Spermidine Wheat Germ Extract

Spermidine Wheat Germ Extract Supplier:

Guanjie Biotech is a spermidine wheat germ extract. Wheat germ is the best source of spermidine extract. Our product is white powder with an assay of 1% and 98%. Spermidine is a naturally occurring polyamine found in living organisms. It is an organic compound with multiple amine groups. You can choose from different sizes. You are welcome to enquire with us at info@gybiotech.com.

 

Product	CAS No.	Grade	Packing specification
spermidine	124-20-9	Food Grade	1kg 25kg

 

Test Items	Specification	Result	MOA
Appearance	White to off-white powder	Off-White Powder	Visual
Purity	≥98%	99.0%	GC
Solubility	Soluble in water	Conform	CP2020
Loss on drying	≤1.0%	0.28%	CP2020
Residue on ignition	0.2%	0.02%	CP2020
Ethanol(GC)	5000ppm	600ppm	GC
Heavy Metal Content
Pb	≤0.1 ppm	Conform	GB5009
Hg	≤0.1ppm	Conform	GB5009
Cd	≤0.2 ppm	Conform	GB5009
As	≤0.1ppm	Conform	GB5009
Total microbial count	≤500CFU/g	<10	GB4789
Coliform	≤0.92MPN/g	Conform	GB4789
Mold and yeast	≤50CFU/g	Conform	GB4789
Staphylococcus aureus	0/25g	Conform	GB4789
Salmonella	0/25g	Conform	GB4789
Conclusion	All inspection items conform with the specifications.
Storage Condition	Sealed packaging, stored at cool, dry and away from light.

 

 

 

Spermidine Wheat Germ Extract is mainly from wheat germ. Spermidine is widely distributed in living organisms. This includes organisms such as bacteria, mammals, birds, insects, and plants. It is found in several organs. Such as, the human kidneys, liver, intestines, and stomach. Spermidine-rich foods mainly include broccoli, cauliflower, mushrooms, soya beans, green peppers, peas and hazelnuts.

 

● Spermine/Spermidine Metabolism

In mammalian cells, spermine is produced from its precursor, putrescine, or through the oxidative degradation of spermine.

 

●Gut microbiota

The gut microbiota is an important source of spermine synthesis. In mice, the concentration of spermine in the intestinal lumen is directly dependent on the colonic microbiota. Oral administration of the polyamine-producing probiotic Bifidobacterium bifidum LKM512 upregulates blood levels of spermidine and spermine, suppressing inflammatory responses and prolonging lifespan in aged mice.

 

●Supplements

Because spermidine wheat germ extract has anti-aging properties, many spermidine supplements have appeared on the market. Wheat germ is the best source of spermine extract. Guanjie Biotech is a spermidine-rich wheat germ extract producer and manufacturer, welcome to consult us. We have all kinds of certificates and production certificates.

●Food sources

Spermidine ingested from food can be rapidly absorbed from the intestines and distributed throughout the body. Therefore, consuming foods with high levels of spermine can help increase the levels of spermine in the body.

 

 

• Antioxidant Activity.

Spermidine has strong antioxidant activity. It can react with free radicals and reduce the oxidative damage to cells caused by free radicals. In vivo, spermidine also promotes the expression of antioxidant enzymes and enhances antioxidant capacity.

• Energy metabolism regulation:

Spermidine is involved in the regulation of energy metabolism in organisms. Spermidine wheat germ extract promotes the absorption and utilization of glucose after food intake and influences the ratio of aerobic to anaerobic metabolism by regulating the effectiveness of mitochondrial energy production.

• Growth and development and immune regulation:

Spermine is also important for growth and development and immune regulation. It can promote the secretion of growth hormone in the body, which helps to enhance the development of various tissues and organs in the body. Meanwhile, in immune regulation, spermidine enhances the body's resistance to viruses and diseases by regulating the production of white blood cells and promoting the removal of reactive oxygen species.

 

• Slowing down aging:

Spermidine promotes autophagy. This is an internal cellular cleansing process. It helps remove damaged organelles and proteins, thereby slowing down aging.

 

• Improves Reproductive Health:

Spermidine levels decline during the reproductive aging process. Supplementing with spermidine may help improve ovarian function and extend reproductive life.

 

• Neuroglial cell regulation:

Spermidine has an important regulatory role in neuroglia. It can be involved in cellular signaling systems and functional connections between nerve cells. It plays an important regulatory role in neuronal development, synaptic transmission, and combating neuropathy.

 

• Cardiovascular protection:

Spermidine in the cardiovascular field can reduce lipid accumulation in atherosclerotic plaques. This reduces cardiac hypertrophy and improves diastolic function, resulting in cardioprotective effects. In addition, dietary intake of spermidine-rich wheat germ extract can improve blood pressure and reduce cardiovascular morbidity and mortality.

 

- Spermidine significantly enhanced the angiogenic capacity of senescent endothelial cells. In turn, it promoted neovascularization in senescent mice under ischemic conditions, showing potential therapeutic value for ischemic cardiovascular disease.

 

- Spermidine improves cardiac function and reduces myocardial damage in diabetic mice and cardiomyocytes by decreasing ROS, ERS, and Pannexin-1-mediated iron deposition, thus effectively alleviating diabetic cardiomyopathy.

 

- Spermidine as a natural polyamine. It not only possesses age-protective properties that extend biological lifespan but also exhibits potential anti-tumor effects. This includes enhancing mitochondrial function and promoting autophagy.

 

- Spermidine effectively alleviates obesity and metabolic disorders by activating brown fat and skeletal muscle, improving insulin resistance, and reducing hepatic steatosis induced by high-fat diet in mice.

- Spermidine wheat germ extract acts as a natural polyamine. It not only maintains telomere length and slows down aging, but also enhances autophagy. This contributes to prolonged lifespan and reduction of age-related diseases in a variety of model systems.

 

- Spermidine promotes hepatitis B virus clearance by increasing the expression of IL-21 and IFN-gamma. This provides new potential drugs for the treatment of hepatitis B.

 

- Spermidine exhibits the potential to dissolve beta-amyloid plaques, which are strongly correlated with age and memory capacity and may be a biomarker for neurocognitive changes such as dementia.

 

- Spermidine works by inhibiting DNA nitration and PARP1 activation. Wheat germ oil spermidine effectively protects the kidneys from ischemia-reperfusion injury and provides a new strategy for the treatment of acute kidney injury.

 

- Spermidine ​​​​​​bulk powder significantly reduced lung inflammation, neutrophil counts, lung tissue damage, collagen accumulation, and endoplasmic reticulum pressure, helping to prevent or treat acute lung injury and pulmonary fibrosis.

 

- In LPS-stimulated BV2 microglia, spermidine demonstrated significant anti-inflammatory effects by inhibiting the production of NO, PGE2, IL-6, and TNF-α via NF-κB, PI3K/Akt, and MAPK pathways.

 

- Wheat germ extract spermidine has powerful antioxidant activity, effectively scavenging DPPH and hydroxyl radicals. It prevents DNA oxidation and increases the expression of antioxidant enzymes, showing potential to prevent ROS-related diseases.

 

- Spermidine powder shows potential for the prevention and treatment of non-alcoholic fatty liver disease, obesity, and type II diabetes symptoms. It holds promise for widespread use in functional foods with significant metabolic health benefits.

 

- Spermidine enhances lachnospiraceaceae bacterial abundance and strengthens intestinal barrier function in obese mice. Demonstrating its potential benefits for gut health in food.

 

- Spermidine wheat germ extract effectively alleviates obesity and metabolic disorders by activating brown fat and skeletal muscle. The prospects for its food applications include combating obesity and promoting metabolic health.

 

- Dietary supplementation with spermidine may increase telomere length, affecting the aging process. Future studies need to further explore spermidine's food applications and longevity potential by inducing autophagy. Based on the current study, food applications of spermine in life extension and anti-aging are highly anticipated.

 

- Spermidine significantly enhances Nb CAR-T cytotoxicity in lymphoma cells by promoting proliferation and memory. Its potential for food application in immune enhancement deserves further exploration.

 

- After one year of administration, wheat germ extract powder positively affected the memory of Alzheimer's patients. Its potential value in food applications will be explored in depth.

 

- Spermidine is used to preserve citrus. It significantly reduces fruit drop while maintaining fruit quality and flavor. Spermidine was applied at a concentration as low as 1 mmol/L to effectively enhance plant immunity.

- Spermidine powder wheat germ extract demonstrated the potential to reduce oxidative stress in the silk glands of domestic silkworms. This provides a beneficial antioxidant for sericulture farmers. It can be applied in silkworm rearing.

 

Our factory:

There are two factories both in Baoji City and Shangluo City, Guanjie factories cover an area of 7000㎡, including the GMP standard workshop of 2000㎡.

 

Product Qualification

Spermidine wheat germ extract is produced in a clean working environment and every step is conducted by highly qualified professionals. Both the production processes of manufacture and the resveratrol 98 powder itself meet all international standards. And if you need our testing report, we can provide you.

 

Testing Center:

Both the production processes of manufacture and the product itself meet all international standards. And if you need our testing report, we can provide you.

 

Certification

We have obtained the NON-GMO from Pony Test International Group. We get certifications in HALAL, ISO 9001, ISO 22000, Kosher, PAHS, SC, and so on.

 

 

Package&Warehouse:

 

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