been used in traditional Chinese medicine to treat liver diseases for centuries. DHM possesses potent antioxidant properties that protect the liver from damage caused by free radicals. DHM also enhances the metabolism of toxins and promotes the regeneration of liver cells.

 

● Treatment of Inflammation

It has been shown to possess anti-inflammatory properties. It reduces the production of pro-inflammatory cytokines and inhibits the activation of immune cells involved in the inflammatory response. DHM Powder has shown promise in the treatment of inflammatory conditions, including rheumatoid arthritis, inflammatory bowel disease, and psoriasis.

 

● Treatment of Viral Infections

Vine Tea Extract Dihydromyricetin possesses potent antiviral properties that have been shown to be effective against a range of viruses, including hepatitis B and C, influenza viruses, and human immunodeficiency virus (HIV). DHM inhibits the replication of the virus, reduces inflammation caused by the virus, and enhances the activity of the immune system.

Factory&Team：

 

Certification

 

Package & Shipment

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