Oxymatrine Powder

Oxymatrine Powder Supplier:

Guanjie Biotech has focused on oxymatrine powder production and trading for 20 years. Oxymatrine is white or off-white crystalline powder, with an odorless, bitter taste. It is easily soluble in water and also has a certain solubility in organic solvents such as ethanol and chloroform. We use the HPLC testing method to ensure the assay≥98%. High quality. Welcome to enquiry:info@gybiotech.com.

COA:

ANALYSIS SPECIFICATION RESULTS Assay ≥98% 98.31% Physical & Chemical Control Identification Positive Complies Appearance white column with ridges form crystal Complies Taste Characteristic Complies Loss on Drying ≤3% 1.51% Ash ≤5% 2.17% Heavy Metal <10ppm 0.50ppm Melt point 205℃～210℃ 209.0℃ Residual Solvents Eur.Pharm. Complies Pesticides Negative Negative无 Microbiology Total Plate Count <1000CFU/gm Complies Yeast & Mold <100CFU/gm Complies E.Coli Negative Complies Salmonella Negative Complies
Conclusion	Conform with specification
Storage	Store in a cool & dry place. Do not freeze. Keep away from strong light and heat.
Shelf life	2 years when properly stored

Methods:

Guanjie Biotech uses the organic solvent method to extract oxymatrine Powder. This is one of the most commonly used extraction methods. Organic solvents such as ethanol and methanol are usually used to extract plant materials such as bitter ginseng or camellia root. For example, bitter ginseng root is crushed and extracted by soaking or refluxing with a certain concentration of ethanol solution at the appropriate temperature. The general extraction process needs to be repeated several times to ensure adequate extraction of the alkaloids. The crude extract containing oxidized Picrasidine is then obtained by filtration, concentration, and other steps. The advantage of this method is that it is relatively simple to operate and capable of extracting a variety of alkaloidal components.

 

Functions:

Oxymatrine Powder as an alkaloid has a variety of effects. Studies have shown that it has a variety of biological activities such as antiviral, anti-inflammatory, antioxidant, and immunomodulatory.

• Antiviral  

Oxymatrine bulk has an inhibitory effect on a variety of viruses. In particular, it shows strong activity in antiviral. For example, Picrasidine oxide was found to inhibit the replication of hepatitis B virus (HBV) and hepatitis C virus (HCV). Therefore, it has potential applications in the treatment of viral hepatitis.

 

• Anti-inflammatory  

It exerts anti-inflammatory effects by inhibiting the release of inflammatory mediators. Studies have shown that oxymatrine inhibits the synthesis of inflammatory mediators such as nitric oxide (NO) and prostaglandin E2 (PGE2). This reduces the inflammatory response. It has potential for the treatment of inflammatory diseases such as rheumatoid arthritis and allergic diseases.

 

• Antioxidant 

Oxidized Picrasidine has strong antioxidant activity, scavenging free radicals from the body and slowing down oxidative damage to cells. Therefore, it has certain application value in delaying aging and anti-aging.

 

• Immunomodulation

The role of oxymatrine powder in the immune system has also been widely studied. It can regulate the function of immune cells and enhance the immune response of the body. To a certain extent, oxidized picaridin has a regulatory effect on the immune system. It has potential applications in therapeutic areas such as anti-tumor and anti-virus.

 

•Hepatoprotective
The hepatoprotective effect of oxymatrine is also one of the important areas of its application in supplements. Oxidized Picrasidine can help prevent and treat liver diseases through mechanisms such as antioxidation, inhibition of hepatocyte apoptosis, and promotion of liver cell repair. This is especially true in the adjunctive treatment of conditions such as chronic hepatitis and cirrhosis. The hepatoprotective effect of oxidized Picrasidine makes it a common ingredient in liver health supplements.

•Cardiovascular
Oxymatrine is also gradually being recognized for its application in cardiovascular health. It can improve the health of the cardiovascular system through mechanisms such as regulating blood lipids, lowering cholesterol, and reducing atherosclerosis. Studies have shown that oxymatrine powder has a certain therapeutic effect on cardiovascular diseases such as hypertension and hyperlipidemia. As a result, related supplements for preserving cardiovascular function have begun to add Picrasidine oxide as an active ingredient.

 

•Antidiabetic
The effect of oxymatrine on diabetes mellitus has also attracted widespread attention. Studies have shown that Picrasidine oxide can improve insulin sensitivity, reduce blood glucose fluctuations, and regulate fat metabolism by improving insulin sensitivity, reducing blood glucose fluctuations, and regulating fat metabolism. It can help lower blood sugar levels and act as an aid in the treatment of diabetes. Therefore, it also has some applications as a supplement in the field of diabetes control.

 

Metabolism and Absorption

• Absorption

Oxymatrine is relatively well absorbed in the gastrointestinal tract. After oral administration, it can be absorbed by the mucosa of the gastrointestinal tract by both passive diffusion and active transport. The extent of its absorption in the intestine may be affected by some factors. Such as the dosage form of the drug, the pH value of the gastrointestinal tract, and the presence of food. For example, when oxymatrine powder is made into a dosage form such as liposomes, it may improve its absorption efficiency in the gastrointestinal tract as liposomes increase the affinity of the drug to the cell membrane.

 

• Distribution

After entering the blood circulation, oxymatrine can be widely distributed in all tissues and organs of the body. It can enter the brain tissue through the blood-brain barrier. It is distributed in relatively high concentrations in metabolic and excretory organs such as the liver and kidney.

Its distribution in tissues is also influenced by the ability of the drug to bind to tissue proteins. Oxy can bind to plasma proteins and tissue proteins. This binding is reversible. Bound drugs are generally not pharmacologically active. Only free-form drugs can exert pharmacological effects. It has been found through research that the binding of oxidized Picrasidine to plasma proteins fluctuates within a certain range. This also affects its distribution and potency in the body.

 

• Metabolism

In vivo, oxymatrine is metabolized by the hepatic cytochrome P450 enzyme system (CYP450), which catalyzes a variety of metabolic reactions, including oxidation, reduction, and hydrolysis of Picrasidine oxide. Among them, oxidation is the main metabolic mode. Through the oxidation reaction, the chemical structure of Picrasidine oxide will be changed to produce a series of metabolites.

The pharmacological activities of these metabolites may be different from those of oxidized Picrasidine. Some metabolites may still have certain pharmacological effects. While some may lose their activity. The study of the metabolic process of a drug is important for understanding the changes in its efficacy and toxicity.

 

• Excretion

Picrasidine oxide and its metabolites are mainly excreted through the kidneys. One part of the drug is excreted in the urine in its original form and the other part is excreted as metabolites. Renal excretion plays a key role in maintaining the stability of drug concentration in the body and preventing drug accumulation and poisoning.

In addition to renal excretion, a small amount of oxymatrine Powder can also be excreted through the bile. The biliary route of excretion can eliminate the drug and its metabolites from the body and may also affect the enterohepatic circulation of the drug. Enterohepatic circulation is the process by which the drug and its metabolites circulate between the liver and the intestine. It affects the residence time of the drug in the body and the duration of its effect.

 

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