Micronized Trans Resveratrol Powder

What Is Micronized Trans Resveratrol Powder?

Guanjie Biotech is a micronized trans resveratrol powder manufacturer and supplier. Resveratrol is a natural polyphenol compound. It is mainly found in grapes, blueberries, peanuts and other plants. It has powerful biological activities such as antioxidant, anti-inflammatory, anticancer and cardiovascular protection. However, the application of resveratrol faces an important bottleneck - its extremely low solubility in water, resulting in low absorption and insufficient bioavailability in the human body.

To overcome this problem, Guanjie Biotech has developed micronized trans-resveratrol powder. Through advanced crushing technology, the size of resveratrol particles is reduced to 2-10 microns, which significantly improves its absorption efficiency and breaks through the bottleneck of bioavailability of traditional resveratrol products.

 

COA:

Product Name: Resveratrol( Micronized)
Item	Specification	Result	Method
Basic Product Information
Genus and Species	Pohygonum cuspidatum Sieb et Zucc．	Conform	/
Part of the Plant	Root	Conform	/
Country of Origin	China	Conform	/
Marker Compounds
Assay(Trans-resveratrol)	>99.0%	99.76%	HPLC
Emodin	<0.07%	0.02%	HPLC
Organoleptic Data
Appearance	Fine Powder	Conform	/
Color	Off-white to light yellow	Conform	/
Odor	Characteristic	Conform	/
Taste	Characteristic	Conform	/
Process Data
Method of Processing	Extraction	Conform	/
Solvent(s) Used	Ethanol & Water	Conform	/
Drying Method	Vacuum drying	Conform	/
Excipient	None	Conform	/
Ratio of Extraction	100:1	Conform	/
Physical Characteristics
Solubility	Soluble in Alcohol	Conform	Visual
Particles size analysis	d(10%)	0.353μm	GB/T 5507-2008
d(50%)	1.392μm
d(90%)	2.951μm
Surface area mean diameter D【3,2】	2.423μm
Volume mean diameter D【4,3】	3.757μm
Size range	0.059-112.0 μm
Loss on drying	<1.0%	0.51%	GB/T 14769-1993
Ash Content	<1.0%	0.48%	AOAC 942.05, 18th
Solvent Residue	Eur Pharm (Alcohol)	298ppm	GJ-QCS-1007
Heavy Metals
Total Heavy Metals	<10 ppm	Conform	USP<231>, method II
As	<2.0 ppm	Conform	AOAC 986.15, 18th
Pb	<2.0 ppm	Conform	AOAC 986.15, 18th
Hg	<0.5 ppm	Conform	AOAC 971.21, 18th
Cd	<0.5 ppm	Conform	AOAC 971.21, 18th
Pesticide Residue
666	<0.2ppm	Conform	GB/T5009.19-1996
DDT	<0.2ppm	Conform	GB/T5009.19-1996
Microbiology
Total Plate Count	<1,000cfu/g	Conform	AOAC 990.12, 18th
Total Yeast & Mold	<100cfu/g	Conform	FDA (BAM) Chapter 18, 8th Ed.
E. Coli	Negative	Negative	AOAC 997.11, 18th
Salmonella	Negative	Negative	FDA (BAM) Chapter 5, 8th Ed.

 

Limitations Of Usual Resveratrol

Although resveratrol shows a wide range of potential in the prevention and treatment of a variety of diseases, its effects in practical applications are limited in many ways, the most important problems being its low water solubility and low bioavailability.

- Low water solubility:

Resveratrol is virtually insoluble in water, resulting in its extremely limited dissolution and absorption in the gastrointestinal tract. Most of the resveratrol ingested by the human body is difficult to be effectively absorbed and eventually excreted from the body. Micronized trans resveratrol powder overcomes this problem.

 

- Low bioavailability:

Even if part of resveratrol is absorbed by the intestinal tract, due to its fast metabolism in the body, especially after the first-pass effect of the liver, the content of the active ingredient in the blood circulation is low, resulting in its actual bioavailability is very low.

- Particle size limitation:

The particle size of common resveratrol is usually between 100-500 microns. Larger particles will further limit its absorption area in the intestinal tract, thus affecting its absorption efficiency.

 

Guanjie Biotech's Micronised Resveratrol Technology

Guanjie Biotech's micronized trans resveratrol powder solves the solubility and bioavailability limitations of regular resveratrol. We use a matrix mill to reduce the particle size of resveratrol to 2-10 microns. The core of this innovative technology is the significant increase in the specific surface area of the particles through pulverization, which in turn improves absorption.

- Introduction to Micronisation

Micronization is the process of reducing the size of solid particles to the micron level, for example, by mechanical comminution or airflow pulverization. Guanjie Biotech's bulk micronized resveratrol is pulverized using a state-of-the-art matrix pulverizer. This pulverizer uses high-speed rotating mechanical forces and airflow impact to break up the raw particles into the 2-10 micron range.

 

- Particle Size Effect on Absorption

Particle size is an important factor in the efficiency of absorption of a drug or nutrient in the body. Ordinary resveratrol particle size is 100-500 microns. While after micronisation the resveratrol particles are reduced to 2-10 microns. The surface area of the particles is significantly increased. According to the principle that the surface area is proportional to the square of the radius of the particles, the absorption area of trans resveratrol micronized particles increases by 1000 times. This results in a dramatic increase in the dissolution rate and absorption efficiency of resveratrol in the gastrointestinal tract.

 

- Principle of increased absorption

Micronized resveratrol due to the significant reduction in particle size. The following aspects significantly increase its absorption rate.

 

- Increase in specific surface area:

The smaller the particle size, the larger its specific surface area. It is able to come into fuller contact with the absorption interface in the intestines, thus accelerating the dissolution and absorption of resveratrol.

 

- Shortened absorption pathway:

Smaller particles of micronized trans resveratrol powder can pass more easily through the cells of the intestinal wall into the blood circulatory system, reducing the obstruction of passage through the intestinal mucosa.

 

- Accelerated dissolution rate:

Micronized particles are smaller in size and their dissolution process is accelerated. More micronized trans-resveratrol is able to enter the body's absorption system in a shorter period of time, thus increasing bioavailability.

 

Advantages of Micronised Resveratrol

- Significant increase in bioavailability

Through micronization, the particle size of resveratrol is significantly reduced. This greatly improves its absorption efficiency in the intestinal tract. Studies have shown that the bioavailability of micronized resveratrol can be increased by several times or even tens of times compared with ordinary resveratrol. The body can absorb and utilize more of the active ingredients when consuming the same dose of resveratrol, resulting in greater biological activity.

 

- Rapid onset of action

Due to the accelerated dissolution rate and absorption of micronized trans resveratrol powder, users are able to experience its effects more quickly. Micronised Resveratrol has significant advantages for users who are in dire need of antioxidant protection or anti-inflammatory effects.

 

- Improves solubility issues

Although resveratrol is inherently insoluble in water, the dissolution rate of resveratrol is significantly improved by micronization. It can be absorbed more readily into the aqueous environment of the gastrointestinal tract. This is important for enhancing the oral administration of resveratrol. In particular, a high absorption rate can be ensured without the use of other chemical solubilizing agents.

 

- Lower dosage to achieve the desired effect

Due to its low absorption rate, ordinary resveratrol usually requires a higher dosage to achieve the desired effect. On the other hand, micronized trans resveratrol powder is much more efficiently absorbed. Users only need to consume a lower dose to achieve the same or even better effect. This not only reduces the side effects that may be brought about by excessive intake but also reduces the production and use costs.

 

Functions Of Resveratrol

Resveratrol has received widespread attention for its multiple biological activities, and the following are its main functions:

- Antioxidant effect:

Resveratrol is a potent antioxidant, capable of neutralizing free radicals in the body, reducing the damage to cells caused by oxidative stress, and slowing down the aging process.

 

- Anti-inflammatory effect:

Through inhibiting the production of inflammatory mediators, resveratrol is able to reduce chronic inflammatory reactions in the body and has potential therapeutic effects on many inflammatory diseases.

 

- Anti-cancer effects:

Studies have shown that resveratrol is able to inhibit the proliferation of cancer cells at the cellular level, induce apoptosis of cancer cells and inhibit angiogenesis of tumors.

 

- Cardiovascular protection:

Resveratrol bulk powder can effectively prevent atherosclerosis and other cardiovascular diseases by regulating blood lipids, lowering blood pressure and improving vascular function.

 

- Neuroprotection:

Pure Resveratrol has a neuroprotective effect and can reduce neuroinflammation, which may have potential prevention and treatment effects on neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease.

 

Application of micronized resveratrol

- Healthcare products

Micronized trans resveratrol powder can provide health products with more efficient bioactive ingredients. Many health product manufacturers have begun to apply micronized resveratrol in the form of capsules, tablets, oral liquids, etc., in order to improve the efficacy of their products.

 

- Cosmetic field

It has antioxidant and anti-aging properties. Micronized trans-resveratrol bulk powder also shows great potential for application in the cosmetic field. Micronisation technology makes resveratrol easier to be absorbed by the skin. Therefore it is often used in anti-aging skin care products. Such as serums, creams, etc.

 

- Pharmaceuticals

In the field of pharmaceuticals, micronization resveratrol for bioavailability and fast absorption. Resveratrol processed through micronization technology can provide a more effective way for drug development.

 

Company Advantages:

Guanjie Biotech's factory is fully qualified. We have many kinds of SC extracts production license, carry out the record production of traditional Chinese medicine extracts, and are the record manufacturer of export food production. We have various quality, HALAL and KOSHER certificates. Our micronized trans resveratrol powder uses advanced pulverization technology to reduce the particle size to 2-10 microns, which increases its specific surface area by 1000 times and dramatically improves absorption efficiency. Micronized resveratrol's high bioavailability, fast onset of action, and low dosage make it promising for a wide range of applications in nutraceuticals, cosmetics, and pharmaceuticals. This innovative product overcomes the limitation of low absorption of traditional resveratrol and provides consumers with a more efficient option for resveratrol supplementation.

 

Certification

 

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