Lutein belongs to the carotenoid family. It contains two distinct violet rosette rings. Bulk Lutein has no vitamin A activity and is widely found in vegetables, fruits, and flowers. Lutein is an important pigment that makes up the macular region of the retina in the human eye and is widely found in all parts of the brain. Its concentration is positively correlated with brain development and cognitive function. The two main luteins in the macular pigment of the retina of the human eye are lutein (lutein) and zeaxanthin (zeaxanthin) which are isomers of each other. The difference is the position of the double bond in one of the zeaxanthin rings.
Studies have shown that lutein protects against vision diseases such as age-related macular degenerative disease and cataracts. It also relieves visual fatigue and has an ameliorative effect on symptoms such as eye swelling, eye pain, photophobia, blurred vision and dry eyes. Zeaxanthin has physiological effects such as protecting eyesight, preventing cardiovascular diseases, preventing cancer and enhancing immunity. At present, lutein has been widely used in medicine, health food, cosmetics, feed and other fields.
The declared health functions of bulk lutein health food mainly include four functions such as relieving visual fatigue, enhancing immunity, antioxidant and radiation protection. Among them, the most claimed health function is relieving visual fatigue, followed by antioxidant. Modern pharmacological research shows that lutein has a variety of pharmacological effects such as antioxidant, enhancement of body immunity, and anti-aging. It has a wide range of preventive and protective effects in cancer, retina protection, cardiovascular disease and so on.
Lutein raw materials use
There are three main types of lutein raw materials used, lutein monomer, lutein ester and commercialised lutein/lutein ester products (powder, oil).Guanjie Biotech produces lutein powder, lutein oil, and support for filling capsules.
Lutein monomer is an oxygenated carotenoid. It is soluble in most organic solvents, but insoluble in ether and water. Lutein is in the cell membrane in such a way that hydrophobic long carbon chains are buried in the molecular layer of phospholipids. The hydrophilic hydroxyl groups remain on either side of the membrane. This makes lutein maximally bound to cell membrane lipids that are highly oxidisable, and so makes lutein unstable to light, heat and oxygen, and susceptible to degradation and destruction. Lutein esters are formed by the esterification of the free hydroxyl group of lutein combined with fatty acids. This combination improves the stability of bulk lutein to light.
Commercialized lutein/lutein ester products (powders and oils) are commercialized lutein/lutein ester products made by mixing lutein/lutein esters with starch/vegetable oils etc. Commercialized lutein products may contain edible vegetable oil, dextrin, antioxidants and other excipients used for standardization and other purposes. The value of key indicators after compounding shall be converted according to the compounding ratio. Commercialized lutein ester products can be obtained through microencapsulation and dilution process production.
At present, the use of lutein raw materials in China based on and quality standards mainly include 'Food Safety Law of the People's Republic of China', 'Regulations for the Implementation of the Food Safety Law of the People's Republic of China', 'Measures for the Administration of Health Food Registration and Record', 'Rules for the Evaluation and Approval of Health Food Registration', 'Health Food Registration Application Service Guidelines', as well as the General Administration of Markets issued by the relevant announcements, notices and so on.
The former Ministry of Health (MOH) approved lutein as a coloring agent and nutrient fortifier in food additives in Announcement No. 8 of 2007. The former Ministry of Health approved lutein esters as a new food ingredient in its Announcement on the Approval of 7 New Resource Foods, including Lactobacillus Acidophilus, No. 12 of 2008, and the former General Office of the Ministry of Health approved bulk lutein esters as a new food ingredient in its Announcement on the Use of Lutein Esters (Supervision Letter of the Office of the Ministry of Health 〔2011〕, No. 449), which clarified that low concentration lutein esters produced by the process of microencapsulation and dilution were not used. ester. It can be used as a food ingredient. Its consumption should be calculated according to the concentration of the product. The quality standard of lutein should be under GB 26405 'Food Safety National Standard for Food Additives Lutein'.
Lutein Dosage Forms And Its Formulation
The declared dosage forms of lutein health food products mainly include capsules, soft capsules, granules, tablets, beverages, and powders in a total 6 dosage forms. Among them, the most used are soft capsules, capsules, and tablets (including chewable tablets, and tablets). On the one hand, it is because the capsule and tablet production equipment is common, and the process technology is mature and simple. On the other hand, the physicochemical properties of lutein are unstable, and there are problems such as poor water solubility, unstable properties and low bioavailability in the preparation process. In the preparation, storage, processing, and other processes will inevitably occur isomerization, oxidation and other reactions. Therefore, it is necessary to change the dosage form through physical embedding or chemical modification. At present, the main dosage forms on the market are oil suspension, water-dispersible dry powder, microcapsules, liposomes and so on. For lutein oil raw materials, soft lutein capsule is the best choice, and the capsule has the characteristics of being portable and convenient to take.
Although the number of raw materials used in bulk lutein health food formulations is not fixed, there are synergies between them. Research studies have found that in the database of lutein health food formulations, common combinations of ingredients with each other are lutein - lingonberry - vitamin A - zinc gluconate, lutein - lingonberry - zinc gluconate, and so on.
In the health care function for the relief of visual fatigue products, in addition to the raw material lutein, the composition of the remaining raw materials can be divided into two categories. One category is rich in anthocyanins, flavonoids, polysaccharides and other health food ingredients with antioxidant functions (such as lutein, lingonberry, grape seed, blueberry, etc.). The other category is beneficial to the eyes of nutrients (such as zinc gluconate, carotene, vitamins, etc.). The two types of ingredients synergize with each other to have a more significant effect, protecting the retina from damage and protecting the eyes by supplementing nutrients.
In addition, Chinese medicine believes that the pathogenesis of visual fatigue is related to the imbalance of yin and yang, and the disorders of qi, blood and fluid. For example, liver depression and stagnation of qi, liver blood deficiency, kidney yin deficiency, spleen and stomach qi deficiency, and heart fire inflammation. In the study of lutein bulk powder health food raw materials, the highest frequency of three kinds of Chinese medicine raw materials are wolfberry, chrysanthemum and cassia seeds. By using bulk lutein as raw material for health food, the principle of selection of traditional Chinese medicine raw materials and the theory of traditional Chinese medicine for the treatment of visual fatigue match.
Lutein-based health food has an exact function. Based on sufficient, raw materials, dosage form and production process are relatively fixed. The declaration of lutein health food is mostly based on the health care function of relieving visual fatigue. Most of the consumer groups are teenagers and young people, and the market demand is large. Therefore, it is the trend of future research and declaration to study the suitable dosage form and taste for the consumer group.
Secondly, lutein health food has declared a large number of products composed of various raw materials. However, the composition and dosage of each raw material are not fixed, and there are fewer studies on the interaction of multiple raw materials to exert health functions. Therefore, bulk lutein health food is composed of a variety of raw materials. The composition and dosage of the formula, health functions, serving size, suitable population, efficacy components/marker components, etc. are the focus of the subsequent research.
Guanjie Biotech is a bulk lutein supplier, we focus on lutein bulk powder and lutein liquid. Different Specifications that you can choose 5%,10%,20%,30%,50%,60%,80%,90% & Customized. Welcome to inquiry us: info@gybiotech.com.
