L-Glutathione Powder

L-glutathione Powder Supplier:

Guanjie is a manufacture of L-Glutathione bulk powder for 20 years. Glutathione is present in the form of a white crystalline powder that can be easily dissolved in water, but is nearly insoluble in ethanol (99.5). Upon decomposition, it has a melting point of approximately 185℃. And tastes sour, astringent, with a fresh taste similar to MSG. Guanjie's CGMP standard workshop of 2000 square meters, and a factory laboratory of 500 square meters to ensure the high qulity of products. Our products are high quality and low price, welcome to consult us.

Why Choose Guanjie?

● Independent factories and labs.

● Provide the third party testing.

● Have been on this field for 20 years.

● Have strong Collaborators:Northwestern University and Chinese Academy of Sciences research center. 

Product Introduction:

Reduced glutathione (GSH) is a tripeptide compound that is formed by the condensation of glutamate, cysteine, and glycine through a peptide bond. GSH is chemically named γ-L-glutamyl-L-cysteinyl-glycine, and its structural formula is shown in the figure provided. Unlike other peptides and proteins, It has a special peptide bond formed by the condensation of the γ-carboxyl group (-COOH) of glutamate with the α-amino group (-NH2) of cysteine.

Certificate of Analysis

Purity:

(1) Clarity and color of solution— Dissolve 1.0 g of Glutathione in 10 mL of water: the solution is clear and colorless.

(2) Heavy metals <1.07>— Proceed with 2.0 g of Glutathione according to Method 2, and perform the test. Prepare the control solution with 2.0 mL of Standard Lead Solution (not more than 10 ppm).

(3) Arsenic <1.11>— Prepare the test solution with 1.0 g of Glutathione according to Method 1, and perform the test (not more than 2 ppm).

Testing Assay:

Weigh accurately about 0.5g L-Glutathione Powder of the substance to be examined, previously dried, dissolve in 50 mL of a solution of metaphosphoric acid (1 in 50), and titrate with 0.05mol/L iodine VS, add 1 mL of starch indicator when the endpoint approaches. Continue titration until the solution appears blue color. Carry out a blank titration  in the same  manner, and  make any  necessary correction.  1 mL of 0.05mol/L iodine  is equivalent to 30.733 mg of C10H17N3O6S.

Calculate the percentage of glutathione (C10H17N3O6S) in the portion of glutathione taken: 

Result = [(V-B) X N X F X 100] / W

V =titrant volume of the sample (ml)

B = titrant volume of the blank(ml)

N = titrant normality (mEq/ml)

F = equivalency factor, 307.33 mg/mEq

W =weight of the Sample(mg)

Acceptance criteria: not less than 98.0%

Flow Chart 

Product methods:

There are two main methods to produce L-Glutathione Powder, but Guanjie has adopted a new method, the enzymatic method, the pros and cons of which are seen below.

● Chemical synthesis method

Serious pollution, high cost, basically eliminated

● Fermentation method

Mainstream method, average cost, large amount of pollution

Currently outdated

● Enzyme method

Traditional method, high cost of ATP

New method, ATP regeneration, low cost, and less pollution

Process Advantages (Compared with Fermentation Method)

● Fast reaction speed and short production cycle: The reaction is completed in 1 day, while the fermentation method of L-Glutathione Powder takes at least 5 days with no interruptions during this time.

● High yield, easy to purify: 

● The amount of enzymatic reaction is 30-50 g/L, and the reaction components are determined and easy to purify. Fermentation is about 10 g/L, the components are complicated, and the purification needs to use toxic substances.

● Green and environmentally friendly, in line with national development requirements: 

● No heavy metals, toxic gases, and organic substances (except alcohol used in the crystallization process) are added.

● Less energy consumption, low cost: 

● ATP is renewable, and it has low raw material and labor cost.

Application:

Factory&Team：

Certification

Package & Shipment

● Handling: 

Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation.

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