Monacolin K Powder

What Is Monacolin K Powder?

Monacolin K powder is a pure natural fermentation product of red yeast rice and is the main active ingredient of red yeast rice flour. It is a cholesterol-lowering substance isolated from the fermentation broth of Aspergillus terreus by Alberts et al. in 1980. It is an unsaturated tricyclic lactone compound that inhibits 3-hydroxy-3-methylglutaryl reductase. Monacolin-K has two forms: Acid Form and the other is Lactone Form. The pure natural fermented Monacolin K has a high proportion of Acid Form and can be directly absorbed by the human body.

Guanjie Biotech controls the quality of Monacolin K Powder. FDA-approved Monacolin K you are purchasing is registered and inspected in a GMP facility here in China. We use no fillers, excipients, binders, milk, egg or preservatives or any other additives in this product. Our products have striking color, light and heat stability, purity, safety, and wide PH-applying scope. It can be used as a natural colorant and health-caring food that can rapidly reduce plasma cholesterol and triglyceride levels in man.

MOA

● Sample preparation:

Weigh accurately400.0mg～600.0mg(W2) of test sample to previously dried 50ml volumetric

flask add 30ml 75%methanol,dissolve and sonicate for 50mins at room temperature,add

75%methanol to close the scale,sonicate for 10mins ,After cool at room temperature,add

75%methanol to the scale,At 3500 r/min rotation speed centrifuge for 10 min.Take that the

supernatant fluid 0.45um microporous membrane filtration.

●Standard Preparation:

Weigh accurately 4mg of Monacolin K Powder to previously dried 100ml volumetric flask by 0.2 mol/L

sodium hydroxide, sonicate for 1 h at 50 ℃ ,cool at room temperature, and putting 1 h.

●HPLC Conditions:

Column: C18 250mm×4.6mm

●Flow rate: 1.0 mL/min

●Detection: 238 nm

●Injection Volume: 20μl

●Mobile phase: Methanol: water: phosphate = 385-385:0.14 (volume fraction)

Non-GMO

What Is Monacolin K Powder Used For?

Monacolin K powder is a versatile ingredient used across multiple industries due to its bioactive properties, stability in formulation, and effectiveness at low concentrations. Its applications can be broadly categorized into cosmetic, food, and pharmaceutical grades.

Cosmetic Grade Applications

In the cosmetic industry, Monacolin K powder is increasingly incorporated into functional skincare formulations, particularly those focusing on anti-aging and skin health.

Used in anti-aging skincare products

Applied in formulations designed to improve microcirculation

Supports skin vitality through improved lipid metabolism

May contribute to reducing oxidative stress-related skin aging

Although its primary function is systemic lipid regulation, its antioxidant-related and circulation-supporting properties make it relevant in cosmetic science. It is often included in high-end functional skincare products targeting mature skin or dull complexion concerns.

Cosmetic-grade Monacolin K is typically processed under strict purity standards to ensure safety for topical applications and compatibility with other active ingredients.

Food Grade Applications

Food-grade Monacolin K powder is widely used in functional foods and dietary supplements aimed at cardiovascular health support.

Incorporated into health supplements for cholesterol management

Used in functional foods such as capsules, tablets, and fortified powders

Often combined with other natural lipid-regulating ingredients

Suitable for long-term dietary support formulations

In food applications, Monacolin K is valued for its natural origin and clinically recognized lipid-lowering effect. It is commonly included in red yeast rice-based products and heart-health supplement blends.

Monacolin K Powder Manufacturers must carefully control dosage and purity to ensure compliance with food safety regulations, as Monacolin K is a biologically active compound.

Pharmaceutical Grade Applications

Pharmaceutical-grade Monacolin K powder represents the highest level of purity and standardization. It is used in medical and clinical formulations under strict regulatory conditions.

Used in lipid-lowering therapeutic formulations

Applied in clinical-grade cardiovascular treatments

Standardized for precise dosage control

Manufactured under GMP (Good Manufacturing Practice) conditions

In pharmaceutical applications, Monacolin K powder is treated as an active pharmaceutical ingredient (API). Its mechanism of action is similar to statin-class drugs, making it relevant in the management of hypercholesterolemia under medical supervision.

Pharmaceutical-grade production requires rigorous quality testing, including purity analysis, stability testing, and contaminant control to ensure safety and efficacy.

What Are Contraindications of Monacolin K Powder?

Monacolin K Powder has some contraindications, so we strongly recommend that you take it under the supervision of a health professional.

● Do not recommend RYR to anyone under the age of 20.

● RYR should always be taken with food.

● It should not be taken while breastfeeding or during pregnancy.

● It is not recommended for people with kidney, thyroid, musculoskeletal, or liver disease.

● Avoid if you have any serious infections or medical conditions, or have had an organ transplant. Or if you drink more than two alcoholic beverages per day.

Allergen-free

● Peanuts, peanut oil

● Tree nuts

● Sesame seeds

● Milk and derivatives

● Eggs

● Fish

● Shellfish

● Soybeans

● Wheat and gluten Sub

● Sulfates

● Other known allergens

● Free of any GMOs

Why Choose Guanjie Biotech?

● Our company has raw material synthesis workshop.

● Our company has advanced quality instruments and equipment.

● Some of the products are apply for discount, but it depends on the quantity.

● Our factory makes sure the Monacolin K Powder quality steps.

First of all, we will prepare samples for approval.

Secondly, after getting approved, our team will set up a process craft, and form a inside drawing to follow it.

Thirdly, during production, we have FQC, IQC, IPQC and OQC to control the quality.

Our factory:

There are two factories both in Baoji city and Shangluo City, Guanjie factories covers an area of 7000㎡, including GMP standard workshop of 2000㎡.

Product Qualification

Monacolin K powder is produced in a clean working environment and every step of the process is conducted by highly qualified professionals.

Testing Center:

Both the production processes of manufacture and the product itself meet all international standards. And if you need our testing report, we can provide you.

Certification

We have obtained the NON-GMO by Pony test international group. And we get the certifications about HALAAL,ISO 9001,ISO 22000,Kosher, PAHS,SC and so on.

Package&Warehouse:

Shipment:

DHL, Sea freight, FEDEX, you can choose.

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