Bulk NMNH Powder

Bulk NMNH Powder Supplier:

Guanjie Biotech provides bulk NMNH powder.As a leader in synthetic biology industry, we have completed the production layout and index test of NMNH. NMNH can be mass produced globally. We adopt the leading enzyme process, the purity of NMNH:≧99.5%. We can provide samples and third party testing, welcome to contact us: info@gybiotech.com.

NMNH as a reduced form of NMN. It is a better NAD+ enhancer than NMN. Naturally occurring in the kidneys. NMNH is rapidly converted to NAD+ in biological cells. It is more than twice as fast and concentrated as NMN, while boosting NAD+ levels in a wide range of tissues.

 

Why Choose Guanjie Biotech's NMNH?

●Available in both free acid bulk NMNH powder and sodium salt forms NMNH bulk powder.

●Leading enzymatic process.

●Has its own factory and laboratory.

●Provide testing report.

● We have ISO, Kosher, Halal, HACCP and other patents.

 

COA:

Product and Batch Information
Product Name	Reduced §-Nicotinamide Mononucleotide (Reduced §-NMN) §-dihydronicotinamide mononucleotide (§-NMNH)
Batch No	NMNH230801 Manufacture Date			May. 04th, 2024
Analvsis Date	May. 14th, 2024 Expiry Date			May. 03rd, 2026
Item	Specification	Result		Test Method
Active Ingredient
Purity	NLT 95%		99.64%	HPLC
Physical Control
Identification	Positive		Conforms	HPLC
Appearance	Off-white or yellowish powder		Conforms	Visua
Water	15%-28%		22.1%	KF
Chemical Control
Arsenic(As)	NMT 0.5 ppm		Conforms	ICP-MS
Cadmium(Cd)	NMT 0.5 ppm		Conforms	ICP-MS
Lead(Pb)	NMT 0.5 ppm		Conforms	ICP-MS
Mercury(Hg)	NMT 0.1 ppm		Conforms	ICP-MS
Microbiological Control
Total Plate Count	NMT 1,000cfu/g		10cfu/g	USP-NF 2022
Yeast & Mold	NMT l00cfu/g		<10 cfu/#	USP-NF 2022
Salmonella	Negative		Negative	USP-NF 2022
E.Coli	Negative		Negative	USP-NF 2022
Staphylococcus Aureus	Negative		Negative	USP-NF 2022
Pseudomonas aeruginosa	Negative		Negative	USP-NT 2022
Bile-tolerant Gram- Negative Bacteria	Negative		Negative	USP-NF 2022
Candida albicans	Negative		Negative	USP-NF 2022
Closrtidia	Negative		Negative	USP-NF 2022
Coliforms	NMT 0.92MPN/g		<0.3MPN/g	USP-NF 2022
Packing and Storage
Storage	Inert atmosphere. Long term : below -20 °C; Short term :2-8 °C
Shelf Life	2 years if sealed and stored properly.

 

Production Advantages： 

For the preparation of bulk NMNH powder, Guanjie Biotech utilizes an enzymatic process. The enzymatic process has the following advantages.
● Environmentally friendly
The enzymatic process is a green chemical process. It uses enzymes as catalysts. These enzymes are proteins extracted from living organisms and are able to catalyze the reaction under mild conditions, reducing the generation of harmful by-products. The enzymatic process is more environmentally friendly than traditional chemical synthesis methods. This is because it reduces the use of hazardous solvents, reduces waste generation and helps to achieve sustainable development.

●Safety
Another advantage of using enzymes as catalysts is safety. Enzymes are highly specialized. They catalyze only specific reactions, which reduces the generation of side reactions and impurities. This means that bulk NMNH powder produced through the enzymatic process has a higher purity and lower impurity content.

● High purity
The enzymatic process allows precise control of the reaction conditions. Such as temperature, pH and substrate concentration. This facilitates the optimization of the reaction path and improves the purity of bulk NMNH powder. This is important to improve product effectiveness and minimize potential side effects.

● Mild reaction conditions
Enzyme-catalyzed reactions are usually carried out under mild conditions close to physiological conditions. For example, room temperature or slightly above room temperature, and neutral or near neutral pH. These conditions help to maintain the activity and stability of the enzyme, and also help to keep the structure and function of the reaction products undamaged.

● Easy to scale up
Another advantage of the enzymatic process is its ease of scale-up. Due to the high catalytic efficiency of enzymes, high conversion rates can be achieved even at low substrate concentrations, which makes the enzymatic process suitable for industrial scale production.

● Wide range of applications
The enzymatic process is not only suitable for the production of bulk NMNH powder, but can also be extended to the synthesis of other bioactive molecules. The flexibility and versatility of this process makes it a promising candidate for a wide range of applications in the biotechnology and pharmaceutical industries.

● Reduced energy consumption
Enzymatic processes typically require a lower energy input compared to traditional chemical synthesis methods. This is because the reaction conditions are milder. This not only reduces the energy consumption in the production process, but also lowers the production cost.

● Improved product stability
The bulk NMNH powder produced by the enzymatic process usually has better stability due to its high purity and fewer impurities.NMNH is less prone to degradation during storage and transportation, and is able to maintain its activity and potency for a longer period of time.

 

Differences Between Free Acid And Sodium Salt NMNH Powder

NMNH is available in both free acid and sodium salt forms. Often, different salt forms may affect properties. Such as, solubility, stability , bioavailability of a substance and other aspects. For example, in medicinal chemistry, different salt forms may affect the absorption and distribution of a drug and thus its efficacy.

 

Differences Between NMN and NMNH:

● Molecular Structure:

NMNH is a reduced form of NMN, which means that there is an extra hydrogen atom in the NMNH molecule, which makes it chemically different from NMN.

 

● Boosting NAD+ Levels:

NMNH has shown the ability to boost NAD+ levels in cells faster than NMN in in vitro assays and is more effective than NMN at the same concentration.NMNH significantly boosts cellular NAD+ levels and can rapidly boost NAD+ levels within 1 hour of supplementation, much more so than NMN.

● In vivo effects:
In in vivo studies, NMNH was shown to more effectively increase blood NAD+ concentrations and sustained a more than 2-fold increase in NAD+ concentrations up to 20 hours after the first injection, whereas NMN decreased blood NAD+ levels to basal levels 4 hours after supplementation.

● Tissue Effects:
Compared to NMN, NMNH elevates NAD+ levels in a wide range of tissues, with the greatest impact particularly in the liver and kidneys, as well as significantly increasing NAD+ levels in the brain, gastrocnemius muscle, brown adipose tissue, and the heart in a way that NMN cannot.

 

● Cellular Repair:
Bulk NMNH powder elevates higher NAD+ concentrations in hypoxic/reoxygenated environments and enhances cellular repair by targeting NAD+ regeneration, enhancing mitochondrial activity and nucleotide metabolism, and reducing cellular damage in hypoxic/reoxygenated injuries.

● Metabolic regulation:
NMNH elevates intracellular NADH accumulation, inhibits cellular glycolysis and the tricarboxylic acid cycle (TCA cycle), and inhibits cell growth, whereas NMN inhibits cellular glycolysis only to a limited extent.

● Safety:
In the analysis of whether high doses of NMNH cause hepatotoxicity, the experimental results showed that high doses of NMNH are not hepatotoxic.

● Production and Application:
Only a few companies are currently able to mass produce NMNH bulk powder with ≥99% purity. They use a proprietary enzymatic process that provides both free acid and sodium salt forms.Guanjie Biotech can provide high quality bulk NMNH powder.

 

Application:

The role of Bulk NMNH powder in the food field is mainly reflected in the following aspects.

● Anti-aging nutraceuticals:

NMNH acts as a precursor of NAD+, NMNH is more effective than NMN in boosting NAD+ concentration. NMNH Bulk powder plays a role in anti-aging.

● Cost savings:

Due to its high unit conversion efficacy, NMNH may require fewer input costs. As a result, the cost of food or health products containing bulk NMNH powder is more competitive.

● Viability advantage:

The proficient change of NMNH might pursue it a better decision for shoppers. This is on the grounds that it can help NAD+ levels all the more successfully, hence giving improved brings about enemy of maturing and keeping up with cell wellbeing.

● Food Ingredients:

As a food ingredient, Bulk NMNH powder can be mixed it up of food sources and refreshments Particularly in items that underscore wellbeing and life span.

● Market Potential:

As research on NMNH intensifies, its potential for application in the food sector is gradually being recognized. The market volume is growing rapidly, and a variety of nutraceuticals with NMNH as the main ingredient are now available in the market.

 

Factory&Team：

 

Certification

 

Package & Shipment

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