Oleanolic Acid Powder

•Raw material preparation: olive leaf screening

The production process starts with the purchase and screening of olive leaves. High-quality olive leaves are the basis for ensuring the purity and yield of oleanolic acid. The screening process mainly removes non-leaf parts such as impurities, branches, and mud.

•Crushing

The screened olive leaves enter the crushing stage. The purpose of crushing is to break the leaves into fine particles suitable for extraction, increase the surface area, and promote the dissolution of active ingredients in the subsequent alcohol extraction process.

•Alcohol extraction and water precipitation (alcohol extraction and water precipitation)

The crushed olive leaf powder is sent to the alcohol extraction stage. The extraction solvent we use is ethanol or ethanol-water mixed solvent. The alcohol extraction process is carried out at a certain temperature (such as 50-70℃) and time (several hours). Oleanolic acid and other active ingredients are dissolved using alcohol-soluble solvents.

After filtering or centrifuging to remove residues, the extract is subjected to water precipitation treatment. In this step, an appropriate amount of water is added to the alcohol extract. This can reduce the solubility of the active ingredient, precipitate some impurities or polysaccharides, facilitate separation, and improve the efficiency of subsequent purification.

•Spray drying

The clarified alcohol extract enters the spray drying process after concentration, and the liquid is quickly converted into powder. Spray drying uses high-temperature hot air to instantly dry the liquid in a spray state to obtain a stable crude powder. This method maintains the activity of the ingredients and is convenient for storage and transportation.

•Crude product

The oleanolic acid powder obtained after spray drying is the crude oleanolic acid, which contains more impurities. This requires further purification. The quality of the crude product affects the purity and efficacy of the final product.

•Refining

The crude product undergoes a refinement process, usually using solvent recrystallization, column chromatography and other technologies to further remove impurities and related components and concentrate the target components. This step increases the content and purity of oleanolic acid and is a key link in improving product quality.

•Decolorization

The refined liquid or solid may contain pigments and other colored impurities. This will affect the appearance and market competitiveness of oleanolic acid powder. Decolorization usually adopts activated carbon adsorption or resin adsorption. Physical adsorption removes pigments to make the product color whiter or light yellow, improving the sensory quality of the product.

•Concentration

The decolorized liquid enters the concentration stage, and the vacuum concentration technology is often used. Removing the solvent at a lower temperature can avoid thermal degradation of the active ingredients, and at the same time concentrate the target substance to a concentration suitable for crystallization, which is convenient for subsequent crystallization operations.

•Crystallization

After the concentrated liquid is cooled to a certain temperature, oleanolic acid begins to crystallize. The crystallization process controls the temperature, stirring speed and time to obtain the ideal crystalline particle morphology and purity. This link is an important step in forming high-purity oleanolic acid powder.

•Recrystallization

In order to further improve the purity of the product, the solid after crystallization is often recrystallized. By dissolving and recrystallizing, residual impurities are removed and the purity of oleanolic acid is significantly improved.