Dextran Powder

Dextran Supplier:

Dextran powder is also known as polyglucose. Guanjie offers high-quality and competitively priced bulk Dextran. As a manufacturer, Guanjie specializes in producing dextran with various specifications. The powder is available in white or light yellow fine powder form. It is a homotypic extracellular polysaccharide composed entirely of α-D-glucopyranose monomers. It is the first industrialized microbial polysaccharide in the world and is recognized as a plasma substitute at home and abroad.

Introduction:

Dextran powder is a macromolecular glucose polymer produced by the fermentation of sucrose. Due to the different number of polymerized glucose molecules, different molecular weight products are produced. There are four types of dextran as following.
● High molecular weight (average molecular weight 100,000 to 200,000)
● Medium molecular weight (60,000 to 80,000)
● Low molecular weight (20,000 to 40,000)
● Small molecular weight (10,000 to 20,000).

 

COA:

T40

Items	Standard
Appearance	White or light yellow fine powder
molecular weight	35,000-45,000
Water	≤ 7.0 %
Ash	≤ 2.0 %
pH (1%solution concentration)	4.5-7.0
O.D.(1%solution concentration,510nm)	≤ 0.02
solubility	Soluble in cold water
Heavy metals, lead	≤ 8 ppm

 

T70

Items	Standard
Appearance	White or light yellow fine powder
molecular weight	64,000 - 76,000
Water	≤ 7.0 %
Ash	≤ 2.0 %
pH (1%solution concentration)	4.5-7.0
O.D.(1%solution concentration,510nm)	≤ 0.02
solubility	Soluble in cold water
Heavy metals, lead	≤ 8 ppm

 

Categories:

The most frequently employed dextran powder varieties are:Dextrose 20, Dextrose 40, Dextrose 70.
1. Molecular weight size:
● Glucose polymer 20 has a molecular weight between 10,000-20,000
● The molecular weight of dextran 40 is between 20,000-40,000
● Dextrose 70 has a molecular weight between 60,000 and 80,000 molecules.

 

2. Rate of elimination from the body:
● Dextrose 20 has a shorter half-life in the body, lasting around 3 hours, and is eliminated more easily in urine.
● Dextrose 40 has a slightly longer half-life of roughly 24 hours, with the kidneys excreting about half of it.
● Dextrose 70 has a relatively longer duration of action, about 12 hours, and about 60% of the drug is excreted in about 24 hours.

3. Clinical uses:
● Dextrose 20 is mainly used to improve microcirculation, prevent or eliminate intravascular red blood cell aggregation and thrombosis, etc. It is also used to expand blood volume transiently.
● Although dextrose 40 can also expand blood volume, but its action time is shorter, and has the function of osmotic diuresis and improve microcirculation, so it is often used in the treatment of shock, cerebral thrombosis and myocardial infarction patients.
● Glucose polymer 70 is mainly used as a plasma substitute to prevent or relieve hemorrhagic shock, traumatic shock and burn shock.

 

Production Process:
Microbial fermentation process for the preparation of dextran 40000 powder,dextran 150000 powder and other specifications.

Strain culture---fermentation [sucrose, peptone, disodium hydrogen phosphate, water, manganese chloride, plus enteromembrane Streptococcus suis strain (LM1226-Institute of Hematology, Chinese Academy of Medical Sciences, or L.M. NRRL B512-NRRL Institute, U.S.A.)] ---- Alcohol precipitation (by-products of fructose, impurities, and the bacteria body is removed) ---hydrolysis (HCl 6mol /L,Calcium Chloride) ---- Neutralization (Sodium Hydroxide 6mol/L) ----5 Grade division (①Azide, macromolecules; ②Medium molecules; ③Dextrinsic anhydride 70; ④Dextrinsic anhydride 40; ⑤Dextrinsic anhydride 20) ---- Filtration ---- Powder mixing (90% ethanol) ---Centrifugation (washing) ---Dispersion ---- Drying ---- Mixing ---- Finished product packaging.

Applications:

1. Pharmaceutical industry:
It is similar to plasma proteins and globulins. Colloidal properties are similar to plasma, with no adverse effects on cell structure and function. It has nutritional effect by hydrolyzing into glucose in the body. Therefore, dextran has the pharmacological effects of expanding blood volume, improving microcirculation, diuresis and swelling, etc.
① It has nearly physiological colloid osmotic pressure;
② Maintains plasma volume for a certain period of time;
③ It should be harmless to the function of any organ, and should not have antigenic, sensitizing or thermogenic reaction;
④ Stable quality, suitable for long-term storage and easy to sterilize;
⑤ There is no risk of plasma products being infected with hepatitis and HIV.
Dextran powder 40 can be used clinically for:
① Prevention and treatment of shock, including hemorrhagic shock, infectious shock, cardiogenic shock and burn shock
② Prevention and treatment of ischemic vascular disease, to prevent the collection of red blood cells in the blood circulation, reduce blood viscosity, improve microcirculation.

 

2. Food industry
Stabilizing, moisturizing, thickening and volume increasing agent in beverage and pastry. Instead of maltose as a filling agent for soft-centered chocolate. Glucose polymer powder can add to the malt in beer brewing to improve the foaming properties.

 

Factory&Team：

 

Certification

 

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