NMNH Powder

NMNH Powder Supplier:

Guanjie Biotech is a high purity NMNH Powder supplier and manufacture. We apply HPLC and other methods to test the quality of Reduced Nicotinamide Mononucleotide (We can provide you the test report if you need). Reduced Nicotinamide Mononucleotide Powder produced by Guanjie Biotech has higher raw material content, lower impurity content, and purity of more than 95%. We have independent factories and labs, And we also cooperate with Northwestern University and Chinese Academy of Sciences research center. Guanjie Biotech acquired more than 14 patents for manufacturing of herbal extracts. If you are interested in our product, Please contact us: info@gybiotech.com

 

Product Advantages:

● High purity:

Guanjie Biotech has a mature synthesis method that can ensure NMNH Powder purity above 98.5%.

● Strong production capacity

Guanjie Biotech Technology covers an area of 7000㎡. Including 2,000 ㎡of GMP standard factory buildings and 500 ㎡of advanced laboratories.

● Compliance:

Our NMNH Powder pass rigorous independent testing to ensure the highest quality products for our customers.

 

Why Choose Guanjie Biotech's Reduced Nicotinamide Mononucleotide?

● Own independent laboratory and professional R&D team

● Two factories and three production lines

● The entire process from raw materials to semi-finished products and finished products undergoes strict quality control

● Cooperate with qualified third-party testing agencies

● Professional and efficient sales and customer service team

 

Certificate of Analysis

Item	Specification	Result	Test Method
Active Ingredient
Purity	NLT 95%	99.14%	HPLC
Physical Control
Identification	Positive	Conforms	HPLC
Appearance	Off-white or yellowish powder	Conforms	Visual
Water	15%-28%	22.1%	KF
Chemical Control
Arsenic(As)	NMT 0.5 ppm	Conforms	ICP-MS
Cadmium(Cd)	NMT 0.5 ppm	Conforms	ICP-MS
Lead(Pb)	NMT 0.5 ppm	Conforms	ICP-MS
Mercury(Hg)	NMT 0.1 ppm	Conforms	ICP-MS
Microbiological Control
Total Plate Count	NMT 1,000cfu/g	10cfu/g	USP-NF 2022
Yeast & Mold	NMT 100cfu/g	<10cfu/g	USP-NF 2022
Salmonella	Negative	Negative	USP-NF 2022
E.Coli	Negative	Negative	USP-NF 2022
Staphylococcus Aureus	Negative	Negative	USP-NF 2022
Pseudomonas aeruginosa	Negative	Negative	USP-NF 2022
Bile-tolerant Gram- Negative Bacteria	Negative	Negative	USP-NF 2022
Candida albicans	Negative	Negative	USP-NF 2022
Closrtidia	Negative	Negative	USP-NF 2022
Coliforms	NMT 0.92MPN/g	<0.3MPN/g	USP-NF 2022
Packing and Storage
Storage	Inert atmosphere. Long term : below -20 °C; Short term :2-8 °C
Shelf Life	2 years if sealed and stored properly.

 

Flow Chart:

 

Product Introduction：

Reduced Nicotinamide Mononucleotide (NMNH) is the reduced form of NMN, the molecular formula is C11H17N2O8P, molecular weight 336.23g/mol, CAS: 108347-85-9. NMNH Powder is an amorphous yellow powder.

Nicotinamide adenine dinucleotide (NAD) is a key coenzyme found in all living cells. It is a dinucleotide consisting of two nucleotides linked by a phosphate group. One nucleotide contains the base adenine and the other contains nicotinamide. It occurs in two forms in the body: NAD+ and its reduced state NADH.

NAD is vital to life because it is one of the most versatile molecules in the body and the focus of anti-aging research. In the body, it supports DNA repair, activates sirtuins known as longevity genes, promotes processes such as glycolysis and the citric acid cycle, participates in redox reactions, and allows the electron transport chain to function in mitochondria in the body. NAD's downstream activities support hundreds of enzymatic reactions and regulate many critical processes in cells. Given the critical role NAD plays in enzyme activity, cellular function, and metabolism, it is why any decline in NAD can lead to metabolic disorders and lay the foundation for a variety of age-related diseases. Multiple studies have shown that as we age, our NAD levels will decrease significantly. Therefore, restoring NAD levels has been a focus of academic research in recent years.

 

NMN and NR have long been considered dietary supplements in the NAD field, but both are not without problems. Both NMN and NR have limitations, such as their maximal NAD boosting effects are around 2-fold and hence require higher and considerably more costly doses. And studies have shown that NR has been shown to increase NAD levels in human blood, but despite the dose Very high, but it cannot increase NAD levels in tissues such as muscle.

 

As one of the most popular molecules in the field of anti-aging, NAD+ has without exception become the core of anti-aging in the past. NMN is considered to be the most suitable NAD+ precursor at present. However, in recent years, researchers have reported a new type of NAD+ supplement NMNH Powder, whose anti-aging ability exceeds that of NMN.

NMNH can be efficiently processed into NAD in cells. Most interestingly, the pathway to achieve this does not involve nicotinamide ribokinase (NRK) or nicotinamide phosphoribosyltransferase (NAMPT), enzymes required for other precursors to become NAD. And NMNH can also protect renal proximal tubular epithelial cells from damage caused by hypoxia. NMNH not only increases NAD levels in their blood, but also increases NAD levels in multiple tissues, including the kidneys, reaching higher levels than NMN at the same concentration.

 

Function

● NMNH increased cellular NAD+ levels

In one experiment, NMNH (100μM) treatment increased cellular NAD+ levels by 5-fold in HepG2 cells, whereas NMN (100μM) only slightly increased NAD+ levels as determined by mass spectrometry. The results show that NMNH is a more potent NAD+ than NMN. In addition to HepG2 cells, we also confirmed that NMNH can also enhance NAD+ in ES-2 (ovary derived cells) cells. We also found that NMNH increased cellular NAM concentration. These results indicate that NMNH is a more potent NAD+ enhancer than NMN in vivo. NMNH powder also significantly increased NAM levels in the liver, and it was confirmed that high doses of NMNH were not hepatotoxic.

 

● NMNH inhibited Glycolysis and TCA Cycle

NMNH can reduce the levels of glycolytic intermediates and the levels of TCA cycle intermediates, including intermediates in the glycolytic pathway. These results indicate that accumulation of NADH produced by NMNH inhibits cellular glycolysis and TCA cycle. In contrast, NMN treatment of glycolysis and TCA cycle only induced a slight decrease in products in glycolysis, and almost no reduction in TCA cycle cells was observed. Overall, NMNH Powder has a very significant inhibitory effect on glycolysis and TCA cycle, while NMN also has an inhibitory effect on glycolysis, but to a much lesser extent than NMNH.

 

● NMNH Repressed Cell Growth

The researchers found that NMNH treatment could inhibit cell growth at concentrations higher than 250 μM. Among them, the expression levels of 289 proteins increased, while the expression levels of another 171 proteins decreased. The study also found that NMNH reduced the levels of key regulatory factors of the cell cycle by 2-fold and changed gene transcription. In cell cycle analysis treated with 1 mM NMNH and NMN for 12 hours, the researchers found that NMNH caused cell cycle arrest, while NMN had no obvious effect on the cell cycle.

 

In conclusion, NMNH performs well in the anti-aging field and is a potent NAD+ enhancer both in vitro and in vivo and is superior to NMN. It can also significantly increase cellular NADH levels, inhibit glycolysis and TCA cycle, and alter key cell cycle regulatory factors and gene transcription to inhibit cell growth. These findings provide strong evidence for the application of NMNH in anti-aging and cell metabolism regulation, demonstrating NMNH Powder huge potential.

 

Effects:

● Improve metabolic function
NAD+ plays a central role in energy metabolism. Especially in the mitochondria of cells, NAD+ is involved in various processes such as fatty acid oxidation, sugar metabolism, and protein synthesis. Studies have shown that NMNH supplementation can effectively increase intracellular NAD+ levels, improve the body's energy metabolism, and increase exercise endurance and stamina.

For example, it has been found that by increasing NAD+ levels, the fat oxidation process in liver cells can be promoted. This will improve fat metabolism, reduce fat accumulation, and prevent obesity and related metabolic syndrome.

 

● Delaying aging
With age, the decline of NAD+ level in the body will lead to the decline of cell function, and then accelerate the aging process.NAD+ is involved in the regulation of a variety of anti-aging mechanisms, such as DNA repair, telomere maintenance, and antioxidant effects.

NMNH Powder supplementation helps to restore the level of NAD+, thus activating the anti-aging mechanisms in the body. Studies have shown that NMNH not only activates the SIRT1 protein, which is associated with longevity, but also promotes autophagy and reduces aging-related cellular damage. Experimental animal studies have also shown that NMNH supplementation can delay aging and prolong lifespan.

 

● Enhance cognitive function
NAD+ is closely related to brain health; it promotes cognitive function by regulating neurotransmitters, improving mitochondrial function, and enhancing the self-repairing ability of brain cells. As we age, the decline in NAD+ levels can lead to the development of neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease.

NMNH supplementation increases NAD+ levels in the brain and enhances neuronal energy metabolism and repair. This can improve memory, and learning ability, and reduce the risk of neurodegenerative diseases. Clinical studies have also shown that NMNH improves cognitive function to some extent and has a positive effect on memory disorders.

 

● Improvement of immune system function
NAD+ is essential for maintaining the normal function of the immune system. It participates in the metabolic process of white blood cells and influences the proliferation and activity of immune cells. When the level of NAD+ in the body is insufficient, the function of the immune system will be suppressed, leading to a decline in the body's immunity.

NMNH bulk Powder can elevate the level of NAD+ in the body, enhance the activity of the immune system, and promote the proliferation of immune cells and the ability to fight infection. This makes NMNH potentially advantageous in enhancing the body's immunity, defending against infections, and improving disease resistance.

 

More significant anti-aging effects

● Enhances mitochondrial function
Declining NAD+ levels are considered one of the core signs of aging.NMNH helps to restore mitochondrial function and improve the efficiency of ATP production by rapidly replenishing NAD+. Improved mitochondrial function directly affects cell viability and metabolic capacity, slowing the aging process.

 

● Activates key longevity proteins
NMNH can activate Sirtuins and PARPs more efficiently. These proteins play important roles in DNA repair, gene expression regulation, and cellular metabolic homeostasis. NMNH's activation ability is stronger than that of conventional NMN, further slowing down the cellular aging process.

 

● Antioxidant and anti-inflammatory capacity
NMNH helps reduce oxidative stress and inflammatory responses in the body when it elevates NAD+ levels. Oxidative stress and chronic inflammation are at the root of several aging-related diseases. This includes cardiovascular disease, diabetes, and neurodegenerative diseases. The role of NMNH Powder provide stronger support for healthy aging.

 

Company Advantages:

● Guanjie Biotech has a professional sales team and an efficient customer service team.

●We are passionate about producing high-quality products and providing excellent service.

●We always follow the business philosophy of people-oriented, quality first, and integrity, adhere to the purpose of integrity, cooperation, development, and innovation, and adhere to the path of innovative development.

●Our products are 100% natural and do not contain any harmful chemicals or additives.

●We trust every employee and recognize their efforts and dedication. The company also strives to create a good working environment and development prospects for employees.

●We use the most advanced technology to manufacture high-quality NMNH Powder to ensure that we meet customer needs.

●We provide comprehensive and systematic quality training for employees.

●The development of users is our development, and the value of users is our value.

●We have a track excellence sell record.

●We have good popularity among our customers because of the fantastic assistance, high-quality goods, aggressive rates and efficient delivery.

 

Certification

 

Package & Shipment

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