Bulk Alpha Lipoic Acid Powder

Bulk Alpha Lipoic Acid Powder Supplier:

Guanjie Biotech is specializing in Bulk Alpha Lipoic Acid Powder production and trading. It is slightly yellow crystal powder with 99% content. We have our own factory and production line. Our products pass HACCP, ISO9001, HALAL, Kosher and other 20 patents. High quality and competitive price. Welcome to enquiry us: info@gybiotech.com.

COA:

Item	Specification	Result	Method
Appearance	Slightly yellow crystal powder	Conforms	Organoleptic
Identification	Meets the requirements	Conforms	HPLC
Melting Point	60-62℃	61.5℃	USP
Specific rotation	-1.0° to +1.0°	0°	USP
Loss on drying	0.20%max	0.1%	USP
Residue on Ignition	0.10%max	0.03%	USP
Heavy metals	10ppm max	<10ppm	USP
Lead	3ppm max	<3ppm	USP
Cadmium	1ppm max	<1ppm	USP
Mercury	0.1ppm max	<0.1ppm	USP
Chromatogrephic purity
Single Impurity	0.10% max	0.05%	HPLC
Total Impurities	2.0% max	0.07%	HPLC
Limit of polymer content	Conforms	Conforms	TLC
Residual Solvent By GC
Cyclohexane	1000ppm max	750ppm	GC
Ethyl Acetate	250ppm max	76ppm	GC
Toluene	20ppm max	Not Detectable	GC
Total plate counts	1000CFU/g max	<10CFU/g	USP
Moulds and Yeasts	100CFU/g max	<10CFU/g	USP
E.coli/Salmonella	Absence/g	Not Detectable	USP
Staphylococcus aureus	Absence/g	Not Detectable	USP
Partice Size	100% through 40mesh	Conforms	USP
Loose Bulk Density		0.406g/ml	USP
Assay	99%-101%	99.9%	HPLC
Conclusion	Conformed USP36

 

Production Methods 

Guanjie Biotech is an Alpha Lipoic Acid Powder supplier. We produce it as following.

What Is Lipoic acid?

Lipoic acid is also known as alpha-lipoic acid. LA is a fatty acid that contains sulfur. It occurs naturally in some foods and can also be synthesised in small amounts in the body. It can not only participate in energy metabolism and other physiological processes in the body, but can also have important biological significance.

Lipoic acid was discovered in 1951. In subsequent studies, scientists have found that lipoic acid plays an extremely important role in energy metabolism, antioxidant defence and so on. And it has a wide range of applications in pharmaceuticals, nutraceuticals and skin care products.

 

Unique structure

Lipoic acid has a unique structure. It has water-soluble + fat-soluble biphasic antioxidant capacity. It plays many functions in medical and health field. For example, it works on cardiovascular, diabetes and its complications. Bulk Alpha Lipoic Acid Powder improves Alzheimer's disease and treats alcohol-related liver damage. Such as alcoholic liver, liver necrosis, hepatitis etc.

 

Functions:

1. Antioxidant

Antioxidant is the prevention of lipid peroxidation/oxidative stress damage. alpha-lipoic acid (ALA, oxidised form) can be converted in vivo to dihydrolipoic acid (DHLA, reduced form). both ALA and DHLA have strong antioxidant properties. Both Bulk Alpha Lipoic Acid Powder and DHLA have strong antioxidant properties. They synergistically exert direct and indirect effects in the body:

(1) Direct effects

- Lipoic acid can directly bind free radicals and scavenge them.

- Alpha Lipoic Acid ALA Powder can react with hydroxyl radicals (-OH), superoxide anion radicals (O₂--) and so on. converting them into relatively stable products.

- It also chelates metal ions with properties that catalyse oxidative reactions, reducing oxidative damage.

- Metal ions such as iron ions (Fe²⁺, Fe³⁺), copper ions (Cu²⁺), etc. can catalyse the production of free radicals under certain conditions. It accelerates the oxidation reaction. Functional groups such as carboxyl and thiol groups as well as disulfide bonds in the molecule of lipoic acid give it the ability to bind to these metal ions. By chelation these metal ions are encapsulated and rendered inactive to catalyse the oxidation reaction. This reduces the generation of free radicals to a certain extent and reduces the damage of oxidative stress on cells and tissues.

 

(2) Indirect efficacy aspects

- Bulk Alpha Lipoic Acid Powder can promote the regeneration of other endogenous antioxidants.

- A system of antioxidant enzymes exists within the cell. These include superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx). These antioxidant enzymes catalyse the decomposition and scavenging of free radicals and maintain the redox balance within the cell.

 

2. Anti-inflammatory

When inflammation is triggered by external stimuli to the skin, lipoic acid can inhibit the production and release of these inflammatory factors and reduce the degree of inflammatory response. It reduces the gene expression of inflammatory factors by regulating the intracellular nuclear factor-κB (NF-κB) signalling pathway and so on.

Lipoic acid also promotes the differentiation and maturation of keratin-forming cells and enhances the barrier function of the stratum corneum. At the same time, it can regulate sebum secretion and maintain the normal structure and function of the sebaceous membrane. This reduces inflammation.

In a study on sensitive skin, the use of skin care products containing lipoic acid significantly reduced inflammatory indicators in the skin. Symptoms such as redness, swelling and itching were relieved.

 

3. Promote collagen production

- Bulk Alpha Lipoic Acid Powder can activate a variety of signalling pathways within skin cells, such as the transforming growth factor-β (TGF-β) signalling pathway. the TGF-β signalling pathway plays a key role in regulating cell growth, differentiation and collagen synthesis. - Lipoic acid promotes collagen synthesis and secretion by fibroblasts by stimulating this signalling pathway.

- Lipoic acid also inhibits the activity of collagen degrading enzymes. It reduces the gene expression levels of MMPs (matrix metalloproteinases) by regulating intracellular signalling molecules and transcription factors. This maintains the balance of collagen in the skin.

In a months-long clinical study, subjects used skin care products containing lipoic acid. Skin biopsies revealed an increase in collagen density and a reduction in the depth and number of wrinkles.

 

Antioxidant components

The scavenging of excess reactive oxygen species in organisms must rely on the combined participation of various antioxidants.

The redox reaction between lipoic acid and dihydrolipoic acid activates the metabolic cycle of other oxidants in the organism, forming a unique biological antioxidant regeneration cycle network. Multiple active antioxidants act simultaneously. This will form a reticulated system that works better.

 

1.With Vitamin C

- Complementary mechanism to deal with free radicals comprehensively.

- Enhance the antioxidant network to protect cells from different areas.

2. With Vitamin E

- Bulk Alpha Lipoic Acid Powder regenerates and stabilises each other to enhance the antioxidant effect.

- Synergises with Vitamin E to combat oxidative stress.

3. With Coenzyme Q10

- Protecting cell vitality at the mitochondrial level.

- Enhance the skin's antioxidant capacity.

4.With plant extracts

- Alpha Lipoic Acid ALA Powder synergises with green tea extract to enhance antioxidants and reduce photo-aging damage.

- Synergise with grape seed extract to form an antioxidant defence system and promote collagen synthesis.

 

Suitable for most skin types

It is generally recommended to use serums containing lipoic acid at night. The nighttime environment is relatively stable and free from direct UV light. This is more conducive to the antioxidant and skin-healing effects of lipoic acid.

In the field of skincare, Bulk Alpha Lipoic Acid Powder is a powerful antioxidant that neutralises free radicals, promotes collagen production and exerts anti-inflammatory effects. This helps to slow down skin ageing, increase skin elasticity and improve skin texture.

It is typically used in skin care products at concentrations of 0.1% - 5%. Numerous clinical studies and practical applications have confirmed that within this concentration range, it is safe for most people.

 

Factory&Team：

 

 

Certification

 

Package & Shipment

- We use aluminum foil bags for packaging Bulk Alpha Lipoic Acid Powder. We can provide you with different specifications of packaging such as 1kg, 5kg, 10kg, etc.

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