Bulk NMN

bulk NMN supplier

Guanjie Biotech is a professional bulk NMN supplier and manufacturer with more than 20 years of experience in product development and production. We specialise in providing high-quality NMN powder products for the global health supplement and nutraceutical industries. By utilising advanced freeze-dried and vacuum-dried processing technologies, we ensure excellent product stability, purity, and activity. Our strict quality control system guarantees consistent standards for every batch. With reliable supply capacity and professional service, our products are trusted by customers in over 100 countries worldwide. Guanjie Biotech is committed to delivering high-quality NMN raw materials and customised OEM/ODM solutions to meet diverse market needs. If interested in our NMN bulk powder, welcome to contact us: info@gybiotech.com.

 

COA

TEST	METHOD	ANALYTE	SPECIFICATION	RESULT
Identify	NMR		Conforms to structure	Conforms to structure
Purity	HPLC/UV(wt%)		≥99.5%	99.80%
Moisture	Karl Fischer	Water	≤ 5%	0.50%
Sodium content			≤ 1%	0.05%
pH value		in water at 100mg/ml	2.0 - 4.0	3.14
Heavy Metals		Lead Arsenic	≤ 5 ppm	0.02 ppm
			≤ 5 ppm	0.03 ppm
Microbial	USP<2021> USP<2022>	Total Plate Count E. coli	≤ 750 CFU/g ≤ 30 MPN/100g	5 CFU/g N.D.
Appearance	NA	Color, Form	White to yellowish powder	yellowish powder

 

What Does NMN dO?

•Improves intestinal barrier function:

Studies have found that NMN restores the integrity of the epithelial barrier in the colon and promotes stem cell regeneration. By increasing the number of cuprocytes and improving intestinal mucosal barrier function, NMN helps prevent harmful molecules such as pathogens from entering the bloodstream and protects intestinal health.

In a study on mice, mice in the NMN group had fewer acute and chronic inflammatory cells in the lamina propria of the intestinal mucosa and a clear intestinal wall structure, showing better intestinal health compared to a control group without bulk NMN supplementation.

 

•Reorganisation of the gut microbiome:

Analyses showed that NMN was able to increase the diversity of intestinal species and alter faecal metabolites, which in turn restructured the gut microbiome of aged mice. Such changes are critical for gut homeostasis and help maintain gut health.

In one study, an increase in beneficial bacteria in the NMN-treated group was accompanied by an upregulation of 118 metabolites and a downregulation of 79 metabolites compared to a control group that was not supplemented with bulk NMN , changes that suggest NMN powder has a positive impact on gut microbiota and metabolism.

 

•Increased gene expression and stem cell viability:

It was found that NMN supplementation can delay intestinal aging by increasing Lgr5 gene expression and promoting intestinal stem cell proliferation. Stem cells play a key role in maintaining intestinal health, and their ability to proliferate and differentiate declines with age, which NMN can improve.

In their study, researchers at Keio University in Japan found that Lgr5 gene expression was significantly lower in older mice compared to younger mice, while bulk NMN powder supplementation resulted in increased levels of Lgr5 gene expression and improved intestinal stem cell proliferation in older mice.

 

•Improvement of intestinal cell function:

NMN was also able to improve intestinal cell function and reduce inflammation and oxidative stress. By upregulating the expression of intestinal deacetylases SIRT3/SIRT6, antioxidant enzyme-related genes SOD2 and Nrf2/HO-1, NMN enhanced the antioxidant and anti-inflammatory capacity of intestinal cells.

A study using the D galactose-induced enterocyte senescence model found that NMN reduced the level of oxidative stress in senescent cells and improved intestinal cell barrier function.

 

•Remodelling gut flora diversity:

NMN was able to remodel the diversity of the intestinal flora and increase the number of beneficial bacteria, which is essential for maintaining intestinal health. The state of balance of the intestinal flora is directly related to the health of the intestinal tract and even the human body, and NMN supplementation helps maintain this balance.

Bulk NMN delays the aging of the gut and keeps the gut younger by improving the gut barrier function, restructuring the gut microbiome, increasing gene expression and stem cell viability, improving intestinal cell function, and reshaping the diversity of the gut flora.

 

Why Choose Guanjie Biotech's NMN?

Currently, most of the world's NMN raw materials are produced in China, and Guanjie Biotech's bulk NMN has developed a mature production system, intellectual property rights and production experience. We have started to adopt a higher level of production system, which requires a higher quality of our products.

 

• Raw material production process

Bio-enzyme catalysed method is the most popular production method. The threshold is high. Several key catalytic enzymes are expensive, accounting for about 80% of the cost of the entire production process, but it is also the safest and most efficient way of production. The use of food-grade raw materials in the production of bulk NMN is an important part of ensuring product safety. The raw materials used in the production of NMN should be those listed in the Chinese Pharmacopoeia and other relevant regulations to ensure that standards are followed.

 

• High standard production conditions

Guanjie Biotech adopts high standards of production conditions. Production conditions refer to the standard of labour consumption necessary to complete a unit of qualified bulk NMN under certain conditions of production organisation and production technology. There are certificates issued by regulatory agencies.

 

• 100,000 class clean room

Guanjie Biotech has more authoritative third-party certifications. For example: ISO9001, British Retail Consortium (BRC) 'Global Standard for Food Safety', Kosher, Halal, etc. Competent manufacturers usually set up higher-level production conditions and usually obtain ISO9001 or even more certificates in the first place.

• High standard product testing

Nicotinamide Mononucleotide NMN powder testing requires reliable testing methods and testing reagents. It runs through the whole production process. Not only the inspection standard of the final product, but also the inspection standard of the intermediate link is needed for control. This includes testing of active ingredients, testing of heavy metals such as lead, arsenic and mercury, and testing of pathogenic bacteria, microorganisms and processing by-products. For bulk NMN products, the more common testing method for active ingredient content is High Performance Liquid Chromatography (HPLC), which is highly efficient, accurate and precise. The standard of the reagents used for the test varies from manufacturer to manufacturer. Rigorous manufacturers purchase high-purity analytical reagents from third-party standards companies to use as controls.

 

• High-performance liquid chromatography analysis and other instruments

In addition, bulk NMN are substantially similar to Chinese health food. The safety indicators of health food shall comply with GB16740-2014 National Standard for Food Safety Health Food. Including safety indicators and test methods. Specifically, such as sensory requirements, pollutant limits, microbiological limits, and so on. This is the reference testing standard for NMN.

 

• Safety Assessment

For newer ingredients such as NMN bulk powder, it is not enough for consumers to judge the safety of the bulk Nicotinamide Mononucleotide based on our word alone. At this point, the third-party authoritative assessment report is particularly important.

There are two types of safety assessment reports in common use today. -Toxicological assessment report. The second is the safety assessment report. It is usually the toxicological assessment report that is predominant. However, there are still very few NMN companies that can issue this report.

 

• Storage and Packaging

NMN powder is usually stored in a freeze-sealed manner. Generally, it can be stored for 12 months, if it can be stored for 24 months, and the change of purity is not obvious, then the stability of NMN is very reliable. Currently, the more common packaging materials for PET or HOPE material, are pharmaceutical packaging materials, non-toxic, odourless, lightweight, easy to carry, effective isolation of air and moisture, of which HDPE material is better than PET material.

 

• Product indicators

Currently, there is no publicly released standard for NMN bulk powder raw materials. Raw material manufacturers implement their own corporate standards. Some of them advertise 99% purity, while others advertise 99.5% purity when it is less than 99%. This results in a wide range of key metrics and even safety indicators for NMN raw materials, and GuanjieBiotech's bulk NMN is based on strict standards. If you are interested in our bulk Nicotinamide Mononucleotide, please feel free to contact us. We will send you back the test report.

 

Factory&Team：

 

Certification

 

Package & Shipment

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