Guanjie has been specializing in Spermidine Wheat Germ Extract for more than 20 years. We have another unique insight into this product. Today we are going to explain some of the anti-aging benefits of Spermidine. Spermidine is a naturally occurring polyamine compound that is found in all plants and animals, and in almost every cell of the human body. As a type of polyamine, spermidine plays an important role in cell growth and tissue differentiation in the body. In addition, it is involved in the regulation of DNA and RNA stability in the body.
In 1974, the Belgian scientist Christian de Diff proposed the concept of "cellular autophagy", and in 2016, the Japanese scientist Ryonori Ohsumi, based on the concept of autophagy, categorized 15 types of autophagy genes and elucidated the mechanism of cellular autophagy, winning the Nobel Prize. Classification of 15 types of autophagy genes, and elucidated the mechanism of cellular autophagy, won the Nobel Prize. The word autophagy comes from the Greek word auto-, meaning "own". and phagein, meaning "to eat". So, cellular autophagy means "to eat oneself". This process can be simply understood as "recycling". Some damaged proteins or organelles are wrapped up by autophagic vesicles and then degraded, digested and absorbed, and finally recycled. In this way, the cell realizes self-renewal and purification, and constantly maintains the homeostatic balance of the cell. In recent years, studies have found that disease phenomena such as chronic diseases, metabolic diseases, and even life phenomena. All have the participation of cell autophagy. Cellular autophagy is the key to slowing down aging and preventing many diseases. Having said that, what is the relationship with today's protagonist - spermidine (Spermidine)?
1.What is spermidine?
In 1674, Anthony Levenhooker, the father of the microscope, invented the world's first light microscope. Then a crystalline compound was discovered while observing semen. This was the first time spermidine was discovered. Since it was discovered from semen, in 1888 German chemists Ladenburg and Abel finally decided to name it Spermine (spermine). It was more than 200 years after Levenhuk discovered this crystalline substance from semen that Rosenheim got the correct chemical composition of this crystalline substance: putrescine, spermine and spermidine. Subsequent research revealed that spermidine is a naturally occurring polyamine found in a wide variety of cells and organisms, not just limited to semen. It plays a variety of important roles in cell biology and biochemistry, including cell growth and value-addition, DNA and RNA stabilization, and cellular autophagy.
Scientists have found that the concentration of spermidine decreases with age in all animals and humans, which may account for the decrease in autophagy and the onset of aging and chronic diseases, and this has piqued their interest in the potential anti-aging benefits of spermidine.
Spermidine activates cellular autophagy
An epidemiologic study reported a positive correlation between spermidine uptake and healthy human lifespan. It found that individuals with a higher intake of dietary spermidine. Reduced incidence of cancer and cardiovascular disease was associated with improved overall survival.
Supplementation with spermidine wheat germ extract may extend lifespan and promote cardiac and neuroprotection. It stimulates anti-tumor immune responses and may avert immune senescence by stimulating memory T-cell formation. These anti-aging properties are linked to the most important action of spermidine - activation of cellular autophagy.
Upon research, scientists have found that spermidine can activate 15 cellular autophagy factors. It is safe in high doses and well tolerated. By inducing cellular autophagy and promoting the restoration of cellular components, spermidine can slow down aging and extend life span.
In 2009, a study published in Nature Cell Biology found that spermidine extended the lifespan of yeast, flies, worms and human immune cells. It also observed that spermine stimulated a significant increase in cellular autophagy activity.
In 2020, an article was published in the Nature medical subseries that selected 14 potential anti-aging substances. Spermidine was among them.
In addition, other mechanisms for the anti-aging potential of spermidine may include:
• Antioxidant effects
Oxidative stress is an important factor contributing to cellular aging and damage. Spermidine also has antioxidant properties. It can help neutralize free radicals and reduce cell damage from oxidative stress.
• DNA Stability
Spermidine may help maintain DNA stability, reducing the risk of DNA damage and mutations. This helps prevent cellular aging.
• Cell cycle regulation
Spermidine may also affect the cell cycle. It helps maintain a normal cell life cycle and reduces the risk of abnormal cell proliferation.
Main Sources of Spermidine
Spermidine in the human body comes from the following 3 main sources:
Nutritional Supplements As mentioned earlier, spermidine is found in almost all living organisms. Then animals, plants and fungi used as food ingredients naturally contain spermidine.
Spermidine ingested orally is rapidly absorbed from the intestines and distributed throughout the body without degradation. Therefore, foods with a high content of wheat germ extract spermidine help to increase the level of spermidine wheat germ extract.
Higher levels are found in wheat germ, cauliflower, soybeans, cheese, natto, and fungal foods such as mushrooms.
• Gut Microbiome Synthesis
The gut microbiota is an important source of spermidine synthesis. For example, the intestinal probiotic Bifidobacterium bifidum synthesizes spermidine in the gut in addition to short-chain fatty acids and vitamins.
Cellular biosynthesis In mammals, spermine can be metabolically converted to spermidine. Guanine can also synthesize spermine in response to enzymes.
In summary, spermidine is a very powerful "cellular autophagy mimic". It has anti-aging potential and can be consumed through food intake. It can be supplemented through food intake, such as legumes, nuts, soybeans, and supplements. Or through biosynthesis and the promotion of intestinal flora synthesis, to increase the body's spermidine life memory levels. However, more research is needed in the future to confirm the exact mechanism of action and efficacy of spermidine.
What are the ingredients in Guanjie's Spermidine?
Guanjie is a Chinese company specializing in plant extracts. Spermidine powder wheat germ extract has been well researched. According to available research results, it has been proven that wheat germ is the richest in spermidine among natural foods.
Therefore, the basic ingredient of our spermine is wheat germ extract which is rich in spermine. And to ensure safety, the wheat germ extract in spermine comes from natural, non-GMO wheat.
In addition, in order to ensure the consistency of the spermidine content of wheat germ and product quality, the company tests each batch of wheat germ for quality, purity and spermidine content.We are a Chinese company specializing in plant extracts. Spermidine powder wheat germ extract has been well researched. According to available research results, it has been proven that wheat germ is the richest in spermidine among natural foods.
Therefore, the basic ingredient of our spermine is wheat germ extract which is rich in spermine. And to ensure safety, spermidine rich wheat germ extract comes from natural, non-GMO wheat.
In addition, in order to ensure the consistency of the spermidine content and product quality, the company tests each batch of spermidine wheat germ extract for quality, purity and spermidine content.
Guanjie is a professional spermidine supplier. Welcome to enquiry us: info@gybiotech.com.
