Spine Date Seed Extract

Spine date seed Extract Supplier:

Guanjie Biotech is specializing in spine date seed extract. All of our spine date seed extract powder adheres to a strict quality control system. Strict testing is carried out at every step of the production process, from raw material procurement. The coproduction is under the construction of GMP standards. And our products have passed many international certifications. Such as ISO9001, HACCP, HALAL, Kosher and so on. If you are interested in our products, please feel free to consult us: at info@gybiotech.com.

COA:

Item	Standard	Method
Appearance	Brownish yellow powder	Visual Inspection
Character	Fine powder, no agglomeration, no foreign matter visible to the naked eye	Visual inspection
Taste and odour	Consistent with the previously provided samples, no odour	Nose, mouth
Granularity (mesh)	95% pass 80 mesh sieve	Chinese Pharmacopoeia, 2015 Edition, Four General Principles
Total saponin, g/100g	≥2.0	HPLC
Moisture, g/100g	≦5.0	GB 5009.3 The first method
Ash, g/100g	≦5.0	GB 5009.4 First Method
Total arsenic (As), mg/kg	≦2.0	GB 5009.11 Second method
Lead (as Pb), mg/kg	≦1.0	GB 5009.12 First Law
Total colony count, CFU/g	n=5, c=2, m=1000CFU/g, M=50000CFU/g	GB 4789.2
Mould, CFU/g	＜50	GB 4789.15
Staphylococcus aureus, CFU/g	n=5, c=1, m=100CFU/g, M=900CFU/g	GB 4789.10
Coliforms, CFU/g	n=5, c=2, m=10CFU/g, M=100CFU/g	GB 4789.3 Second method
Salmonella, CFU/g	n=5, c=0, m=0	GB 4789.4

 

What is Sour Date Kernel?

Spine date seed extract is from a plant in the family of Rhamnaceae. Spine date seed is a wild resource, widely distributed in the northern region of China. Its mature seeds are sour jujube kernels. The main components of sour jujube kernel are saponins, flavonoids, and alkaloids. Modern research has shown that sour jujube kernel has pharmacological effects. Such as, tranquilize the mind and calm the nerves, anti-inflammatory, antioxidant, and antidepressant, enhance the function of the immune system and improving the ability to learn and remember. Sour jujube kernel is used as a traditional Chinese medicine in the category of medicine and food. It has mild medicinal effects and low side effects. It is now widely used in the fields of food, healthcare products and medicines.

 

Health effects

• Sedative and hypnotic

Sour date kernel is firstly known for its sedative and sleep-enhancing effects in pharmacology. Some studies have found through mouse experiments that total flavonoids. The active ingredient in spine date seed extract can inhibit the spontaneous generation of some activities in experimental mice. At the same time, it prolonged the sleep time of mice and inhibited the excitation central nerve of mice. Based on this research, some experts and scholars have shown that the saponin of sour jujube kernel also plays a role in the whole sedation, and also has a hypnotic effect. Sour date nut alkaloids were instilled into the stomachs of mice, and it was found that the spontaneous generation of activity in the experimental mice gradually decreased. The sleep quality of the experimental mice improved, and the sleep time increased significantly. At the same time, a large number of experiments proved. The alkaloids in sour date kernel also have the above effects.

 

• Antioxidant, anti-anxiety

In addition to its sedative and hypnotic effects, sour jujube kernel also has antioxidant and anti-anxiety effects. At present, some experts and scholars have shown that the total flavonoids in sour jujube kernel is a better natural antioxidant. Experimental data have fully proved that the total flavonoids in sour jujube kernel have significant antioxidant effects. Some studies explored the relationship between the content of active ingredients in sour jujube kernel and antioxidant activity, and the results showed that the antioxidant activity of sour jujube is directly proportional to the content of phenolic acids, which are the active ingredients in sour jujube kernel. It is speculated that the reason leading to the above conclusion is that the active ingredient phenolic acids in sour jujube kernel will enhance the activity of antioxidant enzymes. Other researchers have suggested that the total flavonoids in sour jujube kernel not only have antioxidant effects, but also have anti-anxiety effects.

 

• Anti-tumour

Some researchers and scholars have shown that both sour date oil and betulinic acid in spine date seed extract exhibit better anti-tumour activity. Studies have shown that betulinic acid, the active ingredient in sour jujube kernel, can induce the death of tumour cells more obviously, thus indicating that sour jujube kernel has anti-tumour effects. In addition, it was found that a certain dose of sour date oil was instilled into the stomachs of experimental mice, and it was found to prolong the survival days of mice suffering from Ehrlich ascites carcinoma. It is inferred that the oil of sour date kernel plays an anti-tumour role.

 

• Liver protection

Sour date kernel has the effect of unifying and protecting the liver. It is often used in the treatment of chronic hepatitis-induced liver and kidney yin deficiency.

Yin deficiency of the kidney and the heart, insomnia, night sweating and other conditions caused by chronic hepatitis. Some researchers have summarised the previous studies on the effects of sour jujube seed soup on liver protection and hepatitis treatment, with TNF-α, total bilirubin in serum, and plasminogen activity as the main indicators. After the experiment, it was proved that sour jujube nut soup can effectively reduce the damage of inflammatory cells to stem cells, and the body does not produce adverse reactions.

 

The dynamic of Laws and Regulations

• China

In China, spine date seed extract is widely used in health supplements and traditional Chinese medicine. According to the Chinese Pharmacopoeia, sour jujube kernel is mainly used to treat symptoms such as insomnia and palpitations. It is classified as a food supplement and an ingredient of traditional Chinese medicine and has detailed quality control standards. The State Food and Drug Administration (CFDA) regulates it to ensure its safety and efficacy.

 

• United States

In the United States, sour date extract is commonly sold as a dietary supplement. The US Food and Drug Administration (FDA) regulates dietary supplements. However, the regulation is relatively lax compared to drugs. Manufacturers must ensure that their products are safe and that labeling claims comply with regulations. Under the Dietary Supplement Health and Education Act (DSHEA), date palm extract does not require prior approval from the FDA to be marketed. However, the FDA has the authority to take action if there are safety concerns.

 

• Europe

In Europe, spine date seed bulk extract is used as a traditional herbal remedy and dietary supplement. The European Food Safety Authority (EFSA) is responsible for assessing its safety and efficacy. In some countries, such as Germany and France, date palm extract may be subject to a rigorous herbal drug approval process. In other countries, it may be sold as a food supplement. Overall, the regulation of date palm extracts in Europe is more rigorous, with a focus on scientific evidence to support it.

 

• Japan

In Japan, spine date seed extract is considered a traditional herbal medicine and dietary supplement. It is regulated by the Japanese Ministry of Health, Labour and Welfare and manufacturers are required to comply with relevant safety and quality standards. Date palm kernel extract is commonly used in Japan to improve sleep and reduce stress and must comply with the Guidelines for Functional Ingredients in Health Foods.

 

• Australia

In Australia, date palm extract is categorized as a complementary medicine and health food. It is regulated by the Australian Therapeutic Goods Administration (TGA) to ensure its safety and efficacy. Manufacturers are required to provide scientific evidence of efficacy and product labeling needs to comply with TGA regulations.

 

Applications

Spine date seed extract has multiple pharmacological activities such as sedative and tranquilizing, antidepressant, antitumor, hypolipidemic and antioxidant. It has a broad prospect for development in the fields of food, health products and drugs. As people nowadays live and work under pressure and suffer from serious insomnia, sour jujube kernel has the highest demand for application in the field of tranquilizing the mind and calming sleep. At present, the market has launched a variety of healthcare products with sour date kernel extract as the main ingredient. The functions of the products are mostly focused on improving sleep quality and relieving anxiety. In addition, due to the high safety of sour date kernel, it is also commonly used in food. For example, acidic vegetable protein drinks with healthcare functions are developed by fermenting Lactobacillus bulgaricus and Streptococcus thermophilus with sour date kernel powder and sour milk as the main raw materials.

 

Status of production technology

At home and abroad, the extraction method of the active ingredients in the sour date kernel powder mainly adopts the solvent extraction method and the water vapor distillation method in the traditional way. However, the disadvantages of the traditional methods are that there exists a long extraction time, low extraction efficiency, and the extracted active ingredients can not be improved in terms of both yield and quality. For the above shortcomings, in recent years, the separation and purification technology and analytical methods of jujube kernel have been continuously improved and upgraded.

 

Guanjie Biotech adopts a supercritical fluid extraction method and ultrasonic extraction method to extract spine date seed extract. Adopting the current high-tech mainly include supercritical fluid extraction method, membrane separation method, semi-biomimetic extraction method, ultrasonic extraction method, enzyme method, large pore resin adsorption method, ultrafiltration method, molecular distillation method and so on.

 

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Certification

 

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