Nicotinamide Riboside Malate

Nicotinamide Riboside Malate Supplier:

Guanjie is a Nicotinamide riboside malate supplier and manufacture. Nicotinamide riboside hydrogen malate produced by Guanjie has higher raw material content, higher conversion rate, and purity of more than 98%. We have independent factories and labs, And we also cooperate with Northwestern University and Chinese Academy of Sciences research center. Guanjie acquired more than 14 patents for manufacturing of herbal extracts. If you are interested in our products, Please contact us: info@gybiotech.com.

Nicotinamide riboside malate is an ionic compound with the molecular formula C15H20N2O10. It consists of 66% Nicotinamide riboside (NR) and 34% malate. Malate was chosen as the anionic moiety of NR because of its superior manufacturing and solubility parameters when compared to other forms. In addition, malate was theorized to be of low toxicity and well tolerated because of its status as a metabolic intermediate and its significant prevalence in the food supply (such as apple). Nicotinamide Riboside Malate is an innovative nutritional supplement that combines the benefits of Nicotinamide Riboside (NR) and Malic Acid.

 

Product Advantages:

1. High purity:

The advantage of the crystallization process is the good effect of removing impurities: More than 98% purity and less than 0.1% Ignition residue.

2. Low impurities:

● Nicotinamide≤0.5%

● Single Impurity≤0.5%

● Total Impurities≤2.0%

 

3. High production efficiency:

Our workshop production efficiency and batch size is enhanced to meet customer demand faster.

4. Compliance:

Our Nicotinamide riboside malate production line has gone through several compliance checks and continuous production is guaranteed.

 

Specification:

Item	Specification
Appearance	White or Off-white Crystalline or Crystalline Powder
Specific Rotation	-39°~ -42°
Identification	Should Be in Accordance With the Reference
Water	≤0.5%
Related Substances	Nicotinamide≤0.5%
	Single Impurity≤0.5%
	Total Impurities≤2.0%
Residue of Ignition	≤0.1%
Heavy Metals	≤10ppm
Content of L-Malic Acid	33.2%~35.2%
Assay	98.0%~102.0%

 

Flow Chart:

 

Why choose Guanjie's Nicotinamide riboside malate?

● Two factories and three production lines

● Professional research and sales team

● ISO, Halal, Kosher certified

● The Nicotinamide riboside hydrogen malate stable quality is strictly controlled from raw materials to semi-finished products, and the final products.

● Our company cooperates with qualified third-party testing institutions.

● We can reply to you within one hour for any inquiries questions and complaints.

 

Product Introduction：

Nicotinamide riboside (NR) is an analog of vitamin B3, naturally present in trace amounts in selected foods. Several B3 analogs are known precursors in the synthesis of nicotinamide adenine dinucleotide, including nicotinic acid and nicotinamide.

Nicotinamide adenine dinucleotide (NAD+) is an essential factor in all cells, It is involved in hundreds of metabolic processes such as cellular energy, consumption and brain functioning. Unfortunately, as we age, we gradually lose NAD+, leading to a variety of health problems. A Research shows that NAD+ levels drop to half of youth levels in middle age. By 80-year-olds, it drops to 1%. Since our brains absorb large amounts of NAD+, a decrease in NAD+ will directly affect brain function, leading to memory problems, mood problems, and anxiety disorders.

 

Nicotinamide riboside malate is a source of vitamin B3, which increases NAD+ levels and activates SIRT1 and SIRT3. It can be effective in enhancing oxidative metabolism, and protecting against high-fat diet-induced metabolic abnormalities.

Nicotinamide riboside (NR) is an important precursor for the biosynthesis of Nicotinamide adenine dinucleotide (NAD+) and the related NAD family of molecules. Several vitamin B3 analogs are known precursors in the synthesis of Nicotinamide adenine dinucleotide (NAD), including nicotinic acid and nicotinamide. Due to the moiety of Nicotinamide, Nicotinamide riboside (NR) is considered a form of vitamin B3. The nicotinamide moiety of Nicotinamide riboside (NR) is covalently linked to the riboside moiety and carries a positive charge at the nitrogen atom of the pyridine ring.

 

NAD plays a variety of roles within cells. However, NAD's most prominent function is as a hydrogen ion acceptor, donor, and energy regulator in several oxidation-reduction reactions of cellular energy metabolism, including tricarboxylic acid cycle, glycolysis, and oxidative phosphorylation. NAD functions in the degradation of carbohydrates, proteins, fats and alcohol, which are catabolic reactions that produce energy. NAD+ also serves as a substrate for NAD+-dependent enzymes such as poly-adenosine, diphosphate ribose polymerase, sirtuin (SIRT), CD38 and CD157.

 

NAD has multiple biosynthetic pathways, including:

1.The de novo biosynthesis pathway, which employs the amino acid and tryptophan as its precursor.

2.The Preiss-Handler pathway, in which NAD is derived from nicotinic acid.

3.The Salvage Pathway, which utilizes Nicotinamide riboside (NR) or nicotinamide.

Nicotinamide riboside (NR) is found naturally present in cow's milk and is also available as a nutraceutical that can be supplemented to increase NAD.

Malate, an important Kreb's cycle organic acid, supports NR's role in cellular energy production capability. Nicotinamide riboside (NR) that is bound to hydrogen malate is an ingredient that is exclusive to Guanjie. Optimizing NR's benefit can be further achieved when the body's methylation processes are promoted. A researcher has found correlations between the aging of bodily tissues and the extent of DNA methylation known as "epigenetic clocks." Guanjie's Nicotinamide riboside malate which contains nicotinamide riboside also contains nutrients that are well known methyl donors, in contrast to NR products on the market that do not contain methyl-donating nutrients.

 

Functions：

● It can reduce the acetylation status of Ndufa9 and SOD2.

● It can increase intracellular and mitochondrial NAD+ levels in a concentration-dependent manner in C2C12, Hepa1.6 and HEK293 cells in a concentration range of 1-1000 μM.

● It can enhance NAD, restores antiviral poly (ADP-ribose) polymerase (PARP) function, and supports innate immunity to coronavirus (CoVs). (CoVs is one of the causes of COVID-19)

 

Specific performance：

Aging: As we age, NAD+ levels gradually decrease, which may accelerate the aging process of the human body. Nicotinamide riboside hydrogen malate can help maintain the body's NAD+ levels, helping to delay aging and extend lifespan.

● Athletic ability:

NAD+ is involved in energy metabolism and muscle function, and supplementing with this malate can promote these processes, thereby improving exercise performance.

● Cardiovascular health:

In addition to improving the energy extraction process of all cells, NAD+ can also protect mitochondria from premature death and reduce cellular aging. Nicotinamide riboside malate may help reduce the risk of cardiovascular disease and brain disease.

● Brain Health:

Adequate NAD+ levels are important for maintaining brain health, cognitive function, and preventing neurological brain damage.

 

Company Advantages:

● Our expert team is always available to answer any questions or concerns from our customers.

● Our company has conveyed to every member its development concept of advancing with the times, pursuing excellence and the tenacious spirit of unity and hard work. At the same time, with the rapid development of the company, each member shows his passion, wisdom, diligence, ability and pursuit.

● We are a high-quality plant extract supplier and reliable manufacturer

● We have a track sell record of excellence.

● We combine our own scientific and humane management system So that we have a dynamic enterprise team.

● Our products are 100% natural without any harmful chemicals or additives.

● We promise that we will provide customers with the highest quality Nicotinamide riboside malate and the best services to achieve sustained and healthy development.

● Our products are designed to meet the highest industry standards, ensuring that all of them are safe and effective.

● We always take the customers' needs at the center and put the people-oriented concept into every detail of product design.

● We are committed to providing the highest level of service and support to our customers.

● We love the very good popularity among our customers because of the fantastic assistance, high-quality goods, aggressive rates and efficient delivery.

 

Factory&Team：

 

Certification

 

Package & Shipment

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